Transplantation proceedings最新文献

{"title":"Liver Transplantation for Acute Liver Failure Following Regorafenib Treatment for Metastatic Gastrointestinal Stromal Tumor: Case Report and Literature Review.","authors":"Anaïs Tribolet, Clara Dassetto, Laurent Reydellet, Farouk Tradi, Emilie Bollon, Serban Puia-Negulescu, René Gérolami, Jean Hardwigsen, Florence Duffaud, Sophie Chopinet","doi":"10.1016/j.transproceed.2026.06.048","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.06.048","url":null,"abstract":"<p><p>Tyrosine kinase inhibitors (TKI) have improved survival in metastatic gastrointestinal stromal tumors (GIST) but can lead to drug-induced liver injury (DILI), rarely progressing to acute liver failure (ALF). We report the first documented case of regorafenib-induced ALF in a 51-year-old patient with metastatic ileal GIST, necessitating emergency liver transplantation (LT). The patient experienced prior hepatotoxicity with imatinib and disease progression under sunitinib. Following LT, sorafenib was initiated to treat peritoneal recurrence, and partial tumor control was achieved 3 years after transplantation. In literature, 6 cases of LT for TKI-induced ALF were reported, all in patients with chronic myeloid leukemia. This report highlights the critical importance of early detection of TKI-induced hepatotoxicity and LT as a life-saving intervention in severe DILI, while emphasizing the complex oncological considerations-including recurrence risk, immunosuppression-related challenges, and long-term survival-that must be carefully evaluated in the context of organ shortage.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of Prolonged Intermittent Renal Replacement Therapy in Patients With Delayed Graft Function After Renal Transplantation.","authors":"Baoyao Wang, Huaizhou Chen, Junjun Guo, Liusheng Lai, Qiang Yan","doi":"10.1016/j.transproceed.2026.07.028","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.07.028","url":null,"abstract":"<p><strong>Introduction: </strong>Delayed graft function (DGF) is a common early complication after renal transplantation. We aimed to investigate the clinical efficacy and safety of prolonged intermittent renal replacement therapy (PIRRT) in the treatment of patients with DGF after renal transplantation.</p><p><strong>Methods: </strong>Clinical information on 80 patients who underwent renal transplantation in The 924th Hospital of the PLA Joint Logistics Support Force, from August 2021 to April 2024 was collected. According to the different hemodialysis methods, they were divided into: prolonged intermittent renal replacement therapy (PIRRT) and intermittent hemodialysis group (IHD). We investigate the effects of 2 dialysis methods on DGF after renal transplantation by comparing the recovery time of transplanted kidney function, the incidence of dialysis complications, and final blood creatinine level between the 2 groups.</p><p><strong>Results: </strong>Forty patients of PIRRT group and 40 patients of IHD group conformed to our inclusion criteria. Mean DGF time in the PIRRT group was shorter than in the HDF group(10.45 day2 VS 16.43 days, P < .05, urea clearance (Kt/V) in the PIRRT group was better than in the IHD group (1.58VS1.3, P < .05), the incidence of hemodialysis complications was also low in the PIRRT group and there was a statistical difference in total dialysis time between the 2 groups. After therapy, both groups had considerably decreased mean levels of PCT, CRP, and IL-6 (P < .05). However, the IHD group had significantly higher NGAL levels than the PIRRT group (444.39 ± 182.62∶ 274.45 ± 96.34, P < .05). There was no significant difference in KIM-1 levels between the IHD and PIRRT groups. The recovery of renal function in both groups was assessed, and there was no significant difference in serum creatinine levels before therapy (P = .682 > .05). However, there were significant changes in serum creatinine levels between the 2 groups 1 month and 3 months after therapy (P = .021 and P = .016, respectively), showing that the medication was effective in improving renal function recovery. However, there was no statistically significant difference in serum creatinine levels between the 2 groups 6 months later (P = .125), showing that the recovery of renal function in both groups approached similarity after a given amount of time.</p><p><strong>Conclusion: </strong>PIRRT was used for hemodialysis treatment of patients with DGF after renal transplantation. It can shorten the duration of DGF, reduce renal damage during DGF, and promote the recovery of transplanted kidney function.