Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy最新文献

{"title":"Performance of CO-RADS in the diagnosis of COVID-19 in hemodialysis patients.","authors":"Pervin Ozkan Kurtgoz, Fatih Sackan, Meral Buyukterzi, Ibrahim Guney","doi":"10.1111/1744-9987.14215","DOIUrl":"10.1111/1744-9987.14215","url":null,"abstract":"<p><strong>Introduction: </strong>Different data systems have been used to reach a common decision in the interpretation of chest computed tomography (CT) scans for the detection of COVID-19 infection. The aim of our study was to determine the usefulness of the COVID-19 Reporting and Data System (CO-RADS) for COVID-19 in patients undergoing hemodialysis.</p><p><strong>Methods: </strong>We included 90 hemodialysis patients who underwent chest CT and had samples available for real-time reverse transcription-polymerase chain reaction (RT-PCR). The files of the patients were retrospectively reviewed and the data were recorded. Image interpretation and CO-RADS staging were performed retrospectively by two radiologists experienced in COVID-19 patients, blinded to the RT-PCR results. The RT-PCR results were then compared with the CO-RADS stages obtained. The success of CO-RADS in diagnosing COVID-19 was evaluated according to its prediction of a positive RT-PCR result. At the same time, the relationship between CO-RADS stages and prognosis was also evaluated.</p><p><strong>Results: </strong>Patients were divided into two groups according to the RT-PCR results, of which 38 (42.2%) had positive results. Validity tests of CO-RADS were performed according to the RT-PCR test. While 71.1% of patients with CO-RADS ≥4 were RT-PCR (+), 13.2% of patients with CO-RADS ≤2 were RT-PCR (+) (p < 0.001). CO-RADS ≥4 detected COVID-19 with 71.1% sensitivity and 51.9% specificity. ROC analysis confirmed the diagnostic performance of CO-RADS for predicting RT-PCR positivity with AUC = 0.73 (95% CI: 0.63-0.84). The relationship between CO-RADS stages and mortality was not significant (p = 0.21).</p><p><strong>Conclusion: </strong>CO-RADS is moderately sensitive and poorly specific for the diagnosis of COVID-19 in hemodialysis patients. In these patients, CO-RADS would be more useful to exclude other infections than to diagnose COVID-19.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"243-249"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the understandability and actionability of online resources for patients undergoing hemodialysis.","authors":"Emi Furukawa, Tsuyoshi Okuhara, Hiroko Okada, Yumiko Fujitomo, Takahiro Kiuchi","doi":"10.1111/1744-9987.14221","DOIUrl":"10.1111/1744-9987.14221","url":null,"abstract":"<p><strong>Introduction: </strong>This study quantitatively evaluated the understandability and actionability of webpages for patients undergoing hemodialysis (HD).</p><p><strong>Methods: </strong>In June 2022, we searched on Google and Yahoo Japan using the top five keywords associated with end-stage kidney disease and HD to identify relevant materials. Subsequently, we used the Japanese version of the Patient Education Materials Assessment Tool to assess the understandability and actionability of these materials, rating them on a scale from 0% to 100%. The threshold was set at 70%.</p><p><strong>Results: </strong>Among the included 194 materials, the overall understandability was 66.7%, and the actionability was 33.3%. Only 38.7% and 16.5% of the materials were deemed understandable and actionable, respectively. Challenges included the need for plain language and concise summaries to improve understandability, along with the use of effective visual aids for actionability.</p><p><strong>Conclusion: </strong>This study suggests that existing webpages on HD are not presented in a manner that patients can utilize.