Transplantation proceedings最新文献_第3页

Successful Desensitization to Trimethoprim-Sulfamethoxazole for Pneumocystis Pneumonia in a Challenging Case of Second Kidney Transplantation: A Case Report and Literature Review. 甲氧苄啶-磺胺甲恶唑成功脱敏治疗肺囊虫性肺炎1例第二次肾移植病例报告及文献复习。

IF 0.8

Transplantation proceedings Pub Date : 2026-10-03 DOI: 10.1016/j.transproceed.2026.07.042

Jiaxuan Liu, Xiaoyan Hu, Ning Jiang, Wanru Wu, Yun Lu, Qifa Ye

{"title":"Successful Desensitization to Trimethoprim-Sulfamethoxazole for Pneumocystis Pneumonia in a Challenging Case of Second Kidney Transplantation: A Case Report and Literature Review.","authors":"Jiaxuan Liu, Xiaoyan Hu, Ning Jiang, Wanru Wu, Yun Lu, Qifa Ye","doi":"10.1016/j.transproceed.2026.07.042","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.07.042","url":null,"abstract":"Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection that predominantly affects immunocompromised individuals, with trimethoprim-sulfamethoxazole (TMP-SMX) remaining the first-line therapy. However, hypersensitivity reactions to sulfonamides often hinder its administration, leading to a critical therapeutic dilemma. Crucially, desensitization is absolutely contraindicated in severe reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, and should be reserved exclusively for patients with mild-to-moderate hypersensitivity. For these appropriately selected patients, drug desensitization presents a viable solution, robust evidence supporting its application in high-risk transplant recipients, especially in emergent infectious settings, is notably limited. This article reports the successful management of PJP in a second kidney transplant recipient through a tailored TMP-SMX oral desensitization protocol, demonstrating its safety and efficacy in this complex clinical scenario. Accompanied by a systematic literature review, we further synthesize and evaluate existing published desensitization strategies and discuss key practical considerations for protocol implementation and monitoring. Collectively, this detailed case report and integrated review aim to provide clinicians with a structured, evidence-based approach to implementing sulfonamide desensitization, which is particularly crucial for vulnerable patient populations with severely limited therapeutic alternatives.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Dual-Graft Living Donor Liver Transplantation in Uzbekistan: Surgical Technique, Clinical Processes, And Preliminary Results. 乌兹别克斯坦首例双移植活体肝移植：手术技术、临床过程和初步结果。

IF 0.8

Transplantation proceedings Pub Date : 2026-10-01 DOI: 10.1016/j.transproceed.2026.08.010

Jasur Sobirov, Ahror Safarov, Jakhongir Jumaboev, Muhammadali Mamajanov, Sanat Kazakov, Zafar Ibragimov

{"title":"First Dual-Graft Living Donor Liver Transplantation in Uzbekistan: Surgical Technique, Clinical Processes, And Preliminary Results.","authors":"Jasur Sobirov, Ahror Safarov, Jakhongir Jumaboev, Muhammadali Mamajanov, Sanat Kazakov, Zafar Ibragimov","doi":"10.1016/j.transproceed.2026.08.010","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.08.010","url":null,"abstract":"Insufficient graft volume remains a major limitation in adult living donor liver transplantation, particularly in recipients with high body weight or advanced liver disease, increasing the risk of small-for-size syndrome and early graft dysfunction. Dual-graft living donor liver transplantation has emerged as a strategy to overcome graft size limitations in selected high-risk recipients. We report the first case of dual-graft living donor liver transplantation performed in Uzbekistan in a high-risk adult recipient with end-stage liver disease. Two partial liver grafts obtained from separate living donors were implanted using individualized vascular inflow, outflow, and biliary reconstruction techniques. Perioperative management and postoperative monitoring were conducted according to standard transplantation protocols. The combined graft volume provided an adequate graft-to-recipient weight ratio. Postoperative Doppler ultrasonography demonstrated satisfactory vascular inflow and outflow, with no evidence of thrombosis or venous congestion. Early postoperative laboratory evaluation revealed transient elevations of aminotransferases, followed by progressive improvement in bilirubin levels and markers of synthetic liver function. No early biliary complications, ascites, or need for reintervention was observed. At the 8-month follow-up, the recipient demonstrated normal liver function, preserved graft perfusion, and no vascular or biliary complications, while both living donors had uneventful postoperative recovery without donor-related complications. This national experience suggests that dual-graft living donor liver transplantation is a feasible and effective option for carefully selected high-risk adult recipients when performed in a specialized transplant center.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative and Qualitative Hemostatic Response Assessed by ROTEM After Fibrinogen Concentrate and Platelet Administration During Liver Transplantation: A Case Report. 肝移植中纤维蛋白原浓缩物和血小板应用后定量和定性止血反应的ROTEM评价：1例报告。

