Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy最新文献

{"title":"Impact of Medium Cut-Off Dialysis Membranes on Outcomes in COVID-19 Patients With Acute Kidney Injury.","authors":"Omer Faruk Akcay, Handenur Koc Kanik, Arif Burak Kanik, Taha Enes Cetin, Saliha Yildirim, Haci Hasan Yeter, Ulver Derici","doi":"10.1111/1744-9987.70088","DOIUrl":"https://doi.org/10.1111/1744-9987.70088","url":null,"abstract":"<p><strong>Background: </strong>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to significant morbidity and mortality worldwide, with acute kidney injury (AKI) emerging as a significant non-pulmonary complication of COVID-19. This study aimed to evaluate the effect of hemodialysis (HD) membrane type on the outcomes of COVID-19 patients with AKI requiring dialysis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 82 COVID-19 patients with AKI who required HD between January 2020 and January 2022. Patients were categorized based on the type of dialysis membrane used as medium cut-off (MCO) versus low-flux (LF). Demographic data, clinical characteristics, laboratory findings, and hospital outcomes, including 28-day mortality, were analyzed.</p><p><strong>Results: </strong>The mean age of the study population was 69.7 ± 11.6 years, with 45% being female. The median time to HD initiation was shorter in the LF group (p < 0.001). Although ICU admission rates were similar between the groups, the 28-day mortality rate was significantly lower in the MCO group (p = 0.03). Multivariate analysis identified ICU admission as an independent risk factor for mortality while using MCO membranes, associated with a reduced mortality risk (OR: 0.344, p = 0.03). MCO membrane was significantly associated with a higher 28-day survival rate by Kaplan-Meier curve analysis with log-rank test (56.8% vs. 33.3%, p = 0.001).</p><p><strong>Conclusions: </strong>The findings suggest that using MCO membranes in HD may improve survival outcomes in COVID-19 patients with AKI. Further prospective studies are needed to validate these results and elucidate the potential anti-inflammatory benefits of MCO membranes in this patient population.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal Dialysis-Related Peritonitis Caused by Blood Stream Infection After Percutaneous Transluminal Angiography for Arteriovenous Fistula in Hybrid Dialysis Patient.","authors":"Naohiro Toda, Yuri Enomoto, Akira Ishii","doi":"10.1111/1744-9987.70090","DOIUrl":"https://doi.org/10.1111/1744-9987.70090","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Citrate Anticoagulation During Continuous Renal Replacement Therapy; Should It Be the First Choice Over Heparin in Children?","authors":"Guntulu Sık","doi":"10.1111/1744-9987.70087","DOIUrl":"https://doi.org/10.1111/1744-9987.70087","url":null,"abstract":"<p><p>Regional citrate anticoagulation (RCA) has gained increasing attention as a superior anticoagulation strategy in pediatric continuous renal replacement therapy (CRRT). Compared to systemic heparin anticoagulation (SHA), RCA offers significant advantages, including prolonged circuit lifespan, reduced clotting rates, and a lower incidence of bleeding complications. While heparin remains widely used due to its availability and ease of administration, its systemic effects, particularly the risk of bleeding and heparin-induced thrombocytopenia, pose considerable challenges in critically ill children. Studies have consistently demonstrated that RCA reduces transfusion requirements and enhances circuit survival without increasing bleeding risk. Despite potential metabolic concerns such as citrate accumulation, metabolic alkalosis, and electrolyte imbalances, these risks can be effectively managed with careful monitoring and protocol adjustments. As pediatric CRRT protocols continue to evolve, RCA is emerging as the preferred first-line anticoagulation method, particularly in patients with high bleeding risk. The growing body of evidence supports its wider clinical application, promising better treatment outcomes and improved survival rates in critically ill pediatric patients requiring CRRT.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role and Clinical Application of Novel Filters in Sepsis-Associated Acute Kidney Injury Blood Purification.","authors":"Cunhong Deng, Wei Zhang, Yan Liu, Hao Zhang, Zhi Li","doi":"10.1111/1744-9987.70085","DOIUrl":"https://doi.org/10.1111/1744-9987.70085","url":null,"abstract":"<p><p>Sepsis is a life-threatening clinical syndrome, and renal impairment associated with sepsis significantly increases patient mortality. Blood purification techniques are crucial in managing sepsis by removing inflammatory mediators and toxic substances from the bloodstream, thereby improving outcomes. Traditional modalities, including continuous renal replacement therapy, hemodialysis, and hemoperfusion, have demonstrated clinical efficacy in this context. Recent advancements in blood purification filters have enhanced sepsis treatment strategies. This review assesses the mechanisms and clinical applications of novel filters such as the oXiris filter, AN69ST membrane, CytoSorb, Hemopurifier, and others, focusing on their effectiveness in eliminating toxins and inflammatory mediators. The oXiris filter has demonstrated superior capacity to remove small molecular toxins, pro-inflammatory cytokines, and endotoxins while promoting renal protection and enhancing microcirculation. In contrast, the AN69ST membrane and CytoSorb filters have shown promising efficacy in cytokine clearance, though their ability to remove endotoxins is limited. The Hemopurifier specifically targets endotoxins like lipopolysaccharides, effectively suppressing inflammatory responses and mitigating renal damage. Furthermore, the integration of Extracorporeal Carbon Dioxide Removal (ECCO2R) with continuous renal replacement therapy (CRRT) offers benefits, including the regulation of carbon dioxide levels, maintenance of acid-base balance, and enhanced clearance of inflammatory factors from circulation. Additionally, selective removal of lipopolysaccharides (LPS) can alleviate leukopenia and immune dysregulation, preserving renal function. This review aims to provide clinical guidance for optimizing individualized treatment protocols to enhance survival rates and improve the quality of life for patients with sepsis-related AKI. Incorporating these advanced filtration technologies into routine clinical practice can transform sepsis management and pave the way for innovative therapeutic strategies in critical care.