Transplantation proceedings最新文献

{"title":"Short-Term Outcomes Among Lung Transplant Recipients from SARS-CoV-2+ Donors and Evaluation of Lung Function Among SARS-CoV-2+ Donors.","authors":"Toyokazu Endo, Jaimin Trivedi, Erin M Schumer, Victor H van Berkel, Matthew P Fox","doi":"10.1016/j.transproceed.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.transproceed.2024.11.008","url":null,"abstract":"<p><p>There are reports of successful lung transplants using SARS-CoV-2+ donors, but the data on their overall outcome is limited. We used the United Network for Organ Sharing Database (UNOS) to identify all lung transplant patients who received lungs from SARS-CoV-2+ donors between 2020 and 2023. There was no difference in survival between those who received lungs from SARS-CoV-2- and SARS-CoV-2+ donors (P = .60). In addition, the timing of the SARS-CoV-2 test for donors did not affect the outcomes among recipients. Among all SARS-CoV-2+ donors identified since 2020, the lungs used came from younger donors, had better chest x-ray findings, and had a higher P/F ratio. Our data suggest that organ function may be more important than SARS-CoV-2 status when using lungs from SARS-CoV-2+ donors. Further research and follow-up are still needed to adequately address the use of lungs from SARS-CoV-2+ donors, thus further increasing the donor pool.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes, and Willingness Concerning Cornea Donation Among Medical Students in Lanzhou, Northwest of China.","authors":"Yike Li, Lin Liu, Chengying Yan, Rui Ding, Ziyu Du, Xunwen Lei, Xudong Jiu, Wenjie Li, Yang Liu","doi":"10.1016/j.transproceed.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.transproceed.2024.11.001","url":null,"abstract":"<p><strong>Background: </strong>As the will-be medical staff, medical students take the future responsibilities to propaganda knowledge of cornea donation and exert positive influence on the public. We aimed to investigate the knowledge, attitudes, and willingness concerning cornea donation among the medical students in Lanzhou, Northwest of China.</p><p><strong>Methods: </strong>This study was an observational cross-sectional survey in which a detailed questionnaire was used. Medical students from either Lanzhou University (LZU) or Northwest University for Nationalities (NUN) were approached, and the questionnaire was filled out and submitted online. The sociodemographic profile, the correctness of the knowledge, attitudes toward cornea donation, and suggestions on promotion were categorized and compared. Additionally, determinants influencing knowledge and willingness were revealed by using Logistic Regression.</p><p><strong>Results: </strong>A total of 1129 students who completed the questionnaire were enrolled in this study. Most of the respondents were aware of the cornea donation (n = 895, 79.3%), but the knowledge was scarce, pertaining to the process to donate (n = 20, 1.8%), the time limit of recovery (n = 152, 13.5%), the preserved period (n = 97, 8.6%), and legislations on the issues (n = 7, 0.6%). Almost all the students expressed positive attitudes toward cornea donation (n = 1106, 98.0%) and supported their relatives or friends to donate (n = 1049, 92.9%); whereas more than half of them showed unwillingness to donate (n = 520, 46.1%). Age (P = .013), race (P < .001), parents' educational background (tertiary: P = .004); and primary: P = .001), siblings (P = .001), family annual income (high: P < .001; and low: P = .001), years of medical education (P < .001), attitude toward cornea donation (P = .019), attitude toward hypothetical relative donation (P < .001), and willingness to donate (P < .001) distinctly influenced the respondents' knowledge in the logistic regression. Likewise, several factors significantly determined the respondents' willingness to donate, including birth place (P = .028), race (P = .041), siblings (P = .023), family annual income (high: P = .008]; low: P = .002; and middle: P = .004), years of medical education (P = .007), attitude toward cornea donation (P = .005), willingness to persuade donation (P < .001), attitude toward hypothetical relative donation (P < .001), and score (P < .001).</p><p><strong>Conclusions: </strong>The knowledge on cornea donation of the medical students is not satisfied, and their willingness to pledge corneas is relatively low. Several sociodemographic factors could predict the knowledge level and willingness which may be improved by particular curriculums in the future.