IF 0.8

Transplantation proceedings Pub Date : 2026-09-29 DOI: 10.1016/j.transproceed.2026.07.047

Se Hoon Kim, Uzung Yoon

{"title":"Quantitative and Qualitative Hemostatic Response Assessed by ROTEM After Fibrinogen Concentrate and Platelet Administration During Liver Transplantation: A Case Report.","authors":"Se Hoon Kim, Uzung Yoon","doi":"10.1016/j.transproceed.2026.07.047","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.07.047","url":null,"abstract":"Patients undergoing liver transplantation experience dynamic alterations in hemostasis, as impaired fibrinogen synthesis, dysfibrinogenemia, hemodilution, and ongoing surgical bleeding collectively impair clot formation and strength. Fibrinogen abnormalities involve both quantitative deficiency and qualitative dysfunction. We report the case of a 70-year-old male with a Model for End-Stage Liver Disease (MELD) score of 36 who underwent orthotopic liver transplantation for acute liver failure following a cholecystectomy. During the reperfusion phase, diffuse oozing was noted with a plasma fibrinogen of 100 mg/dL and ROTEM-FIBTEM maximum clot firmness (MCF) of 6 mm. An initial 2 g dose of fibrinogen concentrate raised plasma fibrinogen to 150 mg/dL but resulted in only a minimal increase in FIBTEM MCF to 7 mm. A subsequent 2 g dose increased plasma fibrinogen to 175 mg/dL and restored FIBTEM MCF to 13 mm, within the normal range. EXTEM MCF approached the reference range only after one bag of platelet transfusion, suggesting concurrent qualitative platelet impairment. After these interventions, bleeding clinically ceased, and there were no hemorrhagic complications postoperatively. These findings underscore the importance of combined serial quantitative and qualitative hemostatic assessment to guide transfusion management during liver transplantation.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rothia mucilaginosa Sepsis in a Kidney Transplant Recipient Following Dental Procedure Despite Clindamycine Prophylaxis: A Case Report. 尽管有克林霉素预防，肾移植受者在牙科手术后仍发生粘胶罗氏菌脓毒症：一例报告。

IF 0.8

Transplantation proceedings Pub Date : 2026-09-28 DOI: 10.1016/j.transproceed.2026.08.020

Nikolina Basic-Jukic, Petra Magdalena Kes

{"title":"Rothia mucilaginosa Sepsis in a Kidney Transplant Recipient Following Dental Procedure Despite Clindamycine Prophylaxis: A Case Report.","authors":"Nikolina Basic-Jukic, Petra Magdalena Kes","doi":"10.1016/j.transproceed.2026.08.020","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.08.020","url":null,"abstract":"Rothia mucilaginosa is an opportunistic Gram-positive coccus that colonizes the oral cavity. However, in immunocompromised patients, it may cause severe invasive infections. We report a case of R. mucilaginosa sepsis in a kidney transplant recipient following a dental procedure despite prophylactic clindamycin therapy. A 64-year-old female kidney transplant recipient receiving maintenance immunosuppression with tacrolimus, mycophenolate mofetil, and prednisone underwent dental treatment because of profound dental caries with gingival inflammation. Clindamycin was administered because of history of adverse reactions to multiple antibiotics. However, within several days, the patient developed fever, chills, and progressive malaise. Blood cultures yielded R. mucilaginosa. The patient was successfully treated with intravenous piperacillin/tazobactam. Our case demonstrates the importance of recognizing uncommon oral pathogens in transplant recipients presenting with sepsis after dental procedures, as well as the limited antimicrobial activity of clindamycin against Rothia species.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal Membrane Oxygenation Buys Time for Diagnosis and Rescue Lung Transplantation in Severe Isolated Pauci-immune Pulmonary Capillaritis. 体外膜氧合为诊断和抢救肺移植赢得了时间。

