Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy最新文献

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Bibliometric Analysis of the Top 100 Most Cited Publications With the Term "Apheresis" in the Title. 标题中包含“Apheresis”一词的前100篇被引文献计量分析。
IF 1.2
Dilek Urtekin, Nurhan Özpancar Şolpan
{"title":"Bibliometric Analysis of the Top 100 Most Cited Publications With the Term \"Apheresis\" in the Title.","authors":"Dilek Urtekin, Nurhan Özpancar Şolpan","doi":"10.1002/1744-9987.70137","DOIUrl":"10.1002/1744-9987.70137","url":null,"abstract":"<p><strong>Objective: </strong>Apheresis is a medical procedure used to remove harmful blood components across different disciplines. This bibliometric analysis evaluated the scientific characteristics of the 100 most-cited articles (T100) with the term \"apheresis\" in the title published between 1975 and 2025.</p><p><strong>Materials and methods: </strong>Data were retrieved from the Web of Science on August 11, 2025, using the keyword \"apheresis\" in the title field. Among 5765 publications, the T100 articles were identified. Recorded parameters included title, corresponding author, journal, year, total citations, number of authors, adjusted citation index (ACI), and Altmetric score (AmS). Analyses were performed with SPSS 29.0 and VOSviewer.</p><p><strong>Results: </strong>Publication output increased over time, peaking in 2017 (n = 227). The highest number of annual citations occurred in 2024 (n = 2944). Spearman's correlation demonstrated a significant positive relationship between ACI and AmS (r <sub>s</sub>  = 0.665, p < 0.001). The Journal of Clinical Apheresis contributed the largest share of T100 articles. The United States was the most productive country (30%), while no Turkish publications were included. Schwartz J. was the most cited author, with 2653 citations across five studies. Frequently used keywords were \"apheresis\" (16%), \"plasma exchange\" (9%), and \"immunoadsorption\" (8%).</p><p><strong>Conclusion: </strong>Apheresis research exhibits a dynamic, multidisciplinary structure, with citations peaking years after publication. High-income countries and central institutions dominate scientific output, while contributions from Turkey are absent in the T100. This study highlights key research trends and provides a reference point for future investigations in apheresis.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"418-435"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma Exchange for Anti-GBM Disease With Dialysis Dependency: A Case Series on Clinical Outcomes and Safety. 血浆置换治疗伴透析依赖的抗gbm疾病:临床结果和安全性的病例系列
IF 1.2
Minoru Sakuragi, Miho Miyauchi, Misaki Kubo, Mea Aso, Sanae Ogura, Yuko Sokai, Yoshiki Tsuji, Keita P Mori, Kazuo Torikoshi, Hiroyuki Suzuki, Toshiyuki Komiya, Eri Muso, Tomomi Endo, Takeshi Matsubara, Tatsuo Tsukamoto
{"title":"Plasma Exchange for Anti-GBM Disease With Dialysis Dependency: A Case Series on Clinical Outcomes and Safety.","authors":"Minoru Sakuragi, Miho Miyauchi, Misaki Kubo, Mea Aso, Sanae Ogura, Yuko Sokai, Yoshiki Tsuji, Keita P Mori, Kazuo Torikoshi, Hiroyuki Suzuki, Toshiyuki Komiya, Eri Muso, Tomomi Endo, Takeshi Matsubara, Tatsuo Tsukamoto","doi":"10.1002/1744-9987.70121","DOIUrl":"10.1002/1744-9987.70121","url":null,"abstract":"<p><strong>Introduction: </strong>The efficacy of plasma exchange (PEx) in patients with anti-glomerular basement membrane antibody (anti-GBM Ab) disease requiring renal replacement therapy (RRT) at diagnosis remains unclear. This study aimed to investigate the outcomes and safety of patients with uremic anti-GBM Ab disease undergoing PEx.</p><p><strong>Methods: </strong>We retrospectively analyzed nine patients confirmed by renal biopsy who received PEx using fresh frozen plasma or 5% human albumin solution and underwent hemodialysis (HD) concomitantly with standard immunosuppressive therapy. The outcome was determined as dialysis dependency, and safety was evaluated for adverse events.