Transplantation proceedings最新文献

{"title":"Clinical Profile of Patients With Hepatocellular Carcinoma Referred for Transarterial Chemoembolization at a Tertiary Center.","authors":"Beatriz Piaulino de Araujo, João Guilherme Oliveira Vaz, Ana Paula Nunes Bento, Maria Stella Vasconcelos Sales Valente, Juan Mariano Huertas Aguilar, Gabriel Marchetto, Lara Garcia Victório Pessotto, Paolla Ravida Alves de Macedo, Carla Batista Moisés, Fernanda Dias Teramoto, Alexandre Foratto, Aline Garcia, Cristhian Jaillita Meneses, Ilka de Fatima Santana Ferreira Boin, Simone Reges Perales, Elaine Cristina de Ataíde","doi":"10.1016/j.transproceed.2026.03.003","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.03.003","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related mortality worldwide. It is strongly associated with chronic liver diseases such as viral hepatitis, alcohol-related liver disease, and nonalcoholic steatohepatitis. Transarterial chemoembolization (TACE) is indicated for intermediate-stage HCC and may be used for downstaging, bridging to liver transplantation, or palliative treatment.</p><p><strong>Methods: </strong>This cross-sectional observational study evaluated patients with HCC referred for TACE at the University Hospital of Campinas between 2022 and 2023, who underwent the procedure until 2024. Demographic data, liver disease etiology, laboratory findings, tumor staging (Child-Pugh, BCLC, and MELD), transplant listing status, alpha-fetoprotein (AFP) levels, and tumor characteristics were analyzed.</p><p><strong>Results: </strong>A total of 158 patients were included, with a mean age of 64 years and male predominance (77.85%). Hepatitis C virus infection was the most frequent etiology (31%), followed by alcohol-related liver disease (20.9%) and combined HCV and alcohol use (17%). TACE was performed in 100 patients, mainly for downstaging (37.3%) and prevention of transplant waiting-list dropout (32.3%). Half of the patients presented with a single tumor nodule, with a mean lesion size of 3.8 cm. The mean MELD score was 12.5 and AFP levels showed wide variability.</p><p><strong>Conclusion: </strong>The study population demonstrated an epidemiological profile consistent with the literature. TACE was widely used as an effective strategy for tumor control in liver transplant candidates, highlighting its importance in the management of HCC in the Brazilian clinical setting.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Weight of Balance: Anesthetic Management in Liver Transplantation for Critically Ill Patients. A Case Report.","authors":"Priscilla Polanco Fernández, Daniela Yailén González Rodríguez, Laura Isabel Ruiz Torres, José Carlos Vera Gómez, Axel Sánchez Cedillo, Omar Vásquez Gómez, Ángel Augusto Pérez Calatayud, César Enrique Vásquez Corró, Carla Escorza Molina","doi":"10.1016/j.transproceed.2026.04.005","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.04.005","url":null,"abstract":"<p><strong>Background: </strong>Liver transplantation in critically ill patients with multiple organ dysfunction poses a unique anesthetic challenge due to profound coagulopathy, hemodynamic instability, and metabolic derangements.</p><p><strong>Case presentation: </strong>We describe a 50-year-old male with alcoholic cirrhosis (MELD-Na 27) who underwent 2 consecutive liver transplants within 72 hours. The initial surgery involved aspiration of 15 L of purulent ascites and 8000 mL of blood loss. Advanced hemodynamic monitoring, balanced fluid therapy with albumin, vasopressor support (norepinephrine and vasopressin), goal-directed coagulation management (ROTEM), and strict metabolic control were implemented. Post-reperfusion hypotension and bradycardia were managed with adrenaline and atropine. Twelve hours later, he was reoperated for hemoperitoneum and subsequently underwent urgent retransplantation for hepatic artery thrombosis. Hemodynamic stability was achieved during the second procedure. Despite successful graft perfusion, the patient developed pneumonia and renal failure requiring replacement therapy, leading to a fatal outcome.</p><p><strong>Conclusion: </strong>Physiology-guided anesthesia can sustain intraoperative stability in extreme scenarios, but outcome depends on preoperative physiological reserve and timing of intervention.