The American journal of Chinese medicine最新文献_第7页

Poria cocos Polysaccharides Attenuate Cardiac Injury by Inhibiting CaMKII-Mediated P38/NF-[Formula: see text]B/NLRP3 Signaling Pathway to Reduce Sepsis-Induced Apoptosis and Inflammation. 茯苓多糖通过抑制camkii介导的P38/NF- B/NLRP3信号通路减轻脓毒症诱导的细胞凋亡和炎症，减轻心脏损伤。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-08-07 DOI: 10.1142/S0192415X25500697

Manqi Yang, Bo Cui, Shan Hu, Hao Ju, Zheyu Liu, Min Huang, Shuijing He, Mian Cheng, Tao Liu, Gang Wu

{"title":"Poria cocos Polysaccharides Attenuate Cardiac Injury by Inhibiting CaMKII-Mediated P38/NF-[Formula: see text]B/NLRP3 Signaling Pathway to Reduce Sepsis-Induced Apoptosis and Inflammation.","authors":"Manqi Yang, Bo Cui, Shan Hu, Hao Ju, Zheyu Liu, Min Huang, Shuijing He, Mian Cheng, Tao Liu, Gang Wu","doi":"10.1142/S0192415X25500697","DOIUrl":"10.1142/S0192415X25500697","url":null,"abstract":"Sepsis is a life-threatening condition characterized by systemic inflammatory response syndrome, and often results in cardiac damage and poor prognosis. This study aimed to explore the protective effects of Poria cocos polysaccharides (PCP) on sepsis-induced cardiac injury and elucidate the underlying molecular mechanisms. An in vivo sepsis model was established, and an in vitro myocardial cell model was induced using lipopolysaccharide (LPS) to mimic a sepsis environment. Histopathological analysis revealed morphological changes in the myocardial tissue, while apoptosis and oxidative stress in the myocardial cells were assessed using immunofluorescence staining. The Western blot assay was employed to measure the expression levels of CaMKII, NF-[Formula: see text]B, and NLRP3, and myocardial cell apoptosis was quantified by flow cytometry. Inflammatory cytokine levels were determined via ELISA. The results indicated that PCP treatment significantly alleviated myocardial injury, reduced myocardial apoptosis, and lowered the levels of inflammatory markers when compared to the sepsis group. Mechanistic studies revealed that PCP inhibited the P38/NF-[Formula: see text]B/NLRP3 signaling pathway activation induced by CaMKII to thereby mitigate apoptosis and the inflammatory response in sepsis-induced cardiomyocytes. In conclusion, PCP exerts a protective effect against sepsis-induced cardiac injury by inhibiting the CaMKII-mediated P38/NF-[Formula: see text]B/NLRP3 signaling pathway. This study provides a novel theoretical framework and identifies potential therapeutic targets for the prevention and treatment of sepsis-associated cardiac injury.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1865-1886"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Traditional Chinese Medicine Research through Network Pharmacology: Strategies for Target Identification, Mechanism Elucidation and Innovative Therapeutic Applications. 通过网络药理学推进中医药研究：靶点识别、机制阐明和创新治疗应用策略。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-08-30 DOI: 10.1142/S0192415X25500752

Xiaobing Li, Xiaodong Li, Li Wang, Yuanfang Hou, Yongsheng Liu, Jingxin Mao, Li Zhang, Xuemei Li

{"title":"Advancing Traditional Chinese Medicine Research through Network Pharmacology: Strategies for Target Identification, Mechanism Elucidation and Innovative Therapeutic Applications.","authors":"Xiaobing Li, Xiaodong Li, Li Wang, Yuanfang Hou, Yongsheng Liu, Jingxin Mao, Li Zhang, Xuemei Li","doi":"10.1142/S0192415X25500752","DOIUrl":"10.1142/S0192415X25500752","url":null,"abstract":"Traditional Chinese medicine (TCM) is characterized by its multi-component, multi-target, and multi-pathway properties, which make it an ideal candidate for network pharmacology applications. This approach provides a comprehensive framework for understanding the therapeutic effects of TCM in managing complex diseases. This review highlights recent advancements in network pharmacology as applied to TCM, and focuses on key achievements such as the identification of core bioactive components, target prediction, and the elucidation of mechanisms of action. Notable studies, including network pharmacology research on artemisinin and Compound Danshen Droplet Pills, demonstrate the practical application of this methodology in drug discovery and disease management. Furthermore, this review explores the integration of network pharmacology with omics technologies, and enables a more holistic understanding of TCM's efficacy. These advancements are crucial in promoting the modernization of TCM and enhancing its integration into contemporary medicine. In conclusion, network pharmacology is advancing TCM research, providing a scientific basis for its clinical application, and paving the way for its global acceptance.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"2021-2042"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astragaloside IV Binds with RhoA, Inhibits EndMT and Ameliorates Myocardial Fibrosis in Mice. 黄芪甲苷与RhoA结合，抑制末端mt并改善小鼠心肌纤维化。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-09-06 DOI: 10.1142/S0192415X25500818