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"200-209"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seraph 100-A new extracorporeal device to decrease elevated sFlt-1 in preeclamptic plasma?","authors":"Amelie Gienapp, Dan-Nicolae Borchina, Christina Engel, Mohammad Hamid Hossain, Jan T Kielstein","doi":"10.1111/1744-9987.14238","DOIUrl":"10.1111/1744-9987.14238","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"325-326"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond dialysis: Assessing therapeutic regimen compliance and sleep quality in chronic renal failure patients undergoing maintenance hemodialysis in Saudi Arabia.","authors":"Jalal Naeem Alharbi","doi":"10.1111/1744-9987.14224","DOIUrl":"10.1111/1744-9987.14224","url":null,"abstract":"<p><strong>Background: </strong>Given its potential to impact physical and mental health, sleep quality is one of the most significant clinical outcomes among hemodialysis patients. Patients undergoing hemodialysis are required to adhere to an intricate treatment plan that consists of regular hemodialysis treatments, dietary and fluid restrictions, and a multi-drug regimen.</p><p><strong>Aim: </strong>Investigate the relationship between adherence to a therapeutic regimen and sleep quality among chronic renal failure patients undergoing maintenance hemodialysis.</p><p><strong>Method: </strong>A descriptive correlational research design was followed. The study was conducted at the hemodialysis units in Hafr Albatin City, specifically at Hafr Albatin Central Hospital and King Khaled Hospital, Saudi Arabia. A convenience sample of 100 adult patients was selected for the study. The Hemodialysis Patients Adherence Questionnaire and Pittsburgh Sleep Quality Index were utilized to collect the data in 5 months from September 20, 2023 to February 15, 2024.</p><p><strong>Results: </strong>The study revealed that more than half of the studied patients adhered to the therapeutic regimen, while (46%) did not adhere to it. More than half of the patients had poor sleep quality and were nonadherent to diet and fluid restrictions. Overall adherence score is negatively correlated with the global sleep quality score (r = -0.368, p < 0.001), indicating that poorer sleep quality is associated with lower overall adherence to the therapeutic regimen.</p><p><strong>Conclusion: </strong>While a significant proportion of the patients demonstrated adherence to overall therapeutic regimens, including dialysis sessions and medication intake, there was notable nonadherence to fluid and diet restrictions. Poor sleep quality, prevalent among two-thirds of the participants, correlates negatively with adherence to therapeutic regimens.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"257-268"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning models for the prediction of all-cause mortality and time to death in hemodialysis patients.","authors":"Minjie Chen, Youbing Zeng, Mengting Liu, Zhenghui Li, Jiazhen Wu, Xuan Tian, Yunuo Wang, Yuanwen Xu","doi":"10.1111/1744-9987.14212","DOIUrl":"10.1111/1744-9987.14212","url":null,"abstract":"<p><strong>Introduction: </strong>The elevated mortality and hospitalization rates among hemodialysis (HD) patients underscore the necessity for the development of accurate predictive tools. This study developed two models for predicting all-cause mortality and time to death-one using a comprehensive database and another simpler model based on demographic and clinical data without laboratory tests.</p><p><strong>Method: </strong>A retrospective cohort study was conducted from January 2017 to June 2023. Two models were created: Model A with 85 variables and Model B with 22 variables. We assessed the models using random forest (RF), support vector machine, and logistic regression, comparing their performance via the AU-ROC. The RF regression model was used to predict time to death. To identify the most relevant factors for prediction, the Shapley value method was used.</p><p><strong>Results: </strong>Among 359 HD patients, the RF model provided the most reliable prediction. The optimized Model A showed an AU-ROC of 0.86 ± 0.07, a sensitivity of 0.86, and a specificity of 0.75 for predicting all-cause mortality. It also had an R² of 0.59 for predicting time to death. The optimized Model B had an AU-ROC of 0.80 ± 0.06, a sensitivity of 0.81, and a specificity of 0.70 for predicting all-cause mortality. In addition, it had an R² of 0.81 for predicting time to death.