Annals of dermatology最新文献

{"title":"Efficacy and Safety of Needle-Free Microjet Injection Versus Needle Injection of Botulinum Toxin for the Treatment of Crow's Feet: A Randomized Split-Face Pilot Study.","authors":"Young Gue Koh, Woo Geon Lee, Kui Young Park","doi":"10.5021/ad.23.161","DOIUrl":"10.5021/ad.23.161","url":null,"abstract":"<p><strong>Background: </strong>Botulinum toxin is commonly used for cosmetic enhancements in various applications. However, the pain experienced during the injection process remains a significant concern.</p><p><strong>Objective: </strong>This study aimed to evaluate the effectiveness and safety of a needle-free microjet drug injector, powered by an Er:YAG laser, for the injection of botulinum toxin to treat crow's feet wrinkles.</p><p><strong>Methods: </strong>Botulinum toxin injections were randomly administered using a microjet injector on one side and a conventional needle injection on the other. The results were evaluated by two dermatologists, who were blinded to the treatment method. They used a 5-point scale to assess the severity of both static and dynamic crow's feet before and after the treatment. The participants' pain levels during the procedure were measured using a visual analog scale, and the physician/subject global aesthetic improvement scale (GAIS) was used to assess overall aesthetic improvement.</p><p><strong>Results: </strong>Ten Korean women (mean age, 50.7) participated in the study. Both sides exhibited significant improvement in crow's feet wrinkles compared to the baseline, with no noticeable differences between the two sides. The microjet injector side showed a significantly lower mean pain score, while there was no difference between the sides in terms of P/SGAIS scores. The evaluation of the wrinkle scale demonstrated high reliability.</p><p><strong>Conclusion: </strong>The needle-free microjet drug injector, which utilizes an Er:YAG laser, may be a useful option for treating crow's feet wrinkles with botulinum toxin due to its ability to reduce pain.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"355-360"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Effects of Topical Photosensitizer, Photodithazine Using Micro-LED for Acne Bacteria Induced Inflammation.","authors":"Su Min Lee, Soo-Hyun Kim, Zun Kim, Jee-Bum Lee","doi":"10.5021/ad.23.157","DOIUrl":"10.5021/ad.23.157","url":null,"abstract":"<p><strong>Background: </strong>Photodynamic therapy (PDT) using topical photosensitizers has been widely used worldwide as a therapeutic modality for acne. However, there are no published reports on photodithazine PDT for acne treatment.</p><p><strong>Objective: </strong>We investigated the effectiveness of PDT with photodithazine and micro-LED treatment for acne bacteria-induced inflammation.</p><p><strong>Methods: </strong>We established an acne bacteria-induced inflammation model by injecting of <i>Cutibacterium acnes</i> into the backs of HR-1 mice. The mouse models were divided into seven groups for control and comparison. Topical photosensitizer (photodithazine) was administered to the mice, and then their acne lesions were exposed to a micro-light-emitting diode (micro-LED) source. The effectiveness of the treatment on acne lesions was evaluated through clinical findings and measurements of acne inflammation biomarkers using semi-quantitative reverse transcription polymerase chain reaction, and Western blot. Additionally, hematoxylin and eosin staining and immunohistochemical staining were employed to evaluate the changes in inflammatory cells and biomarkers in skin tissues.</p><p><strong>Results: </strong>Compared with the control groups treated with either LED or photosensitizer alone, the acne lesions were significantly reduced in severity and number after PDT. The mRNA and protein levels of biomarkers (interleukin [IL]-1α, IL-1β, tumor necrosis factor-α, Toll-like receptor 2, matrix metalloproteinase-2, and IL-8) exhibited variable decreases in the PDT group relative to the others. Moreover, there was a decline in inflammatory cells and biomarkers in skin specimens after PDT.</p><p><strong>Conclusion: </strong>This <i>in vivo</i> study demonstrated that PDT using photodithazine and micro-LED technology is effective against inflammation induced by acne bacteria.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"329-340"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Patch Test Results Before and After Mask Use in Patients With Facial Dermatoses.","authors":"Woo Kyoung Choi, Hyun Bo Sim, Hui Young Shin, Yu Jeong Park, Ai Young Lee, Seung Ho Lee, Jong Soo Hong","doi":"10.5021/ad.24.003","DOIUrl":"10.5021/ad.24.003","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"389-391"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of Patients Treated With Hair Transplants in Female Pattern Hair Loss.","authors":"Deakwan Yun, Dongho Kim, Chung Juhyun, Kyujin Yeom, Myung Hwa Kim, Mi Soo Choi, Geun Park, Jae Hyun Park, Jisup Ahn, Jinwook Jung, Hangrae Cho, Sungjoo Hwang, Byung Cheol Park","doi":"10.5021/ad.23.158","DOIUrl":"10.5021/ad.23.158","url":null,"abstract":"<p><strong>Background: </strong>Hair transplantation (HT) has been reported to be effective for the treatment of female-pattern hair loss (FPHL). Few studies have investigated HT in FPHL.