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Monitoring CD3(+) T Cells in Kidney Transplantation and Immunosuppression Adequacy. 肾移植中CD3(+) T细胞监测与免疫抑制充分性。
Transplantation proceedings Pub Date : 2025-07-18 DOI: 10.1016/j.transproceed.2025.06.016
Kemal Eyvaz, Arif Aslaner, Arif Ata Kiravkazli
{"title":"Monitoring CD3(+) T Cells in Kidney Transplantation and Immunosuppression Adequacy.","authors":"Kemal Eyvaz, Arif Aslaner, Arif Ata Kiravkazli","doi":"10.1016/j.transproceed.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.016","url":null,"abstract":"<p><strong>Background: </strong>Monitoring CD3(+) T-cell counts in kidney transplant recipients can provide valuable insights into immunosuppressive therapy effectiveness. This study aimed to evaluate the use of CD3(+) T-cell levels as biomarkers for immunosuppression adequacy and to assess their predictive value for acute rejection post-transplantation.</p><p><strong>Methods: </strong>A retrospective review was conducted involving 130 kidney transplant recipients who received induction therapy with antithymocyte globulin (ATG). CD3(+) T-cell percentages and absolute counts were measured using flow cytometry on postoperative day 5. Immunosuppression was maintained with tacrolimus, initiated upon clinical indicators of graft function recovery.</p><p><strong>Results: </strong>Among monitored patients, the median CD3(+) T-cell percentage was 48%, and median absolute count was 0.14 × 10⁹/L. Acute rejection occurred in 9.9% of recipients. Higher CD3(+) T-cell values significantly correlated with acute rejection (64.0% vs 47.5%, p = .011; absolute count 0.28 vs 0.13 × 10⁹/L, p = .032). ROC analysis identified optimal predictive thresholds: 54% for CD3(+) percentage (sensitivity 85.7%, specificity 73.4%) and 0.21 × 10⁹/L for absolute count (sensitivity 85.7%, specificity 75.0%).</p><p><strong>Conclusions: </strong>CD3(+) T-cell monitoring effectively guides individualized immunosuppressive strategies, significantly predicting acute rejection risks and optimizing graft outcomes.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Variceal Band Application in Preventing Bile Leakage Associated With Trans-Cystic Feeding Catheter in Living-Donor Liver Transplantation. 静脉曲张带在活体肝移植中预防经囊性喂养管胆漏中的应用效果。
Transplantation proceedings Pub Date : 2025-07-16 DOI: 10.1016/j.transproceed.2025.06.014
Adem Tuncer, Canan Dilay Dirican, Emrah Sahin, Veysel Ersan, Feyza Sönmez Topcu, Hasret Ayyıldız Civan, Bülent Unal, Abuzer Dirican
{"title":"Effectiveness of Variceal Band Application in Preventing Bile Leakage Associated With Trans-Cystic Feeding Catheter in Living-Donor Liver Transplantation.","authors":"Adem Tuncer, Canan Dilay Dirican, Emrah Sahin, Veysel Ersan, Feyza Sönmez Topcu, Hasret Ayyıldız Civan, Bülent Unal, Abuzer Dirican","doi":"10.1016/j.transproceed.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.014","url":null,"abstract":"<p><strong>Objective: </strong>Despite advancements in surgical techniques, biliary complications remain a significant concern in liver transplantation. This study evaluated the effectiveness of applying a variceal band to the cystic duct stump in preventing bile leakage in patients with a trans-cystic feeding catheter.</p><p><strong>Methods: </strong>The medical records of 328 liver transplant recipients between April 2022 and June 2024 were retrospectively reviewed. A total of 170 patients with trans-cystic external catheters were included in the study. Of these, 116 patients underwent variceal band application to the cystic duct stump, while 54 did not. The 2 groups were compared regarding demographic characteristics, graft weight, number of bile ducts, presence of bile leakage, and MELD scores.