Qiongsen Wang, Ruiqin Zhang, Nan Li, Ke Yu, Yingqian Wang, Yizhou Jiang, Saiyue He, Jia Gu, Xuan Liu

{"title":"Astragaloside IV Binds with RhoA, Inhibits EndMT and Ameliorates Myocardial Fibrosis in Mice.","authors":"Qiongsen Wang, Ruiqin Zhang, Nan Li, Ke Yu, Yingqian Wang, Yizhou Jiang, Saiyue He, Jia Gu, Xuan Liu","doi":"10.1142/S0192415X25500818","DOIUrl":"10.1142/S0192415X25500818","url":null,"abstract":"Astragaloside IV (ASIV), the main active component of the traditional Chinese medicine HuangQi, exhibits ameliorating effects on myocardial fibrosis through unclear mechanisms. To investigate the effects of ASIV on Endothelial-to-mesenchymal transition (EndMT) in myocardial fibrosis, 10 ng/mL TGF-β1 was used to induce EndMT in human umbilical vein endothelial cells (HUVECs) in vitro, and a 5 mg/kg/d subcutaneous injection of Isoproterenol (ISO) was used to induce myocardial fibrosis in mice in vivo. The drug affinity-responsive target stability (DARTS) was used to identify the target proteins of ASIV in endothelial cells. The results showed that ASIV could significantly inhibit the TGF-β1-induced EndMT, which includes changes in cytoskeletal structure, the expression of EndMT markers, cell migration potency, and cell glycolysis rate. ASIV significantly ameliorated ISO-induced myocardial fibrosis in mice and inhibited EndMT in heart tissues. The Ras homolog gene family member A (RhoA) protein was found to be a possible direct binding target of ASIV in endothelial cells. The binding affinity between ASIV and RhoA was confirmed by molecular docking and the cellular thermal shift assay (CETSA). ASIV inhibited the RhoA-related pathway in the heart tissues of myocardial fibrosis mice. In addition, siRNA knockdown of RhoA expression or treatment with RhoA agonists was found to significantly affect the inhibition of EndMT by ASIV. The results suggested that ASIV could significantly inhibit the EndMT by binding with RhoA, and that the inhibition of EndMT by ASIV contributed to its amelioratory effects on myocardial fibrosis. This discovery provided a theoretical basis for the application of ASIV and HuangQi in the treatment of myocardial fibrosis.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"2199-2221"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Panax ginseng in the Treatment of Chronic Airway Diseases. 人参在慢性气道疾病治疗中的应用。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-09-10 DOI: 10.1142/S0192415X25500776

An Guo, Rujia Wang, Jihong Feng, Zengtao Sun

{"title":"Application of Panax ginseng in the Treatment of Chronic Airway Diseases.","authors":"An Guo, Rujia Wang, Jihong Feng, Zengtao Sun","doi":"10.1142/S0192415X25500776","DOIUrl":"10.1142/S0192415X25500776","url":null,"abstract":"Chronic airway diseases are a group of diseases, such as chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA), characterized pathologically by chronic airway inflammation, airway chronic mucus hypersecretion, and airway remodeling. Patients usually present with chronic coughing, expectoration, and dyspnea, and recurrent exacerbation is an important causative factor of increased mortality, along with the important triggers. Currently, existing treatment options cannot meet the clinical needs of chronic airway diseases. Ginseng's great potential for treating chronic airway diseases has been confirmed by various clinical and basic studies, and traditional Chinese medicine compounds composed mainly of ginseng can both improve the symptoms of coughing and expectoration and reduce the number of acute exacerbations. Ginseng and its main biologically active ingredients exhibit the multifaceted mechanisms of effectively improving airway inflammation, mitigating airway mucus secretion, and reducing airway remodeling, which underscores their effectiveness in airway disease treatment. This study was conducted for the further elucidation and extension of the possible value of ginseng in chronic airway diseases. This review summarizes recent studies on the efficacy of ginseng in chronic airway disease treatment, discusses the pharmacological effects of ginseng and ginsenosides, and highlights their roles in the prevention and treatment of chronic airway diseases, airway diseases caused by airway inflammation and high airway mucus secretion, and airway remodeling-induced lung diseases. Finally, this study also predicted future research directions. Findings in this study may lay a robust foundation for investigating ginseng in chronic airway diseases, its underlying mechanisms, and its clinical development and practical application.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"2071-2101"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SNHG5 Upregulated by Dexmedetomidine Alleviates Myocardial Ischemia/Reperfusion Injury Through LIN28A-Mediated BCAT1 mRNA Stabilization and Autophagy Enhancement. 右美托咪定上调SNHG5通过lin28a介导的BCAT1 mRNA稳定和自噬增强减轻心肌缺血/再灌注损伤