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Detection of a Testicular Mixed Germ Cell Tumor by Alpha-Fetoprotein Surveillance After Pediatric Liver Transplantation: Case Report and Literature Review.","authors":"Takahiko Omameuda, Taiichi Wakiya, Yasunaru Sakuma, Yasuharu Onishi, Yukihiro Sanada, Noriki Okada, Yuta Hirata, Toshio Horiuchi, Kiichiro Takadera, Ryosuke Akimoto, Naoki Saegusa, Hironori Yamaguchi","doi":"10.1016/j.transproceed.2026.03.010","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.03.010","url":null,"abstract":"<p><p>Liver transplant (LT) recipients, particularly pediatric survivors, face an elevated lifetime risk of de novo malignancies due to prolonged immunosuppressive therapy. Alpha-fetoprotein (AFP) is widely used as a biomarker for hepatocellular carcinoma (HCC) in post-LT surveillance, but elevations may also reflect extrahepatic tumors. Here, we report a rare case of a testicular tumor incidentally detected through AFP monitoring in a pediatric LT survivor. A 20-year-old male with situs inversus totalis underwent living donor LT for biliary atresia at 1 year of age. Nineteen years post-transplant, AFP was elevated to 493 ng/mL during routine surveillance, raising suspicion for de novo HCC. Imaging studies revealed no liver lesions, but physical examination identified testicular swelling. Scrotal ultrasonography demonstrated a heterogeneous mass, and orchiectomy confirmed a mixed germ cell tumor composed of seminoma, yolk sac tumor, and embryonal carcinoma. AFP normalized postoperatively, and the patient is being carefully monitored during postoperative surveillance. This case highlights both the benefits and limitations of AFP-driven surveillance: while it facilitated early detection of a curable extrahepatic tumor, reliance on AFP alone may miss AFP-negative testicular cancers. Comprehensive surveillance strategies incorporating tumor markers, structured physical examinations, and patient education are warranted, with future emphasis on standardized guidelines for pediatric LT survivors.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Kidney Transplantation With Inferior Vena Cava Outflow: A Single Center Experience.","authors":"Andreia Ministro, Mickael Henriques, Bernardo Marques da Silva, Alice Santana, Teresa Pereira, Carlos Miranda, José Lopes, Luís Mendes Pedro, Augusto Ministro","doi":"10.1016/j.transproceed.2026.02.026","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.02.026","url":null,"abstract":"<p><strong>Introduction: </strong>Standard renal transplantation uses external iliac vessels. Iliac or IVC occlusion often excludes candidates, but a patent proximal IVC offers an alternative outflow.</p><p><strong>Methods: </strong>We retrospectively reviewed kidney transplants with IVC anastomosis at a tertiary hospital (Jan 2000-Aug 2024). Outcomes were 30-day mortality and long-term graft survival.</p><p><strong>Results: </strong>Among 1235 transplants, 14 required IVC anastomosis. Median follow-up was 110 months; median age 34 years; 8/14 were men. Indications included ilio-cava thrombosis, multiple transplants, or adult grafts in low-weight children. Thirteen grafts were placed in the right iliac fossa, one intraperitoneally; 10 were right kidneys, 12 from deceased donors. Seven cases used donor vena cava for vein extension. Two grafts failed (humoral rejection at 5 years; acute ischemia at 3 months). Remaining grafts functioned with mean creatinine 1.55 mg/dL at 5 years. No patient died within 30 days.</p><p><strong>Conclusion: </strong>With longer End Stage Renal Disease survival, cases with limited vascular access or multiple transplants will rise. Proximal IVC anastomosis, though complex, is feasible and provides durable venous drainage.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serologic Evaluation for Severe Acute Respiratory Syndrome Coronavirus 2 in Pediatric Heart Transplantation Recipients and Patients on a Pediatric Heart Transplantation Waiting List in a Quaternary Hospital.","authors":"Clarice Arruda Villari, Adailson Siqueira, Celia Strunz, Christiane Moscan, Marcelo Jatene, Nana Miura, Estela Azeka","doi":"10.1016/j.transproceed.2024.04.023","DOIUrl":"10.1016/j.transproceed.2024.04.023","url":null,"abstract":"<p><strong>Background: </strong>The Coronavirus disease 2019 (COVID-19) pandemic has been a global reality for longer than 3 years. Serologic studies have great importance for understanding the virus's behavior in populations, as it can suggest the status of the epidemic in a community. This cross-sectional study aimed to analyze the serologic profile for COVID-19 in patients before and after pediatric heart transplantation.</p><p><strong>Methods: </strong>Serology data on IgG and IgM antibodies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were collected in patients of the Pediatric Cardiology and Congenital Heart Diseases unit of a Brazilian hospital between January and August 2022. A total of 174 patients were recruited, including 28 on the transplantation waiting list and 146 heart transplant recipients. Information for each patient, including demographics (age, sex, state of origin), type of heart disease (congenital or acquired), and time after transplantation, was analyzed.