Annals of dermatology最新文献_第2页

Factors Affecting the Response and Patient Satisfaction of Topical Immunotherapy in Alopecia Areata: A Nationwide Study. 影响斑秃患者对局部免疫疗法的反应和满意度的因素：一项全国性研究。

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.23.138

Young Lee, Kyungmin Kim, Bark-Lynn Lew, Chang-Hun Huh, Hoon Kang, Yong Hyun Jang, Do Young Kim, Hyun-Tae Shin, Moon-Bum Kim, Jin Park, Min Sung Kim, Gwang Seong Choi

{"title":"Factors Affecting the Response and Patient Satisfaction of Topical Immunotherapy in Alopecia Areata: A Nationwide Study.","authors":"Young Lee, Kyungmin Kim, Bark-Lynn Lew, Chang-Hun Huh, Hoon Kang, Yong Hyun Jang, Do Young Kim, Hyun-Tae Shin, Moon-Bum Kim, Jin Park, Min Sung Kim, Gwang Seong Choi","doi":"10.5021/ad.23.138","DOIUrl":"10.5021/ad.23.138","url":null,"abstract":"Background: Contact immunotherapy using diphenylcyclopropenone (DPCP) is a recommended treatment for severe alopecia areata (AA); however, few clinical factors are known, and few standardized application methods affecting therapeutic efficacy have been devised.Objective: To confirm the therapeutic response of DPCP immunotherapy in AA, first we analyze the factors influencing its outcome and patient satisfaction levels, after which we standardize the DPCP treatment method for better outcomes.Methods: We utilized a nationwide questionnaire-based survey to assess patient satisfaction and undertook a medical record review involving 412 patients currently undergoing treatment for DPCP.Results: The patients' mean age was 36.4 years, and 27% of the cases were diagnosed as AA in childhood. Treatment response was higher when DPCP was used to treat the entire scalp, including subclinical lesions, and longer treatment durations and longer intervals between treatments were associated with a better treatment response. Atopy (atopic dermatitis, allergic rhinitis and bronchial asthma), thyroid disorder, and extent of hair loss were all negatively correlated with the treatment response. However, there was no correlation between the treatment response and factors such as the age of onset, a family history of AA, nail changes, or AA duration, which are commonly known to be associated with a poor prognosis.Conclusion: DPCP immunotherapy is an effective treatment for AA, and the study demonstrated the factors affecting DPCP treatment response and patients' satisfaction and may contribute to standardizing the DPCP treatment method for better outcomes.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"225-230"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail Psoriasis: Clinical Features and Severity Assessment. 指甲银屑病：临床特征和严重程度评估

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.24.026

Sang Woong Youn

引用次数: 0

Up-and-Coming Drugs for the Treatment of Vitiligo. 治疗白癜风的新兴药物。

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.24.038

Seol Hwa Seong, Sang Ho Oh

{"title":"Up-and-Coming Drugs for the Treatment of Vitiligo.","authors":"Seol Hwa Seong, Sang Ho Oh","doi":"10.5021/ad.24.038","DOIUrl":"10.5021/ad.24.038","url":null,"abstract":"Vitiligo is a chronic autoimmune disease that causes depigmented patches on the skin. It affects 0.5%-2.0% of the global population. It goes beyond physical appearance, often leading to stigmatization, low self-esteem, and depression, burdening patients with psychosocial challenges. The pathogenesis of vitiligo involves the loss of melanocytes due to autoreactive CD8+ T cells, triggered by environmental stressors and exacerbated by cellular vulnerabilities and immune responses. The release of danger signals and pro-inflammatory factors initiates an immune cascade perpetuating melanocyte destruction, mainly driven by interferon-γ and the C-X-C motif chemokine ligand 9/10-chemokine receptor 3 axis. Long-lasting tissue-resident memory T cells (Trms) and cytokines contribute to lesion persistence. Current treatments focus on topical steroids and tacrolimus, systemic steroids, and phototherapies, but their efficacy remains suboptimal, necessitating the development of new therapeutic options. Building on recent advancements in understanding the immunological mechanisms in vitiligo pathogenesis, with the initiation of Food and Drug Administration approval of topical ruxolitinib, various potential treatment options such as JAK inhibitors, cytokine blockers, and Trm or regulatory T cell targeting agents are being clinically researched and anticipated for vitiligo based on both preclinical and clinical data. This review aims to categorize and summarize the diverse investigational drugs currently undergoing clinical trials for vitiligo. By examining clinical outcomes, it is anticipated that this review will bring hope to dermatologists and patients regarding vitiligo, a condition that has historically posed challenges and transform it into a realm of potential possibilities.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"197-208"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intralesional Methotrexate Injection for the Treatment of Epithelial Crateriform Tumor. 局部注射甲氨蝶呤治疗上皮环状瘤