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-11 DOI: 10.1142/S0192415X25500442

Jingjia Yu, Fei Ye, Wenzhi Luo, Xu Deng

{"title":"SNHG5 Upregulated by Dexmedetomidine Alleviates Myocardial Ischemia/Reperfusion Injury Through LIN28A-Mediated BCAT1 mRNA Stabilization and Autophagy Enhancement.","authors":"Jingjia Yu, Fei Ye, Wenzhi Luo, Xu Deng","doi":"10.1142/S0192415X25500442","DOIUrl":"10.1142/S0192415X25500442","url":null,"abstract":"SNHG5 serves as a key factor in regulating various cancers, and Dexmedetomidine (Dex) protects against myocardial ischemia/reperfusion (I/R) injury. However, the role of SNHG5 in Dex-mediated protection during myocardial I/R remains uninvestigated. In this study, models of rat myocardial I/R injury and hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury were generated. The infarct size, histological changes and apoptosis in heart tissues were evaluated by TTC, HE, and TUNEL staining. CCK-8, flow cytometry and immunofluorescence were employed to assess cell viability, apoptosis and autophagosome-lysosome fusion in H9c2 cells. The associations among SNHG5, LIN28A and BCAT1 mRNA were detected by RNA pull-down, RIP, and RNA fluorescence in situ hybridization (FISH) assays. Western Blot, qRT-PCR and immunohistochemistry were employed to detect the expression of key molecules. Our results revealed that Dex ameliorated myocardial I/R injury and H/R-induced impairments in H9c2 cells by enhancing autophagy. Moreover, Dex led to a rebound of SNHG5 in the heart tissues of I/R rats and H/R-treated H9c2 cells, and functional studies revealed that Dex protected against cardiac impairments through SNHG5-dependent autophagy in vitro and in vivo. Furthermore, SNHG5 alleviated H/R-induced impairments by recruiting LIN28A protein, which was subsequently bound to BCAT1 mRNA and maintained its stability. In conclusion, our findings demonstrated that SNHG5, when upregulated by Dex, alleviated myocardial I/R injury through LIN28A-mediated BCAT1 mRNA stabilization and autophagy enhancement.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1593-1614"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paeoniflorin Alleviates Metabolic Dysfunction-Associated Fatty Liver Disease by Targeting STING-Mediated Pyroptosis via Inhibiting the NLRP3 Inflammasome. 芍药苷通过抑制NLRP3炎性体靶向sting介导的焦亡，减轻代谢功能障碍相关的脂肪肝疾病。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-18 DOI: 10.1142/S0192415X25500582

Ning Guo, Qianqian Geng, Yong Wang, Yuquan Sun, Hanling Xu, Shuai Wu, Yu Li, Ruxin Leng, Weiwei Qin, Shuo Chen, Yuanyuan Tan, Chengmu Hu

