Transplantation proceedings最新文献

{"title":"The Effect of Portal Vein Variants on the Margin of Error in Graft Volume Calculation in Living Donor Right Lobe Liver Transplantation.","authors":"Feyza Sönmez Topcu, Veysel Ersan, Emrah Şahin, Adem Tunçer, Hasret Ayyıldız Civan, Abuzer Dirican, Bülent Ünal","doi":"10.1016/j.transproceed.2025.06.017","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.017","url":null,"abstract":"<p><strong>Background: </strong>Selecting the appropriate graft for living donor liver transplantation requires accurate calculation of estimated graft volume.</p><p><strong>Purpose: </strong>To investigate the error rate in graft volume calculation in the preoperative evaluation of donor liver and the contribution of donor portal vein type to the error margin.</p><p><strong>Material and methods: </strong>The study included 197 right lobe liver donors. Estimated graft volume calculations based on preoperative radiological images of donors were retrospectively reviewed. Demographic data of the donors and liver portal vein type were recorded. The proportional differences between the weight of the right lobe graft removed during transplantation and the estimated volume were calculated separately according to the portal vein groups. The margin of error in the estimated graft volume measurement and the effect of portal vein type were statistically evaluated.</p><p><strong>Results: </strong>Considering all donors, estimated preoperative volume was calculated to be 6.877% higher than actual graft weight on average. Preoperative estimated graft volume was on average 5.746% higher for Type 1, 8.311% higher for Type 2, and finally 17.883% higher for Type 3 portal vein variant. It was shown that, as the portal vein anatomy in the donor becomes more complex, the negatively proportional difference in preoperative volume estimation increases.</p><p><strong>Conclusion: </strong>Volume estimation showed a negative proportional difference for all three variants of the portal vein. Especially, the presence of a Type 3 portal vein in the liver graft may cause more errors in preoperative graft volume calculation.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Double Renal Artery Anastomosis With Single Renal Artery Anastomosis in Kidney Transplant Recipients; Is There Any Effect on Graft Function?","authors":"Necattin Fırat, Alper Karacan, Emrah Akın, Fatih Altıntoprak, Fehmi Çelebi, Salih Salihi, Enes M Kocatürk, İbrahim F Küçük, Hamad Dheir","doi":"10.1016/j.transproceed.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.07.003","url":null,"abstract":"<p><strong>Objective: </strong>Vascular anatomical variations in the graft are evaluated regarding the number of arteries, early branching, and venous drainage. The aim of this study was to compare the outcomes of patients who underwent double renal artery anastomosis and single renal artery anastomosis in LDKT.</p><p><strong>Methods: </strong>Between April 2019 and December 2023, LDKT cases were retrospectively evaluated in our center. A control group was formed from patients who underwent single renal artery anastomosis with similar characteristics to those who underwent double renal artery anastomosis. Demographic characteristics, graft function tests, routine blood and urine tests, postoperative artery resistivity index (ARI) and pulsatile index (PI) values, post-transplant complications, length of hospitalization, and control parameters at the last follow-up were evaluated.</p><p><strong>Results: </strong>174 living donor kidney transplants were performed during the defined period. The study group consisted of 20 patients (DRA group) who underwent double renal artery anastomosis, and the control group (SRA group) consisted of 33 patients who underwent single renal artery anastomosis. There was no significant difference between the demographic characteristics of the donors and recipients (P > .05). Postop and current ARI and PI values were also similar between the 2 groups (P > .05). However, the albumin/creatinine ratio in spot urine was significantly higher in DRA group compared to SRA group (P = .039).</p><p><strong>Conclusion: </strong>Multiple vessel anastomoses are inevitably performed because of the variations seen in renal arteries. Even if the artery diameter is small, with good surgical technique, similar results can be achieved to anastomoses in single artery grafts.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring CD3(+) T Cells in Kidney Transplantation and Immunosuppression Adequacy.","authors":"Kemal Eyvaz, Arif Aslaner, Arif Ata Kiravkazli","doi":"10.1016/j.transproceed.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.016","url":null,"abstract":"<p><strong>Background: </strong>Monitoring CD3(+) T-cell counts in kidney transplant recipients can provide valuable insights into immunosuppressive therapy effectiveness. This study aimed to evaluate the use of CD3(+) T-cell levels as biomarkers for immunosuppression adequacy and to assess their predictive value for acute rejection post-transplantation.</p><p><strong>Methods: </strong>A retrospective review was conducted involving 130 kidney transplant recipients who received induction therapy with antithymocyte globulin (ATG). CD3(+) T-cell percentages and absolute counts were measured using flow cytometry on postoperative day 5. Immunosuppression was maintained with tacrolimus, initiated upon clinical indicators of graft function recovery.