Annals of dermatology最新文献

{"title":"Consensus-Based Guidelines for the Treatment of Atopic Dermatitis in Korea (Part I): Basic Therapy, Topical Therapy, and Conventional Systemic Therapy.","authors":"Hyun-Chang Ko, Yu Ri Woo, Joo Yeon Ko, Hye One Kim, Chan Ho Na, Youin Bae, Young-Joon Seo, Min Kyung Shin, Jiyoung Ahn, Bark-Lynn Lew, Dong Hun Lee, Sang Eun Lee, Sul Hee Lee, Yang Won Lee, Ji Hyun Lee, Yong Hyun Jang, Jiehyun Jeon, Sun Young Choi, Ju Hee Han, Tae Young Han, Sang Wook Son, Sang Hyun Cho","doi":"10.5021/ad.24.153","DOIUrl":"10.5021/ad.24.153","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a common skin disease with a wide range of symptoms. Due to the rapidly changing treatment landscape, regular updates to clinical guidelines are needed.</p><p><strong>Objective: </strong>This study aimed to update the guidelines for the treatment of AD to reflect recent therapeutic advances and evidence-based practices.</p><p><strong>Methods: </strong>The Patient characteristics, type of Intervention, Control, and Outcome framework was used to determine 48 questions related to AD management. Evidence was graded, recommendations were determined, and, after 2 voting rounds among the Korean Atopic Dermatitis Association (KADA) council members, consensus was achieved.</p><p><strong>Results: </strong>The guidelines provide detailed recommendations on foundational therapies, including the use of moisturizers, cleansing and bathing practices, allergen avoidance, and patient education. Guidance on topical therapies, such as topical corticosteroids and calcineurin inhibitors, is also provided to help manage inflammation and maintain skin barrier function in patients with AD. Additionally, recommendations on conventional systemic therapies, including corticosteroids, cyclosporine, and methotrexate, are provided for managing moderate to severe AD.</p><p><strong>Conclusion: </strong>KADA's updated AD guidelines offer clinicians evidence-based strategies focused on basic therapies, topical therapies, and conventional systemic therapies, equipping them to enhance quality of care and improve patient outcomes in AD management.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 4","pages":"201-215"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase III Clinical Trial.","authors":"Subin Lee, Jung Eun Kim, Bark-Lynn Lew, Chang Hun Huh, Jandee Kim, Ohsang Kwon, Moon Bum Kim, Yang Won Lee, Young Lee, Jin Park, Sangseok Kim, Do Young Kim, Gwang Seong Choi, Hoon Kang","doi":"10.5021/ad.25.048","DOIUrl":"10.5021/ad.25.048","url":null,"abstract":"<p><strong>Background: </strong>Dutasteride, a 5-alpha reductase inhibitor, is prescribed for male androgenetic alopecia (AGA) in Korea and Japan. Despite its efficacy, its use is limited by its long half-life, potent dihydrotestosterone suppression, and adverse effects.</p><p><strong>Objective: </strong>To investigate the efficacy and safety of 0.2 mg dutasteride for male AGA.</p><p><strong>Methods: </strong>Patients with male AGA were randomized to receive 0.2 mg dutasteride, placebo, or 0.5 mg dutasteride (2:2:1) once daily for 24 weeks. Safety and efficacy endpoints were assessed.</p><p><strong>Results: </strong>Overall, 139 men were analyzed. At week 24, the change in hair count within the target area at the vertex from baseline was significantly higher in the 0.2 mg dutasteride group than in the placebo group (21.53 vs. 5.96, <i>p</i>=0.0072). Dutasteride (0.2 mg) treatment led to greater hair growth improvement, as assessed by investigators at week 24 (<i>p</i>=0.0096) and an independent panel at weeks 12 and 24 (<i>p</i>=0.0306, <i>p</i>=0.0001). For all efficacy endpoints, 0.2 mg dutasteride was as effective as 0.5 mg dutasteride. The incidence of adverse events was low and not statistically different between the 0.2 mg dutasteride and placebo groups. The limitation of this study is the limited number of participants.</p><p><strong>Conclusion: </strong>Low-dose (0.2 mg) dutasteride for male AGA showed significant efficacy and favorable safety profile.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04825561.