Transplantation proceedings最新文献

{"title":"Safety and Efficacy of Early Introduction of Angiotensin II Receptor Blockers for Hypertension in Kidney Transplant Recipients: A Retrospective Observational Study Using Propensity Score Matching.","authors":"Shinsuke Kubo, Hiroshi Noguchi, Yu Hisadome, Kenji Ueki, Yuta Matsukuma, Shoji Tsuneyoshi, Yu Sato, Akihiro Tsuchimoto, Toshiaki Nakano, Keizo Kaku, Yasuhiro Okabe, Masafumi Nakamura","doi":"10.1016/j.transproceed.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.05.003","url":null,"abstract":"<p><p>Kidney transplantation (KTx) is the optimal treatment for end-stage kidney disease, but hypertension after KTx is significant complication affecting graft and patient survival. Although angiotensin II receptor blockers (ARBs) are widely used, the effect of their \"early\" introduction on outcomes remains unclear. This retrospective observational cohort study compared KTx recipients who started ARBs within the first 14 days post-transplant (early ARB [eARB] group) to those ARBs initiated after three months (conventional group). Propensity score matching was used to align the groups. Blood pressure control, estimated glomerular filtration rate, and serum potassium levels, urinary protein, and adverse events were analyzed. Between 2020 and 2022, 174 patients underwent living-donor KTx. Propensity score matching refined this to 38 matched pairs (76 individuals), which were analyzed. No significant difference in blood pressure control was observed between the two groups at any time point. Results showed that eARB use led to significantly lower urinary protein levels at 3 months compared to the conventional group (P = .019). There were no significant differences in adverse events, including hyperkalemia, rejection, or hypotension, between groups. Potassium-lowering agents were used slightly more in the eARB group, but the difference was not significant. Although eARBs initiation appears safe and potentially beneficial for kidney transplant recipients, further studies are needed to fully understand the long-term implications of this strategy.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Status of Pig-to-NHP Xenotransplantation Research in Korea.","authors":"Sun Ae Hwang, Sangil Min, Ki Cheul Shin, Hyun Keun Chee, Wan Seop Kim, Young Rok Choi, Hyun Suk Yang, Yu Rim Ahn, Jeong Ho Hwang, Hyunil Kim, Keon Bong Oh, Ik Jin Yun","doi":"10.1016/j.transproceed.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.05.004","url":null,"abstract":"<p><strong>Background: </strong>Xenotransplantation has the potential to mitigate the shortage of transplantable organs in Korea. However, its clinical application is yet to be established. Preclinical studies using non-human primates (NHPs) are required, as these animal models may yield excellent results. Therefore, we aimed to investigate the progress in pig-to-NHP xenotransplantation research in Korea and identify alternative approaches for the clinical application of human xenotransplantation.</p><p><strong>Methods: </strong>We investigated the use of transgenic pigs developed by Optipharm (8; QKO+CD39+CD55+CD46+TBM) and the National Institute of Animal Science (4; GTKO, CMAH, HO1, and CD47) for xenotransplantation in Korea. We further analyzed the outcomes of 100 pig-to-NHP xenotransplantation performed by our xenotransplantation research team since 2011. These included 42, 34, 3, and 21 kidney, heart, liver, and partial corneal transplants, respectively. In addition, the immunosuppressants used were anti-CD154, rituximab, anti-thymocyte globulin, rapamycin, and tacrolimus.</p><p><strong>Results: </strong>The longest survival duration was 221, 217, and 1422 d for the kidney, heterotopic heart, and parietal corneal transplants, respectively. In contrast, the survival duration did not exceed 1 d in cases of liver transplantation. Furthermore, some immunosuppressants and anticoagulants exhibited the potential to improve clinical outcomes. These drugs have become clinically available and have functionally improved since their development.</p><p><strong>Conclusions: </strong>Our findings indicate that the clinical application of xenografts in Korea depends on the development of multiple transgenic pigs and further development of immunosuppressants and anticoagulants.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Postoperative Serum Creatinine Levels in Living Donor Kidney Transplantation: The Role of Donor-Recipient Muscle Mass Differences.","authors":"Ezgi Avanaz, Ali Avanaz","doi":"10.1016/j.transproceed.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.05.001","url":null,"abstract":"<p><strong>Purpose: </strong>In living donor kidney transplantation (LDKT), postoperative serum creatinine (SCr) levels in the recipients are influenced by muscle mass, which can be assessed via psoas muscle area (PMA) measurements. This study aimed to create a formula to predict the postoperative SCr levels by evaluating the difference in muscle mass between donors and recipients.</p><p><strong>Methods: </strong>We retrospectively analyzed data from patients aged 18 years and older who underwent LDKT between January 2020 and December 2022. Recipients and donors with preoperative magnetic resonance imaging (MRI) or computed tomography (CT) scans were included in the PMA measurements. A total of 67 patients were analyzed.