</p><p><strong>Results: </strong>Among monitored patients, the median CD3(+) T-cell percentage was 48%, and median absolute count was 0.14 × 10⁹/L. Acute rejection occurred in 9.9% of recipients. Higher CD3(+) T-cell values significantly correlated with acute rejection (64.0% vs 47.5%, p = .011; absolute count 0.28 vs 0.13 × 10⁹/L, p = .032). ROC analysis identified optimal predictive thresholds: 54% for CD3(+) percentage (sensitivity 85.7%, specificity 73.4%) and 0.21 × 10⁹/L for absolute count (sensitivity 85.7%, specificity 75.0%).</p><p><strong>Conclusions: </strong>CD3(+) T-cell monitoring effectively guides individualized immunosuppressive strategies, significantly predicting acute rejection risks and optimizing graft outcomes.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Liver Transplantation Among Patients Diagnosed With Acute-on-Chronic Liver Failure: A Single-Center Experience.","authors":"Yoshitaka Saegusa, Masahiro Ohira, Naruhiko Honmyo, Ryosuke Nakano, Hiroshi Sakai, Seiichi Shimizu, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Hideki Ohdan","doi":"10.1016/j.transproceed.2025.06.015","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.015","url":null,"abstract":"<p><strong>Background: </strong>Acute-on-chronic liver failure (ACLF) describes the rapid deterioration of liver function triggered by factors including alcohol consumption, infection(s), and exacerbation(s) of chronic liver disease, and is characterized by a persistent \"cytokine storm.\" While liver transplantation is the most effective treatment, comprehensive data regarding patient outcomes are limited.</p><p><strong>Methods: </strong>Clinical data from 187 patients, who underwent liver transplantation (excluding re-transplantations and acute liver failure) between 2009 and 2023, were analyzed in accordance with Japan's ACLF diagnostic criteria. Immunological analysis included a mixed lymphocyte reaction with carboxyfluorescein succinimidyl ester staining (CFSE-MLR).</p><p><strong>Results: </strong>Among 171 patients, 13 had ACLF (grade 0, n = 6; grade 2, n = 5; grade 3, n = 2), and 158 had non-ACLF. Five-year survival rates for the ACLF and non-ACLF groups were similar regardless of ACLF severity. Patients with ACLF had higher preoperative Model for End-stage Liver Disease (ie, \"MELD\") scores and Child-Pugh scores, and higher rates of dialysis, renal dysfunction, and respiratory failure (P < .05). The graft rejection rate was higher in the ACLF group than that in the non-ACLF group, and the CFSE-MLR assay revealed significantly elevated CD8-positive T cell responses to donor antigens in the first week post-transplantation.</p><p><strong>Conclusion: </strong>Patients with ACLF achieved favorable postoperative outcomes despite poor preoperative conditions. High mortality rates among patients with ACLF on transplant waitlists emphasize the importance of timely transplantation. The increased anti-donor immune response after transplantation suggests a role for the underlying cytokine storm and underscores the need for careful postoperative management.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Variceal Band Application in Preventing Bile Leakage Associated With Trans-Cystic Feeding Catheter in Living-Donor Liver Transplantation.","authors":"Adem Tuncer, Canan Dilay Dirican, Emrah Sahin, Veysel Ersan, Feyza Sönmez Topcu, Hasret Ayyıldız Civan, Bülent Unal, Abuzer Dirican","doi":"10.1016/j.transproceed.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.014","url":null,"abstract":"<p><strong>Objective: </strong>Despite advancements in surgical techniques, biliary complications remain a significant concern in liver transplantation. This study evaluated the effectiveness of applying a variceal band to the cystic duct stump in preventing bile leakage in patients with a trans-cystic feeding catheter.</p><p><strong>Methods: </strong>The medical records of 328 liver transplant recipients between April 2022 and June 2024 were retrospectively reviewed. A total of 170 patients with trans-cystic external catheters were included in the study. Of these, 116 patients underwent variceal band application to the cystic duct stump, while 54 did not. The 2 groups were compared regarding demographic characteristics, graft weight, number of bile ducts, presence of bile leakage, and MELD scores.</p><p><strong>Results: </strong>Among the 170 patients who underwent living-donor liver transplantation (LDLT), 58.8% were male, and 41.2% were female. Graft weight was significantly higher in the group with the variceal band application (p < .05). Bile leakage from the cystic duct stump occurred in 2 patients in the group without variceal banding, whereas no bile leakage was observed in the variceal band group. These 2 cases were successfully treated with percutaneous catheter placement under radiologic guidance.</p><p><strong>Conclusion: </strong>The variceal band application is an effective and promising method for reducing bile leakage in LDLT patients utilizing a trans-cystic feeding catheter. However, multicenter studies with larger patient cohorts are necessary to more definitively assess the safety and efficacy of this technique.