</p><p><strong>Results: </strong>Among the 170 patients who underwent living-donor liver transplantation (LDLT), 58.8% were male, and 41.2% were female. Graft weight was significantly higher in the group with the variceal band application (p < .05). Bile leakage from the cystic duct stump occurred in 2 patients in the group without variceal banding, whereas no bile leakage was observed in the variceal band group. These 2 cases were successfully treated with percutaneous catheter placement under radiologic guidance.</p><p><strong>Conclusion: </strong>The variceal band application is an effective and promising method for reducing bile leakage in LDLT patients utilizing a trans-cystic feeding catheter. However, multicenter studies with larger patient cohorts are necessary to more definitively assess the safety and efficacy of this technique.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mid-Term Results of Renal Function in Living Kidney Donors in a Single Center. 单中心活体肾供者肾功能中期结果分析。
Transplantation proceedings Pub Date : 2025-07-10 DOI: 10.1016/j.transproceed.2025.06.011
İbrahim Furkan Küçük, Necattin Fırat, Fatih Altıntoprak, Merve Yeşilsancak, Enes Malik Kocatürk, Hamad Dheir, Salih Salihi, Emrah Akın, Fehmi Çelebi
{"title":"Mid-Term Results of Renal Function in Living Kidney Donors in a Single Center.","authors":"İbrahim Furkan Küçük, Necattin Fırat, Fatih Altıntoprak, Merve Yeşilsancak, Enes Malik Kocatürk, Hamad Dheir, Salih Salihi, Emrah Akın, Fehmi Çelebi","doi":"10.1016/j.transproceed.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.011","url":null,"abstract":"<p><strong>Objective: </strong>Living donor nephrectomy (LDN) has been described as a safe operation with low morbidity and mortality rates. The aim of the study was to evaluate the differences between preoperative and postoperative renal functions in LDN and to identify risk factors predicting possible long-term persistent renal dysfunction.</p><p><strong>Methods: </strong>Donors who underwent LDN operations in our center between April 2019 and January 2023 were evaluated retrospectively. Demographic characteristics, renal function tests, routine blood and urine tests, post-transplant complications, ultrasonographic kidney size measurement, and control parameters 1 year after the operation were compared. Factors affecting renal function at 1-year postdonation were analyzed.</p><p><strong>Results: </strong>A total of 110 who met the inclusion criteria were included. Fifty-eight donors (52.7%) were male, and the mean age was 46.54 ± 12.18 years. During follow-up, kidney size of donors increased significantly 1 year after nephrectomy (109.38 ± 9.70 vs 115.65 ± 11.58 mm, P = .001), and estimated glomerular filtration ratio (e-GFR) values were decreased significantly (107.83 ± 13.72 vs 75.68 ± 17.14 mL/min/1.73 m², P < .001). The urine protein creatinine ratio (PCR) was found to be significantly increased (157.6 ± 89.6 vs 206.6 ± 147.2 g/g, P = .001). Although within normal values, there was a significant increase in serum creatinine levels (P < .001), thyroid stimulating hormone (TSH) (P = .050), and serum potassium (P < .001) levels in one year after donation. The increase rates in serum creatinine after 1 year of follow-up were more significant in male gender and in individuals over 50 years of age (P = .016 and P = .006, respectively).</p><p><strong>Conclusion: </strong>Although renal dysfunction may occur when well-selected donors remain with a single kidney after LDN, long-term outcomes are safe and may carry tolerable minor risks.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Cytochrome b5 Interacts With Cytochrome C and Inhibits Hepatocyte Apoptosis in Brain-dead Rabbit Donors" [Transplantation Proceedings, 51/6 2019: 2108-2115]. “细胞色素b5与细胞色素C相互作用抑制脑死亡兔供体肝细胞凋亡”[中国移植杂志,2019,51/6:2108-2115]。
Transplantation proceedings Pub Date : 2025-06-11 DOI: 10.1016/j.transproceed.2025.05.005
Yan Xiong, Lin Fan, Qiang Tu, Guizhu Peng, Yanfeng Wang, Qifa Ye