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142690211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Prone Positioning as a Bridge to Recovery From Refractory Hypoxemia After Oversized Lung Transplant\" [Transplantation Proceedings, 53/1 2021: 273-275].","authors":"Taehwa Kim, Hye Ju Yeo, Bong Soo Son, Dohyung Kim, Woo Hyun Cho, Hee Yun Seol","doi":"10.1016/j.transproceed.2024.01.001","DOIUrl":"10.1016/j.transproceed.2024.01.001","url":null,"abstract":"","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"2106"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141294065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TEG 6s Global Hemostasis System is Useful for Coagulation Management in Simultaneous Pancreas and Kidney Transplantation: The First Two Cases.","authors":"Muneyuki Matsumura, Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Hiroyuki Ogasawara, Yoshihiro Shono, Michiaki Unno, Takashi Kamei","doi":"10.1016/j.transproceed.2024.10.017","DOIUrl":"10.1016/j.transproceed.2024.10.017","url":null,"abstract":"<p><strong>Introduction: </strong>Hypercoagulability-related graft thrombosis is the leading cause of graft failure after simultaneous pancreas-kidney transplantation (SPK). Addressing this issue is crucial to improve the outcomes of SPK recipients. Thromboelastography (TEG) has been used to assess the coagulation profiles of SPK recipients. Recently, a new-generation TEG device, the TEG 6s Global Hemostasis System, was introduced. This device offers advantages over TEG 5000, including less frequent calibration requirements, ease of use, and reduced sensitivity to movement. We hypothesized that TEG 6s would enhance coagulation management in SPK.</p><p><strong>Methods: </strong>We report two cases of Asian female SPK recipients in whom TEG 6s was used to assess coagulation status at six preset times during and after surgery.</p><p><strong>Results: </strong>Preoperatively, both patients exhibited hypercoagulability on TEG 6s. Postoperative intravenous heparin was administered, and the dose was titrated based on the TEG 6s results. Vascular thrombosis was not observed in either patient. Detailed TEG 6s and standard laboratory test results are reported. This pilot study demonstrates that TEG 6s monitoring can effectively assess coagulation status in SPK recipients, aiding in optimal coagulation management and reducing the risk of thrombotic complications leading to graft loss. The TEG 6s facilitated real-time and accurate coagulation assessment, allowing for tailored anticoagulant therapy.</p><p><strong>Conclusions: </strong>This is the first observational study to use TEG 6s in SPK recipients, indicating its potential benefits in improving patient outcomes. Further studies with larger sample sizes are warranted to validate these findings and establish comprehensive guidelines for using TEG 6s in SPK procedures.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"2021-2026"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Management of Thrombosed Cavoportal Anastomosis After Liver Transplantation Using Catheter Directed Thrombolysis and Stent Placement: A Case Report.","authors":"Lawrence Bonne, Hannah Van Malenstein, Peter Verhamme, Diethard Monbaliu, Chris Verslype, Mauricio Sainz Barriga, Schalk Van der Merwe, Thomas Vanassche, Jacques Pirenne, Geert Maleux","doi":"10.1016/j.transproceed.2024.10.021","DOIUrl":"10.1016/j.transproceed.2024.10.021","url":null,"abstract":"<p><p>Cavoportal hemitransposition (CPHT) is a rarely performed treatment technique in liver transplantation in cases of extensive splanchnic thrombosis, in which the inferior vena cava of the recipient is used to perfuse the portal vein of the allograft. A case of a 65-year-old liver transplantation patient with an acutely thrombosed cavoportal anastomosis is presented. After unsuccessful medical treatment, recanalization was obtained with transfemoral catheter directed thrombolysis, angioplasty and stent placement. Although this type of treatment has been extensively documented for the management of portal anastomotic problems after orthotopic liver transplantation, data on its application in modified transplantation techniques including CPHT are rare. This technique provides a minimally invasive treatment option in CPHT patients with cavoportal anastomotic problems, who might otherwise require complex surgical repair or retransplantation.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"2072-2074"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Remission With Allo-HSCT for t(1;8)(q25;p11) Translocation: A Rare Case Report and Literature Review.","authors":"Li Huang, Xiangjun Fu, Dan Liu, Li Guo, Li-E Lin","doi":"10.1016/j.transproceed.2024.10.018","DOIUrl":"10.1016/j.transproceed.2024.10.018","url":null,"abstract":"<p><strong>Background: </strong>The 8p11 myeloproliferative syndrome (EMS), a rare disorder characterized by translocations and interchanges at chromosome 8p11, is usually refractory to chemotherapy, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the only promising treatment for long-term remission. Among 14 translocation partners associated with EMS, t(1;8)(q25;p11) are very uncommon, with only four cases previously reported in peer-reviewed journals in English.