IF 0.8

Transplantation proceedings Pub Date : 2026-09-28 DOI: 10.1016/j.transproceed.2026.05.031

Gala Giannini, Jacopo Fumagalli, Andrea Meli, Alessio Caccioppola, Lorenzo Rosso, Paolo Mendogni, Valentina Antonella Vespro, Alessandro Santaniello, Valeria Rossetti, Giorgio Alberto Croci, Davide Mangioni, Stefania Crotti, Mauro Panigada, Giacomo Grasselli

{"title":"Extracorporeal Membrane Oxygenation Buys Time for Diagnosis and Rescue Lung Transplantation in Severe Isolated Pauci-immune Pulmonary Capillaritis.","authors":"Gala Giannini, Jacopo Fumagalli, Andrea Meli, Alessio Caccioppola, Lorenzo Rosso, Paolo Mendogni, Valentina Antonella Vespro, Alessandro Santaniello, Valeria Rossetti, Giorgio Alberto Croci, Davide Mangioni, Stefania Crotti, Mauro Panigada, Giacomo Grasselli","doi":"10.1016/j.transproceed.2026.05.031","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.05.031","url":null,"abstract":"We present the clinical course and management of a young man affected by catastrophic Isolated pauci-immune pulmonary capillaritis (IPIPC), who required extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) and ultimately underwent bilateral lung transplantation (LTx) due to unresolving life-threatening respiratory failure. The patient was admitted to emergency department (ED) due to worsening dyspnea. Bilateral infiltrates were detected on the chest X-ray (CXR) and treatment for community acquired pneumonia was established despite negative microbiological testing. The computed tomography (CT) scan showed bilateral diffuse centrilobular ground glass nodules and lower lobes consolidations. Rapidly worsening hypoxemic respiratory failure required intubation, and after prone positioning failed, VV ECMO support was initiated. Extensive infectious and autoimmune screening resulted negative. No extrapulmonary organ dysfunction developed. Prone positioning and high dose methylprednisolone were ineffective, with persistence of intrapulmonary shunt >60% and intermediate-low respiratory system compliance (25 ml/cmH2O). Thoracoscopic lung biopsy established the diagnosis of IPIPC. Given the poor prognosis and the severe condition, the patient was enlisted for LTx. Immediately after the patient was weaned from ECMO. After 106 days the patient was discharged in good clinical conditions.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Outcomes After Kidney Transplantation From Controlled Donation After Circulatory Death Donors: A Single-Center Observational Study. 循环性死亡供者接受对照肾移植后的临床结果：一项单中心观察研究

IF 0.8

Transplantation proceedings Pub Date : 2026-09-28 DOI: 10.1016/j.transproceed.2026.09.005

María O López-Oliva, Ana Mendoza-Cedeño, Korina Peña-Esparragoza, Belén Estébanez-Montiel, Eva Flores-Cabeza, Mario Álvarez-Maestro, Cristina de Castro-Guerin, Lina M León-Machado, Javier Azores-Moreno, Elena González-García, Carlos Jiménez-Martín

