Annals of dermatology最新文献_第2页

Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair. 红参对头发氧化应激损伤的保护作用。

Annals of dermatology Pub Date : 2025-02-01 DOI: 10.5021/ad.24.047

Seung-Won Jung, Long-Quan Pi, Jae Joon Jeon, You Hyun Kim, Solam Lee, Won-Soo Lee

{"title":"Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair.","authors":"Seung-Won Jung, Long-Quan Pi, Jae Joon Jeon, You Hyun Kim, Solam Lee, Won-Soo Lee","doi":"10.5021/ad.24.047","DOIUrl":"10.5021/ad.24.047","url":null,"abstract":"Background: Oxidative stress causes fatal damage to follicular keratinocytes (FKCs) and is a common pathophysiology of many hair disorders.Objective: This study investigated the protective effects of Red ginseng extract (RGE) and its main ginsenosides against oxidative hair damage using an in vitro organ model of human hair follicles.Methods: We examined whether RGE and its constituent ginsenosides could prevent oxidative damage induced by H₂O₂ in FKCs by suppressing apoptosis and promoting hair growth.Results: RGE and its main ginsenoside, G-Rb1, significantly inhibited reactive oxygen species production and apoptosis in FKCs. Furthermore, they effectively alleviated the inhibition of hair growth induced by oxidative damage and inhibited the transition of hair from the anagen to the telogen stage. The hair cycle and apoptosis were associated with the modulation of p53 and Bax/Bcl2 signaling.Conclusion: RGE and G-Rb1 can effectively mitigate the oxidative damage caused by FKCs, thereby affecting hair growth and hair cycles.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age Below 40 Years Is Associated With Human Papillomavirus Vaccination Success for Recalcitrant Warts. 年龄在40岁以下的人乳头瘤病毒疫苗接种对顽固性疣的成功相关。

Annals of dermatology Pub Date : 2025-02-01 DOI: 10.5021/ad.24.061

Sooyun Park, Hyun-Sun Yoon

引用次数: 0

Appropriate Injection Intervals of Dupilumab in Patients With Adult Atopic Dermatitis: A Step Toward Developing Guidelines for Daily Practice. 成人特应性皮炎患者Dupilumab的适当注射间隔：朝着制定日常实践指南迈出的一步。

Annals of dermatology Pub Date : 2025-02-01 DOI: 10.5021/ad.24.084

Heeyeon Kim, Sejin Oh, Hyungrye Noh, Byeonghyun Joo, Joonho Shim, Jihye Park, Dongyoun Lee, Jong Hee Lee

{"title":"Appropriate Injection Intervals of Dupilumab in Patients With Adult Atopic Dermatitis: A Step Toward Developing Guidelines for Daily Practice.","authors":"Heeyeon Kim, Sejin Oh, Hyungrye Noh, Byeonghyun Joo, Joonho Shim, Jihye Park, Dongyoun Lee, Jong Hee Lee","doi":"10.5021/ad.24.084","DOIUrl":"10.5021/ad.24.084","url":null,"abstract":"Background: There is a growing demand for extending dosing intervals of dupilumab injections in patients with atopic dermatitis (AD) due to treatment burden and side effects. However, studies on successful dose reduction in real-world settings are lacking.Objective: To assess the efficacy of a patient-centered dupilumab tapering regimen and to propose guidelines for target patients, appropriate intervals, and timing for tapering.Methods: This single-center retrospective study included moderate to severe adult AD patients who underwent at least 16 weeks of dupilumab treatment. Interval prolongation was considered in controlled patients assessed by Eczema Area and Severity Index (EASI) score and serum inflammatory markers after at least 40 weeks of treatment with a standard regimen. Logistic regression model with generalized estimating equations was used to compare repetitive measurements over time between the two groups.Results: A total of 52 patients were included with 11 patients extending intervals to 3-4 weeks without flare-ups. The mean duration of dupilumab treatment before tapering was 53.27 weeks. The tapering group exhibited significantly lower body mass index. All patients of the tapering group showed EASI scores under 4 and immunoglobulin E (IgE) levels under 1,000 IU/mL at week 40. EASI scores and IgE levels remained consistently low after dose reduction, with a mean follow-up time of 14.36 months.Conclusion: Patients with extended dosing intervals demonstrated sustained effectiveness. Dose tapering might be a valuable option for non-obese patients with positive clinical response characterized by an EASI score under 4 and IgE levels under 1,000 at week 40.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Intra-Nail Location of Nail Psoriasis. 甲型银屑病甲内定位分析。