</p><p><strong>Conclusion: </strong>Two new interpretable clinical tools have been proposed to predict all-cause mortality and time to death in HD patients using machine learning models. The minimal and readily accessible data on which Model B is based makes it a valuable tool for integrating into clinical decision-making processes.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"220-232"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autotaxin concentrations in peritoneal dialysis effluent reflect peritoneal function.","authors":"Keisuke Horikoshi, Norihiko Sakai, Megumi Oshima, Hiroyuki Yamauchi, Megumi Ikeda, Kaho Hayashi, Hiroyoshi Yanagisawa, Fumitaka Yamamori, Sho Kajikawa, Daiki Hayashi, Akihiko Koshino, Keisuke Sako, Takahiro Yuasa, Akira Tamai, Taichiro Minami, Shiori Nakagawa, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Miho Shimizu, Satoshi Oota, Yoichi Ishida, Takashi Wada, Yasunori Iwata","doi":"10.1111/1744-9987.14211","DOIUrl":"10.1111/1744-9987.14211","url":null,"abstract":"<p><strong>Introduction: </strong>Peritoneal equilibration test (PET) has been used to monitor peritoneal function. A more convenient marker would be useful in clinical situations including home medical care. Autotaxin is known to leak into the interstitium as vascular permeability increases during the progression of tissue fibrosis. Therefore, we hypothesized that autotaxin concentrations in peritoneal dialysis (PD) effluent might reflect peritoneal function.</p><p><strong>Methods: </strong>This study enrolled 45 patients undergoing PD from 2016 to 2021. Autotaxin concentrations measured in PD effluent were evaluated for their associations with markers obtained from PET.</p><p><strong>Results: </strong>Mean age was 69 years, and 33 patients were men. Univariate and multivariate analyses revealed that autotaxin concentrations are associated with dialysate/plasma creatinine ratio, end/start dialysate glucose ratio, and the dip in the dialysate sodium concentration, a marker of ultrafiltration capacity, at baseline (all p < 0.05).</p><p><strong>Conclusions: </strong>Autotaxin concentrations in PD effluent might be an adjunct marker that reflects peritoneal function.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"276-284"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of patients undergoing therapeutic plasma exchange in the pediatric intensive care unit and determining the factors affecting prognosis.","authors":"Hatice Yazar, Sümeyye Çeliker, Hazal Ceren Tuğrul, Gürkan Atay, Seher Erdoğan","doi":"10.1111/1744-9987.14220","DOIUrl":"10.1111/1744-9987.14220","url":null,"abstract":"<p><strong>Introduction: </strong>Therapeutic plasma exchange (TPE), an extracorporeal method targeting the removal of large molecular weight pathogens, is explored in this study for indications, complications, prognosis, safety, and effectiveness.</p><p><strong>Methods: </strong>The patients' data were collected retrospectively.</p><p><strong>Results: </strong>Overall, 334 sessions of TPE were applied to 57 patients. Per the American Society for Apheresis classification, 24.6% of indications fell under Category I, 14% Category II, and 50.9% Category III. Sepsis-induced multiorgan dysfunction syndrome (MODS) emerged as the leading indication, correlating with elevated needs for mechanical ventilation (MV), increased failed organs, and heightened mortality. Patients undergoing continuous renal replacement therapy faced a 16.06 times higher mortality risk. Non-survivors exhibited higher comorbidity, prolonged MV, increased inotropic drug requirement, more failed organs, and a higher PRISM score. 33.2% of complications occurred, primarily catheter-related.</p><p><strong>Conclusion: </strong>Sepsis-induced MODS and extracorporeal modalities are associated with increased mortality in TPE patients, with comorbidities, ventilation, and PRISM scores potentially influencing outcomes.