The Effect of PNI Score on Renal Prognosis and Graft Rejection After Kidney Transplantation.

Serap Yadigar, Pınar Özdemir, Erman Özdemir
{"title":"The Effect of PNI Score on Renal Prognosis and Graft Rejection After Kidney Transplantation.","authors":"Serap Yadigar, Pınar Özdemir, Erman Özdemir","doi":"10.1016/j.transproceed.2025.02.038","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Determining effective ways to make prognostic predictions after kidney transplantation of patients is essential for the management of patients. This study examines how the PNI score affects renal outcomes after kidney transplantation. The potential impact of PNI on renal function beyond the overall nutritional status was also examined.</p><p><strong>Methods: </strong>In this retrospective study, 100 kidney transplant patients were divided into three groups according to PNI scores: low (<40), intermediate (40-45) and high (>45). Demographic characteristics, clinical parameters, serum creatinine levels, estimated glomerular filtration rate (eGFR) and parenchymal thickness were evaluated. Logistic regression analysis was applied for the risk of graft rejection. Patients who were followed up for at least 6 months after kidney transplantation and had complete clinical data were included in the study. The mean follow-up period was 36 months (range: 6-60 months).</p><p><strong>Results: </strong>There was no statistically significant correlation between PNI scores and renal function (P > .05). The mean creatinine level was 1.73 ± 1.11 mg/dL in the low PNI group and 1.37 ± 0.52 mg/dL in the high PNI group. Although this difference was close to the limit of statistical significance, it was not significant (P = .083). In logistic regression analysis, no significant effect of PNI score on graft rejection was observed (OR: 1.0015, 95% CI: 0.7975-1.2576, P = .9899). However, age (OR: 0.9247, P = .0347) and serum creatinine levels (OR: 2.8396, P = .0151) significantly affected the risk of graft rejection. No significant effect of PNI score on complication rates was observed.</p><p><strong>Conclusions: </strong>This study demonstrated that PNI score alone is not a sufficient predictor of renal prognosis and graft rejection risk after kidney transplantation. Factors such as age and serum creatinine levels were found to be more predictive of the risk of graft rejection.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplantation proceedings","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.transproceed.2025.02.038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Determining effective ways to make prognostic predictions after kidney transplantation of patients is essential for the management of patients. This study examines how the PNI score affects renal outcomes after kidney transplantation. The potential impact of PNI on renal function beyond the overall nutritional status was also examined.

Methods: In this retrospective study, 100 kidney transplant patients were divided into three groups according to PNI scores: low (<40), intermediate (40-45) and high (>45). Demographic characteristics, clinical parameters, serum creatinine levels, estimated glomerular filtration rate (eGFR) and parenchymal thickness were evaluated. Logistic regression analysis was applied for the risk of graft rejection. Patients who were followed up for at least 6 months after kidney transplantation and had complete clinical data were included in the study. The mean follow-up period was 36 months (range: 6-60 months).

Results: There was no statistically significant correlation between PNI scores and renal function (P > .05). The mean creatinine level was 1.73 ± 1.11 mg/dL in the low PNI group and 1.37 ± 0.52 mg/dL in the high PNI group. Although this difference was close to the limit of statistical significance, it was not significant (P = .083). In logistic regression analysis, no significant effect of PNI score on graft rejection was observed (OR: 1.0015, 95% CI: 0.7975-1.2576, P = .9899). However, age (OR: 0.9247, P = .0347) and serum creatinine levels (OR: 2.8396, P = .0151) significantly affected the risk of graft rejection. No significant effect of PNI score on complication rates was observed.

Conclusions: This study demonstrated that PNI score alone is not a sufficient predictor of renal prognosis and graft rejection risk after kidney transplantation. Factors such as age and serum creatinine levels were found to be more predictive of the risk of graft rejection.

PNI评分对肾移植术后肾预后及移植排斥反应的影响。
背景:确定对肾移植患者进行预后预测的有效方法对患者的管理至关重要。本研究探讨了PNI评分对肾移植后肾脏预后的影响。除了总体营养状况外,PNI对肾功能的潜在影响也进行了研究。方法:在本回顾性研究中,100例肾移植患者根据PNI评分分为三组:低(45分)。评估了人口统计学特征、临床参数、血清肌酐水平、估计肾小球滤过率(eGFR)和实质厚度。采用Logistic回归分析移植排斥风险。肾移植术后随访至少6个月且临床资料完整的患者纳入研究。平均随访36个月(6 ~ 60个月)。结果:PNI评分与肾功能无统计学意义(P < 0.05)。低PNI组平均肌酐为1.73±1.11 mg/dL,高PNI组平均肌酐为1.37±0.52 mg/dL。虽然这一差异接近统计学意义的极限,但并不显著(P = .083)。在logistic回归分析中,PNI评分对移植排斥反应无显著影响(OR: 1.0015, 95% CI: 0.7975 ~ 1.2576, P = 0.9899)。然而,年龄(OR: 0.9247, P = 0.047)和血清肌酐水平(OR: 2.8396, P = 0.0151)显著影响移植排斥风险。PNI评分对并发症发生率无显著影响。结论:本研究表明,单独的PNI评分并不能充分预测肾移植后肾脏预后和移植排斥风险。年龄和血清肌酐水平等因素被发现更能预测移植排斥的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信