Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy最新文献
{"title":"Trained Innate Immunity in Extracorporeal Photopheresis.","authors":"Yandy Marx Castillo-Aleman","doi":"10.1111/1744-9987.70057","DOIUrl":"10.1111/1744-9987.70057","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"933-934"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Wen You, Soo Kun Lim, Boon Hong Kong, Shian Feng Cheng, Reena Rajasuriar, Hui Wei You
{"title":"Exploring the Immune Response to COVID-19 Vaccines in Dialysis and Transplant Patients.","authors":"Hui Wen You, Soo Kun Lim, Boon Hong Kong, Shian Feng Cheng, Reena Rajasuriar, Hui Wei You","doi":"10.1111/1744-9987.70066","DOIUrl":"10.1111/1744-9987.70066","url":null,"abstract":"<p><strong>Introduction: </strong>This study explores immune responses to SARS-CoV-2 vaccination among dialysis patients and kidney transplant recipients (KTRs). Dialysis patients and KTRs often exhibit lower seroconversion rates, particularly the latter, due to immunosuppressive therapies.</p><p><strong>Methods: </strong>The prospective study was conducted at the University Malaya Medical Centre (UMMC), involving 62 dialysis patients and 49 KTRs.</p><p><strong>Results: </strong>Dialysis patients exhibited high seroconversion (97.8%) and T-cell response (77.4%). In contrast, KTRs had poor seroconversion (59.2%) and a weak T-cell response (44.9%) after a third dose. Furthermore, 32.7% of KTRs were non-reactive in both antibody and T-cell responses. A moderate correlation was found between antibody levels and T-cell responses in KTRs (p = 0.033, r = 0.305). Among dialysis patients, lower BMI was significantly associated with reduced seroconversion, while longer dialysis duration and the presence of hypertension were positively associated with antibody response. Other clinical factors, including age, gender, diabetes, and prior COVID-19 infection, showed no significant association.</p><p><strong>Conclusion: </strong>The findings suggest dialysis patients respond better to vaccination, while KTRs experience impaired immune responses. Within dialysis patients, BMI, dialysis duration, and hypertension influenced antibody response. Monitoring post-vaccination immune responses in KTRs may help identify non-responders, who could benefit from alternative vaccination strategies or adjustments in immunosuppressive therapy. This study was approved by the University Malaya Medical Centre Medical Research Ethics Committee (UMMC-MREC), Approval No: 202131-9888.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"839-849"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Başak Can, Esra Deniz Kahvecioğlu, Fatih Palıt, Egemen Cebeci, Mehmet Küçük, Zeynep Karaali
{"title":"Assessing the performance of chat generative pretrained transformer (ChatGPT) in answering chronic kidney disease-related questions.","authors":"Başak Can, Esra Deniz Kahvecioğlu, Fatih Palıt, Egemen Cebeci, Mehmet Küçük, Zeynep Karaali","doi":"10.1111/1744-9987.14239","DOIUrl":"10.1111/1744-9987.14239","url":null,"abstract":"<p><strong>Background: </strong>Chatbots produced by artificial intelligence are frequently used in health information today. We aimed to investigate the reliability and reproducibility of the answers given by Chat Generative Pretrained Transformer (ChatGPT), one of the most used chatbots, to frequently asked questions related to chronic kidney failure.</p><p><strong>Methods: </strong>We reviewed frequently asked questions related to chronic kidney disease (CKD) from social media platforms and Internet. The questions were asked to ChatGPT, and the answers were scored from 1 to 4 by two experienced nephrologists.</p><p><strong>Results: </strong>Eighty-five frequently asked questions about chronic renal failure were examined and 60 of them were included in the study after exclusion criteria. Fifty-one (85%) of the questions received 1 point, 7 (11.7%) received 2 points and 2 (3.3%) received 3 points. The similarity rates of the answers to the repeated questions were between 80% and 100%.</p><p><strong>Conclusion: </strong>ChatGPT has provided reliable responses with high reproducibility to inquiries related to CKD.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"760-765"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prospective Evaluation of Continuous Plasma Exchange With Dialysis With Suspected Thrombotic Microangiopathy in Intensive Care Unit.","authors":"Kasumi Satoh, Manabu Okuyama, Hajime Nakae","doi":"10.1111/1744-9987.70039","DOIUrl":"10.1111/1744-9987.70039","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"802-803"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunoabsorption Therapy for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Retrospective Study.","authors":"Dongxue Wang, Yunjin Xiong, Jing Liu, Yiduo Feng, Changqin Zhang, Yin Zhang, Xia Ding, Xiaoyuan Wu, Akehu Alemasi, Qi Huang, Yu Wu, Huabing Wang, Yong Gong, De-Cai Tian, Yilun Zhou","doi":"10.1111/1744-9987.70063","DOIUrl":"10.1111/1744-9987.70063","url":null,"abstract":"<p><strong>Introduction: </strong>The elimination of myelin oligodendrocyte glycoprotein (MOG) antibodies using immunoadsorption (IA) is a therapeutic approach, but has not yet been specifically evaluated in MOG antibody-associated disease (MOGAD). This study aimed to provide evidence on the efficacy and safety of IA therapy for MOGAD.</p><p><strong>Methods: </strong>This retrospective study included patients diagnosed with MOGAD, who were treated with IA. Clinical data of the patients were collected. The extended disability score scale (EDSS) before and after IA therapy was used to evaluate neurological status.