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"303-311"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not everything shining is gold: Strawberry can mimic hemoperitoneum.","authors":"Abdullah Al-Hwiesh, Abdelgalil Moaz Mohammed, Amani Al-Hwiesh, Ibrahiem Saeed Abdul-Rahman, Khadija M Alshehabi, Reema Al-Hwiesh, Nadia Al-Audah","doi":"10.1111/1744-9987.14254","DOIUrl":"10.1111/1744-9987.14254","url":null,"abstract":"","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"321-323"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- to post-dialysis potassium gradient and mortality in patients on hemodialysis: A propensity-matched analysis.","authors":"Huixian Zhang, Jing Liu, Xu Liu, Wang Guo, Hongdong Huang, Wenhu Liu, Zongli Diao","doi":"10.1111/1744-9987.14213","DOIUrl":"10.1111/1744-9987.14213","url":null,"abstract":"<p><strong>Introduction: </strong>Pre- to post-dialysis potassium gradient (ΔK) has arrhythmogenic effects; however, its effect on mortality remains unclear. The relationship between ΔK and mortality was assessed.</p><p><strong>Methods: </strong>All patients undergoing hemodialysis in Beijing in 2014 were eligible for inclusion. The low (≤1.2 mmol/L), median (1.2-1.8 mmol/L), and high (>1.8 mmol/L) ΔK groups were matched by sex, age, diabetes, and dialysis time for enrollmen. The primary and secondary outcomes were all-cause and cardiovascular death within the follow-up. Cox regression analysis was performed to evaluate the effect of ΔK on mortality. We also analyzed the associations of combinations of ΔK and pre-dialysis potassium with mortality.</p><p><strong>Results: </strong>We enrolled 2181 patients in three matched groups (n = 727 per group). The median follow-up was 72.0 (interquartile range, 53.7-72.0) months. All-cause mortality occurred in 215/727 (29.6%), 95/727 (13.1%), and 198/727 (27.2%) patients in the low-, median-, and high-ΔK groups, respectively. After adjusting for multiple factors, the median ΔK group had better survival than the low- (hazard ratio (HR), 1.91; 95% confidence interval [95% CI], 1.45-2.52; p < 0.001) and high-ΔK groups (HR, 2.17; 95% CI, 1.57-2.99; p < 0.001). Further analysis based on pre-dialysis potassium revealed that when maintaining a level of 4.5-5.5 mmol/L and ΔK of 1.2-1.8 mmol/L, patients had the lowest risk of mortality, whereas the highest risk was observed when pre-dialysis potassium was >5.5 mmol/L and ΔK was >1.8 mmol/L.</p><p><strong>Conclusion: </strong>Maintaining serum potassium within a appropriate range and reducing potassium fluctuations during dialysis may help to reduce the mortality risk of maintenance hemodialysis patients. These findings provide important data support for the quality control of hemodialysis.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"189-199"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of zinc supplementation on body fat mass in hemodialysis patients: An open-label randomized controlled trial.","authors":"Hirotaka Fukasawa, Mito Yamawaki, Jun Furuya, Kyosuke Omata, Mai Kaneko, Takashi Matsuyama, Hideo Yasuda, Ryuichi Furuya","doi":"10.1111/1744-9987.14218","DOIUrl":"10.1111/1744-9987.14218","url":null,"abstract":"<p><strong>Introduction: </strong>Zinc deficiency is highly prevalent in HD patients. On the other hand, it remains unknown about the role of zinc in their nutritional status.</p><p><strong>Methods: </strong>We conducted an open-label randomized controlled trial. We investigated (i) the relationship between serum zinc levels and body composition and (ii) the effects of zinc supplementation on the composition of 48 HD patients with zinc deficiency.</p><p><strong>Results: </strong>Serum zinc levels were significantly correlated with body fat weight (p < 0.01), but not with nonfat tissue weight. Multiple regression analyses demonstrated that serum zinc levels were a significant independent predictor of body fat weight (p < 0.001). Furthermore, the weight of body fat significantly increased in the group that received 1-year zinc supplementation (p < 0.05), but not in the group that did not.</p><p><strong>Conclusion: </strong>Our findings indicate that zinc deficiency plays an important role in fat metabolism in HD patients with its deficiency.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"170-177"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}