Canadian Journal of Kidney Health and Disease最新文献

{"title":"Development and Validation of a Canadian Prediction Equation for Incident CKD Using Population-Based, Administrative Data.","authors":"Manish M Sood, Stephanie N Dixon, Sarah E Bota, Thomas W Ferguson, Gregory L Hundemer, Ayub Akbari, Douglas G Manuel, Gregory Knoll, Navdeep Tangri","doi":"10.1177/20543581261439677","DOIUrl":"10.1177/20543581261439677","url":null,"abstract":"<p><strong>Background: </strong>Identifying individuals at risk for incident chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m²) could aid in prevention and disease surveillance.</p><p><strong>Objective: </strong>Develop and validate prediction equations to identify individuals at risk of incident CKD using routinely collected administrative data with and without urine albumin-to-creatinine ratio (ACR).</p><p><strong>Design: </strong>This is a retrospective cohort study using administrative data.</p><p><strong>Setting: </strong>This study was conducted in Manitoba and Ontario, Canada.</p><p><strong>Patients: </strong>This study included 413 948 adults (18 or older) with an eGFR > 70 mL/min/1.73 m² from Manitoba (derivation cohort; 2006-2016) with external validation in 7 747 513 adults from Ontario, Canada.</p><p><strong>Measurements: </strong>Routinely available variables (demographics, comorbidities, laboratory values) in administrative data sets were used to predict the outcome of incident CKD (stage G3+) defined by a single outpatient eGFR measure <60 mL/min/1.73 m² during and up to 10 years of follow-up. In an additional analysis, we defined incident CKD using repeat eGFR measures.</p><p><strong>Methods: </strong>Time-to-event models, accounting for the competing risk of death, were used to predict new-onset CKD from one to nine years with a data-driven model reduction. Prediction equations stratifying individuals with and without ACR measurements were derived internally and externally validated.</p><p><strong>Results: </strong>Among individuals from Manitoba [53% women, mean (SD) age 51 (17), mean (SD) baseline eGFR 95 (14) mL/min/1.73 m², median (interquartile range) ACR 0.7 mg/mmol (1-3)], incident CKD occurred in 11.4% during a median follow-up time of 4.5 (Q1 = 2.3, Q3 = 7.6) years of follow-up. The final model included six variables (age, sex, baseline eGFR, hemoglobin, hypertension, and diabetes) and yielded a five-year area under the curve of 86.0 (no ACR) and 80.2 (with ACR). Model performance was excellent in external validation.</p><p><strong>Limitations: </strong>Only individuals with measures of all model predictors (complete case analysis) were included.</p><p><strong>Conclusion: </strong>Equations using routinely collected population-level, administrative data variables can accurately predict the onset of CKD with or without ACR.</p>","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261439677"},"PeriodicalIF":1.6,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review of C3 Glomerulopathy: From Pathogenesis to Targeted Therapy.","authors":"Arenn Jauhal, Bryce Barr, Louis Girard, Louis-Philippe Laurin, Durhane Wong-Rieger, Christoph Licht","doi":"10.1177/20543581261442656","DOIUrl":"10.1177/20543581261442656","url":null,"abstract":"<p><strong>Purpose of the review: </strong>Complement factor 3 (C3) glomerulopathy (C3G) is an ultra-rare, progressive, complement-mediated kidney disease. Despite many advances in the understanding of its underlying pathophysiology, C3G remains a clinical challenge due to the overall burden of disease, diagnostic complexity, poor prognosis, lack of approved therapies, and limited access to drugs for kidney diseases in Canada. This narrative review explores the diagnosis and management of individuals with C3G, including novel complement-mediated therapies and their potential impact on patients and outcomes.</p><p><strong>Sources of information: </strong>This narrative review is based on the best available data, current treatment guidelines, and the authors' clinical experiences. Information for the patient perspective section was collected through discussions with two individuals with C3G.</p><p><strong>Methods: </strong>A panel of Canadian nephrologists who actively care for individuals with C3G was assembled. A rare disease advocate and two individuals with C3G were invited to share their lived experiences. The authors conducted a comprehensive review of the literature to explore the state of the science and future directions in C3G, highlighting current limitations and unmet needs.</p><p><strong>Key findings: </strong>C3 glomerulopathy is caused by dysregulation of the alternative complement pathway, leading to the deposition of complement proteins and their cleavage products in kidney glomeruli. The consequence of deposition of C3 is glomerular inflammation and tissue damage, which lead to proliferative glomerulonephritis and remodeling of the glomerular capillary walls. Individuals diagnosed with C3G experience significant symptoms that adversely impact their quality of life. Nearly half of patients develop kidney failure within 10 years of diagnosis. C3 glomerulopathy recurrence after kidney transplant occurs in more than half of patients. Severity of proteinuria and reduced estimated glomerular filtration rate (eGFR) are among the most important clinical predictors of kidney failure with further research required for the utility of biomarkers to guide prognosis. There is no established standard of care and no therapies specifically approved for individuals with C3G in Canada. Complement-directed therapies, iptacopan and pegcetacoplan, have demonstrated significant reductions in proteinuria and stabilization in kidney function, offering hope for individuals with C3G, including post-transplant. This review offers an up-to-date synthesis of current knowledge on C3G for Canadian nephrologists at a juncture where targeted therapies are becoming available.