</p><p><strong>Results: </strong>Two patients (22.2%) achieved dialysis independence at 10 and 11 months. Both patients had relatively preserved normal glomeruli (15.8%-37.2%) and achieved early remission. Retroperitoneal hemorrhage and recalcitrant anti-GBM Ab were noteworthy in other cases.</p><p><strong>Conclusion: </strong>PEx can facilitate renal recovery in selected patients with anti-GBM disease requiring RRT. Pathological evaluation may be useful to determine the intensity and duration of treatment, including PEx.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"353-362"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism. Upacicalcet:一种用于血液透析伴继发性甲状旁腺功能亢进患者的新型静脉溶钙剂。
IF 1.2
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa
{"title":"Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism.","authors":"Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa","doi":"10.1002/1744-9987.70126","DOIUrl":"10.1002/1744-9987.70126","url":null,"abstract":"<p><p>Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium-sensing receptor sensitivity and reducing parathyroid hormone secretion. Upacicalcet is a novel intravenous calcimimetic that was specifically developed for hemodialysis patients. It is efficiently removed by hemodialysis, does not undergo hepatic metabolism, and has minimal potential for drug-drug interactions. Clinical studies have shown that upacicalcet effectively lowers serum intact parathyroid hormone and improves associated biochemical markers such as fibroblast growth factor-23 and bone turnover indices. It demonstrates a low incidence of gastrointestinal symptoms and hypocalcemia. Upacicalcet achieves sustained biochemical control with good tolerability in long-term use. These features suggest that upacicalcet is a safe and ideal option for the long-term management of SHPT in patients undergoing hemodialysis.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"309-322"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythropoiesis-Stimulating Agent Therapy in Maintenance Hemodialysis. 促红细胞生成剂在维持性血液透析中的应用。
IF 1.2
Masayuki Tanemoto
{"title":"Erythropoiesis-Stimulating Agent Therapy in Maintenance Hemodialysis.","authors":"Masayuki Tanemoto","doi":"10.1002/1744-9987.70124","DOIUrl":"10.1002/1744-9987.70124","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"441"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative Collection of Ascitic Fluid With Intra- or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method. 术中收集腹水并在卵巢癌中或术后再输注:滚轴泵送方法的安全性和可行性。
IF 1.2
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami
{"title":"Intraoperative Collection of Ascitic Fluid With Intra- or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method.","authors":"Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami","doi":"10.1002/1744-9987.70123","DOIUrl":"10.1002/1744-9987.70123","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell-free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.</p><p><strong>Methods: </strong>We retrospectively evaluated patients who underwent intraoperative CART for ovarian cancer treatment between March 2022 and 2025, compared two ascitic fluid collection methods (syringe and roller pumping), and analyzed operative parameter, fluid collection efficiency, albumin recovery, and adverse event-related data.</p><p><strong>Results: </strong>Among the 12 patients included in this study, seven (58.3%) underwent CART using the roller pumping method, which significantly reduced the collection time compared with the syringe method (9 vs. 22 min, p < 0.05). The median collection speed was also significantly higher with the roller pumping method (404 vs. 140 mL/min, p < 0.05). Approximately 70% of the albumin in the collected ascitic fluid was successfully reinfused. Adverse events included transient hypotension (16.7%) and hypertension (25.0%), both of which resolved without intervention.</p><p><strong>Conclusion: </strong>Intraoperative CART is a feasible and safe technique for protein loss management in patients undergoing surgery for ovarian cancer. The roller pumping method significantly shortened ascites collection time and reduced surgical burden.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"371-376"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjunctive Therapeutic Plasma Exchange in Refractory Adult-Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single-Center Experience. 伴继发性巨噬细胞激活综合征的成年性顽固性斯蒂尔氏病的辅助治疗血浆置换:单中心研究
