{"title":"Managing Oral RAE Tube Malpositioning After Neck Extension.","authors":"Masanori Tsukamoto, Michi Eto, Yusuke Oku, Marika Marutani, Kazuya Matsuo, Takeshi Yokoyama","doi":"10.2344/25-0010","DOIUrl":"10.2344/25-0010","url":null,"abstract":"<p><p>Cleft lips and palate are orofacial deformities that require surgical repair in childhood to promote speech development, facial growth, and improved aesthetics. In these cases, preformed oral Ring-Adair-Elwyn (RAE) endotracheal tubes (ETTs) are frequently used for airway management during general anesthesia. Due to its acute U-shaped curve, the oral RAE ETT was our first choice. However, the ability to adjust the intubation depth can be limited because of the preformed curve, and insertion length is fixed based on the internal tube diameter. During neck extension after intubation, the ETT moves away from the carina, which can cause the ETT cuff to compress the vocal cords. Therefore, oral RAE ETTs are associated with a risk of inadvertent ETT malpositioning. Our study assessed ETT positioning in 186 patients in whom oral RAE ETTs were initially used, and we found an 8% incidence rate of inadvertent ETT malpositioning after head and neck extension. In such cases, we replaced the malpositioned oral RAE ETT with a wire-reinforced ETT, which we feel was ideal to serve as a secondary option. Wire-reinforced ETTs tolerate extreme flexion without kinking and can withstand high pressure without collapsing. Although oral RAE ETTs can be advantageous for cleft lip and palate surgery, they can become malpositioned after neck extension and should be assessed accordingly. Consideration for using a wire-reinforced ETT as a replacement is warranted in such instances.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"112-115"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to Commentary: Govind A. Commentary: Inhalational Induction Without Vascular Access Should Be Rare in OMS. Anesthesia Progress. 2025;72(4):251-252. doi: 10.2344/24-0056.","authors":"Michael K Rollert","doi":"10.2344/26-0008","DOIUrl":"10.2344/26-0008","url":null,"abstract":"","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"119"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the Effects of Remimazolam and Propofol, With Epinephrine-containing Lidocaine, on Rocuronium-induced Muscle Relaxation.","authors":"Mai Shionoya, Kyotaro Koshika, Tatsuya Ichinohe","doi":"10.2344/25-0005","DOIUrl":"10.2344/25-0005","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the effects of remimazolam and propofol on neuromuscular blockade induced by the nondepolarizing neuromuscular blocking agent (NMBA) rocuronium and to evaluate the additional influence of epinephrine-containing lidocaine administered as a local anesthetic during general anesthesia.</p><p><strong>Methods: </strong>A total of 38 patients undergoing Le Fort I osteotomy were randomly assigned to the remimazolam group (R group) or propofol group (P group). All patients also received remifentanil and rocuronium. The rocuronium infusion rate was adjusted to maintain a train-of-four (TOF) ratio of 30% ± 10% and recorded. After administering the local anesthetic solution (2% lidocaine containing 1:80,000 epinephrine), the TOF ratio was recorded every minute for 20 minutes.</p><p><strong>Results: </strong>The mean (SD) continuous infusion rate of rocuronium required to maintain a similar TOF ratio was significantly smaller in R group (5.3 (0.5) µg/kg/min) than in P group (6.5 (0.8) µg/kg/min; P < .001). The mean (SD) TOF ratio before administering the epinephrine-containing lidocaine was 26.4% (11.8%) in P group and 30.1% (11.8%) in R group (P = 1.0) and after administration was 7.5% (7.8%) in P group and 8.3% (10.1%) in R group (P = 1.0), all of which lacked statistical significance.</p><p><strong>Conclusion: </strong>Our results suggested that remimazolam and epinephrine-containing lidocaine administered for local anesthesia enhanced the NMBA effect of rocuronium.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Changing the General Anesthesia Method on Postoperative Nausea and Vomiting Incident and Severity.","authors":"Rina Sato, Yoshito Ohyama, Hikaru Sato, Shota Abe, Hiroyoshi Kawaai, Shinya Yamazaki","doi":"10.2344/25-0003","DOIUrl":"10.2344/25-0003","url":null,"abstract":"<p><strong>Objective: </strong>Among patients who underwent general anesthesia (GA) multiple times with different methods, we aimed to compare the incidence and severity of postoperative nausea and vomiting (PONV) when the GA method was changed.