{"title":"Corrigendum to \"Cytochrome b5 Interacts With Cytochrome C and Inhibits Hepatocyte Apoptosis in Brain-dead Rabbit Donors\" [Transplantation Proceedings, 51/6 2019: 2108-2115].","authors":"Yan Xiong, Lin Fan, Qiang Tu, Guizhu Peng, Yanfeng Wang, Qifa Ye","doi":"10.1016/j.transproceed.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.05.005","url":null,"abstract":"","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting Postoperative Serum Creatinine Levels in Living Donor Kidney Transplantation: The Role of Donor-Recipient Muscle Mass Differences. 预测活体肾移植术后血清肌酐水平:供受体肌肉质量差异的作用。
Transplantation proceedings Pub Date : 2025-06-03 DOI: 10.1016/j.transproceed.2025.05.001
Ezgi Avanaz, Ali Avanaz
{"title":"Predicting Postoperative Serum Creatinine Levels in Living Donor Kidney Transplantation: The Role of Donor-Recipient Muscle Mass Differences.","authors":"Ezgi Avanaz, Ali Avanaz","doi":"10.1016/j.transproceed.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.05.001","url":null,"abstract":"<p><strong>Purpose: </strong>In living donor kidney transplantation (LDKT), postoperative serum creatinine (SCr) levels in the recipients are influenced by muscle mass, which can be assessed via psoas muscle area (PMA) measurements. This study aimed to create a formula to predict the postoperative SCr levels by evaluating the difference in muscle mass between donors and recipients.</p><p><strong>Methods: </strong>We retrospectively analyzed data from patients aged 18 years and older who underwent LDKT between January 2020 and December 2022. Recipients and donors with preoperative magnetic resonance imaging (MRI) or computed tomography (CT) scans were included in the PMA measurements. A total of 67 patients were analyzed.</p><p><strong>Results: </strong>The recipients had a mean age of 42 ± 12.8 years and a mean postoperative SCr of 1.24 ± 0.33 mg/dl. Multivariate analysis revealed that donor age and the difference in the PMA between recipients and donors were significant predictors of postoperative SCr levels. The derived formula is as follows: Recipient postoperative SCr = 0.320 + (0.016 × recipient-donor PMA difference/100) + (0.006 × donor age).</p><p><strong>Conclusion: </strong>This study highlights that considering the difference in muscle mass between donors and recipients can enhance the prediction of postoperative SCr levels. Further multicenter studies are needed to validate and refine this predictive model.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recommendations for Hepatic Artery Anastomosis in Liver Transplantation: A Group Experience. 肝移植中肝动脉吻合的建议:一组经验。
Transplantation proceedings Pub Date : 2025-04-28 DOI: 10.1016/j.transproceed.2025.03.007
Hüseyin Yönder, Faik Tatlı, Mehmet Sait Berhuni, Hasan Elkan, Mehmet Salih Aydın, Fırat Erkmen, Felat Çiftçi, Vedat Kaplan, Abdullah Özgönül, Mehmet Yılmaz
{"title":"Recommendations for Hepatic Artery Anastomosis in Liver Transplantation: A Group Experience.","authors":"Hüseyin Yönder, Faik Tatlı, Mehmet Sait Berhuni, Hasan Elkan, Mehmet Salih Aydın, Fırat Erkmen, Felat Çiftçi, Vedat Kaplan, Abdullah Özgönül, Mehmet Yılmaz","doi":"10.1016/j.transproceed.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.03.007","url":null,"abstract":"<p><strong>Background: </strong>Hepatic artery thrombosis (HAT) is a severe complication following living-donor liver transplantation that can be fatal if revascularization is not achieved. This study aims to present the 8-year experience of the Organ Transplantation Clinic at Harran University Faculty of Medicine.</p><p><strong>Methods: </strong>From 2014 to 2021, a total of 56 patients, comprising 35 men (62.5%) and 21 women (37.5%), who underwent either living-donor or cadaveric liver transplantation were included in the study. In cadaveric recipients, a continuous suture technique with 7/0 polypropylene was used, and in living-donor graft recipients, an interrupted suture technique with 7/0 polypropylene was performed in anastomosis. All patients received an intraoperative dose of 2500 to 5000 units (60 U/kg) of heparin prior to anastomosis. Doppler ultrasound was performed on all patients following the anastomosis.