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.23.135

Jun Hyuk Cho, Hyun Mo Lee, Yoon Jae Kim, Dai Hyun Kim, Hyo Hyun Ahn, Soo Hong Seo

{"title":"Intralesional Methotrexate Injection for the Treatment of Epithelial Crateriform Tumor.","authors":"Jun Hyuk Cho, Hyun Mo Lee, Yoon Jae Kim, Dai Hyun Kim, Hyo Hyun Ahn, Soo Hong Seo","doi":"10.5021/ad.23.135","DOIUrl":"10.5021/ad.23.135","url":null,"abstract":"Background: Intralesional methotrexate injection (IL-MTX) is an appropriate strategy for treating epithelial crateriform tumors (ECTs) when surgical excision can result in functional or cosmetic defects; however, not all ECTs are responsive to this treatment.Objective: This study aimed to evaluate the effectiveness of IL-MTX for ECTs and to determine the differences in clinical response according to the pathological features.Methods: The medical records of patients treated with IL-MTX for their ECTs were retrospectively reviewed. Effectiveness was evaluated in terms of size reduction and flattening.Results: Twenty-five cases of ECTs with biopsy were included in this study. Eight cases of keratoacanthoma (KA) and 15 cases of squamous cell carcinoma (SCC) were identified, but 2 cases could not be clearly distinguished. Seventeen patients (68%) showed a response after injection, and response rate in KA and SCC were 75% (6/8) and 60% (9/15), respectively. Nine patients showed complete resolution with IL-MTX. Patients received 3 injections, and regression was observed in 7.56 weeks after the first injection. According to histopathological results, patients with KA and SCC received 2 and 3.33 injections, respectively, and complete resolution was observed after 7 and 7.67 weeks, respectively.Conclusion: IL-MTX is safe and effective, and could be considered as a useful non-surgical treatment option for ECTs. Both KA and crateriform SCC showed good response; However, KA showed a better response.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"209-214"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: Review of Scoring Systems for Hidradenitis Suppurativa. 撤回：湿疹评分系统综述

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.36.001

Youngbeom Kim, Jungsoo Lee, Hoon-Soo Ki, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim, Kihyuk Shin

引用次数: 0

Assessment of Serum Zonulin Levels in Individuals Diagnosed With Chronic Spontaneous Urticaria. 评估慢性自发性荨麻疹患者的血清 Zonulin 水平。

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.24.020

Alkım Ünal, Gözde Ülfer

{"title":"Assessment of Serum Zonulin Levels in Individuals Diagnosed With Chronic Spontaneous Urticaria.","authors":"Alkım Ünal, Gözde Ülfer","doi":"10.5021/ad.24.020","DOIUrl":"10.5021/ad.24.020","url":null,"abstract":"Background: There have been reports indicating a correlation between heightened intestinal permeability and many autoimmune and chronic inflammatory disorders. The involvement of autoimmunity is now recognized as a significant factor in the development of chronic spontaneous urticaria (CSU). Zonulin is an important biomarker that regulates tight junction permeability within cells in the gastrointestinal tract, hence facilitating intestinal permeability.Objective: To evaluate the correlation of CSU with intestinal permeability by measuring the serum levels of zonulin in patients diagnosed with CSU.Methods: The study included 60 patients diagnosed with CSU and 64 age- and sex-matched healthy individuals as controls. Levels of serum zonulin were determined using the ELISA method.Results: Although the serum zonulin value of the patients was higher compared to the controls, the difference did not reach a significant level (24.65±8.49 ng/ml vs. 21.03±7.36 ng/ml, p=0.077). The serum zonulin level had a significant correlation with the urticaria activity score in the CSU group (p=0.013). The results of the current study revealed that serum zonulin values significantly differed between patients with CSU and healthy controls.Conclusion: This study is important in terms of being the first to investigate the serum zonulin levels in CSU. However, there is a need for further studies with larger patient groups.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"231-235"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term Safety of Dimethyl Fumarate for Psoriasis in Korea. 富马酸二甲酯治疗牛皮癣在韩国的短期安全性。

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.23.054

Tae Min Kim, Seong Jin Jo

引用次数: 0

Biomaterial Stiffness of Wharton's Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium Modulates Fibroblasts Proliferation and Migration: A Preliminary Study. 沃顿果冻衍生间充质干细胞调节介质的生物材料硬度可调节成纤维细胞的增殖和迁移：初步研究。

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.23.048

Sangmin Choi, Jaeyun Kim, Soyul Kim, Yoonsung Lee, Man S Kim, Bark-Lynn Lew, Soon-Hyo Kwon