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Pregnancy Following Heterologous in Vitro Fertilization in a Kidney Transplant Recipient With Autosomal Dominant Polycystic Kidney Disease: A Case Report.","authors":"Luca Apicella, Sarah Hamzeh, Renata Angela Di Pietro, Chiara Crescenzo, Nicoletta Vecchione, Dora Russo, Carmine Secondulfo, Antonio Pisani, Rosa Carrano, Candida Iacuzzo, Giancarlo Bilancio","doi":"10.1016/j.transproceed.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.013","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is often associated with infertility and adverse pregnancy outcomes. Kidney transplantation improves fertility and maternal-fetal health, while assisted reproductive technologies, including in vitro fertilization (IVF), offer additional opportunities. However, there are no documented cases of heterologous IVF in kidney transplant recipients in the literature.</p><p><strong>Case presentation: </strong>We report the case of a 47-year-old female with autosomal dominant polycystic kidney disease (ADPKD) who underwent a kidney transplant in 2018. In 2022, she underwent heterologous IVF to prevent the transmission of ADPKD. Pregnancy was achieved after the third embryo transfer, with stable graft function and no major complications. A cesarean section at 37 weeks resulted in the birth of a healthy female newborn. One year postpartum, renal function remained stable.</p><p><strong>Discussion and conclusion: </strong>Pregnancy in kidney transplant recipients is high-risk, requiring careful immunosuppressive management and multidisciplinary monitoring. This case highlights the feasibility of heterologous IVF in transplant recipients, expanding reproductive options for patients with hereditary kidney diseases.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-Term Results of Renal Function in Living Kidney Donors in a Single Center.","authors":"İbrahim Furkan Küçük, Necattin Fırat, Fatih Altıntoprak, Merve Yeşilsancak, Enes Malik Kocatürk, Hamad Dheir, Salih Salihi, Emrah Akın, Fehmi Çelebi","doi":"10.1016/j.transproceed.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.011","url":null,"abstract":"<p><strong>Objective: </strong>Living donor nephrectomy (LDN) has been described as a safe operation with low morbidity and mortality rates. The aim of the study was to evaluate the differences between preoperative and postoperative renal functions in LDN and to identify risk factors predicting possible long-term persistent renal dysfunction.</p><p><strong>Methods: </strong>Donors who underwent LDN operations in our center between April 2019 and January 2023 were evaluated retrospectively. Demographic characteristics, renal function tests, routine blood and urine tests, post-transplant complications, ultrasonographic kidney size measurement, and control parameters 1 year after the operation were compared. Factors affecting renal function at 1-year postdonation were analyzed.</p><p><strong>Results: </strong>A total of 110 who met the inclusion criteria were included. Fifty-eight donors (52.7%) were male, and the mean age was 46.54 ± 12.18 years. During follow-up, kidney size of donors increased significantly 1 year after nephrectomy (109.38 ± 9.70 vs 115.65 ± 11.58 mm, P = .001), and estimated glomerular filtration ratio (e-GFR) values were decreased significantly (107.83 ± 13.72 vs 75.68 ± 17.14 mL/min/1.73 m², P < .001). The urine protein creatinine ratio (PCR) was found to be significantly increased (157.6 ± 89.6 vs 206.6 ± 147.2 g/g, P = .001). Although within normal values, there was a significant increase in serum creatinine levels (P < .001), thyroid stimulating hormone (TSH) (P = .050), and serum potassium (P < .001) levels in one year after donation. The increase rates in serum creatinine after 1 year of follow-up were more significant in male gender and in individuals over 50 years of age (P = .016 and P = .006, respectively).</p><p><strong>Conclusion: </strong>Although renal dysfunction may occur when well-selected donors remain with a single kidney after LDN, long-term outcomes are safe and may carry tolerable minor risks.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living Kidney Donor Perceptions About Organ Donation: Who are They, and How Do They Feel About the Process?","authors":"Manuela Almeida, Inês Carvalho Frade, Alexandra Sousa, La Salete Martins, Miguel Silva Ramos, Jorge Malheiro, Isabel Fonseca, Alice Lopes","doi":"10.1016/j.transproceed.2025.05.036","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.05.036","url":null,"abstract":"<p><strong>Background: </strong>The panorama of living kidney donors (LKDs) in Portugal has changed over the past decade, including kidney-paired exchange programs, undirected donations, and more complex kidney transplants, which could affect the predisposition to donation. We sought to describe the sociodemographic characteristics of a cohort of LKDs at our center and assess their perceptions of the donation process.</p><p><strong>Material and methods: </strong>LKDs who donated between January 2018 and December 2019 underwent a predonation psychosocial evaluation and a follow-up evaluation in May 2022, which included questionnaires about perceptions regarding donation. We analyzed the results descriptively.