</p><p><strong>Results: </strong>Three out of the 56 patients (5.35%) developed HAT on postoperative day 1. One of these patients underwent hepatic artery revision on postoperative day 1, with no subsequent rethrombosis. The second patient underwent retransplantation on postoperative day 1. However, this patient could not tolerate the reoperation and passed away on the second day after transplantation. The last patient underwent endovascular stenting on postoperative day 1. However, this patient experienced rethrombosis on the first day after the procedure and rapidly deteriorated hemodynamically, which proved fatal.</p><p><strong>Conclusions: </strong>HAT directly affects postoperative patient morbidity and mortality. The outcomes are favorable when hepatic artery anastomosis is performed using 7/0 polypropylene, with a continuous suture technique for cadaveric cases and an interrupted suture technique for living-donor cases, and is carried out by experienced hands.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Living Donor Liver Transplantation for Iatrogenic Vascular Injury During Laparoscopic Cholecystectomy: Case Report. 活体供肝移植治疗腹腔镜胆囊切除术中医源性血管损伤一例报告。
Transplantation proceedings Pub Date : 2025-03-21 DOI: 10.1016/j.transproceed.2025.02.039
Adem Tuncer, Canan Dilay Dirican, Emrah Sahin, Veysel Ersan, Bulent Unal, Abuzer Dirican
{"title":"Living Donor Liver Transplantation for Iatrogenic Vascular Injury During Laparoscopic Cholecystectomy: Case Report.","authors":"Adem Tuncer, Canan Dilay Dirican, Emrah Sahin, Veysel Ersan, Bulent Unal, Abuzer Dirican","doi":"10.1016/j.transproceed.2025.02.039","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.02.039","url":null,"abstract":"<p><p>Acute liver failure (ALF) caused by hepatic vascular injury during cholecystectomy is a rare but serious indication of liver transplantation (LT). We present a case of acute liver failure secondary to portal vein, hepatic artery, and common bile duct injury during laparoscopic cholecystectomy, requiring a same-day emergency living donor liver transplantation (LDLT). A 57-year-old man underwent elective laparoscopic cholecystectomy at an external facility. During the operation, uncontrolled bleeding from the liver hilum led to conversion to open surgery. Despite attempts to control the bleeding with sutures, the patient developed abnormal liver enzymes postoperatively. A computed tomography scan revealed necrosis of the right liver lobe and hypoplasia of the left lobe, leading to the patient to be transferred to our center. Upon admission, the patient was found to have encephalopathy, coagulopathy, hypotension, and oliguria, with elevated transaminase levels. Based on these findings, an emergency LT was deemed necessary. Due to the unavailability of a cadaveric organ, the patient's daughter was prepared as a living donor. Exploratory laparotomy revealed a necrotic right liver lobe, atrophic left lobe, transection of the right hepatic artery and common bile duct, and a thrombosed right portal vein. The patient successfully underwent LDLT from his daughter within 24 hours. At the seventh-month follow-up, he had no complications. Hepatic vascular injury during laparoscopic cholecystectomy can lead to ALF, which carries a high mortality risk. In such cases, LDLT may be a life-saving strategy. Early referral of a patient with ALF to a transplant center is life-saving.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Empagliflozin on Cardiac Arrhythmias and Heart Rate Variability in Kidney Transplant Recipients. 恩格列净对肾移植受者心律失常和心率变异性的影响。
Transplantation proceedings Pub Date : 2025-03-20 DOI: 10.1016/j.transproceed.2025.02.045