Annals of dermatology Pub Date : 2025-02-01 DOI: 10.5021/ad.24.075

Kyungho Paik, Bo Ri Kim, Sang Woong Youn

{"title":"Analysis of the Intra-Nail Location of Nail Psoriasis.","authors":"Kyungho Paik, Bo Ri Kim, Sang Woong Youn","doi":"10.5021/ad.24.075","DOIUrl":"10.5021/ad.24.075","url":null,"abstract":"Background: Although nail psoriasis is a common manifestation among patients with psoriasis, large-scale research exploring the association between nail psoriasis lesions and their intra-nail locations has not been conducted. This study is necessary to elucidate the shared pathophysiology among various phenotypes of nail psoriasis.Objective: We aimed to understand the association between nail psoriasis lesions and analyze their intra-nail locations.Methods: We obtained a total of 5,602 cropped fingernail images from 636 patients with psoriasis. We employed the Computer Vision Annotation Tool to annotate the intra-nail locations of nail psoriasis lesions. We computed χ² statistic to examine the relationship between nail psoriasis lesions and conducted an analysis of their intra-nail locations.Results: Based on the number of lesions, nail pitting was the most common, followed by leukonychia, with the red spots in the lunula being the rarest. We elucidated the associations between different nail psoriasis lesions, pinpointing a significant association between onycholysis and oil spots (χ² statistic=1,623.88), followed by onycholysis-subungual hyperkeratosis (1,607.50), and subungual hyperkeratosis-oil spots (985.76). A spatial relationship was observed between onycholysis and oil spots, with the intra-nail location of onycholysis being more distal compared to the nearest oil spots. A distribution pattern of nail psoriasis was also demonstrated, where nail matrix lesions were primarily located at the center of the nail, and nail bed lesions were predominantly located near the lateral nail folds.Conclusion: This study represents a pioneering analysis of the intra-nail location of nail psoriasis lesions, revealing substantial associations and spatial relationships between different lesions.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 1","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Risk of Superficial Fungal Infections Among Psoriasis Patients Receiving Systemic Treatment: A Nationwide Retrospective Population-Based Cohort Study. 接受全身治疗的银屑病患者表面真菌感染的风险增加：一项全国性的回顾性人群队列研究

Annals of dermatology Pub Date : 2024-12-01 DOI: 10.5021/ad.24.027

Ji-In Seo, Hasung Kim, Jung Kuk Lee, Hye-Jin Ahn, Ki-Heon Jeong, Min Kyung Shin

引用次数: 0

Assessment of Treatment Modalities in Patients With Keloids: A Vancouver Scale Comparison. 瘢痕疙瘩患者治疗方式的评估：温哥华量表比较。

Annals of dermatology Pub Date : 2024-12-01 DOI: 10.5021/ad.23.160

Hui Young Shin, Yu Jeong Park, Woo Kyoung Choi, Hyun Bo Sim, Seung Ho Lee, Ai Young Lee, Jong Soo Hong

{"title":"Assessment of Treatment Modalities in Patients With Keloids: A Vancouver Scale Comparison.","authors":"Hui Young Shin, Yu Jeong Park, Woo Kyoung Choi, Hyun Bo Sim, Seung Ho Lee, Ai Young Lee, Jong Soo Hong","doi":"10.5021/ad.23.160","DOIUrl":"10.5021/ad.23.160","url":null,"abstract":"Background: Various treatment modalities are used to treat keloids. However, a comprehensive assessment comparing the effectiveness of these modalities in terms of patient-reported outcomes is warranted.Objective: To assess and compare the effectiveness of various treatment modalities for keloids.Methods: We assessed treatment outcomes in a cohort of 250 patients diagnosed with keloids. The patients were categorized into four treatment groups: triamcinolone acetonide (TA), TA + cryotherapy, TA + pulsed dye laser (PDL), and TA + cryotherapy + PDL. The Vancouver Scar Scale was used to evaluate the keloid severity before and after treatment.Results: Significant differences were noted in the Vancouver Scale scores among the treatment groups (p=0.023). Notably, the TA + cryotherapy + PDL group exhibited the most substantial improvement in the Vancouver Scale scores, whereas the TA + PDL group showed the least difference. Pliability was the most significantly improved in the TA + cryotherapy + PDL group (p=0.039). Male patients experienced a greater reduction in pigmentation scores than female patients (p=0.037).Conclusion: Our findings highlight the effectiveness of combined therapies, particularly TA + cryotherapy + PDL, in improving keloid-related parameters. These results offer valuable insights for clinicians in tailoring keloid treatment strategies and support the implementation of combination therapies for enhanced outcomes. This study underscores the importance of comprehensively assessing treatment modalities for keloid management. Combination therapies such as TA + cryotherapy + PDL irradiation have demonstrated significant promise in improving keloid characteristics.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"348-354"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey on Alopecia Areata Patients' Reported Factors that Determine Severity of Alopecia Areata: A Nationwide Multicenter Study. 斑秃患者报告的决定斑秃严重程度的因素调查：一项全国多中心研究。