</p><p><strong>Limitations: </strong>A systematic review of the literature was not undertaken. Key takeaways are based on currently available evidence, of which head-to-head clinical trials are lacking. The possibility for bias based on the authors' clinical experiences may have occurred.</p>","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261442656"},"PeriodicalIF":1.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Canadian Survey of Prescribing Practices of Erythropoiesis-Stimulating Agents in Dialysis-Dependent and Non-Dialysis-Dependent Chronic Kidney Disease.","authors":"Rammdeep Saini, Keigan More, Jo-Anne S Wilson, David A Clark, Amanda J Vinson, David Collister, Mark Canney, Karthik K Tennankore","doi":"10.1177/20543581261437775","DOIUrl":"10.1177/20543581261437775","url":null,"abstract":"<p><strong>Background: </strong>Erythropoiesis-stimulating agents (ESAs) are commonly used to manage chronic kidney disease (CKD)-associated anemia. There is a paucity of clear guidelines on their use in patients with CKD and with history of stroke or malignancy.</p><p><strong>Objective: </strong>To identify hemoglobin targets/thresholds, ESA prescribing practices and patterns, and prescriber comfort in patients with CKD and with history of stroke or malignancy.</p><p><strong>Study design and setting: </strong>We administered an online, cross-sectional survey to nephrologists, nephrology trainees, nurse practitioners, and pharmacists affiliated with the Canadian Society of Nephrology (CSN) from March 11 to June 30, 2024.</p><p><strong>Methods: </strong>Survey questions were designed to determine the prescribing practices of ESAs for both general patients with CKD and those with CKD and history of stroke, active malignancy, or prior malignancy. Survey design was finalized using a 4-stage modified Delphi process. Ordinal regression was used to assess the association between baseline characteristics and prescriber comfort.</p><p><strong>Results: </strong>In all, 24% (127/540) of potential participants responded, with 121 responses included in the final survey analysis. Most respondents were nephrologists (67%, 81/121). Only 9%, 7%, and 4% of respondents reported having an institutional protocol for anemia management for patients with CKD and history of stroke, active malignancy, or previous malignancy, respectively. The most common hemoglobin target for general patients with CKD was 95 to 115 g/L. For those with history of stroke, active, or previous malignancy, it was 90 to 105 g/L. Self-reported prescriber comfort was greatest in general patients with CKD. Among all prescribers, comfort ratings were significantly lower when prescribing ESAs in those with stroke or malignancy. Nephrologists and nephrology trainees were more likely to report higher comfort ratings when prescribing ESAs in patients with CKD and active malignancy (odds ratio [OR] = 2.80, 95% confidence interval [CI] = 1.12-6.96) compared with nonphysicians.</p><p><strong>Limitations: </strong>There was a potential for nonresponse bias given the response rate of 24%. Sampling bias may have been introduced with convenience sampling of solely kidney care providers affiliated with the CSN.</p><p><strong>Conclusion: </strong>This study highlights the variability of ESA prescribing practices and anemia management across Canada in patients with CKD and with stroke or malignancy. Our findings emphasize the need for guidelines to manage ESA prescribing in these populations.</p>","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261437775"},"PeriodicalIF":1.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conference Report-The Past, Current, and Future Challenges in Transplantation: A Festschrift in Honor of Professor Paul Anthony Keown.","authors":"John Gill, Calvin Stiller, James Lan, Anthony Jevnikar, Philip F Halloran, David Rush, Peter Nickerson, Edward Cole, Arthur J Matas, Richard Formica, Deirdre Sawinski, Christopher D Blosser, Roslyn B Mannon, Paul A Keown","doi":"10.1177/20543581261434082","DOIUrl":"10.1177/20543581261434082","url":null,"abstract":"<p><strong>Purpose: </strong>Canadian researchers have made significant contributions to the advancement of organ transplantation globally. The COVID-19 pandemic made transparent the importance of reflecting on our accomplishments and the current and future challenges that limit the lives of our patients and to celebrate individual and collective achievement.</p><p><strong>Sources of information/methods: </strong>On October 6, 2025, thought leaders in the field of organ transplantation assembled in Vancouver to recognize the contributions of Paul Keown, a clinician scientist and translational researcher, whose work has directly impacted thousands of transplant recipients worldwide.