Transplantation proceedings最新文献

{"title":"Association Between Serum Bilirubin and Gingivitis in Kidney Transplant Patients.","authors":"Kwang Ho Mun","doi":"10.1016/j.transproceed.2025.08.023","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.08.023","url":null,"abstract":"<p><strong>Background: </strong>Bilirubin has been reported to have anti-inflammatory and anti-oxidant properties. These effects have shown to reduce oral complications in patients with chronic kidney disease (CKD). However, studies have been limited in immunosuppressed patients, such as kidney transplant recipients. This study therefore studied whether serum bilirubin has a protective effect against gingivitis even in immunosuppressed conditions.</p><p><strong>Methods: </strong>Kidney transplant recipients who visited Dongan Hospital from 2018 to 2024 were recruited for the study. Patients with an unhealthy range of serum bilirubin were excluded. A total of 834 patients were divided into tertiles by serum bilirubin levels. The association between serum bilirubin and gingivitis was studied.</p><p><strong>Results: </strong>From a total of 923 patients, 834 patients were eligible for the study. Patients were divided by the tertile of serum bilirubin levels. Compared to the lowest tertile, high serum bilirubin was associated with a lower odds ratio (OR) of 0.32 (95% confidence interval CI] = 0.11-0.77) in T2 and an OR of 0.22 (95% CI = 0.06-0.60) in T3. Associations were consistent after adjusting for both T2 (OR = 0.28, 95% CI = 0.10-0.72) and T3 (OR = 0.21, 95% CI = 0.06-0.58).</p><p><strong>Conclusions: </strong>This study has shown that high bilirubin levels are associated with a decrease in gingivitis in kidney transplant recipients.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Transplantation Using High-Vascular-Resistant Renal Allografts From a Donor Who Had Calcineurin-Induced Functional Acute Kidney Injury.","authors":"S Li, C A Hostetler, J B Nave, A N Milam, M L Lenhart, K M Peoples, R A Squires, J P Orlowski","doi":"10.1016/j.transproceed.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.09.003","url":null,"abstract":"<p><strong>Background: </strong>High renal vascular resistance (RR) during hypothermic machine perfusion (HMP) is a common cause for declining renal allografts for transplantation. We report 2 kidney allografts with high RR that were successfully used for transplantation.</p><p><strong>Donor data: </strong>Two kidneys were procured from a 34-year-old female donation after circulatory death (DCD) donor with functional acute kidney injury (AKI) due to high-dose chronic calcineurin inhibitor (CNI) therapy. The donor had 56 minutes of warm ischemic time (WIT) and was connected to the HMP. After 29 hours of HMP, the RR of the right and left kidneys were 0.83 and 0.70 mm Hg/mL/min, respectively. The donor's terminal serum creatinine (Cr) was 0.83 mg/dL, and urine output decreased from 101 mL/hour to 16.5 mL/hour 3 days prior to organ recovery. Both kidneys were accepted for transplantation.</p><p><strong>Results: </strong>Both kidneys were successfully transplanted, with recipients discharged home on postoperative days 4 and 5 without oliguria. The preimplant high RR on HMP was likely due to tacrolimus-induced reversible AKI. The right kidney recipient's Cr values were 4.4 mg/dL preimplant, 3.6 mg/dL at discharge, and 2.4 mg/dL 1 year posttransplant. The left kidney recipient's Cr values were 7.2, 7.6, and 3.3 mg/dL, respectively. The cold ischemic time (CIT) for the right and left allografts was 47.2 and 42.8 hours, respectively. The left kidney experienced delayed graft function (DGF), requiring 1 dialysis treatment postoperatively. Neither recipient required dialysis after discharge.</p><p><strong>Conclusion: </strong>Kidney allografts with high RR during HMP, from donors with CNI drug-induced functional AKI, can be successfully used for transplantation.