Therapeutic apheresis treatment in rheumatic diseases: Insights from a single-center experience.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2025-02-01 Epub Date: 2024-08-26 DOI:10.1111/1744-9987.14199

Ezgi Çimen Güneş, Emre Tekgöz, Seda Çolak, Selim Sayın, Hülya Şirin, Meltem Aylı, Muhammet Çınar, Sedat Yılmaz

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Abstract

Introduction: We aimed to evaluate the characteristics of the patients with a rheumatologic disease who underwent TPE.

Method: A single-center, retrospective study was conducted between January 2016 and June 2023.

Results: Twenty patients with a median age of 51 years received a median of 6 TPE sessions. Concurrently, immunosuppressive therapy was administered to 18 (90%) of them. During the follow-up period, 9 patients (45%) died. Creatinine (p = 0.001), C-reactive protein (p = 0.001), sedimentation rate (p = 0.002), leukocyte (p = 0.003), thrombocyte (p = 0.003), and neutrophil (p = 0.003) counts was decreased after TPE. Similarly, in the ROC analysis of post TPE laboratory parameters, urea, creatinine, CRP, hemoglobin, platelets, and lymphocytes predicted mortality with areas under the curve values ranging from 0.747 to 0.869. In the Cox regression analysis for mortality, creatinine was predictive for mortality (p = 0.030), HR 1.59 (95% CI: 1.05-2.41).

Conclusion: In rheumatologic conditions, TPE is beneficial to fill the gap until the effects of immunosuppressants become apparent.

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风湿病的治疗性血液净化疗法：单中心经验的启示

简介我们旨在评估接受 TPE 治疗的风湿病患者的特征：方法：在 2016 年 1 月至 2023 年 6 月期间进行了一项单中心回顾性研究：20名中位数年龄为51岁的患者接受了6次TPE治疗。其中 18 人（90%）同时接受了免疫抑制治疗。在随访期间，9 名患者（45%）死亡。TPE 治疗后，肌酐（p = 0.001）、C 反应蛋白（p = 0.001）、血沉（p = 0.002）、白细胞（p = 0.003）、血小板（p = 0.003）和中性粒细胞（p = 0.003）计数均有所下降。同样，在 TPE 后实验室参数的 ROC 分析中，尿素、肌酐、CRP、血红蛋白、血小板和淋巴细胞预测死亡率的曲线下面积值为 0.747 至 0.869。在死亡率的 Cox 回归分析中，肌酐可预测死亡率（p = 0.030），HR 为 1.59（95% CI：1.05-2.41）：结论：在风湿病患者中，在免疫抑制剂的效果显现之前，TPE 有助于填补空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

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