</p><p><strong>Key findings: </strong>This article summarizes the invited speaker presentations and represents a unique opportunity to celebrate the past and to focus on current challenges and future opportunities to advance the field of organ transplantation.</p>","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261434082"},"PeriodicalIF":1.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multipronged Intervention to Improve Outpatient Care Following Hospitalization With Acute Kidney Injury: An Implementation Study Protocol.","authors":"Michelle M Y Wong, Peter Birks, Omosomi Enilama, Janelle S W Yu, Anurag Singh, Adeera Levin","doi":"10.1177/20543581261429009","DOIUrl":"10.1177/20543581261429009","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Acute kidney injury (AKI)-related hospitalizations are associated with long-term health consequences, but post-AKI management and monitoring in the outpatient primary care setting are suboptimal. Documentation and communication about in-hospital AKI episodes to patients' primary care providers are often inadequate. Awareness of AKI among patients is generally poor.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To develop a multifaceted intervention package to improve post-AKI care, to evaluate its implementation using feasibility and process metrics, and to observe its short-term effectiveness.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;Mixed-methods feasibility study with type 3 hybrid implementation/effectiveness design.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Participants: &lt;/strong&gt;Kidney specialist physicians on inpatient consultation service at three hospital sites in British Columbia (in New Westminster, Prince George, Vancouver) will deliver the intervention package to patients with AKI and their primary care providers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Measurements: &lt;/strong&gt;Implementation outcomes include reach, adoption, fidelity, and sustainment of the intervention. Implementation determinants, including acceptability, adaptability, feasibility, appropriateness, and satisfaction, will be assessed with surveys and focus groups with kidney specialist physicians, primary care providers, and patients/caregivers. Short-term effectiveness outcomes include: patient follow-up visits with primary care providers, and kidney lab testing at three months; AKI awareness and self-efficacy among primary care providers and patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Guided by the Theoretical Domains Framework, we conducted focus groups with interest holders to identify the barriers, challenges, and needs in post-AKI care and then applied this information to develop an intervention package, including an AKI-specific discharge/sign-off template, a post-AKI medication management guide, educational websites for providers and patients, and a patient handout. In this six-month implementation feasibility study, the implementation strategies will be initiated sequentially at each site for four to eight weeks. Quantitative data will be collected via self-report, chart review, surveys, and website hits and analyzed using descriptive statistics. Postimplementation qualitative data will be collected from focus groups/interviews and will be analyzed by identifying codes and categorizing them into themes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;The study will take place in the setting of nephrology consultation services. Adaptations to implementation strategies would be required for delivery of the intervention by other inpatient providers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The study will evaluate feasibility and preliminary effectiveness of a multifaceted intervention aimed at improving care coordination between specialists and primary care providers and care transition following hospital discharge in pati","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261429009"},"PeriodicalIF":1.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of Patients With Chronic Kidney Disease Undergoing Hemodialysis: A Qualitative Study in Bangladesh.","authors":"Muhammed Arshad Ul Azim, Md Enamul Kabir, Md Obaidul Haque, Md Afzalul Bashar, Zannatul Ferdous, Banga Kamal Basu, Moyeenuddin Amin, Asma Begum, Kazi Maria Haque Semme, Syed Abdullah Jami, Nazim Uzzaman, Gm Monsur Habib","doi":"10.1177/20543581261429257","DOIUrl":"10.1177/20543581261429257","url":null,"abstract":"<p><strong>Background: </strong>Despite the increasing burden of chronic kidney disease (CKD) and its associated challenges, there is limited understanding of the lived experiences, awareness, and treatment perspectives of patients in Bangladesh.</p><p><strong>Objective: </strong>We aimed to explore the experiences of patients with CKD undergoing maintenance hemodialysis in Bangladesh, identifying key challenges and areas for improvement.</p><p><strong>Design: </strong>Descriptive qualitative study.</p><p><strong>Setting: </strong>Khulna, Bangladesh.</p><p><strong>Participants: </strong>Individuals with CKD undergoing maintenance hemodialysis.</p><p><strong>Methods: </strong>We recruited people with CKD undergoing maintenance hemodialysis from two tertiary hospitals in Khulna, Bangladesh, using purposive sampling. Semi-structured interviews were conducted, and the data were analyzed using Braun and Clarke's inductive thematic analysis approach.