</p><p><strong>Results: </strong>The recipients had a mean age of 42 ± 12.8 years and a mean postoperative SCr of 1.24 ± 0.33 mg/dl. Multivariate analysis revealed that donor age and the difference in the PMA between recipients and donors were significant predictors of postoperative SCr levels. The derived formula is as follows: Recipient postoperative SCr = 0.320 + (0.016 × recipient-donor PMA difference/100) + (0.006 × donor age).</p><p><strong>Conclusion: </strong>This study highlights that considering the difference in muscle mass between donors and recipients can enhance the prediction of postoperative SCr levels. Further multicenter studies are needed to validate and refine this predictive model.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-for-Size Graft in Cadaveric Liver Transplantation: Application of BSA (Body Surface Area) for Prompt Evaluation.","authors":"Yasuhiro Fujimoto, Norihiro Goshima, Yuki Masano, Nobuhiko Kurata, Yasuhiro Ogura","doi":"10.1016/j.transproceed.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.03.024","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, with the increase in the number of brain-dead donors in Japan, brain-dead liver transplantation has been on the rise. In partial living donor liver transplantation, which accounts for the majority of liver transplants in Japan, small-for-size graft has been a problem in adult recipients, whereas large-for-size graft has not been a matter of debate. We experienced a case in which a large-for-size graft resulted in difficulty when closing the wound. With the increase in brain death transplantation, the exclusion of large-for-size grafts becomes an issue when selecting grafts.</p><p><strong>Methods: </strong>Retrospective chart review. At Nagoya University, 80 brain-dead liver transplants were performed between Feb. 2005 and Dec. 2023. Comparative evaluation of BSA (body surface area) and was performed on 72 patients, excluding 8 split liver transplants, based on the height and weight of the donor and recipient at the time of transplantation. The state of wound closure was also ascertained from the surgical records.</p><p><strong>Results: </strong>Seven cases out of 72 were considered \"large-for-size\" regarding BSA. Among them, 1 \"large-for-size\" patient had difficulty in closing the abdomen during the surgical procedure.</p><p><strong>Conclusions: </strong>Prompt screening for matching graft size and donor body size may be possible with BSA. The algorithm allows for rapid and efficient donor-recipient matching while reducing the reliance on advanced imaging in most cases.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for Hepatic Artery Anastomosis in Liver Transplantation: A Group Experience.","authors":"Hüseyin Yönder, Faik Tatlı, Mehmet Sait Berhuni, Hasan Elkan, Mehmet Salih Aydın, Fırat Erkmen, Felat Çiftçi, Vedat Kaplan, Abdullah Özgönül, Mehmet Yılmaz","doi":"10.1016/j.transproceed.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.03.007","url":null,"abstract":"<p><strong>Background: </strong>Hepatic artery thrombosis (HAT) is a severe complication following living-donor liver transplantation that can be fatal if revascularization is not achieved. This study aims to present the 8-year experience of the Organ Transplantation Clinic at Harran University Faculty of Medicine.</p><p><strong>Methods: </strong>From 2014 to 2021, a total of 56 patients, comprising 35 men (62.5%) and 21 women (37.5%), who underwent either living-donor or cadaveric liver transplantation were included in the study. In cadaveric recipients, a continuous suture technique with 7/0 polypropylene was used, and in living-donor graft recipients, an interrupted suture technique with 7/0 polypropylene was performed in anastomosis. All patients received an intraoperative dose of 2500 to 5000 units (60 U/kg) of heparin prior to anastomosis. Doppler ultrasound was performed on all patients following the anastomosis.</p><p><strong>Results: </strong>Three out of the 56 patients (5.35%) developed HAT on postoperative day 1. One of these patients underwent hepatic artery revision on postoperative day 1, with no subsequent rethrombosis. The second patient underwent retransplantation on postoperative day 1. However, this patient could not tolerate the reoperation and passed away on the second day after transplantation. The last patient underwent endovascular stenting on postoperative day 1. However, this patient experienced rethrombosis on the first day after the procedure and rapidly deteriorated hemodynamically, which proved fatal.</p><p><strong>Conclusions: </strong>HAT directly affects postoperative patient morbidity and mortality. The outcomes are favorable when hepatic artery anastomosis is performed using 7/0 polypropylene, with a continuous suture technique for cadaveric cases and an interrupted suture technique for living-donor cases, and is carried out by experienced hands.