Anesthesia progress最新文献_第3页

Dexamethasone and Ondansetron Combined Decreases Postoperative Nausea and Vomiting in Orthognathic Surgery Compared With Dexamethasone Alone: A Prospective Randomized Controlled Trial. 与单独使用地塞米松相比，地塞米松和昂丹司琼联合使用可减少正颌手术术后恶心和呕吐：一项前瞻性随机对照试验

Anesthesia progress Pub Date : 2025-03-12 DOI: 10.2344/23-0019

Yuna Kang, Kyotaro Koshika, Keiko Takashima, Ai Nakakuki, Kazuya Hasunuma, Mayuko Hayashi, Kaori Miyamoto, Maho Yamamoto, Kaori Yoshida, Tatsuya Ichinohe

{"title":"Dexamethasone and Ondansetron Combined Decreases Postoperative Nausea and Vomiting in Orthognathic Surgery Compared With Dexamethasone Alone: A Prospective Randomized Controlled Trial.","authors":"Yuna Kang, Kyotaro Koshika, Keiko Takashima, Ai Nakakuki, Kazuya Hasunuma, Mayuko Hayashi, Kaori Miyamoto, Maho Yamamoto, Kaori Yoshida, Tatsuya Ichinohe","doi":"10.2344/23-0019","DOIUrl":"10.2344/23-0019","url":null,"abstract":"Objective: This study aimed to compare the efficacy of dexamethasone alone and dexamethasone-ondansetron combined for preventing postoperative nausea and vomiting (PONV) in patients undergoing orthognathic surgery.Methods: Patients scheduled to undergo mandibular orthognathic surgery who were 18 to 50 years of age and American Society of Anesthesiologists physical status I or II were enrolled. Dexamethasone 6.6 mg was administered after intubation, followed by either ondansetron 4 mg (group DO) or saline placebo (group D) 15 minutes before the end of surgery. Nausea severity was assessed at 3 times postoperatively (immediately after the end of anesthesia, 2 hours later, and 24 hours later) using a 11-point numeric rating scale (NRS). If a patient complained of postoperative nausea or vomited, the NRS score was reevaluated. If the NRS score was 3 or higher, intravenous metoclopramide 10 mg was administered for PONV rescue. Assessed data included nausea NRS scores, vomiting, metoclopramide use, and other patient demographics.Results: Mean nausea NRS scores at 2 hours were significantly lower in group DO vs group D (0.3 vs 2.1; P = .003), but differences in vomiting rates were not significant (P > .05). PONV rescue rates with metoclopramide were lower overall and at 2 hours later in group DO (P < .001).Conclusion: Dexamethasone combined with ondansetron was more effective in preventing early postoperative nausea and reducing need for PONV rescue than dexamethasone alone for patients undergoing orthognathic surgery.","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"72 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Dexmedetomidine vs Esmolol on Postintubation Hemodynamics: A Meta-Analysis. 右美托咪定与艾司洛尔对插管后血流动力学的影响：荟萃分析。

Anesthesia progress Pub Date : 2025-03-12 DOI: 10.2344/23-0059

Abbass Saleh, Stacy Kan, Sonica Singhal, Aviv Ouanounou, Michelle Wong

{"title":"Effects of Dexmedetomidine vs Esmolol on Postintubation Hemodynamics: A Meta-Analysis.","authors":"Abbass Saleh, Stacy Kan, Sonica Singhal, Aviv Ouanounou, Michelle Wong","doi":"10.2344/23-0059","DOIUrl":"10.2344/23-0059","url":null,"abstract":"Objective: Tracheal intubation (TI) consistently induces tachycardia and elevated blood pressure which may be deleterious to patients, particularly those with existing cardiac conditions. Use of dexmedetomidine or esmolol has been described to attenuate this sympathetic response. This study aimed to determine the effectiveness of dexmedetomidine vs esmolol in attenuating the hemodynamic response during TI.Methods: A systematic review and meta-analysis were performed using PRISMA guidelines. A systematic literature search in electronic databases and grey literature was completed. Researchers assessed article eligibility, performed data extraction, and completed risk of bias assessment. Results were expressed as pooled differences for cardiovascular parameters between the drugs as the weighted mean difference with 95% CI. A P < .05 was considered statistically significant. Heterogeneity was quantified using the I2 statistic. Subgroup analyses exploring different drug regimens were performed.Results: Of 112 publications, 19 randomized controlled trials were included for descriptive analysis and 15 were selected for the meta-analysis with 948 patients. The use of dexmedetomidine vs esmolol provided lower heart rates and mean arterial pressures at 1, 3, 5, and 10 minutes and lower systolic and diastolic pressures at 1, 3, and 5 minutes after TI.Conclusion: Dexmedetomidine blunts the hemodynamic response to TI more effectively vs esmolol.","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"72 1","pages":"9-23"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothyroidism Revealed During General Anesthesia in a Patient With Treatment-Resistant Depression: A Case Report. 全麻期间出现甲状腺功能减退的患者治疗难治性抑郁症：1例报告。