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Native Right Nephrectomy and Extraperitoneal Pediatric Kidney Transplantation Using the Same Incision for Both Surgeries.","authors":"Gaetano Ciancio, Marina M Tabbara, Jeffrey J Gaynor, Javier Gonzalez, Mahmoud Morsi, Angel Alvarez, Marissa Defreitas, Francesco Angioli, Jayanthi Chandar","doi":"10.1016/j.transproceed.2025.07.032","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.07.032","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplantation is the best option for pediatric patients with end-stage kidney disease but remains challenging due to donor-recipient size mismatch. The intraperitoneal approach is associated with high morbidity, while the extraperitoneal approach is safer and more feasible. The latter approach often requires performing a native kidney nephrectomy to create sufficient space for graft placement. Clinical outcomes following simultaneous native right nephrectomy and extraperitoneal kidney transplantation through the same incision in pediatric recipients were assessed.</p><p><strong>Methods: </strong>We retrospectively reviewed all pediatric patients (age ≤18yr) at our center during 2017-2023 who received a simultaneous right native nephrectomy and open extraperitoneal kidney transplant through the same incision.</p><p><strong>Results: </strong>Among 125 pediatric patients who received an extraperitoneal kidney transplant, 7 patients underwent a right native nephrectomy through the same incision at the time of kidney transplant. Median age-at-transplant was 4yr (range: 3-10yr); all patients were male. Median recipient weight was 16.5kg (range: 11.9-29.7kg). Median donor age was 26yr (range: 13-46yr). Three were deceased donors after brain death; 4 were living related donors. Median warm and cold ischemia times were 30min (range: 24-42min) and 171min (range: 26-1166min), respectively. Median estimated blood loss was 15ml (range: 5-50ml). There were no cases of delayed graft function. Median creatinine at 1, 3, 6, and 12 months' post-transplant was 0.5 (range: 0.3-0.8), 0.4 (range: 0.4-0.8), 0.5 (range: 0.4-0.7), and 0.6 (range: 0.5-0.9) mg/dL, respectively, with no reported post-operative vascular or urological complications.</p><p><strong>Conclusion: </strong>The extraperitoneal surgical approach of performing simultaneous right nephrectomy and kidney transplantation using the same incision was safe and feasible without postoperative complications, avoiding 2-step procedures or 2 incisions.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserved Kidney Function and Renal Recovery in Living Kidney Donors.","authors":"Eva Carlsson, Markus Gäbel, Niclas Kvarnström, Maria K Svensson","doi":"10.1016/j.transproceed.2025.07.031","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.07.031","url":null,"abstract":"<p><strong>Background: </strong>Living kidney transplantation is considered the most favorable treatment for end-stage kidney disease. The aim of this study was to assess the impact of clinical pre-donation factors upon post-donation kidney function and renal recovery.</p><p><strong>Methods: </strong>Sixty kidney donors (age = 46 ± 11 years, 63% women) were included. Associations between pre-donation factors and post-donation kidney function and renal recovery at 2 and 6 months were examined. Iohexol or ⁵¹Cr-EDTA was used to measure glomerular filtration rate. Multiple regression analyses and machine learning were applied.</p><p><strong>Results: </strong>Pre-donation measured glomerular filtration rate (mGFR) was 107 ± 18 and single-kidney (sk) mGFR 55 ± 10 mL/min. Sk mGFR increased by 29% and 35% at 2 and 6 months, respectively (P < .001 vs pre-donation). In univariable regression analysis, age, female sex, mGFR₀, sk mGFR₀, eGFR₀, body surface area (BSA), triglycerides (TGs), high-density lipoprotein (HDL), and waist-hip ratio (WHR) were significantly associated with post-donation mGFR. Age and pre-donation mGFR were the main determinants of post-donation mGFR at 2 and 6 months (adjusted [adj.] R² = 0.64, F = 71.5 and adj. R² = 0.63, F = 51.6, respectively, P < .001 for both models). Renal recovery (∆mGFR 0-2 and 0-6 months post donation) was associated with age, sk mGFR, and side of the donated kidney (left vs right; adj. R² = 0.37 and R² = 0.44, respectively, P < .001 for both models). The findings were similar when applying machine learning (data not shown).</p><p><strong>Conclusions: </strong>This study confirms that age and pre-donation kidney function (mGFR) are key determinants of post-donation kidney function and renal recovery.