</p><p><strong>Objective: </strong>To evaluate the clinical features of FPHL treated with HT and analyze the real-world results of HT.</p><p><strong>Methods: </strong>We conducted a retrospective chart review of 195 FPHL patients who underwent hair transplants. The patients' demographics, clinical features, and clinical courses of HT were recorded.</p><p><strong>Results: </strong>The mean (±SD) age of patients was 49.1±11.9 years. Analysis of the severity of hair loss showed that 31.8%, 49.7%, and 18.5% of patients had F1, F2, and F3 types of hair loss (according to the BASP Classification); 88.2% of patients had more than 75% satisfaction with HT. The satisfaction level was significantly higher in the group that had the highest number of hairs implanted. Complications such as pain, facial edema, folliculitis, scar, paresthesia, telogen effluvium were found.</p><p><strong>Conclusion: </strong>This study could provide substantial information of HT in FPHL. Clinicians could deliver more sufficient counsel to FPHL patients about HT.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"341-347"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYR61 Is Overexpressed in Human Melanoma Tissue <i>Ex Vivo</i> and Promotes Melanoma Cell Survival and Proliferation Through Its Binding Ligand Integrin β3 <i>In Vitro</i>.","authors":"Yoon Jin Lee, Ki Dam Kim, Sukh Que Park, Dong Sung Kim, Yu Sung Choi, Hae Seon Nam, Sang Han Lee, Moon Kyun Cho","doi":"10.5021/ad.24.008","DOIUrl":"10.5021/ad.24.008","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"392-394"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Differential Diagnosis of Poroma and Poroma Mimicker: Retrospective, Multi-Center Study in Korea.","authors":"Jung Eun Seol, Sang Woo Ahn, Seung Hee Jang, Seong Min Hong, So Young Jung, So Hee Park, Un Ha Lee, Hai Jin Park, Hyojin Kim","doi":"10.5021/ad.23.070","DOIUrl":"10.5021/ad.23.070","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 5","pages":"318-321"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1.","authors":"Lipeng Tang, Bowen Zhang, Guanzhuo Li, Xinmin Qiu, Zixin Dai, Hongying Liu, Ying Zhu, Bing Feng, Zuqing Su, Wenhui Han, Huilin Huang, Qiuping Li, Zihao Zhang, Maojie Wang, Huazhen Liu, Yuchao Chen, Yanmei Zhang, Dinghong Wu, Xirun Zheng, Taohua Liu, Jie Zhao, Chutian Li, Guangjuan Zheng","doi":"10.5021/ad.23.118","DOIUrl":"10.5021/ad.23.118","url":null,"abstract":"<p><strong>Background: </strong>Excessive growth of keratinocytes is the critical event in the etiology of psoriasis. However, the underlying molecular mechanism of psoriatic keratinocyte hyperproliferation is still unclear.</p><p><strong>Objective: </strong>This study aimed to figure out the potential contributory role of S-phase kinase-associated protein 2 (SKP2) in promoting the hyperproliferation of keratinocytes in psoriasis.</p><p><strong>Methods: </strong>We analyzed microarray data (GSE41662) to investigate the gene expression of <i>SKP2</i> in psoriatic lesion skins compared with their adjacent non-lesional skin. Then, we further confirmed the mRNA and protein expression of SKP2 in human psoriatic skin tissues, imiquimod (IMQ)-induced psoriatic mice back skins and tumor necrosis factor α (TNF-α), interleukin (IL)-17A and IL-6-stimulated keratinocytes by using real-time quantitative polymerase chain reaction and western blot (WB). Furthermore, we explored the potential pathogenic role and its underlying cellular mechanism of SKP2 in promoting keratinocytes hyperproliferation through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, cell cycle detection, 5-ethynyl-2'-deoxyuridine staining and WB. Finally, we determined whether inhibition of SKP2 can effectively alleviate the keratinocytes hyperproliferation <i>in vivo</i>.</p><p><strong>Results: </strong>We identified that SKP2 is aberrantly upregulated in the psoriatic lesion skin and cytokines-stimulated keratinocytes. Moreover, upregulated SKP2 augments cytokines-induced keratinocytes hyperproliferation. Mechanistically, enhanced SKP2 increased the S phase ratio through inhibiting Cyclin-Dependent Kinase Inhibitor p27 (P27 Kip1) expression. Correspondingly, suppression of SKP2 with SMIP004 can significantly ease the epidermis hyperplasia <i>in vivo</i>.</p><p><strong>Conclusion: </strong>Our results suggest that elevated SKP2 can empower keratinocytes proliferation and psoriasis-like epidermis hyperplasia via downregulation of P27 Kip1. Therefore, targeting SKP2-P27 Kip1 axis might be a promising therapeutic strategy for the treatment of psoriasis in future.