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 4","pages":"183-190"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalp Bacterial Profile and Antibiotics Susceptibility Pattern in Patients With Primary Cicatricial Alopecia.","authors":"Geon-Jong Lee, So-Yeon Kim, Thi Quynh Trang Tran, Jaehyeon Lee, Kyung-Hwa Nam, Seok-Kweon Yun, Jin Park","doi":"10.5021/ad.25.022","DOIUrl":"10.5021/ad.25.022","url":null,"abstract":"<p><strong>Background: </strong>Primary cicatricial alopecia (PCA) is a group of disorders causing irreversible hair loss because of hair follicle destruction. Although bacterial colonization is suspected to contribute to PCA pathogenesis, its role remains unclear.</p><p><strong>Objective: </strong>To investigate bacterial colonization patterns and antibiotic susceptibility profiles in patients with PCA compared to those with non-inflammatory scalp conditions.</p><p><strong>Methods: </strong>This retrospective study analyzed bacterial cultures from scalp swabs of 161 subjects (68 patients with PCA and 93 controls) at a tertiary hospital between June 2011 and December 2023. Bacterial species and antibiotic resistance rates were evaluated using subgroup analyses of neutrophilic PCA (NCA).</p><p><strong>Results: </strong>PCA cultures showed a higher prevalence of <i>Staphylococcus aureus</i> (24.3%) and <i>S. lugdunensis</i> (8.1%) than controls, where <i>S. capitis</i> (54.5%) was predominant. Gram-negative bacteria were more frequent in the PCA group (13.5%) than in the control group (9.9%), with <i>Klebsiella</i> spp. (10.9%) being the most prevalent. Resistance rates were significantly higher in PCA for benzylpenicillin, fusidic acid, erythromycin, clindamycin, oxacillin, and telithromycin (<i>p</i><0.05). Methicillin-resistant <i>S. aureus</i> was identified in 15% of <i>S. aureus</i> isolates from NCA cases. Gram-negative bacteria in PCA also exhibited increased resistance to ampicillin and ampicillin/sulbactam.</p><p><strong>Conclusion: </strong>PCA exhibits distinct bacterial colonization and elevated antibiotic resistance, particularly in the neutrophilic subtypes. Bacterial culture and susceptibility testing are essential for targeted therapies in clinical practice. Further multicenter microbiome analyses with mechanistic studies are needed to elucidate bacterial contributions to PCA pathogenesis.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 4","pages":"241-249"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunophenotypic and Transcriptomic Analysis of Peripheral Blood Mononuclear Cells in Bullous Pemphigoid.","authors":"Jeewoo Choi, Jae-Yong Nam, Min Sung Kim, You Won Choi, Hae Young Choi, Ji Yeon Byun","doi":"10.5021/ad.25.032","DOIUrl":"10.5021/ad.25.032","url":null,"abstract":"<p><strong>Background: </strong>Bullous pemphigoid (BP) is an autoimmune blistering disease driven by autoantibodies against BP180 and BP230. While type 2 inflammation plays a key role, the precise immune cell alterations and transcriptomic changes remain unclear.</p><p><strong>Objective: </strong>To characterize immune cell composition and transcriptomic changes in BP patients using fluorescence-activated cell sorting (FACS)-based immunophenotyping and RNA sequencing.</p><p><strong>Methods: </strong>A case-control study was conducted on 10 newly diagnosed, treatment-naive BP patients and six healthy controls. Disease activity was assessed using the Bullous Pemphigoid Disease Area Index (BPDAI). Peripheral blood mononuclear cells were isolated for FACS analysis to determine immune cell subsets. RNA sequencing was performed to identify differentially expressed genes (DEGs) and enriched pathways. Statistical analyses included t-tests, Mann-Whitney U tests, and correlation analysis.</p><p><strong>Results: </strong>FACS analysis revealed a reduction in CD4⁺ T cells, T helper 2 (Th2), and B cells in BP patients (<i>p</i><0.05), alongside an increase in M2a-like monocytes (<i>p</i><0.001). RNA sequencing identified 262 DEGs, with secretory leukocyte peptidase inhibitor (SLPI) and transmembrane protein 237 being the most significantly upregulated. Proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) and SAM domain, SH3 domain, and nuclear localization signals 1 (SAMSN1) positively correlated with BPDAI (<i>p</i><0.001). Gene ontology analysis highlighted enrichment in inflammatory responses and neutrophil degranulation pathways.</p><p><strong>Conclusion: </strong>BP patients show distinct immune dysregulation, including decreased CD4⁺ T cells, Th2, and B cells, increased M2a-like monocytes, altered gene expression profiles, and correlations between PSTPIP2, SAMSN1 and disease activity. These findings provide insights into pathogenesis and potential therapeutic targets of BP.