IF 1.2
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda
{"title":"Adjunctive Therapeutic Plasma Exchange in Refractory Adult-Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single-Center Experience.","authors":"Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda","doi":"10.1002/1744-9987.70133","DOIUrl":"10.1002/1744-9987.70133","url":null,"abstract":"<p><strong>Introduction: </strong>Adult-onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain.</p><p><strong>Methods: </strong>We retrospectively analyzed patients with AOSD-MAS treated with TPE at a single-center.</p><p><strong>Results: </strong>All five patients had arthralgia, a salmon-pink rash, extreme hyperferritinemia, and multiorgan dysfunction including liver dysfunction. Prior to TPE, all patients received pulse glucocorticoids; three also received calcineurin inhibitors and one tocilizumab. TPE was initiated at a median of 12.0 days after diagnosis; the patients underwent a median of six sessions without major adverse events. Following TPE, fever and rash resolved; C-reactive protein (CRP), ferritin, and liver enzyme levels decreased without further corticosteroid escalation during and immediately after TPE. At 1 month, four patients achieved CRP < 1.0 mg/dL, four recovered with tapered immunosuppression. One patient died from cytomegalovirus infection despite MAS improvement.</p><p><strong>Conclusions: </strong>Adjunctive TPE was associated with rapid clinical and biochemical improvement.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"389-396"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to Shower Water Without Dressings Is Associated With Increased Risk of Catheter-Related Infection in Peritoneal Dialysis Patients: A Retrospective Cohort Study. 腹膜透析患者无敷料暴露于淋浴水与导管相关感染风险增加相关:一项回顾性队列研究
IF 1.2
Shingo Urate, Ayaka Kaihara, Chiaki Kasahara, Yuka Inaba, Tomoki Sato, Ryoichi Shirai, Shugo Doi, Hirotoshi Kakiwaki, Rena Sumura, Mai Yanagi, Satoshi Kinugasa, Kiyotaka Uchiyama, Yoshitaka Ishibashi
{"title":"Exposure to Shower Water Without Dressings Is Associated With Increased Risk of Catheter-Related Infection in Peritoneal Dialysis Patients: A Retrospective Cohort Study.","authors":"Shingo Urate, Ayaka Kaihara, Chiaki Kasahara, Yuka Inaba, Tomoki Sato, Ryoichi Shirai, Shugo Doi, Hirotoshi Kakiwaki, Rena Sumura, Mai Yanagi, Satoshi Kinugasa, Kiyotaka Uchiyama, Yoshitaka Ishibashi","doi":"10.1002/1744-9987.70132","DOIUrl":"10.1002/1744-9987.70132","url":null,"abstract":"<p><strong>Introduction: </strong>Preventing catheter-related infection (CRI) and peritonitis remains a challenge in peritoneal dialysis (PD). This study assessed whether showering without covering the catheter exit site increases CRI risk.</p><p><strong>Methods: </strong>This single-center retrospective cohort study was conducted between January 2019 and December 2022, and included all patients who were receiving PD at the beginning of the study or initiated PD during the study period. Participants were classified into two groups: those who covered the exit site with waterproof dressings during showering (dressing group), and those who took showers with the exit site uncovered (uncovered group). The primary outcome was CRI-free catheter survival; the secondary outcome was catheter-related peritonitis.