Annals of dermatology Pub Date : 2024-12-01 DOI: 10.5021/ad.24.033

Jung Eun Kim, Subin Lee, Hoon Kang, Young Lee, Do-Young Kim, Hyunsun Park, Hyun-Tae Shin, Yong Hyun Jang, Kihyuk Shin, Ji Hae Lee, Jee Woong Choi, Byung Choel Park, Beom Joon Kim, Soo Hong Seo, Chong Hyun Won, Jin Park, Min Sung Kim, Sang Seok Kim, Bark-Lynn Lew, Chang-Hun Huh, Ohsang Kwon, Yang Won Lee, Moon-Bum Kim

{"title":"Survey on Alopecia Areata Patients' Reported Factors that Determine Severity of Alopecia Areata: A Nationwide Multicenter Study.","authors":"Jung Eun Kim, Subin Lee, Hoon Kang, Young Lee, Do-Young Kim, Hyunsun Park, Hyun-Tae Shin, Yong Hyun Jang, Kihyuk Shin, Ji Hae Lee, Jee Woong Choi, Byung Choel Park, Beom Joon Kim, Soo Hong Seo, Chong Hyun Won, Jin Park, Min Sung Kim, Sang Seok Kim, Bark-Lynn Lew, Chang-Hun Huh, Ohsang Kwon, Yang Won Lee, Moon-Bum Kim","doi":"10.5021/ad.24.033","DOIUrl":"10.5021/ad.24.033","url":null,"abstract":"Background: Alopecia areata (AA) is characterized by hair loss on the scalp and body, significantly impacting patients' quality of life based on its severity.Objective: This study aims to identify crucial factors influencing the perception of severe AA from the patients' viewpoint.Methods: A web-based survey was conducted among AA patients attending dermatology departments at 21 university hospitals in Korea. The survey comprised 17 criteria, exploring both clinical characteristics of AA patients and subjective determinants of disease severity.Results: A total of 791 AA patients and their caregivers participated in the survey. Approximately 30% of respondents developed AA during childhood, with 43.5% experiencing chronic courses lasting over 3 years. Half of the participants exhibited more than 20% scalp hair loss, and 42% reported additional hair loss on other body parts, such as eyelashes and nose hair. Most respondents agreed that patients with ≥20% scalp hair loss should be categorized as having severe AA. They also identified longer disease duration, involvement of non-scalp body hair, treatment refractoriness, and social or mental impairment requiring medical intervention as factors indicating increased disease severity.Conclusion: This survey underscores the significant impact of AA on patients' quality of life and highlights existing unmet needs in current treatment modalities.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"376-383"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers for Short-Term Omalizumab Response in Chronic Spontaneous Urticaria. 慢性自发性荨麻疹中Omalizumab短期反应的生物标志物。

Annals of dermatology Pub Date : 2024-12-01 DOI: 10.5021/ad.24.004

Wanjin Kim, Su Min Kim, Jongwook Oh, HeeUng Park, Jiwon Lee, Soorack Ryu, Lark Kyun Kim, Han Kyoung Cho, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park, Chang Ook Park

{"title":"Biomarkers for Short-Term Omalizumab Response in Chronic Spontaneous Urticaria.","authors":"Wanjin Kim, Su Min Kim, Jongwook Oh, HeeUng Park, Jiwon Lee, Soorack Ryu, Lark Kyun Kim, Han Kyoung Cho, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park, Chang Ook Park","doi":"10.5021/ad.24.004","DOIUrl":"10.5021/ad.24.004","url":null,"abstract":"Background: Omalizumab, a monoclonal antibody targeting immunoglobulin E (IgE), is approved for adults and adolescents (12 years or older) with chronic spontaneous urticaria (CSU) that does not respond to high-dose antihistamines. In Korea, there is limited research on predictive biomarkers for omalizumab response in CSU patients.Objective: This retrospective, single-institution study aimed to identify clinical parameters predicting omalizumab response in Korean CSU patients.Methods: We analyzed records of CSU patients aged 19 or older starting omalizumab between January 2017 and October 2019. Omalizumab efficacy was assessed using the Urticaria Activity Score summed over 7 days (UAS7), categorized as well-controlled, mild, moderate, or severe. Ninety CSU patients participated in this study.Results: Among these, improvements in UAS7 categories from baseline to 12 weeks of treatment were observed in 78 patients, while 12 patients showed no significant efficacy. The present study identified potential biomarkers that could predict a patient's response to omalizumab, including disease duration and total serum IgE levels (p=0.022, p=0.046). Notably, a significant correlation was observed between higher detection rates in multiple antigen simultaneous test (MAST) food testing and lower treatment responses (p=0.033).Conclusion: Shorter disease duration of CSU and elevated initial serum total IgE level may serve as potential predictive biomarkers for the responsiveness to omalizumab. Furthermore, a higher MAST food detection rate seemed to correlate with a less favorable treatment response, suggesting patients with a high MAST food detection rate might benefit from a food evaluation in addition to omalizumab treatment.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"367-375"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Manifestation of Alopecia Areata After COVID-19 Infection or Vaccination. 新冠肺炎感染或接种后斑秃的临床表现。