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 4","pages":"191-200"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Approaches to Diagnosis and Treatment of Sensitive Skin.","authors":"Hye One Kim, Ji Young Um, Han Bi Kim, So Yeon Lee, Hyun Choi, Jihye Kim, Eunbi Ko, Bo Young Chung, Chun Wook Park","doi":"10.5021/ad.24.157","DOIUrl":"10.5021/ad.24.157","url":null,"abstract":"<p><p>Sensitive skin (SS) is increasingly recognized as a complex syndrome characterized by discomfort and heightened sensitivity to otherwise harmless stimuli, such as environmental changes, physical contact, and cosmetic products. This condition poses challenges in both diagnosis and treatment due to its variable presentation and subjective nature. The pathophysiological features of SS include neurogenic inflammation and small fiber neuropathy, largely driven by the hyperactivation of sensory nerves. This hyperactivation is closely associated with transient receptor potential (TRP) channels, particularly TRPV1, which contribute to the exaggerated sensory responses seen in SS. Furthermore, psychological factors like stress and anxiety, along with environmental stressors such as pollution and ultraviolet exposure, play significant roles in exacerbating symptoms. The diverse and individualized responses to stimuli make it difficult to establish standardized diagnostic criteria for SS, necessitating a combination of subjective diagnostic tools (e.g., the Sensitive Scale-10) and objective assessments (e.g., transepidermal water loss and lactic acid sting test) to accurately identify and assess SS. This paper provides a comprehensive review of SS, covering its definition, prevalence, pathogenesis, diagnostic challenges, and management strategies, and highlights the importance of personalized care in effectively managing SS and improving patient quality of life.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 4","pages":"173-182"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Onset of Hair Loss Disorders During the Coronavirus Disease 2019 Pandemic: A Korean Nationwide Population-Based Study.","authors":"Youngjoo Cho, Ji Won Lim, Yi Na Yoon, Chang Yong Kim, Yang Won Lee, Yong Beom Choe, Da-Ae Yu","doi":"10.5021/ad.25.007","DOIUrl":"10.5021/ad.25.007","url":null,"abstract":"<p><strong>Background: </strong>An increased incidence of hair loss disorders has been noted among patients with coronavirus disease 2019 (COVID-19) and individuals vaccinated against COVID-19. However, research involving large populations on this topic is lacking.</p><p><strong>Objective: </strong>To investigate the risks associated with developing hair loss disorders in patients with COVID-19 and individuals vaccinated against COVID-19.</p><p><strong>Methods: </strong>This nationwide, population-based, cross-sectional study included patients diagnosed with COVID-19 and healthy individuals without a history of COVID-19 infection registered in the Korean National Health Insurance Service (NHIS) database between January 1, 2021, and December 31, 2021. COVID-19 infection and vaccine databases were integrated using this NHIS database. The odds ratios of hair loss disorders were compared using multivariate logistic regression models.</p><p><strong>Results: </strong>COVID-19 infection was associated with an increased risk of total alopecia (adjusted odds ratio [aOR], 1.076; 95% confidence interval [CI], 1.002-1.156), although this association was not significant after propensity score matching. No significant associations were found between COVID-19 infection and alopecia areata or telogen effluvium. However, COVID-19 vaccination was positively correlated with total alopecia (aOR, 1.266; 95% CI, 1.191-1.346), alopecia areata (aOR, 1.243; 95% CI, 1.154-1.339), and telogen effluvium (aOR, 1.495; 95% CI, 1.133-1.974).</p><p><strong>Conclusion: </strong>COVID-19 vaccination was positively correlated with hair loss disorders but not COVID-19 infection. However, given the advantages of vaccines in reducing COVID-19 mortality and morbidity, alopecia may be relatively reversible and less severe. Physicians need to understand the benefits and possible side effects of the COVID-19 vaccine.