Anesthesia progress Pub Date : 2025-03-12 DOI: 10.2344/23-0031

Makiko Shibuya, Yuya Sakurai, Yukifumi Kimura, Takayuki Hojo, Saori Tada, Toshiaki Fujisawa, Kanta Kido

{"title":"Hypothyroidism Revealed During General Anesthesia in a Patient With Treatment-Resistant Depression: A Case Report.","authors":"Makiko Shibuya, Yuya Sakurai, Yukifumi Kimura, Takayuki Hojo, Saori Tada, Toshiaki Fujisawa, Kanta Kido","doi":"10.2344/23-0031","DOIUrl":"10.2344/23-0031","url":null,"abstract":"General anesthesia in patients with undiagnosed hypothyroidism can lead to neurological, pulmonary, and cardiovascular complications. We report a case of hypothyroidism in a patient with treatment-resistant depression detected intraoperatively based on multiple clinical findings. A 49-year-old woman was scheduled for orthognathic surgery for mandibular prognathism. She had depression since the age of 36 and was taking multiple psychotropic medications. After induction, she had persistent hypotension, bradycardia, low bispectral index, and hypothermia that were resistant to treatment. After ruling out common causes and reducing the anesthetic agents, blood tests were performed intraoperatively to examine thyroid function which revealed hypothyroidism. No delayed recovery or postoperative abnormalities were observed. Lithium carbonate was identified as the most likely cause of hypothyroidism by an endocrinologist. Given the overlap in signs and symptoms, hypothyroidism may be overlooked in a patient with depression. The possibility of hypothyroidism should be considered especially noted in patients taking lithium carbonate. Furthermore, suspicion of hypothyroidism based on clinical findings during anesthesia may prompt the need for further evaluation.","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"72 1","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anesthetic Management With Remimazolam for Adolescent Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-like Episodes (MELAS): A Case Report. 雷马唑仑麻醉治疗青少年线粒体脑肌病伴乳酸酸中毒和卒中样发作（MELAS） 1例报告。

Anesthesia progress Pub Date : 2025-03-12 DOI: 10.2344/23-0051

Mie Ueda, Nobuhiro Tanaka, Yoshihiro Momota, Masahiko Kawaguchi

引用次数: 0

Examining Liposomal Bupivacaine's Use in Dentistry. 布比卡因脂质体在牙科中的应用研究。

Anesthesia progress Pub Date : 2024-12-04 DOI: 10.2344/321278

Kyle J Kramer

引用次数: 0

Postoperative Nausea and Vomiting After Minor Oral Surgery: A Retrospective Cohort Study. 小口腔手术后恶心呕吐：一项回顾性队列研究。

Anesthesia progress Pub Date : 2024-12-04 DOI: 10.2344/611198

Fumika Ogata, Tina Nakamura, Hiroshi Hoshijima, Katsushi Doi, Hiroshi Nagasaka, Tsutomu Mieda

{"title":"Postoperative Nausea and Vomiting After Minor Oral Surgery: A Retrospective Cohort Study.","authors":"Fumika Ogata, Tina Nakamura, Hiroshi Hoshijima, Katsushi Doi, Hiroshi Nagasaka, Tsutomu Mieda","doi":"10.2344/611198","DOIUrl":"10.2344/611198","url":null,"abstract":"Objective: This study aimed to determine whether PONV rates differed over time and to identify potential differences in PONV risk factors for oral surgery patients undergoing general inhalational anesthesia (IA) or propofol-based total intravenous anesthesia (TIVA).Methods: This retrospective cohort study included patients between 16 and 85 years of age and who received intubated general anesthesia with either IA or TIVA for minor oral surgery between January 2021 and July 2022. Primary outcomes were PONV overall (onset at 0-24 hours), early (onset at 0-2 hours), and late (onset at 2-24 hours). Known PONV risk factors as identified from existing literature were included for analysis.Results: Data were obtained from 188 patients. A total of 41 (21.8%) patients developed overall PONV, 35 patients (18.6%) had early PONV, and 14 patients (7.4%) had late PONV. Any PONV that occurred across 2 periods was categorized in each period. IA compared with TIVA had higher overall PONV (29.6% vs 13.3%; P = .008) and early PONV (25.5% vs 11.1%; P = .034). Female sex and increased Apfel scores were associated with increased overall, early, and late PONV. Per multivariate analysis, females were 2.5 to 6 times higher than males to have overall, early, and late PONV (P < .05), and IA was 3 times higher than TIVA to have overall and early, but not late, PONV (P < .05).Conclusion: Our results suggested that the method of anesthesia may impact the incidence of overall and early PONV and that female sex and increase Apfel scores correlated with increased PONV through all times.","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 4","pages":"163-170"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Current Literature of Interest to the Office-Based Anesthesiologist. 对办公室麻醉师感兴趣的当前文献综述。