Annals of dermatology Pub Date : 2024-12-01 DOI: 10.5021/ad.24.001

Seungjin Son, Soyoung Jin, Ji Yeon Hong, Jung-Min Shin, Kyung Eun Jung, Young-Joon Seo, Chang-Deok Kim, Dongkyun Hong, Young Lee

{"title":"Clinical Manifestation of Alopecia Areata After COVID-19 Infection or Vaccination.","authors":"Seungjin Son, Soyoung Jin, Ji Yeon Hong, Jung-Min Shin, Kyung Eun Jung, Young-Joon Seo, Chang-Deok Kim, Dongkyun Hong, Young Lee","doi":"10.5021/ad.24.001","DOIUrl":"10.5021/ad.24.001","url":null,"abstract":"Background: Alopecia areata (AA) is characterized by an autoimmune inflammatory response to hair follicles. Several studies have suggested that infection and vaccination can trigger an autoimmune process around hair follicles. Moreover, reports of AA and various other autoimmune diseases have increased since the coronavirus disease 2019 (COVID-19) pandemic became established.Objective: We assessed the clinical characteristics and treatment response in patients who developed AA following COVID-19 infection or vaccination.Methods: This retrospective study involved patients who had developed COVID-19 or received a COVID-19 vaccination within 3 months before the onset or aggravation of AA from January 2020 to December 2022.Results: Fifty patients met the inclusion criteria. Eighteen patients had a history of COVID-19 infection, and 32 had a history of COVID-19 vaccination. The mean onset of AA after COVID-19 infection and vaccination was 5.22±3.35 and 4.13±2.73 weeks, respectively. The most common COVID-19-associated symptoms before AA were fever (88.9%) in the infection group and myalgia (50.0%) in the vaccination group. In the vaccination group, AA most commonly occurred after receiving the Pfizer-BioNTech vaccine (BNT162b2, 46.9%) or Moderna vaccine (mRNA-1273, 34.4%). The vaccination group showed more rapid improvement than the infection group; however, both showed significant improvement after 6 months of treatment of AA.Conclusion: We examined the clinical characteristics and treatment responses of patients who developed AA after COVID-19 infection or vaccination. Further research is needed to evaluate the detailed pathogenesis and association between COVID-19 and AA.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"361-366"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telogen Effluvium Associated With Weight Loss: A Single Center Retrospective Study. 休止期排出物与体重减轻相关：一项单中心回顾性研究。

Annals of dermatology Pub Date : 2024-12-01 DOI: 10.5021/ad.24.043

Da-Hyun Kang, Soon-Hyo Kwon, Woo-Young Sim, Bark-Lynn Lew

{"title":"Telogen Effluvium Associated With Weight Loss: A Single Center Retrospective Study.","authors":"Da-Hyun Kang, Soon-Hyo Kwon, Woo-Young Sim, Bark-Lynn Lew","doi":"10.5021/ad.24.043","DOIUrl":"10.5021/ad.24.043","url":null,"abstract":"Background: Telogen effluvium (TE) is characterized by diffuse hair loss following stressful events such as childbirth, prolonged surgery or anesthesia, and severe febrile illnesses, as well as intentional or unintentional rapid weight loss. However, literature regarding the relationship between TE and weight loss is limited.Objective: To describe the clinical characteristics of TE induced by weight loss and assess their quantitative relationship.Methods: This retrospective study was performed on patients diagnosed with TE induced by weight loss in our institution, between June 2006 and March 2021. Information on age, sex, weight before weight loss, reduced weight, and weight loss period was collected.Results: This study enrolled 140 patients with TE, of whom 30 were men and 110 were women, with a mean age of 34.57±13.89 years. The mean weight loss percentage was 15.21±7.18% and mean weight loss rate was 3.54±2.85 kg/months. The mean weight loss rate in men (5.03±3.92 kg/month) was significantly faster than that in women (3.14±2.35 kg/month) (p=0.026). The mean weight loss percentage was mostly higher in 10's and became significantly smaller with age (p=0.004). There were no significant differences by the causes of weight loss.Conclusion: TE induced by weight loss occurred at a mean weight loss percentage and mean weight loss rate of approximately 15.21% and 3.54 kg/months, respectively. Women and older adults are especially vulnerable to TE, even if the degree of weight loss is not more severe than in men and young adults.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 6","pages":"384-388"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0