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 4","pages":"250-258"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and Combined Effects of Particulate Matter and Sleep Deprivation on Human Skin Barrier.","authors":"Il Joo Kwon, Eun Jung Lee, Jong Ho Park, Ji Young Kim, Seohyun Park, Yu Jeong Bae, Shinwon Hwang, Hye-Won Na, Nari Cha, Geunhyuk Jang, Hyoung-June Kim, Hae Kwang Lee, Sang Ho Oh","doi":"10.5021/ad.25.003","DOIUrl":"10.5021/ad.25.003","url":null,"abstract":"<p><strong>Background: </strong>The exposome encompasses all factors people encounter through life, with the skin constantly exposed. While particulate matter (PM) and sleep deprivation are known to contribute to barrier dysfunction, their combined effects remain unclear.</p><p><strong>Objective: </strong>To evaluate the independent and combined effects of PM exposure and short-term sleep deprivation on skin barrier function.</p><p><strong>Methods: </strong>Forty healthy Korean women (aged 24-58 years) were enrolled in this study. Forearms were divided into 4 sites: control, PM exposure, sleep deprivation, and PM plus sleep deprivation. Parameters such as trans-epidermal water loss (TEWL), hydration, elasticity, roughness, and redness were measured at baseline and post-exposure. RNA sequencing and reverse transcription-polymerase chain reaction were conducted on tape-stripped skin samples.</p><p><strong>Results: </strong>PM exposure significantly increased TEWL (+25.59%, <i>p</i><0.01), roughness (+21.9%, <i>p</i><0.01), and redness (+13.7%, <i>p</i><0.0001) while reducing elasticity (-3.98%, <i>p</i><0.01). Sleep deprivation modestly reduced elasticity (-1.39%, <i>p</i><0.05) without affecting other parameters. Combined PM and sleep deprivation did not further exacerbate barrier dysfunction compared to PM alone. RNA sequencing revealed reduced <i>FLG</i> and <i>LORICRIN</i> expression and upregulated endoplasmic reticulum (ER) stress markers (<i>HSP90B1</i>, <i>CANX</i>) in both PM and sleep deprivation conditions.</p><p><strong>Conclusion: </strong>PM exposure impaired skin barrier function, while short-term sleep deprivation alone did not significantly affect the barrier, either independently or in combination with PM. However, it was observed that the sleep deprivation-only, while not directly causing barrier damage, induced changes in ER stress-related gene expression in tape-stripped skin samples, like the PM exposure-only. This suggests that such signaling pathways could potentially exacerbate skin barrier deterioration.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 3","pages":"131-139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Patterns and Risk Factors of Occupational Contact Dermatitis in Hairdressers: A Questionnaire-based Cross-sectional Study.","authors":"Jin Ju Lee, Da Yeon Kim, Heera Lee, Ji Yeon Byun, You Won Choi, Joo Young Roh, Hae Young Choi","doi":"10.5021/ad.25.019","DOIUrl":"10.5021/ad.25.019","url":null,"abstract":"<p><strong>Background: </strong>Occupational contact dermatitis (OCD) is prevalent among hairdressers due to frequent exposure to chemicals like hair dyes and bleaching agents. Despite the risks, awareness among hairdressers remains low, leading to underreporting and inadequate preventive measures.</p><p><strong>Objective: </strong>This study evaluated hairdressers' awareness of harmful hair dye ingredients, their experiences with OCD, and the association with product usage patterns.</p><p><strong>Methods: </strong>A cross-sectional study involving 100 hairdressers in Korea examined the relationship between work experience, product usage, and OCD. Chi-square tests and multivariate regression identified significant correlations.</p><p><strong>Results: </strong>Among the participants, 51% reported experiencing adverse skin reactions, with the hands being the most commonly affected area. Longer work experience as a hairdresser was significantly associated with the occurrence of adverse effects (<i>p</i>=0.046). Notably, shampoo was identified as a suspected causative material significantly more often by the severe group compared to the non-severe group (28.0% vs. 3.8%, <i>p</i>=0.04).</p><p><strong>Conclusion: </strong>Chemical exposure and frequent wet work contribute to high rates of OCD among hairdressers. Poor glove usage, especially during shampooing due to inconvenience, is a major risk factor. Raising awareness, promoting proper glove use, and improving workplace safety training are essential for reducing these skin conditions.