Preoperative Calcimimetic Treatment may Prevent Serum Creatinine Elevation after Parathyroidectomy in Kidney Transplant Recipients: A Retrospective Cohort Study.

Background: Hyperparathyroidism (HPT) often persists after successful kidney transplantation (KTx). Although parathyroidectomy (PTx) is an effective treatment option for post-KTx HPT, it is associated with postoperative elevation of serum creatinine levels. We hypothesized that pre-PTx calcimimetic treatment could alleviate the post-PTx increase in serum creatinine levels.

Methods: This retrospective cohort study enrolled KTx patients who underwent initial PTx between 2004 and 2023. Patients' background characteristics and laboratory data were investigated. The primary outcome was a change in the estimated glomerular filtration rate (eGFR). The cohort was divided into 2 groups based on the presence of pre-PTx calcimimetic treatment. Multivariate linear regression analysis assessed the association between calcimimetic treatment and percent eGFR 1 week after PTx.

Results: Of the 77 KTx patients who underwent PTx, 28 were treated with pre-PTx calcimimetics (calcimimetic group), and the others were not (noncalcimimetic group). Compared with the noncalcimimetic group, the calcimimetic group had lower serum calcium levels before PTx (10.3 vs 11.2 mg/dL, P < .001) and a significantly higher percentage of eGFR 1 week after PTx (95.1% vs 81.5%, P < .001). According to the multivariate analysis, pre-PTx calcimimetic treatment was positively associated with percent eGFR (regression coefficient estimate, 13.76; 95% confidence interval, 7.02-20.50; P < .001) 1 week after PTx.

Conclusion: Pre-PTx calcimimetic treatment may prevent post-PTx elevation of serum creatinine levels in KTx patients.