Anesthesia progress Pub Date : 2024-12-04 DOI: 10.2344/690585

Mark A Saxen

引用次数: 0

Liposomal Bupivacaine Use in Third Molar Impaction Surgery: INNOVATE Study. 布比卡因脂质体在第三磨牙嵌塞手术中的应用：创新研究。

Anesthesia progress Pub Date : 2024-12-04 DOI: 10.2344/333161

Stuart E Lieblich, Hassan Danesi

{"title":"Liposomal Bupivacaine Use in Third Molar Impaction Surgery: INNOVATE Study.","authors":"Stuart E Lieblich, Hassan Danesi","doi":"10.2344/333161","DOIUrl":"10.2344/333161","url":null,"abstract":"The analgesic efficacy and safety of liposomal bupivacaine (LB) in third molar extraction was evaluated in this phase 3, double-blind, placebo-controlled study of subjects undergoing bilateral third molar extraction. Subjects were randomized 2: 1 to infiltration with LB (133 mg/10 mL) or placebo, and received opioid rescue medication as needed. Primary efficacy measure was cumulative area under the curve (AUC) of numeric rating scale (NRS) pain severity scores through 48 hours (AUC of NRS0-48) postsurgery. Other measures included AUC of NRS0-24, AUC of NRS0-72, and AUC of NRS0-96, and incidence of adverse events. There were 150 subjects in the primary efficacy population (n = 99 LB, n = 51 placebo) and 89 in the per-protocol population (n = 59 LB, n = 30 placebo). Least-squares mean for AUC of NRS0-48 was 172.3 LB versus 194.7 placebo (P = .227) in the primary efficacy population and 120.8 LB versus 183.3 placebo (P = .023) in the per-protocol population. At all time points, between-group differences in AUC of NRS scores were significant in the per-protocol population (LB lower than placebo, P < .05) but not in the primary efficacy population. The adverse event profile was similar between groups. LB produced significantly lower cumulative pain scores versus placebo at all time points in the per-protocol analysis but not in the primary efficacy analysis because of protocol violations. This study indicates significant improvement in pain scores in the third molar model, but because of extensive protocol violations additional studies are warranted to demonstrate effectiveness.","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 4","pages":"199-207"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Ketamine's Influence on In Vitro Angiogenesis. 氯胺酮对体外血管生成影响的评价。

Anesthesia progress Pub Date : 2024-12-04 DOI: 10.2344/23-0011

Kazumi Takaishi, Marina Takata, Mika Nishikawa, Hiroshi Kitahata, Shinji Kawahito

{"title":"Assessment of Ketamine's Influence on In Vitro Angiogenesis.","authors":"Kazumi Takaishi, Marina Takata, Mika Nishikawa, Hiroshi Kitahata, Shinji Kawahito","doi":"10.2344/23-0011","DOIUrl":"10.2344/23-0011","url":null,"abstract":"Objective: Angiogenesis is associated with angiogenic therapy and wound healing processes. It is important for anesthesiologists to understand the effects of perioperative and long-term use of anesthetics on angiogenesis. This study aimed to determine the effects of ketamine on in vitro angiogenesis: the proliferation of human umbilical vein endothelial cells (HUVEC) and normal human diploid fibroblasts (NHDF), HUVEC migration, and in vitro capillary tube formation in cocultured HUVEC and NHDF.Methods: The effects of ketamine at concentrations of 1, 10, and 50 µM on the proliferation of HUVEC and NHDF for 48 hours were determined by using a water-soluble tetrazolium salt reagent. Quantitation of migration for 22 hours was achieved by measuring the fluorescence of migrating HUVEC exposed to ketamine using an angiogenesis system. The effects of ketamine on capillary tube formation with or without vascular endothelial growth factor (VEGF) were investigated in cocultured HUVEC and NHDF incubated for 3 and 10 days.Results: Ketamine did not show any enhancing or suppressive effects on the in vitro proliferation of HUVEC and NHDF, HUVEC migration, or capillary tube formation in cocultured HUVEC and NHDF for either 3 or 10 days in the presence or absence of VEGF.Conclusion: Ketamine had no effects on in vitro angiogenesis using cultured HUVEC and NHDF. Ketamine can potentially be used as an anesthetic agent with no influence on angiogenesis.","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"71 4","pages":"176-182"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suspected Sinus Arrest After Sugammadex Administration: A Case Report. 糖美德给药后疑似窦性停搏1例。

Anesthesia progress Pub Date : 2024-12-04 DOI: 10.2344/anpr-23-0054

Takuya Uchida, Tamao Ikuno, Yoshinori Ikeda, Mie Ueda, Akina Toya, Yozo Manabe, Yoshihiro Momota

引用次数: 0