</p><p><strong>Results: </strong>Six patients aged 14-53 years were enrolled in this study. Each patient received 3-7 sessions of IA therapy. Half of the patients showed significant clinical improvement after IA, with EDSS scores decreasing by more than 1.0, whereas the other patients were unresponsive to IA. Partial remission of visual acuity was obtained in three of the four patients with visual impairment. Repeated detection of MOG antibodies in one case showed that the titer declined from 1:100 to 1:32 after five sessions of IA. Only one episode of mild hypotension was observed in 29 IA sessions.</p><p><strong>Conclusion: </strong>IA therapy may be a potential treatment option for patients with MOGAD.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"776-781"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abbreviation usage in nephrology: A nephrologist's perspective.","authors":"Chia-Ter Chao","doi":"10.1111/1744-9987.70033","DOIUrl":"10.1111/1744-9987.70033","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"808-809"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esra Ensari, Esra Nagehan Akyol Onder, Pelin Ertan
{"title":"A Comparative Assessment of Large Language Models in Pediatric Dialysis: Reliability, Quality and Readability.","authors":"Esra Ensari, Esra Nagehan Akyol Onder, Pelin Ertan","doi":"10.1111/1744-9987.70058","DOIUrl":"10.1111/1744-9987.70058","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the reliability, quality, and readability of ChatGPT (OpenAI, San Francisco, CA), Gemini (Google, Mountain View, CA), and Copilot (Microsoft Corp., Washington, DC) which are among the most widely used large language models (LLMs) today in answering frequently asked questions (FAQs) related to pediatric dialysis.</p><p><strong>Methods: </strong>A total of 45 FAQs were entered into LLM. The Modified DISCERN (mDISCERN) scale assessed reliability; the Global Quality Score (GQS) evaluated quality; and readability was assessed using five metrics: Coleman-Liau Index (CLI), Simple Measure of Gobbledygook (SMOG), Gunning Fog Index (GFI), Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL). Questions were directed to the chat robots twice, on January 25, 2025, and February 1, 2025.</p><p><strong>Results: </strong>All three chatbots displayed high reliability, achieving median mDISCERN scores of 5. Quality scores on the GQS were similarly high, with median scores of 5 across platforms; however, Gemini exhibited greater variability (range 1-5) compared to ChatGPT-4o and Copilot (ranges 3-5). Readability scores revealed that chatbot responses were written at an advanced level.</p><p><strong>Conclusion: </strong>This study found that LLMs responses to dialysis FAQs were reliable and high quality, but difficult to read; improving readability through expert-reviewed content could increase their impact on public health.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"739-746"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mostafa Javanian, Mohammad Barary, Soheil Ebrahimpour
{"title":"Commentary on \"Association of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-to-high-density lipoprotein ratio with diabetic nephropathy\".","authors":"Mostafa Javanian, Mohammad Barary, Soheil Ebrahimpour","doi":"10.1111/1744-9987.70030","DOIUrl":"10.1111/1744-9987.70030","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"806-807"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasmapheresis as rescue therapy for steroid-resistant isolated optic neuritis: A case report.","authors":"Eiman Abdel Wahab Fayez Hussein, Mohamed Hussein","doi":"10.1111/1744-9987.70034","DOIUrl":"10.1111/1744-9987.70034","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"800-801"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyza Doğan, Fatih Ergül, Mikail Dağ, Süleyman Karaköse, İbrahim Güney
{"title":"The Effect of Arteriovenous Fistula Creation on GFR Decline.","authors":"Beyza Doğan, Fatih Ergül, Mikail Dağ, Süleyman Karaköse, İbrahim Güney","doi":"10.1111/1744-9987.70054","DOIUrl":"10.1111/1744-9987.70054","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic kidney disease (CKD) poses a significant public health challenge, severely affecting patients' quality of life. The Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines recommend discussing renal replacement therapy options when patients reach CKD stage 4. Arteriovenous fistula (AVF) creation is considered the gold standard for vascular access in hemodialysis. This retrospective study aims to evaluate whether any changes in kidney function occur during the follow-up period after AVF creation in patients with end-stage kidney disease (ESKD).</p><p><strong>Methods: </strong>We analyzed data from 60 CKD patients who underwent AVF creation and were monitored in our nephrology outpatient clinics. Seventeen patients who consistently attended follow-up visits were included for detailed analysis. We performed a retrospective review of laboratory and medical records from 6 months before and 6 months following AVF creation.</p><p><strong>Results: </strong>The cohort comprised 41.2% males, with a mean age of 62.4 years. The predominant underlying conditions were diabetes mellitus (58.8%), hypertension (29.4%), and polycystic kidney disease (11.8%). Statistical analysis of laboratory values before and after AVF creation (at 1, 3, and 6 months) revealed a significant decline in estimated glomerular filtration rate (eGFR) before AVF placement, followed by stabilization in the subsequent 6 months.</p><p><strong>Conclusion: </strong>The rate of eGFR decline was significantly reduced in CKD patients with AVF. This may be attributed to increased awareness of impending hemodialysis, leading to better dietary adherence and treatment compliance.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"747-751"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}