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Cases of Post-Kidney Transplantation Thrombotic Microangiopathy From a Single Donor With Candidemia.","authors":"Tiffany Shi, William H Schwieterman, Olanrewaju Eletta, Madison Cuffy, Robert L Plews","doi":"10.1016/j.transproceed.2025.07.025","DOIUrl":"10.1016/j.transproceed.2025.07.025","url":null,"abstract":"<p><p>Thrombotic microangiopathy (TMA) secondary to donor-derived infections remains a rare, yet serious source of graft loss and increased patient morbidity and mortality. Among TMA etiologies, donor-derived fungal infections remain particularly challenging to test for pre-operatively and treat post-operatively. We describe 2 cases of post-kidney transplant TMA from a single donor with suspected candidemia. Despite prophylactic treatment for Candida with fluconazole and eculizumab for TMA, 1 of the 2 patients unfortunately succumbed to TMA-related complications. The other patient, who also received fluconazole and eculizumab, had persistent hemolysis and ultimately required a transplant nephrectomy. Following nephrectomy, the patient's symptoms and laboratory values improved and the patient was able to be discharged to inpatient rehab before returning home. Despite appropriate treatment for Candida and TMA, patient outcomes were unfavorable. These 2 cases underscore the difficulties in treating TMA in the setting of organ transplantation and candidemia, pointing to the necessity for more research into improved treatment approaches.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Transplant Renal Artery Stenosis: A Meta-analysis.","authors":"Pande Made Wisnu Tirtayasa, Gerhard Reinaldi Situmorang, Gede Wirya Kusuma Duarsa, Tanaya Ghinorawa, Etriyel Myh, Eriawan Agung Nugroho, Athaya Febriantyo Purnomo, Gede Wira Mahadita, Yenny Kandarini, Arry Rodjani, Nur Rasyid","doi":"10.1016/j.transproceed.2025.08.017","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.08.017","url":null,"abstract":"<p><strong>Background: </strong>Transplant renal artery stenosis (TRAS) is a typical vascular complication that accounts for 75% of all vascular events following kidney transplantation. Post-transplant complications such as allograft dysfunction, allograft loss, and post-transplant hypertension have been attributed to TRAS. This study aims to evaluate the risk factors related to TRAS after kidney transplantation.</p><p><strong>Methods: </strong>A meta-analysis of studies that were published from inception until January 2024 was accomplished from the Science Direct and PubMed databases. Publications evaluating the prevalence of TRAS after kidney transplantation and assessing its risk factors were included in the study.</p><p><strong>Results: </strong>Sixteen publications were included in the study. The incidence of TRAS was 1465 cases (3.37%) from 43,446 patients. Several variables relating to the occurrence of TRAS after kidney transplantation were examined. The variables that related to the development of TRAS were multiple allograft arteries (OR 3.08 [95% CI 1.30-7.28], P = .01, I² = 33%), cold ischemia times (MD 4.40 [95% CI 3.72-5.08], P < .00001, I² = 0%), hypertension (RR 1.07 [1.03-1.11], P = .0006, I² = 0%), diabetes (RR 1.16 [1.04-1.29], P = .007, I² = 24%), ischemic heart disease (RR 1.51 [1.26-1.82], P < .00001, I² = 0%), systolic blood pressure (MD 10.98 [9.44-12.51], P < .00001, I² = 0%), diastolic blood pressure (MD 7.64 [2.30-12.97], P = .005, I² = 85%), delayed graft function (OR 2.11 [1.31-3.38], P = .002, I² = 58%), and acute rejection (RR 1.84 [1.24-2.71], P = .002, I² = 0%).</p><p><strong>Conclusions: </strong>Multiple variables have been identified as risk factors for TRAS. Since TRAS is linked to allograft dysfunction and poorer outcomes, effectively managing and improving these factors could result in better long-term results for kidney transplant recipients.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Sarcopenia, Myosteatosis, and Malnutrition on Renal Function of Kidney Transplant Recipients.","authors":"Leandro Siragusa, Luca Orecchia, Alice Gismondi, Giulia Marrone, Carlo Chiaramonte, Renato De Martino, Luigi Eduardo Conte, Andrea Collini, Annalisa Noce, Giuseppe Tisone, Alessandro Anselmo","doi":"10.1016/j.transproceed.2025.08.021","DOIUrl":"10.1016/j.transproceed.2025.08.021","url":null,"abstract":"<p><strong>Background: </strong>Patients with end-stage renal disease eligible for kidney transplant face multiple comorbidities and often are affected by malnutrition, sarcopenia, and myosteatosis. The role of the latter on post-transplantation renal function remains controversial; therefore, this study was conducted to evaluate the influence of sarcopenia, malnutrition, and myosteatosis on delayed graft function (DGF) and renal function of renal transplant recipients (RTR).