{"title":"Paeoniflorin Alleviates Metabolic Dysfunction-Associated Fatty Liver Disease by Targeting STING-Mediated Pyroptosis via Inhibiting the NLRP3 Inflammasome.","authors":"Ning Guo, Qianqian Geng, Yong Wang, Yuquan Sun, Hanling Xu, Shuai Wu, Yu Li, Ruxin Leng, Weiwei Qin, Shuo Chen, Yuanyuan Tan, Chengmu Hu","doi":"10.1142/S0192415X25500582","DOIUrl":"https://doi.org/10.1142/S0192415X25500582","url":null,"abstract":"Paeoniflorin (PF) is a key active ingredient with anti-inflammatory and antioxidant properties extracted from the root of Paeonia lactiflora. Non-alcoholic fatty liver disease (NAFLD), recently referred to as metabolic dysfunction-related fatty liver disease (MAFLD), is the leading cause of chronic liver disease worldwide. However, the potential mechanisms and targets of paeoniflorin's anti-inflammatory and antioxidant therapy for MAFLD remain to be thoroughly investigated. Thus, in cellular experiments, we added free fatty acids (P/O) to AML-12 cells and cultured them for 24 h. In animal experiments, mice were administered a high-fat diet (HFD) for a duration of 16 weeks in order to create an animal model of fatty liver disease. Our study confirmed that PF significantly reduced steatosis and alleviated oxidative stress and inflammation levels in P/O-induced AML-12 hepatocytes and mouse livers with HFD. Cellular experiments showed that PF-attenuated Phosphoric acid/Oleic acid (P/O) induced lipid deposition in AML-12 cells, indicators related to cellular focal death were downregulated, and mitochondrial oxidative damage was alleviated. In animal experiments, ALT, AST, TG, TC and the hepatic index were elevated in the model group, and lipid deposition and cell infiltration were shown by HE, Oil Red O staining. These were significantly reduced in the PF groups. Network pharmacology studies indicated PF may target the Stimulator of interferon genes (STING) as a crucial molecule for the treatment of MAFLD, and the validation of C-176 (STING inhibitor) and DXMAA (STING promoter) further supported that PF could target STING to regulate hepatocyte cellular pyroptosis.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 5","pages":"1521-1543"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valeriana Jatamansi: An Overview of Phytochemistry, Pharmacology, Clinical Prospects, and Network Analysis of Drug Targets. 缬草：植物化学、药理学、临床前景和药物靶点网络分析综述。

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X25500399

Siyu Zhao, Xiaoyun Ji, Junxian Li, Delong Han, Lijiao Yang, Yushen Huang, Rui Tan, Zhiyong Yan, Hezhong Jiang

{"title":"Valeriana Jatamansi: An Overview of Phytochemistry, Pharmacology, Clinical Prospects, and Network Analysis of Drug Targets.","authors":"Siyu Zhao, Xiaoyun Ji, Junxian Li, Delong Han, Lijiao Yang, Yushen Huang, Rui Tan, Zhiyong Yan, Hezhong Jiang","doi":"10.1142/S0192415X25500399","DOIUrl":"https://doi.org/10.1142/S0192415X25500399","url":null,"abstract":"Valeriana jatamansi Jones (V. jatamansi) has a long history of medicinal use owing to its significant therapeutic effects, particularly in the treatment of mental diseases such as depression, and on account of its cytotoxicity against various cancer cells. The chemical composition, pharmacological properties, and mechanisms of V. jatamansi have been extensively explored in various studies published between 2017 and 2023 on major databases such as Web of Science, PubMed, and CNKI[Formula: see text] Investigations have identified 128 compounds including iridoids, sesquiterpenoids, volatile oils, lignans, and miscellaneous compounds based on their structural characteristics. Pharmacological research has documented its impact on the central nervous system, and its antitumor, gastroprotective, antioxidant, and anti-inflammatory effects. In particular, iridoids stand out among these compounds, and iridoid-enriched fraction from V. jatamansi (IEFV), identified by several pharmacological experiments, exhibits notable protective properties against diseases of the central nervous system and several cancers. In summary, V. jatamansi holds potential as an adjunct in cancer treatment, enhancing its therapeutic efficacy.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 4","pages":"1027-1063"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbiota and Osteoarthritis: From Pathogenesis to Novel Therapeutic Opportunities. 肠道微生物群和骨关节炎：从发病机制到新的治疗机会。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1142/S0192415X2550003X

Yujiang Xi, Zhifeng Wang, Yuanyuan Wei, Niqin Xiao, Li Duan, Ting Zhao, Xiaoyu Zhang, Liping Zhang, Jian Wang, Zhaofu Li, Dongdong Qin