Kenan Evren Öztop, Yusuf Can, Mahmud İslam, Taner Demirci, Gözde Cakırsoy Çakar, Necattin Fırat, Musa Pınar, Zafer Ercan, Emrah Akın, Salih Salihi, Ahmed Cihad Genç, Fatih Altıntoprak, Hamad Dheir
{"title":"Impact of Empagliflozin on Cardiac Arrhythmias and Heart Rate Variability in Kidney Transplant Recipients.","authors":"Kenan Evren Öztop, Yusuf Can, Mahmud İslam, Taner Demirci, Gözde Cakırsoy Çakar, Necattin Fırat, Musa Pınar, Zafer Ercan, Emrah Akın, Salih Salihi, Ahmed Cihad Genç, Fatih Altıntoprak, Hamad Dheir","doi":"10.1016/j.transproceed.2025.02.045","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.02.045","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to investigate the effects of Empagliflozin on cardiac arrhythmias and heart rate variability in kidney transplant recipients (KTRs).</p><p><strong>Methods: </strong>Twenty-seven diabetic patients who underwent kidney transplantation between August 2020 and August 2023 were included. Patients with HbA1c >8% were received Empagliflozin treatment. A 24-hour Holter ECG monitoring was performed before and one year after beginning Empagliflozin. Holter ECGs were evaluated by a single cardiologist, comparing ventricular ectopic beats (VEB) and supraventricular ectopic beats (SEB) arrhythmias and heart rate variability parameters before and after one year of Empagliflozin treatment.</p><p><strong>Results: </strong>Twenty-seven patients completed the study, and the mean patient age was 56.1 ± 10 years. Fifteen of the patients (55.6%) were male. The mean duration since transplant before starting Empagliflozin was 62.8 ± 46.2 months. In follow-up, HbA1c decreased from 8.2% to 7.7%(P = .075), urine protein/creatinine ratio reduced from 0.437 ± 0.428 to 0.267 ± 0.146 gr/g (P = .056), and platelet count increased significantly (P = .004). After one year of treatment, the number of VEBs and SEBs in the patients decreased compared to pretreatment. They decreased from 173.5 ± 460.8 and 514.8 ± 265 beats before treatment to 125.1 ± 231.7 and 125.1 ± 231.7 beats after treatment, respectively, but did not reach statistical significance (P > .05). No significant changes were found in heart rate variability parameters (P > .05). No significant correlation was found between VEBs and SEBs and cardiac inflammation indicators (P > .05).</p><p><strong>Conclusion: </strong>This study, for the first time, investigated the effect of Empagliflozin on cardiac arrhythmias and heart rate variability in diabetic KTRs. Empagliflozin did not significantly affect cardiac arrhythmias and heart rate variability in KTRs.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of PNI Score on Renal Prognosis and Graft Rejection After Kidney Transplantation. PNI评分对肾移植术后肾预后及移植排斥反应的影响。
Transplantation proceedings Pub Date : 2025-03-17 DOI: 10.1016/j.transproceed.2025.02.038
Serap Yadigar, Pınar Özdemir, Erman Özdemir
{"title":"The Effect of PNI Score on Renal Prognosis and Graft Rejection After Kidney Transplantation.","authors":"Serap Yadigar, Pınar Özdemir, Erman Özdemir","doi":"10.1016/j.transproceed.2025.02.038","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.02.038","url":null,"abstract":"<p><strong>Background: </strong>Determining effective ways to make prognostic predictions after kidney transplantation of patients is essential for the management of patients. This study examines how the PNI score affects renal outcomes after kidney transplantation. The potential impact of PNI on renal function beyond the overall nutritional status was also examined.</p><p><strong>Methods: </strong>In this retrospective study, 100 kidney transplant patients were divided into three groups according to PNI scores: low (<40), intermediate (40-45) and high (>45). Demographic characteristics, clinical parameters, serum creatinine levels, estimated glomerular filtration rate (eGFR) and parenchymal thickness were evaluated. Logistic regression analysis was applied for the risk of graft rejection. Patients who were followed up for at least 6 months after kidney transplantation and had complete clinical data were included in the study. The mean follow-up period was 36 months (range: 6-60 months).