</p><p><strong>Case presentation: </strong>Here we report a 43-year-old man who presented with atypical peripheral T-cell lymphomas. Translocations between chromosomes 1q25 and 8p11 were detected during a bone marrow karyotype examination of 20 metaphases, and fluorescence in situ hybridization (FISH) revealed a positive rearrangement for the FGFR1 locus, confirming the diagnosis of EMS with t(1;8)(q25;p11). Despite rapid disease progression, he maintained remission for 27 months after admission due to aggressive chemotherapy combined with early allogeneic peripheral blood stem cell transplantation. We also conducted a literature review for 12 EMS patients treated with allo-HSCT who had rare karyotypes to better understand their clinicopathologic features and disease management.</p><p><strong>Conclusion: </strong>we report the first case of EMS with t(1;8)(q25;p11) to have a favorable outcome after allo-HSCT. The encouraging results support the use of aggressive chemotherapy in conjunction with early allo-HSCT for EMS patients with t(1;8)(q25;p11).</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"2100-2105"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Long-Term Atorvastatin Therapy on the Development of Chronic Lung Allograft Dysfunction in Patients with Azithromycin Prophylaxis after Lung Transplantation.","authors":"Dan Zhang, Xiaoxing Wang, Wenwen Du, Pengmei Li","doi":"10.1016/j.transproceed.2024.10.015","DOIUrl":"10.1016/j.transproceed.2024.10.015","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of long-term atorvastatin (ATO) therapy on reducing recipient inflammation and immune response, thus lowering the risk of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. This study aimed to investigate the effects of ATO on overall survival, lung function recovery, and its influence on inflammatory factors alongside azithromycin (AZI) prophylaxis.</p><p><strong>Methods: </strong>This retrospective single-center study included lung transplant recipients from January 2017 to December 2022. Patients who survival >1 year after lung transplantation and who were receiving AZI prophylaxis for >6 months were selected. Outcome measures involved pulmonary function assessments at various time points after AZI treatment, complete blood cell analysis, and inflammatory factor evaluations.</p><p><strong>Results: </strong>The incidence of CLAD was significantly lower in the long-term ATO group compared with those not on ATO (P = .011). Long-term ATO treatment significantly delayed CLAD onset after lung transplantation (850 days vs. 630 days; P = .041), with patients showing notably enhanced lung function recovery within 6 months of AZI therapy compared with the non-ATO group. Neutrophil levels decreased in patients with CLAD, and interleukin-6 concentrations significantly decreased in the AZI + ATO group compared with the AZI group. Overall patient survival was significantly better in the AZI+ATO group than in the AZI group (P = .02).</p><p><strong>Conclusion: </strong>In cases where CLAD develops despite AZI prophylaxis, long-term ATO treatment may lead to short-term improvements in lung function. It could also decrease inflammation levels in lung transplant recipients and enhance overall survival. The combination of AZI and long-term ATO therapy may be beneficial for CLAD prevention.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"2012-2020"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote Kidney and Liver Injury After Transplantation of Lung Allografts in an Allogeneic Mouse Model.","authors":"Marcin L Sander, Volker Eulenburg, Tatsuo Maeyashiki, Jae-Hwi Jang, Sarah D Müller, Sebastian N Stehr, Wolfgang Jungraithmayr, Tobias Piegeler","doi":"10.1016/j.transproceed.2024.10.020","DOIUrl":"10.1016/j.transproceed.2024.10.020","url":null,"abstract":"<p><strong>Background: </strong>Remote organ dysfunction is common after lung transplantation and might negatively affect the outcome. The local anesthetic ropivacaine was previously demonstrated to attenuate acute rejection after allogeneic lung transplantation in mice. We hypothesized that lung transplantation might result in detectable molecular signs of injury in kidneys and liver and that ropivacaine might attenuate this damage.</p><p><strong>Methods: </strong>Organs from C57BL/6 mice undergoing allogeneic orthotopic single-lung transplantation were procured at postoperative day 5 and analyzed using Western blot and real-time quantitative polymerase chain reaction probing for Src protein tyrosine kinase, STAT3, and bax/bcl-2. During cold ischemia, the allograft had either been flushed with normal saline only or in combination with ropivacaine (1 µM). A nontransplanted group of animals served as the baseline controls.