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Renal Transplantation in Patients with Cystinosis.","authors":"Fatih Ergül, Mustafa Yıluzar, Mert Ünal, Abdullah Kısaoğlu, İsmail Demiryılmaz, Vural Taner Yılmaz, Hüseyin Koçak","doi":"10.1016/j.transproceed.2026.06.033","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.06.033","url":null,"abstract":"<p><strong>Background and aims: </strong>Cystinosis is a rare autosomal recessive lysosomal storage disorder caused by mutations in the CTNS gene, leading to cystine accumulation and progressive multisystem involvement. Renal failure is the clinical outcome, and renal transplantation markedly improves survival. However, long-term post-transplant outcomes remain limited. This study aimed to evaluate long-term graft and patient outcomes in cystinosis patients undergoing renal transplantation.</p><p><strong>Methods and results: </strong>This single-center retrospective case series included 6 male patients with cystinosis who underwent renal transplantation during childhood. The mean age at diagnosis was 3.9 years, and the mean follow-up period after transplantation was 12.3 years. Five patients received kidneys from living donors and one from a deceased donor. All patients were treated with cysteamine. No graft loss was observed during follow-up, and renal function remained stable in all patients. One patient developed antibody-mediated rejection while on cyclosporine, whereas no rejection episodes occurred in patients receiving tacrolimus-based regimens. Extrarenal involvement was predominantly ocular, with occasional thyroid, skeletal, and cardiac manifestations. Growth retardation was evident in all patients despite treatment.</p><p><strong>Conclusion: </strong>Renal transplantation provides excellent long-term graft and patient outcomes in cystinosis. Favorable graft survival, even in the presence of HLA mismatch, suggests a potentially protective disease-related effect. Early diagnosis, timely transplantation, and continued cysteamine therapy are essential for optimal long-term outcomes.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcome of Third Myeloablative Allogeneic Stem Cell Transplantation Using Unrelated Cord Blood: A Case Report.","authors":"Jun Ooi, Seiko Kato, Takaaki Konuma","doi":"10.1016/j.transproceed.2026.05.030","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.05.030","url":null,"abstract":"<p><p>Although a second allogeneic stem cell transplantation (SCT2) may cure leukemia relapse after the first allogeneic SCT (SCT1), relapse frequently occurs after SCT2. Recently, several reports on the outcomes of the third allogeneic SCT (SCT3) in patients with relapse after SCT2 have been published. However, no reports have detailed the long-term survival of patients with myeloablative SCT3 using unrelated cord blood (CB). Here, we report the results of our clinical experience in a patient with acute myeloid leukemia (AML) treated with SCT3 using CB after myeloablative conditioning. The patient remains alive and disease-free for 16.8 years after SCT3. To our knowledge, this patient is the longest survivor of AML after SCT3.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: \"Transplantation of Microencapsulated Cells Expressing VEGF Improves Angiogenesis in Implanted Xenogeneic Acellular Dermis on Wound\".","authors":"","doi":"10.1016/j.transproceed.2026.05.012","DOIUrl":"https://doi.org/10.1016/j.transproceed.2026.05.012","url":null,"abstract":"","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":"58 6","pages":"1223"},"PeriodicalIF":0.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148538024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serologic Evaluation for Severe Acute Respiratory Syndrome Coronavirus 2 in Pediatric Heart Transplantation Recipients and Patients on a Pediatric Heart Transplantation Waiting List in a Quaternary Hospital.","authors":"Clarice Arruda Villari, Adailson Siqueira, Celia Strunz, Christiane Moscan, Marcelo Jatene, Nana Miura, Estela Azeka","doi":"10.1016/j.transproceed.2024.04.023","DOIUrl":"10.1016/j.transproceed.2024.04.023","url":null,"abstract":"<p><strong>Background: </strong>The Coronavirus disease 2019 (COVID-19) pandemic has been a global reality for longer than 3 years. Serologic studies have great importance for understanding the virus's behavior in populations, as it can suggest the status of the epidemic in a community. This cross-sectional study aimed to analyze the serologic profile for COVID-19 in patients before and after pediatric heart transplantation.</p><p><strong>Methods: </strong>Serology data on IgG and IgM antibodies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were collected in patients of the Pediatric Cardiology and Congenital Heart Diseases unit of a Brazilian hospital between January and August 2022. A total of 174 patients were recruited, including 28 on the transplantation waiting list and 146 heart transplant recipients. Information for each patient, including demographics (age, sex, state of origin), type of heart disease (congenital or acquired), and time after transplantation, was analyzed.