引用次数: 0

Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities. 具有双重抗皱功效的可溶解微针贴片的临床安全性和有效性评估，安全且长期有效

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.23.136

Ju Yeop Shin, DongHoon Han, Ki Young Yoon, Do Hyeon Jeong, Yong Il Park

{"title":"Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities.","authors":"Ju Yeop Shin, DongHoon Han, Ki Young Yoon, Do Hyeon Jeong, Yong Il Park","doi":"10.5021/ad.23.136","DOIUrl":"10.5021/ad.23.136","url":null,"abstract":"Background: Anti-aging products are widely used, but the desire for safe and more efficient anti-aging products continues to increase. Dissolving microneedle patches (MNPs) have provided a more efficient transdermal drug delivery solution. MNP is a promising candidate for developing better anti-aging products.Objective: To develop a more efficient anti-aging MNP product, we fabricated a dual anti-wrinkle microneedle patch (named DA-MNP) using droplet extension (DEN®) technology and evaluated its skin puncture ability, safety, and efficacy through clinical studies.Methods: A DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN® technology. Placebo MNPs comprising only HA were also fabricated. Twenty-four healthy subjects were enrolled in this comparative clinical study. The DA-MNP or placebo MNP was separately applied to the left and right eyes of subjects for overnight. Assessments, including wrinkle improvement, trans-epidermal water loss (TEWL), eye lifting and adverse effects were evaluated at each scheduled visit day for 28 days.Results: The DA-MNP showed mechanical strength enough for puncturing the stratum corneum. Compared to placebo MNP group, the DA-MNP treated group showed an effective eye wrinkles improvement and better anti-aging of skin, with reduced TEWL, enhanced skin elasticity and lifting, and no adverse effects.Conclusion: The present study demonstrated that the fabricated DA-MNP exhibited fast acting on deep wrinkles and enhanced anti-aging efficacy, with no skin safety concern. Thus, this DA-MNP may serve as a new transdermal delivery solution for skin wrinkling and aging.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"215-224"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Korean Consensus Criteria for the Severity Classification of Alopecia Areata. 韩国脱发严重程度分类共识标准》。

Annals of dermatology Pub Date : 2024-08-01 DOI: 10.5021/ad.24.058

Yong Hyun Jang, Seung Soo Lee, Do Young Park, Young Lee, Do-Young Kim, Hyunsun Park, Hyun-Tae Shin, Jung Eun Kim, Kihyuk Shin, Ji Hae Lee, Jee Woong Choi, Byung Choel Park, Beom Joon Kim, Soo Hong Seo, Chong Hyun Won, Jin Park, Min Sung Kim, Sang Seok Kim, Bark-Lynn Lew, Chang-Hun Huh, Ohsang Kwon, Yang Won Lee, Moon-Bum Kim

{"title":"Korean Consensus Criteria for the Severity Classification of Alopecia Areata.","authors":"Yong Hyun Jang, Seung Soo Lee, Do Young Park, Young Lee, Do-Young Kim, Hyunsun Park, Hyun-Tae Shin, Jung Eun Kim, Kihyuk Shin, Ji Hae Lee, Jee Woong Choi, Byung Choel Park, Beom Joon Kim, Soo Hong Seo, Chong Hyun Won, Jin Park, Min Sung Kim, Sang Seok Kim, Bark-Lynn Lew, Chang-Hun Huh, Ohsang Kwon, Yang Won Lee, Moon-Bum Kim","doi":"10.5021/ad.24.058","DOIUrl":"10.5021/ad.24.058","url":null,"abstract":"Background: A set of criteria for severity classification is essential in alopecia areata (AA). Currently, no guidelines are universally accepted for defining AA severity.Objective: This study aimed to establish a set of consensus criteria for classifying the severity of and identifying treatment refractoriness in AA.Methods: A preliminary draft of the definition for moderate-to-severe AA was crafted based on available evidence, and members of the Korean Hair Research Society (KHRS) subsequently endorsed the recommendation through an online survey.Results: In the first Delphi round, consensus was attained on 15 questions. After refining certain items in the second round, consensus was achieved on 23 out of 26 questions. The KHRS first defined AA severity using the severity of alopecia tool (SALT). SALT ≥50 was defined as severe, 20≤ SALT <50 as moderate, and SALT <20 as mild. Moderate AA was considered severe if it meets one or more of the following criteria: dermatology life quality index >10, presence of accompanying eyebrow or eyelash loss, positive hair loss activity, or treatment-refractory AA.Conclusion: These consensus criteria can help clinicians accurately diagnose AA, provide appropriate treatment, and monitor its progression.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"236-246"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0