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 5","pages":"282-291"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dickkopf-related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-catenin Signaling Pathway in Human Dermal Papilla Cells.","authors":"Seon Bok Lee, Jae Won Lee, Hyemin Lee, Kyung-Ju Lee, Hye Won Hwang, Hyun-Tae Shin, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi","doi":"10.5021/ad.23.128","DOIUrl":"10.5021/ad.23.128","url":null,"abstract":"<p><strong>Background: </strong>The Wnt/β-catenin signaling pathway is crucial for the development, initiation, and growth of hair follicles (HFs). The Dickkopf-related protein (DKK) gene family encodes secreted proteins modulating the Wnt/β-catenin signaling pathway. Studies have reported that DKK1 promotes the regression of HFs and serves as a pathogenic mediator in male pattern baldness. However, the role of DKK2 on human hair growth has not yet been explored.</p><p><strong>Objective: </strong>This study investigates direct effect of DKK2 on hair growth using human dermal papilla cell (DPC) cultures and <i>ex vivo</i> human HF organ cultures.</p><p><strong>Methods: </strong>To elucidate the effect of DKK2 on hair growth, we examined the effect of recombinant human DKK2 (rhDKK2) treatment on cell viability, expression of mRNA and protein related to the Wnt/β-catenin signaling pathway, and cell growth in cultured human DPCs. We also performed <i>ex vivo</i> organ culture of HFs with rhDKK2 and measured changes in hair shaft length for 8 days.</p><p><strong>Results: </strong>Treatment with rhDKK2 led to a dose-dependent rise in the proliferation of human DPCs (<i>p</i><0.05), reaching levels comparable to those induced by 1 μM minoxidil. Moreover, rhDKK2 increased the expression of Wnt/β-catenin target genes, phosphorylated extracellular signal-regulated kinase, and cyclin-D1; it also increased the BAX-to-Bcl-2 ratio and downregulated the bone morphogenetic protein 2 gene. In human HF organ cultures, relative to the control treatment, rhDKK2 treatment significantly increased hair shaft elongation (<i>p</i><0.01).</p><p><strong>Conclusion: </strong>Our results indicate that rhDKK2 could promote hair growth by facilitating the proliferation of human DPCs through activation of the Wnt/β-catenin signaling pathway.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 5","pages":"292-299"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Hydration Measurement: Comparison Between Devices and Clinical Evaluations.","authors":"Ju Heon Park, YoungHwan Choi, Yeon Joo Jung, Taemin Lee, Heeyeon Kim, Youngjoo Cho, Jong Hee Lee","doi":"10.5021/ad.23.103","DOIUrl":"10.5021/ad.23.103","url":null,"abstract":"<p><strong>Background: </strong>The need for an objective method for measuring skin hydration levels is becoming increasingly important. Various devices with different measuring principles for assessing skin hydration have been developed and are widely used.</p><p><strong>Objective: </strong>This study aimed to investigate the reproducibility and correlation between clinical evaluation and skin hydration measurement devices that are the most widely used in the field.</p><p><strong>Methods: </strong>A prospective comparative clinical trial was conducted on 184 healthy volunteers. Skin hydration levels were measured using the Corneometer (CM820) and hydration probe (HP: DermaLab Combo) at 3 points: the ventral forearm, the dorsal forearm, and the shin. We used the intraclass correlation coefficient (ICC) to evaluate the reproducibility and Pearson's correlation coefficient (PCC) to evaluate the correlation of each measurement. Simple linear regression was used to analyze the Corneometer and HP skin hydration value changes according to changes in xerosis severity scale (XSS) values, which were evaluated by clinicians.</p><p><strong>Results: </strong>Both the Corneometer and HP showed significant, excellent reproducibility (ICC for Corneometer: 0.954-0.971, ICC for HP: 0.980-0.986) and significant high positive correlations (PCC: 0.708-0.737) regardless of the measurement site. Both devices showed negative regression coefficients in all measurement sites in XSS analysis, but this was not statistically significant.</p><p><strong>Conclusion: </strong>The Corneometer and HP were both accurate and objective skin hydration measuring devices, regardless of the measurement site. Using reliable and objective devices such as the Corneometer or HP can aid in understanding an individual's skin condition and making more informed decisions for skin care.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0005146.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 5","pages":"275-281"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Family Dermatology Life Quality Index of Spouses of Patients With Psoriasis: A Cross-Sectional Study.","authors":"Min Wu, Yingyuan Yu, Dawei Huang, Kai Wang, Yangfeng Ding, Yi Zhang, Yuling Shi, Xiaoping Zhu","doi":"10.5021/ad.23.073","DOIUrl":"10.5021/ad.23.073","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 5","pages":"322-325"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}