</p><p><strong>Methods: </strong>This was a monocentric retrospective study of RTR with preoperative computed tomography (CT) scans undergoing kidney transplantation between January 2014 and December 2022. Participants were stratified into matched cohorts based on sarcopenia (skeletal muscle index), malnutrition (CONUT score), and myosteatosis (IMAT) status. The primary outcome was delayed graft function (DGF), while secondary outcomes included creatinine level, azotemia level, and estimated glomerular filtration rate for each matched cohort at 3 and 6 months and 1, 2, 3, and 5 years. A multivariate analysis was performed as well.</p><p><strong>Results: </strong>Eighty-six patients were included. No differences in DGF between malnourished and nonmalnourished patients, between sarcopenic and nonsarcopenic patients, or between IMAT groups were observed. Malnutrition was correlated with higher long-term azotemia, creatinine, and eGFR levels, while sarcopenia was associated with higher short-term creatinine and azotemia levels. Multivariate analysis revealed significant interactions among IMAT, CONUT score, and eGFR at 6 months.</p><p><strong>Conclusion: </strong>There are slight differences in DGF prevalence between sarcopenic and nonsarcopenic patients and between malnourished and nonmalnourished patients. More studies with larger cohorts are needed to validate the link between post-transplantation kidney graft, renal function, and preoperative metabolic status.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Suboptimal Graft Function at 1 Month Post-Transplantation on Long-Term Outcomes in Living Donor Kidney Transplant Recipients: A Retrospective Cohort Study.","authors":"Young Jun Park, Sang Seob Yun, Sun Cheol Park, Eun Ju Jang, Jeong Kye Hwang, Mi Hyeong Kim, Hyung Jin Cho, Kang Woong Jun, Ji Il Kim, Sangkyun Mok","doi":"10.1016/j.transproceed.2025.09.008","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.09.008","url":null,"abstract":"<p><strong>Introduction: </strong>While most recipients of living donor kidney transplantation experience rapid recovery of renal function, a subset shows suboptimal recovery of graft function despite sufficient postoperative time. The long-term implications of this suboptimal recovery of graft function remain unclear. This study aimed to assess the long-term outcomes of patients with suboptimal renal function 1-month post-transplantation.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 411 living donor kidney transplant recipients at a single center from January 2006 to February 2014, with a mean follow-up of 11.3 years. Patients were categorized into 2 groups based on 1-month post-transplant serum creatinine: suboptimal (>1.2 mg/dL) and standard (≤1.2 mg/dL). Clinical, immunological, and donor-recipient variables were compared. Primary outcomes included acute rejection, graft survival, and patient survival. Kaplan-Meier and log-rank analysis were used for outcome assessment.</p><p><strong>Results: </strong>The suboptimal group comprised 84 patients (20.4%). They were younger, predominantly male, had higher body mass index, and more frequently received smaller grafts from older donors with lower donor-to-recipient weight ratios. Acute rejection within 1 month occurred more frequently in this group (8.3% vs. 1.8%, P = .007). Despite these differences, no significant differences were observed in graft failure, mortality, infections, or malignancies, and long-term graft or patient survival did not differ significantly between the suboptimal and standard groups.</p><p><strong>Conclusions: </strong>Suboptimal graft function at 1-month post-transplantation is associated with increased acute rejection but does not independently predict inferior long-term graft or patient survival. These findings suggest that long-term outcomes can be preserved despite suboptimal functional recovery.