{"title":"Clinical Outcomes After Kidney Transplantation From Controlled Donation After Circulatory Death Donors: A Single-Center Observational Study.","authors":"María O López-Oliva, Ana Mendoza-Cedeño, Korina Peña-Esparragoza, Belén Estébanez-Montiel, Eva Flores-Cabeza, Mario Álvarez-Maestro, Cristina de Castro-Guerin, Lina M León-Machado, Javier Azores-Moreno, Elena González-García, Carlos Jiménez-Martín","doi":"10.1016/j.transproceed.2026.09.005","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.09.005","url":null,"abstract":"Introduction: Controlled donation after circulatory death (cDCD) has become a key strategy to expand the kidney donor pool. The aim of this study was to evaluate the short- and mid-term outcomes of kidney transplantation from these donors in our center, with special attention to the impact of donor age.Patients and methods: We performed a retrospective single-center observational study including all recipients of kidney transplantation from cDCD donors between April 2015 and December 2024. Patients were divided according to donor age: ≥65 years and <65 years. Delayed graft function (DGF), renal function, graft survival, and patient survival were analyzed using Kaplan-Meier curves and Cox regression analysis.Results: A total of 171 recipients were included; 37 (21.6%) received kidneys from donors ≥65 years. DGF was more frequent in recipients of older donors (81.1% vs 49.3%; P = .002), with lower estimated glomerular filtration rate at 1 year (39 vs 52 mL/min). Death-censored graft survival was comparable between both groups (P = .29). Mortality was higher in recipients of donors ≥65 years (21.6% vs 6.7%; P = .013), with lower patient survival (P = .005). In multivariate analysis, recipient age >65 years was the only independent predictor of mortality (HR 3.9; P = .04), whereas eGFR <30 mL/min at 1 year was the only independent predictor of graft loss (HR 7.3; P = .02).Conclusion: Kidney transplantation from elderly cDCD donors provides favorable mid-term outcomes and represents a safe strategy to expand the donor pool.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune Hemolytic Anemia Complicated by Portal Vein Thrombosis in a Pediatric Liver Transplant Recipient: A Case Report. 小儿肝移植受者自身免疫性溶血性贫血并发门静脉血栓1例报告

IF 0.8

Transplantation proceedings Pub Date : 2026-09-26 DOI: 10.1016/j.transproceed.2026.07.044

Zehra İkbal Karabal, Tonguç Utku Yılmaz, Aziz Polat, Hamdi Karakayalı

{"title":"Autoimmune Hemolytic Anemia Complicated by Portal Vein Thrombosis in a Pediatric Liver Transplant Recipient: A Case Report.","authors":"Zehra İkbal Karabal, Tonguç Utku Yılmaz, Aziz Polat, Hamdi Karakayalı","doi":"10.1016/j.transproceed.2026.07.044","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.07.044","url":null,"abstract":"Post-transplant autoimmune hemolytic anemia (AIHA) occurs in approximately 1% to 3% of pediatric liver transplant recipients. Its co-occurrence with portal vein thrombosis (PVT) is exceedingly rare and potentially life-threatening. We report a 10-month-old female who underwent living-donor liver transplantation for biliary atresia and presented with AIHA 5 months later. Laboratory evaluation revealed severe hemolytic anemia (hemoglobin 7.5 g/dL), markedly elevated lactate dehydrogenase (1751 IU/L), hyperbilirubinemia (total bilirubin 4.92 mg/dL), thrombocytopenia (75 × 103/μL), prolonged PT/INR, critically reduced Protein S activity (48.1%), and elevated D-dimer (3.78 mg/L; 7.6 × upper normal). A strongly positive Direct Antiglobulin Test confirmed AIHA. Abdominal computed tomography demonstrated hepatomegaly with portal vein thrombosis, confirmed by color-flow Doppler ultrasonography with turbulent, reduced flow. Tacrolimus dose was reduced and simultaneous high-dose methylprednisolone (4 mg/kg/d intravenously), rituximab, and therapeutic heparin were initiated. Complete portal vein recanalization was confirmed by Doppler on Day 5, with full immunologic remission (Direct Antiglobulin Test-negative) thereafter. This case demonstrates that post-transplant AIHA can precipitate PVT through a hemolysis-driven hypercoagulable cascade involving Protein S consumption, thrombocytopenia, and pro-coagulant erythrocyte microparticle release. Systematic coagulation profiling and Doppler ultrasonography at AIHA onset are mandatory in pediatric liver transplant recipients to prevent potentially fatal vascular complications.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Low-Grade Myxofibrosarcoma Arising in a Nonfunctioning Renal Allograft 25 Years After Transplantation: A Rare Case Report. 原发性低级别黏液纤维肉瘤发生在移植后25年无功能的同种肾移植：一个罕见的病例报告。

IF 0.8

Transplantation proceedings Pub Date : 2026-09-26 DOI: 10.1016/j.transproceed.2026.07.037

Dionysios Prevezanos, Konstantinos Kossenas, Dimitrios Vlachos, Michael K Konstantinidis, Leonardos Chaikalis, Evangelos Tagkalos, Stylianos Kykalos, Spyridon Vernadakis