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 3","pages":"162-168"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interferon Gamma and Secretory Immunoglobulin A Levels Decrease in Persistent Anal Condyloma Acuminatum Infection.","authors":"Yuanli Guo, Zi Zhang, Lipei Zhao, Xiaohui Ma, Tingting Mao, Xiaolei Cheng, Qiulin Gao, Manli Qi","doi":"10.5021/ad.24.145","DOIUrl":"10.5021/ad.24.145","url":null,"abstract":"<p><strong>Background: </strong>Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV). In recent years, research on anal CA has primarily focused on treatment rather than underlying mechanisms. The mechanism of HPV persistence and recurrence in CA require further exploration. It needs multiple researches in mechanisms to focalize treatment targets.</p><p><strong>Objective: </strong>To investigate the relationship between intestinal mucosal immunity and the relapse of anal CA and persistent infection.</p><p><strong>Methods: </strong>Levels of interferon gamma (IFN-γ) and secretory immunoglobulin A (sIgA) were measured using enzyme-linked immunosorbnent assay in anal mucosal cells obtained from patients treated at Tianjin Union Medical Center from September 2022 to December 2024. All the participants signed Informed Consent and the whole plan was approved by Institutional Review Board in Tianjin Union Medical Center (No. B155).</p><p><strong>Results: </strong>The levels of IFN-γ and sIgA significantly decreased after infection, and persistent infection exhibited even lower levels. These two factors increased following treatment, reaching peak concentrations at 4 weeks before decreasing again.</p><p><strong>Conclusion: </strong>These findings demonstrate a significant association between persistent anal CA infection and dysregulation of intestinal mucosal immunity.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 3","pages":"140-145"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Clinical Practice on Skin Rejuvenation Among Korean Board-Certified Dermatologists: Survey-Based Results.","authors":"Sejin Oh, Yeong Ho Kim, Bo Ri Kim, Hyun-Min Seo, Soon-Hyo Kwon, Hoon Choi, Haewoong Lee, Jung-Im Na, Chun Pill Choi, Joo Yeon Ko, Hwa Jung Ryu, Suk Bae Seo, Jong Hee Lee, Hei Sung Kim, Chang-Hun Huh","doi":"10.5021/ad.24.167","DOIUrl":"10.5021/ad.24.167","url":null,"abstract":"<p><strong>Background: </strong>Skin rejuvenation has become an increasingly popular noninvasive approach to address age-related changes such as sagging, wrinkles, and skin laxity. Energy-based devices (EBDs) and injectables are widely used, but their application requires careful customization based on individual patient characteristics to optimize outcomes and minimize potential adverse effects.</p><p><strong>Objective: </strong>This study aimed to explore clinical practice patterns among board-certified dermatologists in South Korea, focusing on their strategies for tailoring skin rejuvenation treatments to individual patients, including the integration of EBDs, injectables, and senotherapeutics.</p><p><strong>Methods: </strong>A structured survey comprising 10 questions was administered to 13 experienced dermatologists specializing in skin rejuvenation. The survey covered treatment strategies for patients with varying facial fat volumes, pain management approaches, and the use of EBDs, injectables and senotherapeutics.</p><p><strong>Results: </strong>High-intensity focused ultrasound (HIFU) and radiofrequency (RF) were the most employed EBDs, often combined with injectables for enhanced outcomes. For patients with higher facial fat, HIFU and deoxycholic acid injections were preferred for contouring and tightening. For those with lower facial fat, biostimulatory agents such as poly-D, L-lactic acid and microneedle RF were favored to restore volume and elasticity. Pain management strategies included topical anesthetics and stepwise protocols. Although less commonly used, senotherapeutics were occasionally prescribed for specific conditions, such as melasma and extensive photoaging.</p><p><strong>Conclusion: </strong>Dermatologists in South Korea employ a variety of patient-specific strategies for skin rejuvenation, combining various EBDs, injectables, and senotherapeutics. These findings highlight the importance of personalized treatment protocols and the need for further research to optimize treatment efficacy and safety.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"37 3","pages":"123-130"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}