{"title":"Impact of peritoneal dialysis and hemodialysis on mortality in patients with end-stage renal disease: A systematic review and meta-analysis.","authors":"Zhou Wu, Fen Chen, Ping Li, Mingrui Zhao","doi":"10.1111/1744-9987.14195","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The mortality impact of peritoneal dialysis (PD) and hemodialysis (HD) in end-stage renal disease (ESRD) remains uncertain.</p><p><strong>Methods: </strong>A meta-analysis comparing mortality in ESRD patients on PD versus HD was conducted, including 9 studies with 7556 HD and 2651 PD patients.</p><p><strong>Results: </strong>No significant difference was found in all-cause mortality, cardiovascular-related mortality, or infection-related mortality between HD and PD patients. Hemoglobin, ferritin, and iron levels were similar in groups, but HD patients had higher albumin and BUN levels (p < 0.05). Regarding cardiovascular factors and bone minerals, total cholesterol and LDL levels were significantly lower, and calcium levels were significantly higher in the HD group compared with the PD group (p < 0.01).</p><p><strong>Conclusion: </strong>Mortality does not significantly differ between HD and PD in ESRD patients, though HD is linked to higher serum albumin levels and lower levels of total cholesterol and LDL.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"79-88"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/1744-9987.14195","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/26 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Introduction: The mortality impact of peritoneal dialysis (PD) and hemodialysis (HD) in end-stage renal disease (ESRD) remains uncertain.
Methods: A meta-analysis comparing mortality in ESRD patients on PD versus HD was conducted, including 9 studies with 7556 HD and 2651 PD patients.
Results: No significant difference was found in all-cause mortality, cardiovascular-related mortality, or infection-related mortality between HD and PD patients. Hemoglobin, ferritin, and iron levels were similar in groups, but HD patients had higher albumin and BUN levels (p < 0.05). Regarding cardiovascular factors and bone minerals, total cholesterol and LDL levels were significantly lower, and calcium levels were significantly higher in the HD group compared with the PD group (p < 0.01).
Conclusion: Mortality does not significantly differ between HD and PD in ESRD patients, though HD is linked to higher serum albumin levels and lower levels of total cholesterol and LDL.
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