</p><p><strong>Results: </strong>We interviewed 16 participants with CKD. Our findings revealed that most participants had limited knowledge about chronic kidney disease and experienced delays in diagnosis. While maintenance hemodialysis provided temporary relief, it also resulted in considerable physical and emotional distress. Financial strain was a major concern, with many participants struggling to afford treatment. Accessibility issues, such as long waiting times and transportation challenges, were common. Participants expressed a strong desire for better service delivery and reduced treatment costs.</p><p><strong>Limitations: </strong>All participants were recruited from two tertiary care hospitals in Khulna, an urban setting, which may limit the applicability of the findings to other regions of Bangladesh.</p><p><strong>Conclusion: </strong>Our study underscores the need for improved financial support, enhanced mental health services, greater patient awareness, and healthcare policy reforms to alleviate the burden on patients with chronic kidney disease and improve their overall quality of life.</p>","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261429257"},"PeriodicalIF":1.6,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Three-Year Survival in Patients Receiving Maintenance Dialysis: An External Validation and Updated Multivariable Prediction Model for iChoose Kidney in Ontario, Canada.","authors":"Kyla L Naylor, Yuguang Kang, Eric McArthur, Amit X Garg, Rachel E Patzer, Susan McKenzie, S Joseph Kim, Matthew Weir, Seychelle Yohanna, Gregory Knoll, Darin Treleaven","doi":"10.1177/20543581261437298","DOIUrl":"10.1177/20543581261437298","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;A significant barrier to kidney transplantation is limited knowledge about its potential benefits. To help patients who are receiving maintenance dialysis make more informed treatment decisions, a risk calculator (iChoose Kidney) was developed in the United States to provide individualized survival estimates for dialysis versus kidney transplantation. This tool was externally validated in Ontario, Canada, and was found to accurately predict mortality (Ontario version of the tool \"Dialysis vs. Kidney Transplant-Estimated Survival in Ontario Risk Calculator\"). The United States risk calculator has been updated to include additional variables (e.g., dialysis modality).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To externally validate the updated iChoose Kidney risk calculator in patients from Ontario, Canada, with kidney failure using more recent data, removing race (race in clinical algorithms may perpetuate racial bias in medicine) and using a refined cohort definition (i.e., restricting to patients with no recorded contraindications to transplant).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;External validation study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Linked administrative health care databases from Ontario, Canada.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients: &lt;/strong&gt;24 793 patients receiving maintenance dialysis and 5398 kidney transplant recipients from January 1, 2011, to August 31, 2021.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Measurements: &lt;/strong&gt;Three-year mortality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Model discrimination was evaluated using the C-statistic. Calibration was assessed by comparing the observed versus predicted mortality risks, and further assessed by using loess-smoothed calibration plots. To address over- or under-prediction (calibration-in-the-large), intercepts were adjusted using a correction factor. In our updated model, we used logistic regression to calculate mortality risk, incorporating the following variables: sex assigned at birth (male vs female), age (continuous), cardiovascular disease, hypertension, diabetes, time on dialysis (i.e., &lt;6 months, 6 to 12 months, &gt;1 to 2 years, &gt;2 to 3 years, &gt;3 to 5 years, &gt;5 to 7 years, &gt;7 to 10 years, &gt;10 to 14 years, &gt;14 years), and dialysis modality (peritoneal dialysis, home hemodialysis, in-center dialysis). In a post-hoc analysis, we used the simplified equations from our original Canadian external validation study of the iChoose Kidney tool (i.e., age, sex, hypertension, diabetes, cardiovascular disease, time on dialysis [&lt;6 months, 6-12 months, &gt;12 months]), with removal of the race variable as the only modification.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the dialysis cohort, over a median follow-up of 2.5 years, 30.3% of patients died. In the kidney transplant recipient cohort, over a median follow-up of 2.9 years, 7.3% died. Our updated model had moderate discrimination (C-statistic for dialysis cohort: 0.67 [95% CI: 0.67, 0.68] and C-statistic for kidney transplant cohort: 0.76 [95% CI: 0.74, 0.79]). After rec","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261437298"},"PeriodicalIF":1.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Kidney Research Scientist Core Education and National Training (KRESCENT) Program: A 20-Year Qualitative Thematic Analysis.","authors":"Ian D Petula, Alison F Chung, Jamie E Knight, Sunny Hartwig, Adeera Levin, Theone S E Paterson","doi":"10.1177/20543581261434652","DOIUrl":"10.1177/20543581261434652","url":null,"abstract":"<p><strong>Background: </strong>The Kidney Research Scientist Core Education and National Training (KRESCENT) program was established to enhance kidney research capacity in Canada by providing salary support and specialized training for kidney researchers in Canada. This study is a qualitative evaluation to gain insight into participants' experiences in the program.