</p><p><strong>Results: </strong>Of 188 eligible patients, 42 were excluded. Among the remaining 146, 54 were in the dressing group and 92 in the uncovered group. The mean age was 70.4 ± 11.1 years and 63.3 ± 12.9 years, respectively; 59% and 72% were male. CRI occurred in 29 patients in the dressing group and 76 patients in the uncovered group. The uncovered group had a significantly higher risk of CRI by the log-rank test (p < 0.01). In a multivariate Cox proportional-hazards model adjusted for potential confounders, uncovered showering remained an independent predictor of CRI (hazard ratio 2.29; 95% confidence interval 1.40-3.76; p < 0.01), along with a history of prior CRI. No cases of catheter-related peritonitis occurred in either group.</p><p><strong>Conclusion: </strong>Showering without covering the exit site is associated with an increased risk of CRI in PD patients.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"397-402"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147392250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma Separation Efficiency in Double Filtration Plasmapheresis: A Retrospective Study of Patients With Hyperlipidemia. 双滤过血浆分离法血浆分离效率:对高脂血症患者的回顾性研究。
IF 1.2
Yandy Marx Castillo-Aleman, Carlos Agustin Villegas-Valverde, Shinnette Lumame, Jay Mary Rose-Roque, Charisma Castelo, Marlene Cato, Maysoon Al-Karam, Ashwag Shamkhi Al Dhuhaibat, Stefano Benedetti, Fatema Mohammed Al-Kaabi, Rene Antonio Rivero-Jimenez, Yendry Ventura-Carmenate, Antonio Alfonso Bencomo-Hernandez, Stefan R Bornstein, Joan Cid
{"title":"Plasma Separation Efficiency in Double Filtration Plasmapheresis: A Retrospective Study of Patients With Hyperlipidemia.","authors":"Yandy Marx Castillo-Aleman, Carlos Agustin Villegas-Valverde, Shinnette Lumame, Jay Mary Rose-Roque, Charisma Castelo, Marlene Cato, Maysoon Al-Karam, Ashwag Shamkhi Al Dhuhaibat, Stefano Benedetti, Fatema Mohammed Al-Kaabi, Rene Antonio Rivero-Jimenez, Yendry Ventura-Carmenate, Antonio Alfonso Bencomo-Hernandez, Stefan R Bornstein, Joan Cid","doi":"10.1002/1744-9987.70116","DOIUrl":"10.1002/1744-9987.70116","url":null,"abstract":"<p><strong>Background: </strong>Double filtration plasmapheresis (DFPP) is a membrane-based apheresis technique that separates plasma components using two sequential filters; it is commonly used to remove high-molecular-weight substances across various indications. While various metrics such as \"plasma removal efficiency\" are well established in therapeutic plasma exchange, \"plasma separation efficiency\" (PSE) remains unreported in DFPP. This study aims to evaluate PSE across DFPP sessions performed with plasma filters of different pore sizes.</p><p><strong>Materials and methods: </strong>A retrospective study of DFPP procedures performed in patients with hyperlipidemia at a single center between April and July 2025 was conducted. Patient demographics, laboratory values, and procedural parameters were collected. PSE was calculated with and without hematocrit (HCT) adjustment (PSE<sub>1</sub> and PSE<sub>2</sub>). Associations with procedural variables were assessed using paired tests and multivariate linear regression.</p><p><strong>Results: </strong>A total of 42 DFPPs were performed in 19 patients using the Inuspheresis system, alternating two plasma fractionators (DFPP-1 and DFPP-2 with large and small pore size, respectively). PSE<sub>2</sub> and PSE<sub>1</sub> declined significantly from DFPP-1 to DFPP-2 (p = 0.0002 and p = 0.0014, respectively), with Cohen's d indicating large and moderate-to-large effect sizes. DFPP also resulted in significant reductions in total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, lipoprotein(a), and C-reactive protein. Multivariate models showed that the plasma separation rate and HCT shifts were significantly associated with PSE<sub>2</sub> and PSE<sub>1</sub> during DFPP-2 but not during DFPP-1.</p><p><strong>Conclusions: </strong>PSE is a reproducible parameter influenced by membrane pore size and procedural factors. Incorporating PSE monitoring, particularly with HCT adjustment, may support optimization of individualized DFPP protocols in routine apheresis practice.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"332-339"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing of Kidney Replacement Therapy Initiation in Patients With Septic Shock: A Descriptive Study Using a Japanese Inpatient Database. 脓毒性休克患者开始肾脏替代治疗的时机:一项使用日本住院患者数据库的描述性研究。