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological Rejection in a Heterotopic Rat Liver Transplant Model.","authors":"Camryn Thompson, Bret Verhoven, Min Zhang, Weifeng Zeng, Isaac Alderete, Ahmed Hassan, Peter Chlebeck, Kristina Matkowskyj, Heather Jennings, Andrew S Barbas, David Al-Adra","doi":"10.1016/j.transproceed.2025.06.024","DOIUrl":"10.1016/j.transproceed.2025.06.024","url":null,"abstract":"<p><strong>Background: </strong>Rat liver transplant (LT) studies typically utilize the technically demanding orthotopic transplant model, which is stressful for the recipient animal. Therefore, we developed a less technically challenging heterotopic LT model that reduces post-operative animal stress and used this model to characterize rejection in 2 genetically mismatched rat pairs.</p><p><strong>Methods: </strong>Syngeneic transplants were performed with Lewis rats as liver donors and recipients. Allogeneic transplants utilized Dark Agouti donors and Lewis recipients or Lewis donors and Brown Norway recipients. The whole donor liver was transplanted in a heterotopic position in the left side of the abdominal cavity after a left nephrectomy. At pre-defined endpoints, liver grafts were excised and examined using the Banff rejection activity index (RAI).</p><p><strong>Results: </strong>In 9 sequential syngeneic transplants there were 2 technical errors that resulted in deaths. The Dark Agouti-Lewis cohort of 7 allogeneic transplants had 1 technical error resulting in death and 2 thrombosis-related graft failures. The Lewis-Brown Norway cohort of 10 transplants had 2 technical errors resulting in death and 3 thrombosis-related graft failures. All technical errors and thrombosis occurred early in each series. Syngeneic transplants demonstrated no rejection (mean RAI of 0). Allogeneic transplants demonstrated mild rejection by post-operative day 3 (mean RAI of 4.5) and severe rejection by post-operative day 8 (mean RAI of 9).</p><p><strong>Conclusion: </strong>Heterotopic LT is a viable rejection model that minimizes surgical complexity and animal distress. Allogeneic heterotopic LT demonstrated severe rejection in a timeline similar to the commonly used orthotopic model.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Evaluation of the Effect of Laparoscopic and Conventional Donor Nephrectomy on Graft Functions.","authors":"Azat Kozgun, Mehmet Yilmaz, Murat Sevmis, Mehmet Veysi Bahadir, Abdullah Oguz, Hatice Gulsen Yilmaz","doi":"10.1016/j.transproceed.2025.08.013","DOIUrl":"https://doi.org/10.1016/j.transproceed.2025.08.013","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare conventional and laparoscopic living donor nephrectomy procedures performed in our hospital in terms of clinical and laboratory findings, morbidity, and mortality for donors and recipients.</p><p><strong>Methods: </strong>Recipients were categorized into 2 groups according to the surgical approach taken to procure the graft transplanted to them. Variables that are compared include demographic information, number of mismatches, underlying pathology, length of hemodialysis, crossmatch results, nephrectomy side, side of the transplant, number of donor arteries/veins/ureters, preoperative /intraoperative /postoperative immunosuppression protocols, urea, creatine and glomerular filtration rate values at preoperative /postoperative /discharge times, first month and year creatine levels, hospital stay lengths, postoperative complication, rejection, and mortality rates.</p><p><strong>Findings: </strong>In the recipient patient group, the warm and cold ischemia times of the grafts in the LDN group were found to be significantly longer than those in the ODN group (P < .001 and P = .002). The LDN group had higher complication rates compared to the ODN group (P = .004). In the donor group, hospital stay duration was shorter for patients who underwent LDN (P = .021). When examining graft rejection and function, chronic rejection was found to be higher in grafts with ODN (P = .004). Grafts with higher warm and cold ischemia times had worse 1-year creatinine change outcomes (P = .009, P = .013).</p><p><strong>Conclusion: </strong>The LDN procedure increases the warm and cold ischemia times of the graft compared to ODN. However, it does not significantly affect graft survival and kidney function in long-term follow-ups.</p>","PeriodicalId":94258,"journal":{"name":"Transplantation proceedings","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}