</p><p><strong>Results: </strong>Overall, 72 patients had a positive serology for anti-N antibodies (48.0%), including 62 heart transplant recipients and 10 patients on the transplantation waiting list, The positivity rates in these 2 groups were 48.1% and 47.6%, respectively. Positivity rates for previously infected individuals were 62.5% and 62.1%, respectively.</p><p><strong>Conclusions: </strong>Approximately one-half of our study sample had IgM or IgG antibodies against the SARS-CoV-2 virus. Serologic studies on the duration and level of protection provided by these antibodies are relevant public health tools for health promotion of vulnerable groups and can be useful for future studies on antibody behavior.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"1112-1114"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of COVID-19 Infection in Kidney Transplant Recipients.","authors":"Thamiris Quiqueto Marinelli, Heloisa Cristina Caldas, Maria Alice Sperto Ferreira-Baptista, Fernanda Salomão Gorayeb-Polacchini, Ana Carolina Brecher Souza, Ludimila Leite Marzochi, Guilherme Jairo Luiz da Silva, Ida Maria Maximina Fernandes-Charpiot, Mario Abbud-Filho","doi":"10.1016/j.transproceed.2024.04.016","DOIUrl":"10.1016/j.transproceed.2024.04.016","url":null,"abstract":"<p><strong>Background: </strong>COVID-19, caused by SARS-CoV-2, was responsible for higher morbidity and mortality in renal transplant recipients (RTx). The objective of the study was to evaluate the impact of COVID-19 infection on RTx in a single center in Brazil.</p><p><strong>Methods: </strong>A cohort of 135 RTx was evaluated between December 2019 and June 202l, and demographics, clinical, and laboratory profiles were analyzed from deceased donors with COVID-19.</p><p><strong>Results: </strong>Diabetic and RTx from extended criterion donors presented more frequently the severe form of the disease. Serum creatinine (sCr) after 3 months of diagnosis of COVID-19 varied according to the severity of infection. The lethality rate was higher in the group with severe symptoms (65%) compared with those with mild infection (1.5%).</p><p><strong>Conclusion: </strong>The increase in sCr was associated with disease severity. The lethality rate for COVID-19 was 26.6%. These rates are 10-20 times higher than those reported in the general population and suggest that rigorous observation, early diagnosis, and disease prevention measures are crucial in RTx.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"1048-1051"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumocystis jirovecii Pneumonia in a Liver Transplant Recipient With an Adverse Reaction to Trimethoprim/Sulfamethoxazole Treated With a Sulfonamide Desensitization Protocol: Case Report.","authors":"Karolina Baran, A. Furmańczyk-Zawiska, R. Wieczorek-Godlewska, Przemysław Nitek, Magdalena Durlik","doi":"10.1016/j.transproceed.2024.03.022","DOIUrl":"https://doi.org/10.1016/j.transproceed.2024.03.022","url":null,"abstract":"","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":"284 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Data on Organ Donation and Transplantation in Poland: Poltransplant Activity 2017 to 2022.","authors":"Jarosław Czerwiński, Anna Pszenny, Krystyna Antoszkiewicz, Teresa Danek, Łukasz Górski, Małgorzata Hermanowicz, Anna Łęczycka, Piotr Malanowski, Adam Parulski, Łukasz Szemis, Jacek Ziaja, Artur Kamiński","doi":"10.1016/j.transproceed.2024.03.027","DOIUrl":"10.1016/j.transproceed.2024.03.027","url":null,"abstract":"<p><strong>Background: </strong>In this paper, we present organ donation and transplantation activities in Poland from 2017 to 2022. Data came from registries maintained by the Polish Transplant Coordinating Center Poltransplant and consisted of the national waiting list, deceased donor registry, transplant registry, and the live donor registry. Poltransplant is the Competent Authority in Organs, with tasks related to preparing assessments, analyses, information, and reports in transplantation medicine and publishing and disseminating these results in the country and abroad. Poltransplant edits the Poltransplant Bulletin on its web pages and presents its activities at Polish Transplantation Society congresses, published consecutively as professional papers.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":"758-762"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E. Solowiej, J. Solowiej, M. Godlewski, et al. Regarding the article \"Application of Sulforaphane: histopathological study of intraportal transplanted pancreatic islets into livers of diabetic rats,\" Transplant Proc (2006 Jan/Feb) 38(1): pages 282-283.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":"41 5","pages":"2006"},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}