</p><p><strong>Results: </strong>The allogeneic stimulus induced by transplantation led to an increase in Src-phosphorylation and STAT3-expression in the kidneys and livers of lung-transplanted mice compared to nontransplanted animals. Bax/bcl-2 as a marker of cellular apoptosis was not affected by the transplantation. In contrast to the findings in the transplanted lungs, the addition of ropivacaine did not have an effect on the examined markers of inflammation in the remote organs.</p><p><strong>Conclusions: </strong>The observed increase in the inflammatory signaling provides first insight into a possible mechanism, by which remote organ dysfunction after lung transplantation might occur.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"2046-2053"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-Assisted Partial Nephrectomy for Multiple Allograft Renal Cell Carcinomas: A Case Report.","authors":"Ayane Tachiki, Kazuhiko Yoshida, Yuki Kobari, Shinsuke Mizoguchi, Ryo Minoda, Hironori Fukuda, Kouhei Unagami, Junpei Iizuka, Hideki Ishida, Toshio Takagi","doi":"10.1016/j.transproceed.2024.08.045","DOIUrl":"10.1016/j.transproceed.2024.08.045","url":null,"abstract":"<p><strong>Background: </strong>Partial nephrectomy (PN) is strongly recommended as nephron-sparing surgery for T1 renal tumors. Although there have been some reports of robot-assisted PN (RAPN) for solitary allograft renal tumors, only a few cases of RAPN for multifocal allograft renal tumors have been reported. Herein, we report a case of a patient who underwent RAPN for multifocal allograft renal cell carcinoma (RCCs).</p><p><strong>Case presentation: </strong>A 77-year-old male was diagnosed with 24- and 15-mm lesions in the middle portion of a right iliac fossa renal allograft. RAPN was performed using a transperitoneal approach 22 years after the kidney transplantation. The allograft renal artery was clamped, and the tumors were resected. Pathological examination revealed clear-cell RCC with negative surgical margins. There were no perioperative complications, and kidney function did not significantly change during surgery.</p><p><strong>Conclusion: </strong>RAPN is a feasible and effective treatment option for multiple allograft RCCs. The successful preservation of renal function coupled with minimal perioperative complications underscores the potential of RAPN. Our observations suggest that RAPN can be safely implemented in similar high-risk cases, offering a nephron-sparing alternative that might extend quality of life and reduce the need for dialysis in transplant recipients.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"2063-2067"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Volatile Anesthetics on Early Clinical Outcomes in Liver Transplantation: A Systematic Review and Meta-Analysis.","authors":"Insun Park, Eun-Ki Min, Jae Hyon Park, Ah-Young Oh, Jung-Hee Ryu","doi":"10.1016/j.transproceed.2024.09.003","DOIUrl":"10.1016/j.transproceed.2024.09.003","url":null,"abstract":"<p><strong>Background: </strong>The aim of this systematic review and meta-analysis was to evaluate the effects of volatile anesthesia (VA) on early clinical outcomes in liver transplantation.</p><p><strong>Methods: </strong>We searched electronic databases to identify relevant studies comparing VA to non-VA in liver transplant recipients. The primary outcome assessed was early allograft dysfunction (EAD), and secondary outcomes were postoperative peak liver function tests (LFT) including aspartate transaminase (AST) and alanine transaminase (ALT) levels, and hospitalization time.</p><p><strong>Results: </strong>Six relevant studies involving 919 patients were analyzed. In meta-analysis of prospective studies, VA was associated with fewer incidence of EAD than non-VA (RR: 0.45; 95% CI: 0.25, 0.84; P = .012; I² = 0%; P_h = 0.334) but this association was not significant in meta-analysis of retrospective studies (OR: 0.83; 95% CI: 0.58, 1.19; P = .310; I² = 0%; P_h = 0.624). No significant difference in peak AST (SMD: -0.14 U/L; 95% CI: -0.65, 0.37 U/L; P = .594; I² = 69.9%; P_h = 0.036) and ALT (SMD: -0.16 U/L; 95% CI: -0.65, 0.33 U/L; P = .529; I² = 67.0%; P_h = 0.048) were found between VA and non-VA. The hospitalization time also did not differ between the two groups (SMD: -0.09 days; 95% CI: -0.29, 0.10 days; P = .350; I² = 0%; P_h = 0.864).</p><p><strong>Conclusions: </strong>While there is potential protective effect of VA against EAD in liver transplant recipients, certainty remains low, whereas VA was not associated with postoperative LFT or hospitalization time.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"1984-1994"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}