</p><p><strong>Results: </strong>There was no statistically significant correlation between PNI scores and renal function (P > .05). The mean creatinine level was 1.73 ± 1.11 mg/dL in the low PNI group and 1.37 ± 0.52 mg/dL in the high PNI group. Although this difference was close to the limit of statistical significance, it was not significant (P = .083). In logistic regression analysis, no significant effect of PNI score on graft rejection was observed (OR: 1.0015, 95% CI: 0.7975-1.2576, P = .9899). However, age (OR: 0.9247, P = .0347) and serum creatinine levels (OR: 2.8396, P = .0151) significantly affected the risk of graft rejection. No significant effect of PNI score on complication rates was observed.</p><p><strong>Conclusions: </strong>This study demonstrated that PNI score alone is not a sufficient predictor of renal prognosis and graft rejection risk after kidney transplantation. Factors such as age and serum creatinine levels were found to be more predictive of the risk of graft rejection.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the Relationship Between Health Literacy and Adherence to Immunosuppressive Therapy in Heart Transplant Patients: A Cross-Sectional Study. 心脏移植患者健康素养与免疫抑制治疗依从性关系的横断面研究
Transplantation proceedings Pub Date : 2025-03-17 DOI: 10.1016/j.transproceed.2025.01.008
Nihal Celikturk Doruker, Tugba Nur Oden, Fatma Demir Korkmaz
{"title":"Investigation of the Relationship Between Health Literacy and Adherence to Immunosuppressive Therapy in Heart Transplant Patients: A Cross-Sectional Study.","authors":"Nihal Celikturk Doruker, Tugba Nur Oden, Fatma Demir Korkmaz","doi":"10.1016/j.transproceed.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.01.008","url":null,"abstract":"<p><strong>Background: </strong>Nonadherence to immunosuppressive therapy after heart transplantation, driven by factors such as patient, caregiver, institutional, policy-related issues, and health literacy, leads to rejection and increased mortality. This study aimed to investigate the relationship between health literacy and adherence to immunosuppressive therapy in heart transplant patients.</p><p><strong>Methods: </strong>The sample of this cross-sectional study consisted of 57 patients who underwent heart transplantation in a university hospital in Izmir, Turkey. \"Sociodemographic and Descriptive Characteristics Form\", \"Data on Immunosuppressive Drug Therapy Form\", \"Rapid Estimate of Adult Health Literacy in Medicine (REALM) Scale\", and \"Immunosuppressive Therapy Adherence Scale (ITAS)\" were used to collect the data..</p><p><strong>Results: </strong>The median score on the REALM scale was 64.00 (IQR = 3.00, min = 18.00, max = 66.00) and 80.7% of the patients scored adequately. The median score of the immunosuppressive therapy adherence scale was 11.00 (IQR= 1.00, min= 5.00, max= 12.00) and 42.1% of the patients scored full score. There was no statistically significant relationship between the median total scores of the REALM and ITAS scales in heart transplant patients (r = 0.181, P = .178).</p><p><strong>Conclusions: </strong>In this study, the majority of heart transplant patients had adequate health literacy. It was found that less than half of these patients adhered to immunosuppressive therapy. Less than half of these patients were found to comply with immunosuppressive therapy. In this study, no relationship was found between health literacy and adherence to immunosuppressive therapy.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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