IF 1.2
Ken-Ichi Kano, Kayoko Mizuno, Hiroki Shimada, Chikashi Takeda, Koji Kawakami
{"title":"Timing of Kidney Replacement Therapy Initiation in Patients With Septic Shock: A Descriptive Study Using a Japanese Inpatient Database.","authors":"Ken-Ichi Kano, Kayoko Mizuno, Hiroki Shimada, Chikashi Takeda, Koji Kawakami","doi":"10.1002/1744-9987.70134","DOIUrl":"10.1002/1744-9987.70134","url":null,"abstract":"<p><strong>Background: </strong>Kidney Replacement Therapy (KRT) timing in septic shock remains debated. We assessed temporal trends in KRT initiation and outcomes in Japan.</p><p><strong>Methods: </strong>Using a nationwide EMR database (2016-2023), we included adults (≥ 20 years) with septic shock admitted to the intensive care unit (ICU) or high-dependency care unit (HDU) on day 0 who received KRT. Outcomes were KRT timing by hospital day, in-hospital mortality, and KRT dependency at discharge; sensitivity analyses used consistently reporting hospitals.</p><p><strong>Results: </strong>Among 688 hospitalizations (median age 74 years), KRT initiation shifted later, with day ≥ 2 initiation reaching 38.5% in 2023. In 2022, mortality was 54.3% (n = 25), and KRT dependency was 43.5% (n = 20). Patterns were similar across modalities/settings.</p><p><strong>Conclusions: </strong>KRT initiation shifted toward later timing after 2022. Studies with granular severity and indication data are needed to clarify drivers of variation and outcomes.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"403-411"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Usefulness of Selective Plasma Exchange for Treating Pediatric Autoimmune Neurological Diseases. 选择性血浆置换治疗小儿自身免疫性神经系统疾病的临床应用
IF 1.2
Tomoya Nakamizo, Toru Kanamori, Tomoya Kaneda, Kei Osaka, Miki Murakoshi, Mika Okutsu, Atsushi Ohkubo, Tomohiro Udagawa, Tomoko Mizuno, Shotaro Naito, Masatoshi Takagi, Masaki Shimizu
{"title":"Clinical Usefulness of Selective Plasma Exchange for Treating Pediatric Autoimmune Neurological Diseases.","authors":"Tomoya Nakamizo, Toru Kanamori, Tomoya Kaneda, Kei Osaka, Miki Murakoshi, Mika Okutsu, Atsushi Ohkubo, Tomohiro Udagawa, Tomoko Mizuno, Shotaro Naito, Masatoshi Takagi, Masaki Shimizu","doi":"10.1002/1744-9987.70136","DOIUrl":"10.1002/1744-9987.70136","url":null,"abstract":"<p><strong>Introduction: </strong>Selective plasma exchange (SePE) using the Evacure Plus EC-4A10D selective membrane separator is a useful therapeutic option for removing immunoglobulin G (IgG) in autoimmune diseases while retaining coagulation factors, including fibrinogen. This study aimed to clarify the clinical usefulness of SePE in pediatric autoimmune neurological disorders.</p><p><strong>Methods: </strong>We reported five pediatric patients with pediatric autoimmune neurological disorders successfully treated with SePE. We analyzed the removal rates of IgG and fibrinogen in a total of 29 SePE sessions and 3 conventional plasma exchange (PE) sessions performed on five pediatric patients.</p><p><strong>Results: </strong>Clinical symptoms improved in all patients without coagulation factor supplementation, and no severe adverse events of SePE/PE were observed. The mean IgG removal rates were similar for SePE and PE, at 55.5% and 61.8%, respectively. In contrast, the mean fibrinogen removal rate was lower for SePE than for PE, at 17.9% and 61.3%, respectively.</p><p><strong>Conclusions: </strong>SePE might be effective for pediatric autoimmune neurological disorders.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"412-417"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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