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living Donor Liver Transplantation for Iatrogenic Vascular Injury During Laparoscopic Cholecystectomy: Case Report.","authors":"Adem Tuncer, Canan Dilay Dirican, Emrah Sahin, Veysel Ersan, Bulent Unal, Abuzer Dirican","doi":"10.1016/j.transproceed.2025.02.039","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.02.039","url":null,"abstract":"<p><p>Acute liver failure (ALF) caused by hepatic vascular injury during cholecystectomy is a rare but serious indication of liver transplantation (LT). We present a case of acute liver failure secondary to portal vein, hepatic artery, and common bile duct injury during laparoscopic cholecystectomy, requiring a same-day emergency living donor liver transplantation (LDLT). A 57-year-old man underwent elective laparoscopic cholecystectomy at an external facility. During the operation, uncontrolled bleeding from the liver hilum led to conversion to open surgery. Despite attempts to control the bleeding with sutures, the patient developed abnormal liver enzymes postoperatively. A computed tomography scan revealed necrosis of the right liver lobe and hypoplasia of the left lobe, leading to the patient to be transferred to our center. Upon admission, the patient was found to have encephalopathy, coagulopathy, hypotension, and oliguria, with elevated transaminase levels. Based on these findings, an emergency LT was deemed necessary. Due to the unavailability of a cadaveric organ, the patient's daughter was prepared as a living donor. Exploratory laparotomy revealed a necrotic right liver lobe, atrophic left lobe, transection of the right hepatic artery and common bile duct, and a thrombosed right portal vein. The patient successfully underwent LDLT from his daughter within 24 hours. At the seventh-month follow-up, he had no complications. Hepatic vascular injury during laparoscopic cholecystectomy can lead to ALF, which carries a high mortality risk. In such cases, LDLT may be a life-saving strategy. Early referral of a patient with ALF to a transplant center is life-saving.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Empagliflozin on Cardiac Arrhythmias and Heart Rate Variability in Kidney Transplant Recipients.","authors":"Kenan Evren Öztop, Yusuf Can, Mahmud İslam, Taner Demirci, Gözde Cakırsoy Çakar, Necattin Fırat, Musa Pınar, Zafer Ercan, Emrah Akın, Salih Salihi, Ahmed Cihad Genç, Fatih Altıntoprak, Hamad Dheir","doi":"10.1016/j.transproceed.2025.02.045","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.02.045","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to investigate the effects of Empagliflozin on cardiac arrhythmias and heart rate variability in kidney transplant recipients (KTRs).</p><p><strong>Methods: </strong>Twenty-seven diabetic patients who underwent kidney transplantation between August 2020 and August 2023 were included. Patients with HbA1c >8% were received Empagliflozin treatment. A 24-hour Holter ECG monitoring was performed before and one year after beginning Empagliflozin. Holter ECGs were evaluated by a single cardiologist, comparing ventricular ectopic beats (VEB) and supraventricular ectopic beats (SEB) arrhythmias and heart rate variability parameters before and after one year of Empagliflozin treatment.</p><p><strong>Results: </strong>Twenty-seven patients completed the study, and the mean patient age was 56.1 ± 10 years. Fifteen of the patients (55.6%) were male. The mean duration since transplant before starting Empagliflozin was 62.8 ± 46.2 months. In follow-up, HbA1c decreased from 8.2% to 7.7%(P = .075), urine protein/creatinine ratio reduced from 0.437 ± 0.428 to 0.267 ± 0.146 gr/g (P = .056), and platelet count increased significantly (P = .004). After one year of treatment, the number of VEBs and SEBs in the patients decreased compared to pretreatment. They decreased from 173.5 ± 460.8 and 514.8 ± 265 beats before treatment to 125.1 ± 231.7 and 125.1 ± 231.7 beats after treatment, respectively, but did not reach statistical significance (P > .05). No significant changes were found in heart rate variability parameters (P > .05). No significant correlation was found between VEBs and SEBs and cardiac inflammation indicators (P > .05).</p><p><strong>Conclusion: </strong>This study, for the first time, investigated the effect of Empagliflozin on cardiac arrhythmias and heart rate variability in diabetic KTRs. Empagliflozin did not significantly affect cardiac arrhythmias and heart rate variability in KTRs.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of PNI Score on Renal Prognosis and Graft Rejection After Kidney Transplantation.","authors":"Serap Yadigar, Pınar Özdemir, Erman Özdemir","doi":"10.1016/j.transproceed.2025.02.038","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.02.038","url":null,"abstract":"<p><strong>Background: </strong>Determining effective ways to make prognostic predictions after kidney transplantation of patients is essential for the management of patients. This study examines how the PNI score affects renal outcomes after kidney transplantation. The potential impact of PNI on renal function beyond the overall nutritional status was also examined.</p><p><strong>Methods: </strong>In this retrospective study, 100 kidney transplant patients were divided into three groups according to PNI scores: low (<40), intermediate (40-45) and high (>45). Demographic characteristics, clinical parameters, serum creatinine levels, estimated glomerular filtration rate (eGFR) and parenchymal thickness were evaluated. Logistic regression analysis was applied for the risk of graft rejection. Patients who were followed up for at least 6 months after kidney transplantation and had complete clinical data were included in the study. The mean follow-up period was 36 months (range: 6-60 months).