{"title":"Gut Microbiota and Osteoarthritis: From Pathogenesis to Novel Therapeutic Opportunities.","authors":"Yujiang Xi, Zhifeng Wang, Yuanyuan Wei, Niqin Xiao, Li Duan, Ting Zhao, Xiaoyu Zhang, Liping Zhang, Jian Wang, Zhaofu Li, Dongdong Qin","doi":"10.1142/S0192415X2550003X","DOIUrl":"10.1142/S0192415X2550003X","url":null,"abstract":"Osteoarthritis (OA) is the most common chronic degenerative joint disease, characterized by cartilage damage, synovial inflammation, subchondral bone sclerosis, marginal bone loss, and osteophyte development. Clinical manifestations include inflammatory joint pain, swelling, osteophytes, and limitation of motion. The pathogenesis of osteoarthritis has not yet been fully uncovered. With ongoing research, however, it has been gradually determined that OA is not caused solely by mechanical injury or aging, but rather involves chronic low-grade inflammation, metabolic imbalances, dysfunctional adaptive immunity, and alterations in central pain processing centers. The main risk factors for OA include obesity, age, gender, genetics, and sports injuries. In recent years, extensive research on gut microbiota has revealed that gut dysbiosis is associated with some common risk factors for OA, and that it may intervene in its pathogenesis through both direct and indirect mechanisms. Therefore, gut flora imbalance as a pathogenic factor in OA has become a hotspot topic of research, with potential therapeutic connotations. In this paper, we review the role of the gut microbiota in the pathogenesis of OA, describe its relationship with common OA risk factors, and address candidate gut microbiota markers for OA diagnosis. In addition, with focus on OA therapies, we discuss the effects of direct and indirect interventions targeting the gut microbiota, as well as the impact of gut bacteria on the efficacy of OA drugs.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"43-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and Perspectives on the Anti-Fibrotic Mechanisms of the Quercetin. 槲皮素抗纤维化机制研究进展及展望。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-07 DOI: 10.1142/S0192415X25500545

Xiaoqin Liu, Qingzhi Liang, Yufeng Qin, Zhengtao Chen, Rensong Yue

{"title":"Advances and Perspectives on the Anti-Fibrotic Mechanisms of the Quercetin.","authors":"Xiaoqin Liu, Qingzhi Liang, Yufeng Qin, Zhengtao Chen, Rensong Yue","doi":"10.1142/S0192415X25500545","DOIUrl":"10.1142/S0192415X25500545","url":null,"abstract":"Fibrosis is a pathological process that affects multiple tissues and organs and a significant contributor to mortality, particularly in developed countries. Dietary flavonoids, especially quercetin (QUR), have emerged as key bioactive compounds with protective effects on vital organs such as the liver, heart, lungs, and kidneys. As a prominent focus in natural product research, QUR exhibits diverse anti-fibrotic mechanisms across various fibrotic conditions, including modulation of the TGF-[Formula: see text], NF-[Formula: see text]B, Nrf2, and AREG/EGFR signaling pathways. This review consolidates current knowledge on QUR and its derivatives, covering their anti-fibrotic mechanisms, drug interactions, pharmacokinetics, safety, and toxicological profiles. It offers insights for developing novel QUR-based formulations. Our findings highlight QUR's potential, which is supported by substantial evidence, as a natural therapeutic agent in functional foods and dietary supplements that target fibrosis. However, further high-quality studies are essential to validate its safety, optimize formulation stability, and confirm clinical efficacy in order to ultimately expand its therapeutic applications.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1411-1440"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephroprotective Effects of Formononetin in Diabetic Kidney Disease: Mechanistic Insights and Therapeutic Potential. 刺芒柄花素在糖尿病肾病中的肾保护作用：机制见解和治疗潜力。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-09-10 DOI: 10.1142/S0192415X25500843

Siyuan Song, Xiqiao Zhou, Liji Huang, Jiangyi Yu

{"title":"Nephroprotective Effects of Formononetin in Diabetic Kidney Disease: Mechanistic Insights and Therapeutic Potential.","authors":"Siyuan Song, Xiqiao Zhou, Liji Huang, Jiangyi Yu","doi":"10.1142/S0192415X25500843","DOIUrl":"10.1142/S0192415X25500843","url":null,"abstract":"Formononetin exhibits potent anti-oxidative and anti-inflammatory properties, but its precise therapeutic targets and mechanisms in diabetic kidney disease (DKD) remain insufficiently defined. This study evaluated the nephroprotective potential of formononetin using both in vitro (HK-2 cells) and in vivo (db/db mice) DKD models. By integrating network pharmacology and RNA sequencing, the antifibrotic actions of formononetin were further elucidated. Mechanistic investigations revealed that the compound reduced renal fibrosis by suppressing TGF-[Formula: see text]1, FN, and [Formula: see text]-SMA expression, and also alleviated renal dysfunction markers, including UACR, Scr, BUN, 24hUTP, KIM-1, and NGAL. These effects were mediated through the modulation of two key pathways such that the inhibition of the PI3K/AKT/mTOR cascade reduced inflammatory and fibrotic signaling, while the activation of the p38/MAPK axis enhanced autophagic flux, and thus promoted tubular epithelial cell homeostasis. Collectively, these findings support formononetin as a promising candidate for DKD therapy due to its combined anti-inflammatory and pro-autophagic mechanisms.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"2277-2305"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0