</p><p><strong>Results: </strong>Forty-four LKDs were included, aged 47.3 ± 10.3 years. Most were female (68.2%). A total of 52.4% only attended primary school; 52.3% were genetically related to the recipients, and 40.9% were spouses. In 86.4% of the LKDs, the decision to donate was easy; in 13.6%, it was a little difficult, with some doubts. All donors said that the information provided was adequate. Most LDs (79.5%) stated that the relationship with the recipient did not change, and most (88.6%) believed that the recipient's health state improved significantly. Only one LD would not donate again, and 77.3% would strongly encourage others to do it.</p><p><strong>Conclusions: </strong>The perceptions about donation in our cohort were very positive, and most donors would encourage others to donate. All felt well-informed about the process, and the regret rate was very low. Although these results must be studied in larger cohorts, sharing previous donors' experiences can add value to the dissemination of LKD programs.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Decline in Renal Allograft Function After Severe COVID-19 in Kidney Transplant Recipients: Evidence From a Four-Year Retrospective Cohort Study.","authors":"Suzimar Silveira Rioja, Amanda Orlando Reis, Conrado Lysandro Rodrigues Gomes","doi":"10.1016/j.transproceed.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.012","url":null,"abstract":"<p><strong>Background: </strong>While coronavirus disease (COVID-19) has been extensively studied, long-term follow-up data in kidney transplant recipients (KTRs), particularly concerning the impact of severe COVID-19 on graft function, remain limited. This study provides critical evidence of sustained renal injury in KTRs with severe COVID-19, focusing on acute kidney injury (AKI) as a predictor of accelerated graft dysfunction over a 4-year follow-up period.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 43 KTRs hospitalized with COVID-19 in Brazil (April 2020 and July 2024). The survivors were followed up for a median of 2.5 years (range: 1.2-4.2 years). Longitudinal graft function was assessed using estimated glomerular filtration rate (eGFR) trajectories modeled with linear mixed-effects analysis.</p><p><strong>Results: </strong>The in-hospital mortality rate was 37.2%. AKI occurred in 65.1% of patients and was more frequent among nonsurvivors (87.5% vs 51.9%, P < .05). Of the 13 patients requiring kidney replacement therapy, only 2 survived. Among the 27 survivors, we observed a significant decline in eGFR from 47.99 to 40.57 mL/min/1.73 m² (P = .032) in the follow-up period, driven by a steeper annual decline in those with AKI (-6.99 mL/min/1.73 · m² per year vs stable eGFR in non-AKI patients, P = .049). By the final follow-up, AKI survivors had a significantly lower eGFR than non-AKI patients (12.58 vs 47.57 mL/min/1.73 m², P = .003).</p><p><strong>Conclusion: </strong>Severe COVID-19 has a lasting impact on graft function in KTRs, particularly in those with AKI. These findings underscore the importance of long-term nephrological surveillance and individualized post-COVID-19 management strategies for slowing graft dysfunction progression in this high-risk population.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor Transmission of an Intravascular Large B-Cell Lymphoma in Multiorgan Transplantation: A Case Report From a Rare Pitfall in the Predonation Screening for Donor Disease.","authors":"Beatriz P Fernandes, Ana C Pimenta, Andreia Henriques, Clara Pardinhas, Rita Leal, Maria G Marques, Lídia Santos, Catarina Romãozinho, Vítor Sousa, Arnaldo Figueiredo, Rui Alves, Luís Rodrigues","doi":"10.1016/j.transproceed.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.06.010","url":null,"abstract":"<p><p>The prevention of donor-transmitted diseases in solid organ transplantation depends on the thorough screening of donors while maintaining a high level of clinical suspicion. The evolution in these practices reduced the incidence of donor-transmitted tumors to minimal and unexpected events. Nevertheless, the recipients of these exceptional transmissions hold significant clinical consequences, challenging decisions, and poor outcomes. The intravascular large B-cell lymphoma (IVLBCL) is an extremely rare and aggressive tumor with almost exclusive intrasmall vessel growth. Its clinical and morphological features make diagnosing potential deceased donors virtually impossible. We report the case of the post-transplant diagnosis of the transmission of this cancer in a multiorgan kidney and liver transplantation. Following the IVLBCL diagnosis on a routine preimplantation kidney biopsy, the transplanted kidney grafts were removed, and a conservative management approach was adopted for the liver recipient. Histological examination of the kidney grafts revealed multifocal involvement by an IVLBCL neoplasm. Subsequent liver recipient biopsy showed no evidence of the known IVLBCL. After three years of follow-up, both kidney recipients have undergone a second kidney transplant, and the liver recipient continues to demonstrate no signs of the IVLBCL disease.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}