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the performance of chat generative pretrained transformer (ChatGPT) in answering chronic kidney disease-related questions.","authors":"Başak Can, Esra Deniz Kahvecioğlu, Fatih Palıt, Egemen Cebeci, Mehmet Küçük, Zeynep Karaali","doi":"10.1111/1744-9987.14239","DOIUrl":"10.1111/1744-9987.14239","url":null,"abstract":"<p><strong>Background: </strong>Chatbots produced by artificial intelligence are frequently used in health information today. We aimed to investigate the reliability and reproducibility of the answers given by Chat Generative Pretrained Transformer (ChatGPT), one of the most used chatbots, to frequently asked questions related to chronic kidney failure.</p><p><strong>Methods: </strong>We reviewed frequently asked questions related to chronic kidney disease (CKD) from social media platforms and Internet. The questions were asked to ChatGPT, and the answers were scored from 1 to 4 by two experienced nephrologists.</p><p><strong>Results: </strong>Eighty-five frequently asked questions about chronic renal failure were examined and 60 of them were included in the study after exclusion criteria. Fifty-one (85%) of the questions received 1 point, 7 (11.7%) received 2 points and 2 (3.3%) received 3 points. The similarity rates of the answers to the repeated questions were between 80% and 100%.</p><p><strong>Conclusion: </strong>ChatGPT has provided reliable responses with high reproducibility to inquiries related to CKD.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"760-765"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Evaluation of Continuous Plasma Exchange With Dialysis With Suspected Thrombotic Microangiopathy in Intensive Care Unit.","authors":"Kasumi Satoh, Manabu Okuyama, Hajime Nakae","doi":"10.1111/1744-9987.70039","DOIUrl":"10.1111/1744-9987.70039","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"802-803"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoabsorption Therapy for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Retrospective Study.","authors":"Dongxue Wang, Yunjin Xiong, Jing Liu, Yiduo Feng, Changqin Zhang, Yin Zhang, Xia Ding, Xiaoyuan Wu, Akehu Alemasi, Qi Huang, Yu Wu, Huabing Wang, Yong Gong, De-Cai Tian, Yilun Zhou","doi":"10.1111/1744-9987.70063","DOIUrl":"10.1111/1744-9987.70063","url":null,"abstract":"<p><strong>Introduction: </strong>The elimination of myelin oligodendrocyte glycoprotein (MOG) antibodies using immunoadsorption (IA) is a therapeutic approach, but has not yet been specifically evaluated in MOG antibody-associated disease (MOGAD). This study aimed to provide evidence on the efficacy and safety of IA therapy for MOGAD.</p><p><strong>Methods: </strong>This retrospective study included patients diagnosed with MOGAD, who were treated with IA. Clinical data of the patients were collected. The extended disability score scale (EDSS) before and after IA therapy was used to evaluate neurological status.</p><p><strong>Results: </strong>Six patients aged 14-53 years were enrolled in this study. Each patient received 3-7 sessions of IA therapy. Half of the patients showed significant clinical improvement after IA, with EDSS scores decreasing by more than 1.0, whereas the other patients were unresponsive to IA. Partial remission of visual acuity was obtained in three of the four patients with visual impairment. Repeated detection of MOG antibodies in one case showed that the titer declined from 1:100 to 1:32 after five sessions of IA. Only one episode of mild hypotension was observed in 29 IA sessions.</p><p><strong>Conclusion: </strong>IA therapy may be a potential treatment option for patients with MOGAD.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"776-781"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Assessment of Large Language Models in Pediatric Dialysis: Reliability, Quality and Readability.","authors":"Esra Ensari, Esra Nagehan Akyol Onder, Pelin Ertan","doi":"10.1111/1744-9987.70058","DOIUrl":"10.1111/1744-9987.70058","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the reliability, quality, and readability of ChatGPT (OpenAI, San Francisco, CA), Gemini (Google, Mountain View, CA), and Copilot (Microsoft Corp., Washington, DC) which are among the most widely used large language models (LLMs) today in answering frequently asked questions (FAQs) related to pediatric dialysis.</p><p><strong>Methods: </strong>A total of 45 FAQs were entered into LLM. The Modified DISCERN (mDISCERN) scale assessed reliability; the Global Quality Score (GQS) evaluated quality; and readability was assessed using five metrics: Coleman-Liau Index (CLI), Simple Measure of Gobbledygook (SMOG), Gunning Fog Index (GFI), Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL). Questions were directed to the chat robots twice, on January 25, 2025, and February 1, 2025.</p><p><strong>Results: </strong>All three chatbots displayed high reliability, achieving median mDISCERN scores of 5. Quality scores on the GQS were similarly high, with median scores of 5 across platforms; however, Gemini exhibited greater variability (range 1-5) compared to ChatGPT-4o and Copilot (ranges 3-5). Readability scores revealed that chatbot responses were written at an advanced level.</p><p><strong>Conclusion: </strong>This study found that LLMs responses to dialysis FAQs were reliable and high quality, but difficult to read; improving readability through expert-reviewed content could increase their impact on public health.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"739-746"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abbreviation usage in nephrology: A nephrologist's perspective.","authors":"Chia-Ter Chao","doi":"10.1111/1744-9987.70033","DOIUrl":"10.1111/1744-9987.70033","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"808-809"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Association of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-to-high-density lipoprotein ratio with diabetic nephropathy\".","authors":"Mostafa Javanian, Mohammad Barary, Soheil Ebrahimpour","doi":"10.1111/1744-9987.70030","DOIUrl":"10.1111/1744-9987.70030","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"806-807"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}