</p><p><strong>Methods: </strong>Subjects were healthy intellectually disabled patients who underwent multiple dental procedures under GA. Methods of general anesthesia were classified as (1) nitrous oxide-sevoflurane (NOS), (2) sevoflurane-remifentanil (SRF), and (3) propofol-remifentanil (PRF). Patients who experienced PONV had an alternative method of GA utilized for subsequent cases. PONV incident rates and severity scores overall and between groups were calculated and compared statistically for analysis.</p><p><strong>Results: </strong>PONV occurred in 186 (6.5%) of the 2872 cases and in 85 (28.8%) of the 295 patients included in this study. Statistical paired comparisons of the mean incidence of PONV demonstrated a decrease of 25.2% when the GA method was changed from NOS to SRF, 40.4% when changed from NOS to PRF, and 36.4% when changed from SRF to PRF (P < .05). Statistical paired comparisons of the mean 5-point PONV severity score similarly demonstrated a decrease of 0.53 when the GA method was changed from NOS to SRF, 0.92 when changed from NOS to PRF, and 0.62 when changed from SRF to PRF (P < .05).</p><p><strong>Conclusion: </strong>The highest PONV incidence rates and severity were noted with NOS, whereas PONV decreased significantly with SRF and PRF use. The absence of nitrous oxide and use of propofol were suggested as ways to alter the method of general anesthesia to reduce the incidence and improve the severity of PONV.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Desflurane-Induced Delayed Onset of Malignant Hyperthermia: A Case Report.","authors":"Hideaki Seki, Niki Takei, Mie Kajiwara, Madoka Tsumura, Nozomi Naito, Miho Tsujiuchi, Mami Higa, Yuko Koyanagi, Shunichi Oka, Keisuke Kaneko","doi":"10.2344/25-0006","DOIUrl":"10.2344/25-0006","url":null,"abstract":"<p><p>Malignant hyperthermia (MH) is a rare but life-threatening pharmacogenetic disorder triggered by volatile anesthetics and/or depolarizing muscle relaxants, resulting in a hypermetabolic crisis. We report a case of postoperative fulminant MH in a 26-year-old man who underwent general anesthesia with desflurane and rocuronium for mandibular fracture repair. Despite a history of multiple uneventful anesthetics, the patient developed acute hypercapnia, tachycardia, muscle rigidity, and rapid hyperthermia during emergence, following sugammadex administration. Initial treatment for presumed bronchospasm and postoperative shivering-including sevoflurane sedation, hyperventilation, and inhaled bronchodilators-proved ineffective. A clinical diagnosis of MH was made based on the progression of clinical findings, and treatment with intravenous dantrolene 100 mg, active cooling, and antipyretics was initiated. The patient responded well to intervention and recovered without sequelae. This case highlights the importance of considering MH even in the postoperative phase, particularly with the use of desflurane and potentially contributory agents such as sugammadex and ondansetron. Early clinical suspicion, rapid administration of dantrolene, and supportive measures are critical for favorable outcomes. Anesthesia providers must remain vigilant for MH at all perioperative stages and ensure that emergency protocols, appropriate drug stock, and staff readiness are in place.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"97-105"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cornelia de Lange Syndrome and General Anesthesia for Dental Treatment: A Case Report.","authors":"Kira Douglas, Paul Schwartz, Craig McKenzie","doi":"10.2344/25-0002","DOIUrl":"10.2344/25-0002","url":null,"abstract":"<p><p>Cornelia de Lange syndrome (CdLS) is a rare genetic disorder with a wide variation of presentations affecting several organ systems. Most patients with CdLS have a mutation of the NIPBL (Nipped-B-like protein) gene responsible for making delangin, a protein important in human development. Patients with CdLS typically present with intellectual disability, growth delay, cleft palate, and extremely limited mouth opening. These findings can complicate induction of general anesthesia, airway management, and intubation. Treatment of CdLS is based on clinical presentation and includes pharmacologic, therapeutic, and surgical intervention. Cleft palate repair is common in these patients which may impact the anesthetic plan. Additionally, the anesthesiologist should be aware of associated cardiovascular anomalies, ranging from innocent murmurs to persistent structural defects and leading to increased morbidity and mortality in these patients. This case report discusses CdLS and its implications on the general anesthetic management of a 37-year-old woman undergoing treatment for dental caries in an ambulatory care setting. Although CdLS is a rare genetic disorder, anesthesiologists treating such patients with special needs should be familiar with its presentation and anesthetic considerations.