</p><p><strong>Results: </strong>Overall, 72 patients had a positive serology for anti-N antibodies (48.0%), including 62 heart transplant recipients and 10 patients on the transplantation waiting list, The positivity rates in these 2 groups were 48.1% and 47.6%, respectively. Positivity rates for previously infected individuals were 62.5% and 62.1%, respectively.</p><p><strong>Conclusions: </strong>Approximately one-half of our study sample had IgM or IgG antibodies against the SARS-CoV-2 virus. Serologic studies on the duration and level of protection provided by these antibodies are relevant public health tools for health promotion of vulnerable groups and can be useful for future studies on antibody behavior.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"1112-1114"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of COVID-19 Infection in Kidney Transplant Recipients.","authors":"Thamiris Quiqueto Marinelli, Heloisa Cristina Caldas, Maria Alice Sperto Ferreira-Baptista, Fernanda Salomão Gorayeb-Polacchini, Ana Carolina Brecher Souza, Ludimila Leite Marzochi, Guilherme Jairo Luiz da Silva, Ida Maria Maximina Fernandes-Charpiot, Mario Abbud-Filho","doi":"10.1016/j.transproceed.2024.04.016","DOIUrl":"10.1016/j.transproceed.2024.04.016","url":null,"abstract":"<p><strong>Background: </strong>COVID-19, caused by SARS-CoV-2, was responsible for higher morbidity and mortality in renal transplant recipients (RTx). The objective of the study was to evaluate the impact of COVID-19 infection on RTx in a single center in Brazil.</p><p><strong>Methods: </strong>A cohort of 135 RTx was evaluated between December 2019 and June 202l, and demographics, clinical, and laboratory profiles were analyzed from deceased donors with COVID-19.</p><p><strong>Results: </strong>Diabetic and RTx from extended criterion donors presented more frequently the severe form of the disease. Serum creatinine (sCr) after 3 months of diagnosis of COVID-19 varied according to the severity of infection. The lethality rate was higher in the group with severe symptoms (65%) compared with those with mild infection (1.5%).</p><p><strong>Conclusion: </strong>The increase in sCr was associated with disease severity. The lethality rate for COVID-19 was 26.6%. These rates are 10-20 times higher than those reported in the general population and suggest that rigorous observation, early diagnosis, and disease prevention measures are crucial in RTx.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"1048-1051"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumocystis jirovecii Pneumonia in a Liver Transplant Recipient With an Adverse Reaction to Trimethoprim/Sulfamethoxazole Treated With a Sulfonamide Desensitization Protocol: Case Report.","authors":"Karolina Baran, A. Furmańczyk-Zawiska, R. Wieczorek-Godlewska, Przemysław Nitek, Magdalena Durlik","doi":"10.1016/j.transproceed.2024.03.022","DOIUrl":"https://doi.org/10.1016/j.transproceed.2024.03.022","url":null,"abstract":"","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":"284 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Data on Organ Donation and Transplantation in Poland: Poltransplant Activity 2017 to 2022.","authors":"Jarosław Czerwiński, Anna Pszenny, Krystyna Antoszkiewicz, Teresa Danek, Łukasz Górski, Małgorzata Hermanowicz, Anna Łęczycka, Piotr Malanowski, Adam Parulski, Łukasz Szemis, Jacek Ziaja, Artur Kamiński","doi":"10.1016/j.transproceed.2024.03.027","DOIUrl":"10.1016/j.transproceed.2024.03.027","url":null,"abstract":"<p><strong>Background: </strong>In this paper, we present organ donation and transplantation activities in Poland from 2017 to 2022. Data came from registries maintained by the Polish Transplant Coordinating Center Poltransplant and consisted of the national waiting list, deceased donor registry, transplant registry, and the live donor registry. Poltransplant is the Competent Authority in Organs, with tasks related to preparing assessments, analyses, information, and reports in transplantation medicine and publishing and disseminating these results in the country and abroad. Poltransplant edits the Poltransplant Bulletin on its web pages and presents its activities at Polish Transplantation Society congresses, published consecutively as professional papers.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"758-762"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E. Solowiej, J. Solowiej, M. Godlewski, et al. Regarding the article \"Application of Sulforaphane: histopathological study of intraportal transplanted pancreatic islets into livers of diabetic rats,\" Transplant Proc (2006 Jan/Feb) 38(1): pages 282-283.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":"41 5","pages":"2006"},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}