{"title":"Primary Low-Grade Myxofibrosarcoma Arising in a Nonfunctioning Renal Allograft 25 Years After Transplantation: A Rare Case Report.","authors":"Dionysios Prevezanos, Konstantinos Kossenas, Dimitrios Vlachos, Michael K Konstantinidis, Leonardos Chaikalis, Evangelos Tagkalos, Stylianos Kykalos, Spyridon Vernadakis","doi":"10.1016/j.transproceed.2026.07.037","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.07.037","url":null,"abstract":"Background/aim: Myxofibrosarcoma is an uncommon mesenchymal tumor which is categorized in the soft tissue sarcomas. Most commonly occurs in the subcutaneous tissue of the extremities. Our aim is to report a rare case of MFS arising from the non-functional renal graft which has never been reported in the past.Case presentation: A 74-year-old man with past medical history of renal transplantation and lymphoma non-Hodgkin was admitted for elective renal transplanectomy after random radiological findings. The patient did not refer other symptoms and, after proper imaging with enhanced-contrast Computed Tomography and Magnetic Resonance Imaging, he was led to the operation room.Results: The renal graft was excised successfully. The postoperative course of the patient was uneventful. The histological examination of the specimen demonstrated low grade Myxofibrosarcoma and clear margins were achieved.Conclusions: In spite of a wide range of therapeutic options for MFS described in the literature, the efficacy of those available therapies is not well established. Additionally, the high percentage of local recurrence resulting the clear-margins excision to be the gold standard therapy.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Graft-Versus-Host Disease in a Liver Transplant Recipient Receiving an HCV NAT Positive Organ: Does HCV NAT Matter? 一例接受HCV NAT阳性器官的肝移植受者发生移植物抗宿主病：HCV NAT有影响吗？

IF 0.8

Transplantation proceedings Pub Date : 2026-09-26 DOI: 10.1016/j.transproceed.2026.06.049

Bryant B Summers

{"title":"A Case of Graft-Versus-Host Disease in a Liver Transplant Recipient Receiving an HCV NAT Positive Organ: Does HCV NAT Matter?","authors":"Bryant B Summers","doi":"10.1016/j.transproceed.2026.06.049","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.06.049","url":null,"abstract":"Introduction: Graft-versus-host disease (GVHD) is a rare but fatal complication in solid organ transplant. Ruxolitinib is a JAK-1/2 inhibitor that has been utilized mostly in hematopoietic stem cell transplant (HCST) GVHD and has limited data for its use in solid organ transplant GVHD.Case: A 57-year-old female presented for orthotopic liver transplant for metabolic and alcohol associated liver disease (metALD) and received an HCV NAT positive organ. One month after her transplant, patient was found to have rash and gastrointestinal complaints which were biopsied and scoped, showing findings of GVHD. Patient's serum was tested for donor lymphocytes which revealed 45% donor lymphocytes. She started on intravenous methylprednisolone and ruxolitinib. HCV PCR was also increasing at the time of her diagnosis of GVHD, so patient started on glecaprevir/pibrentasvir as well. After starting ruxolitinib and methylprednisolone, patient's donor lymphocytes decreased and remained undetectable. Finally, patient also achieved SVR at 12 weeks following treatment.Discussion: Ruxolitinib has demonstrated to be efficacious with treating GVHD in the solid organ transplant population. There are hypothetical effects of HCV on immune system markers, but from this case report it appears that concurrently treating GVHD with ruxolitinib and HCV with glecaprevir/pibrentasvir does not affect patient outcomes.Conclusion: Treating GVHD with ruxolitinib and HCV with glecaprevir/pibrentasvir simultaneously is both effective and safe.","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allograft Beating for a Century: An Update on the Oldest Surviving Donor Heart: A Case Report. 同种异体移植心脏跳动了一个世纪：关于存活时间最长的供体心脏的最新情况：一个病例报告。

IF 0.8

Transplantation proceedings Pub Date : 2026-09-26 DOI: 10.1016/j.transproceed.2026.07.041

Jonathan Evans, Megan Pelter, Liset Stoletniy

引用次数: 0