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"90-96"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of Current Literature of Interest to the Office-Based Anesthesiologist.","authors":"Mark A Saxen","doi":"10.2344/73.2.130","DOIUrl":"10.2344/73.2.130","url":null,"abstract":"","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"130-132"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shota Tsukimoto, Hidetaka Kuroda, Atsuki Yamaguchi, Rina Yamamoto, Uno Imaizumi, Aiji Sato-Boku, Naotaka Kishimoto, Kanta Kido, Takahiro Abe, Takuro Sanuki
{"title":"Tracing the Footsteps of Dental Anesthesiology: A Bibliometric Analysis of Anesthesia Progress.","authors":"Shota Tsukimoto, Hidetaka Kuroda, Atsuki Yamaguchi, Rina Yamamoto, Uno Imaizumi, Aiji Sato-Boku, Naotaka Kishimoto, Kanta Kido, Takahiro Abe, Takuro Sanuki","doi":"10.2344/24-0047","DOIUrl":"10.2344/24-0047","url":null,"abstract":"<p><strong>Objective: </strong>The widespread availability of the internet in recent years has made it easier to use electronic databases, and bibliometric analysis is now being carried out in a variety of fields. This method aimed to investigate the characteristics and trends of dental anesthesiology research published in Anesthesia Progress, the oldest and most authoritative journal in the field, from its inception in 1966 to 2023. We identified the 50 most-cited articles to evaluate the impact and evolution of research in this field.</p><p><strong>Methods: </strong>The search was conducted by entering \"Anesthesia Progress\" in the \"Source Title\" field, which is one of the search items in the Scopus database. The results were sorted by number of citations, and the bibliographic information for the top 50 most-cited articles was downloaded.</p><p><strong>Results: </strong>The analysis revealed that most of these influential papers originated in the United States (60%), highlighting its dominance in dental anesthesiology research. Key topics identified included \"sedation\" and \"local anesthesia,\" reflecting an increasing emphasis on pain management and psychological support in dental care. The findings also indicated a modest decline in the proportion of scientific reports, suggesting potential stagnation in new research contributions over time. Furthermore, index keyword analysis illustrated a growing specialization in addressing anxiety and pain associated with dental procedures.</p><p><strong>Conclusion: </strong>This study underscores the need for enhanced research and innovation in dental anesthesiology to meet the evolving needs of clinical practice and improve patient care.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"83-89"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"General Anesthesia for Partial Tongue Resection in a Patient With Mixed Connective Tissue Disease: A Case Report.","authors":"Hitoshi Higuch, Fumika Hashimoto, Kota Miyake, Saki Miyake, Yukiko Nishioka, Takuya Miyawaki","doi":"10.2344/25-0023","DOIUrl":"10.2344/25-0023","url":null,"abstract":"<p><p>Mixed connective tissue disease (MCTD) is an autoimmune disorder characterized by overlapping features of multiple connective tissue diseases in addition to anti-U1-ribonucleoprotein (RNP) antibodies and Raynaud's phenomenon. A 53-year-old female patient with MCTD, interstitial pneumonia, and idiopathic thrombocytopenic purpura underwent partial tongue resection under general anesthesia. Perioperative management included steroid coverage and careful titration of the oxygen concentration. Although venous access was difficult, the anesthetic course was uneventful. MCTD can present perioperative challenges including pulmonary and cardiac complications, effects of long-term steroid use, and airway and cardiovascular disturbances. Safe anesthesia for patients with MCTD requires assessment of disease activity and severity across multiple conditions and individualized management accordingly.</p>","PeriodicalId":94296,"journal":{"name":"Anesthesia progress","volume":"73 2","pages":"110-111"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}