</p><p><strong>Results: </strong>There was no statistically significant correlation between PNI scores and renal function (P > .05). The mean creatinine level was 1.73 ± 1.11 mg/dL in the low PNI group and 1.37 ± 0.52 mg/dL in the high PNI group. Although this difference was close to the limit of statistical significance, it was not significant (P = .083). In logistic regression analysis, no significant effect of PNI score on graft rejection was observed (OR: 1.0015, 95% CI: 0.7975-1.2576, P = .9899). However, age (OR: 0.9247, P = .0347) and serum creatinine levels (OR: 2.8396, P = .0151) significantly affected the risk of graft rejection. No significant effect of PNI score on complication rates was observed.</p><p><strong>Conclusions: </strong>This study demonstrated that PNI score alone is not a sufficient predictor of renal prognosis and graft rejection risk after kidney transplantation. Factors such as age and serum creatinine levels were found to be more predictive of the risk of graft rejection.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Relationship Between Health Literacy and Adherence to Immunosuppressive Therapy in Heart Transplant Patients: A Cross-Sectional Study.","authors":"Nihal Celikturk Doruker, Tugba Nur Oden, Fatma Demir Korkmaz","doi":"10.1016/j.transproceed.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.01.008","url":null,"abstract":"<p><strong>Background: </strong>Nonadherence to immunosuppressive therapy after heart transplantation, driven by factors such as patient, caregiver, institutional, policy-related issues, and health literacy, leads to rejection and increased mortality. This study aimed to investigate the relationship between health literacy and adherence to immunosuppressive therapy in heart transplant patients.</p><p><strong>Methods: </strong>The sample of this cross-sectional study consisted of 57 patients who underwent heart transplantation in a university hospital in Izmir, Turkey. \"Sociodemographic and Descriptive Characteristics Form\", \"Data on Immunosuppressive Drug Therapy Form\", \"Rapid Estimate of Adult Health Literacy in Medicine (REALM) Scale\", and \"Immunosuppressive Therapy Adherence Scale (ITAS)\" were used to collect the data..</p><p><strong>Results: </strong>The median score on the REALM scale was 64.00 (IQR = 3.00, min = 18.00, max = 66.00) and 80.7% of the patients scored adequately. The median score of the immunosuppressive therapy adherence scale was 11.00 (IQR= 1.00, min= 5.00, max= 12.00) and 42.1% of the patients scored full score. There was no statistically significant relationship between the median total scores of the REALM and ITAS scales in heart transplant patients (r = 0.181, P = .178).</p><p><strong>Conclusions: </strong>In this study, the majority of heart transplant patients had adequate health literacy. It was found that less than half of these patients adhered to immunosuppressive therapy. Less than half of these patients were found to comply with immunosuppressive therapy. In this study, no relationship was found between health literacy and adherence to immunosuppressive therapy.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Postoperative Acid-Base Balance and Lactate Levels as Predictors of ICU Length of Stay in Liver Transplant Patients.","authors":"Reyhan Arslantas, Mustafa Kemal Arslantas","doi":"10.1016/j.transproceed.2025.02.030","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.02.030","url":null,"abstract":"<p><strong>Purpose: </strong>Liver transplantation is a life-saving procedure for patients with end-stage liver disease. The postoperative period presents significant challenges, particularly in managing acid-base balance and lactate levels, which are crucial indicators of metabolic stability and tissue perfusion. While these parameters provide valuable insights into patient recovery, their role in predicting intensive care unit (ICU) length of stay remains unclear. This study evaluates whether early postoperative acid-base balance and lactate levels can reliably predict ICU length of stay in liver transplant recipients, aiming to enhance postoperative care strategies.</p><p><strong>Methods: </strong>A retrospective observational study was conducted on 53 adult liver transplant recipients. Acid-base and lactate parameters were measured at two-time points: early (within the first 6 hours) and late (6-24 hours) postoperatively. Paired t-tests and Wilcoxon signed-rank tests were used to compare these measurements. Multiple linear regression modeling was employed to assess the impact of these parameters on ICU length of stay.</p><p><strong>Results: </strong>Significant changes were observed in FiO₂, pH, Base Excess, HCO₃, lactate, and Strong Ion Difference (SID) between early and late postoperative measurements (P < .05). However, regression analysis revealed that maximum lactate and early SID were not strong predictors of ICU length of stay (R² = 0.062). Exploratory analyses indicated that patients with elevated SID and markedly high lactate levels tended to have prolonged ICU stays.</p><p><strong>Conclusions: </strong>While postoperative acid-base balance and lactate levels are important indicators of physiological status in liver transplant recipients, they do not serve as strong independent predictors of ICU length of stay.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}