</p><p><strong>Objective: </strong>To explore participants' perspectives of the KRESCENT program to (1) identify potential differences in perspectives between early and recent program cohorts and (2) understand perceived impact on participants' career trajectory and professional development.</p><p><strong>Design: </strong>A qualitative interview study using semi-structured interviews.</p><p><strong>Setting: </strong>Semi-structured interviews were conducted online via Zoom.</p><p><strong>Participants: </strong>Individuals who have previously completed, or who are currently enrolled in the KRESCENT program.</p><p><strong>Methods: </strong>Participants were selected through purposive sampling, and semi-structured interviews were conducted to explore their experiences in the program. Data were analysed using thematic analysis in NVivo software.</p><p><strong>Results: </strong>Participants (N = 30; M_age = 41.2, SD_age = 8.3, 53% Female) were interviewed, and the following emergent themes from the data were identified: (1) Navigating Expectations within KRESCENT, (2) Developing a Foundation for Success in Kidney Research, (3) Perceived Program Impact, (4) Fostering Multidisciplinary Collaboration and Diversity, (5) Considerations for Future Awardees.</p><p><strong>Limitations: </strong>The initial coding was conducted by a single researcher.</p><p><strong>Conclusions: </strong>This study highlights the long-term impact of the KRESCENT program on kidney research in Canada by exploring participants' experiences and valued program elements beyond traditional career milestones. Findings emphasize that structured funding programs enhanced with opportunities for mentorship, networking, and skill development significantly support career advancement. These results reinforce the importance of continued investment in KRESCENT to build kidney research capacity and suggest that similar training models could benefit other health research fields.</p>","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261434652"},"PeriodicalIF":1.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of People Receiving Dialysis About Climate Change and Environmentally Sustainable Kidney Care: A Knowledge, Attitudes and Practices Survey in Canada.","authors":"Camilia Minville, Carven Cambry, Daphne Esquivel Sada, Éliane Boucher, Alexia Mihalache, Ximena Fabiola Iraheta Palacios, Shaifali Sandal, Caroline Stigant, Isabelle Ethier","doi":"10.1177/20543581261434815","DOIUrl":"10.1177/20543581261434815","url":null,"abstract":"<p><strong>Background: </strong>Knowledge, attitudes and practices (KAP) of kidney care providers regarding climate change, environmental impacts of kidney care and environmentally sustainable kidney care have been assessed in diverse regions worldwide, but little is known about the perspectives of people who receive dialysis therapies. We aimed to assess the KAP of people on dialysis about these subjects.</p><p><strong>Methods: </strong>An electronic KAP survey, based on a previous survey of Canadian kidney care providers, was administered to people receiving all available dialysis modalities in a single center in Canada, from December 2024 to May 2025.</p><p><strong>Results: </strong>A total of 69 people responded to the survey, of whom 67% identified as men, and 70% were undergoing in-center hemodialysis (ICHD), 14% home hemodialysis (HHD) and 16% peritoneal dialysis (PD). Most (87%) of the respondents felt informed about climate change to at least an average degree. Nearly half were either extremely or very concerned about climate change (44%) and the waste generated by dialysis treatments (43%), and the levels of concern differed across dialysis modalities. Overall, 51% of respondents never felt guilt or anxiety related to the carbon footprint of dialysis treatment. However, there were significant differences (χ² test; <i>P</i> < .001) in the occurrence of these feelings depending on the dialysis modality (more frequent in people receiving home modalities, and more in PD than HHD). Most respondents were either very (45%) or slightly (45%) interested in obtaining more information about the themes explored in the survey.</p><p><strong>Conclusions: </strong>This survey showed that most respondents receiving a dialysis therapy felt informed and at least moderately concerned about climate change. Higher levels of concern about climate change and the amount of waste generated by dialysis treatment, as well as more frequent occurrence of guilt/anxiety about the carbon footprint of dialysis were observed in people on home therapies (PD and HHD) compared with ICHD.</p>","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261434815"},"PeriodicalIF":1.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Things to Know About Obesity in Kidney Transplant Candidates.","authors":"Somaya Zahran, Jason Y Lee, Sunita K S Singh","doi":"10.1177/20543581261434826","DOIUrl":"10.1177/20543581261434826","url":null,"abstract":"","PeriodicalId":9426,"journal":{"name":"Canadian Journal of Kidney Health and Disease","volume":"13 ","pages":"20543581261434826"},"PeriodicalIF":1.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}