The American journal of Chinese medicine最新文献_第10页

Research Progress of Chinese Medicine in Treating Chronic Liver Disease by Regulating Autophagy. 中药调节自噬治疗慢性肝病的研究进展。

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-11-29 DOI: 10.1142/S0192415X24500794

Shihao Zheng, Chengyuan Xue, Tianyu Xue, Size Li, Xiaobin Zao, Xiaoke Li, Xu Cao, Yu Chen, Wenying Qi, Wei Wang, Peng Zhang, Yongan Ye

{"title":"Research Progress of Chinese Medicine in Treating Chronic Liver Disease by Regulating Autophagy.","authors":"Shihao Zheng, Chengyuan Xue, Tianyu Xue, Size Li, Xiaobin Zao, Xiaoke Li, Xu Cao, Yu Chen, Wenying Qi, Wei Wang, Peng Zhang, Yongan Ye","doi":"10.1142/S0192415X24500794","DOIUrl":"10.1142/S0192415X24500794","url":null,"abstract":"In recent years, rising living standards and an accelerated lifestyle have led to an increase in the incidence of chronic liver disease. Modern medicine has yet to fully develop effective methods for preventing and treating these conditions due to their complex pathogenesis. Autophagy, a cellular process that maintains homeostasis by removing abnormal proteins, has emerged as a promising therapeutic target for chronic liver diseases. These diseases include liver fibrosis, liver cirrhosis, non-alcoholic steatohepatitis, chronic hepatitis B, and hepatocellular carcinoma. Chinese medicine, with its multi-component, multi-target, and multi-pathway approach, offers unique advantages in treating these conditions, especially given the unclear etiology of chronic liver diseases. Recent research demonstrates that Chinese medicine - comprising single herbs, herbal combinations, and proprietary formulas - can effectively regulate autophagy, thereby providing therapeutic and preventive benefits for chronic liver diseases. This paper reviews recent studies, categorizes various chronic liver diseases, and examines the impact of active ingredients and compound formulas from Chinese medicine on autophagy. These insights are crucial for slowing the progression of chronic liver diseases and pave the way for the future application of Chinese medicine in preventing and managing these conditions through autophagy modulation.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"2053-2077"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ursolic Acid Inhibits Glycolysis of Ovarian Cancer via KLF5/PI3K/AKT Signaling Pathway. 熊果酸通过KLF5/PI3K/AKT信号通路抑制卵巢癌糖酵解

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-11-29 DOI: 10.1142/S0192415X2450085X

Meng Xu, Xiaoqi Li, Chenyue Yuan, Tingting Zhu, Mengfei Wang, Ying Zhu, Yanqiu Duan, Jialiang Yao, Bin Luo, Ziliang Wang, Sheng Yin, Yuqing Zhao

{"title":"Ursolic Acid Inhibits Glycolysis of Ovarian Cancer via KLF5/PI3K/AKT Signaling Pathway.","authors":"Meng Xu, Xiaoqi Li, Chenyue Yuan, Tingting Zhu, Mengfei Wang, Ying Zhu, Yanqiu Duan, Jialiang Yao, Bin Luo, Ziliang Wang, Sheng Yin, Yuqing Zhao","doi":"10.1142/S0192415X2450085X","DOIUrl":"10.1142/S0192415X2450085X","url":null,"abstract":"Glycolysis is one of the key metabolic reprogramming characteristics of ovarian cancer. Ursolic Acid (UA), as a natural compound, exerts a beneficial regulatory effect on tumor metabolism. In this study, we have confirmed through RNA-seq analysis and a series of in vitro and in vivo functional experiments that UA significantly inhibits ovarian cancer cell proliferation, promotes tumor apoptosis, and reduces glycolysis levels. Additionally, it demonstrates synergistic therapeutic effects with cisplatin in both in vitro and in vivo experiments. Furthermore, at the molecular level, we found that UA inhibits glycolysis in ovarian cancer by binding to the transcription factor KLF5 and blocking the transcriptional expression of the downstream PI3K/AKT signaling pathway, thereby exerting its therapeutic effect. In conclusion, our research indicates that UA can inhibit the proliferation, apoptosis, and glycolysis levels of ovarian cancer cells through the KLF5/PI3K/AKT signaling axis. Our findings offer a new perspective on the therapeutic application of the natural compound UA in ovarian cancer and support its potential development as a candidate for chemotherapy.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"2211-2231"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rb1 Relieves Cellular Senescence and Pulmonary Fibrosis by Promoting NRF2/QKI/SMAD7 Axis. 人参皂苷Rb1通过促进NRF2/QKI/SMAD7轴缓解细胞衰老和肺纤维化。

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-12-30 DOI: 10.1142/S0192415X24500952

Qing Zheng, Feng-Ping Lei, Shan Hui, Ming Tong, Li-Hui Liang

{"title":"Ginsenoside Rb1 Relieves Cellular Senescence and Pulmonary Fibrosis by Promoting NRF2/QKI/SMAD7 Axis.","authors":"Qing Zheng, Feng-Ping Lei, Shan Hui, Ming Tong, Li-Hui Liang","doi":"10.1142/S0192415X24500952","DOIUrl":"https://doi.org/10.1142/S0192415X24500952","url":null,"abstract":"Cellular senescence is an adverse factor in the development of pulmonary fibrosis (PF). Ginsenoside Rb1 has been found to inhibit both cellular senescence and PF. This study aimed to elucidate the molecular mechanisms by which ginsenoside Rb1 regulates cellular senescence and PF. A PF mouse model was established by Bleomycin (BLM) administration, and a cell model of senescence was constructed using MRC-5 cells treated with Adriamycin RD (ARD) administration. Hematoxylin and Eosin (HE) staining and Masson staining were employed to evaluate cellular structure and collagen fiber content. RT-qPCR and western blotting were used to detect mRNA and protein expression of the target genes. Enzyme-linked Immunosorbent Assay (ELISA) was applied to measure the protein concentration of IL-1[Formula: see text] and IL-18. SA-[Formula: see text]-gal staining was used to evaluate cellular senescence. Our results show that ginsenoside Rb1 effectively suppressed BLM-induced PF in mice. ARD administration to induce cellular senescence reduced NRF2, QKI, and SMAD7 expression in MRC-5 cells. By inducing NRF2 overexpression, ARD-induced cellular senescence and fibrosis in MRC-5 cells were relieved. Notably, NRF2 knockdown abolished the mitigating effects of ginsenoside Rb1 on ARD-induced cellular senescence and fibrosis in MRC-5 cells. Mechanistically, NRF2 increased SMAD7 mRNA stability through the transcriptional regulation of QKI. As expected, ginsenoside Rb1 alleviated ARD-induced senescence and fibrosis in MRC-5 cells by activating the NRF2/QKI/SMAD7 axis. Therefore, it was found that ginsenoside Rb1 mitigates cellular senescence and fibrosis during PF progression by activating the NRF2/QKI/SMAD7 axis. This study provides a potential therapeutic strategy for the treatment of PF and elucidates its mechanism of action.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"52 8","pages":"2491-2509"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Products on Inflammatory Bowel Disease: Role of Gut Microbes. 天然产品对炎症性肠病的影响：肠道微生物的作用

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-08-28 DOI: 10.1142/S0192415X24500514

Wen-Wen Cheng, Bao-Hong Liu, Xiao-Ting Hou, Huan Meng, Dan Wang, Cheng-Hao Zhang, Shuo Yuan, Qing-Gao Zhang

{"title":"Natural Products on Inflammatory Bowel Disease: Role of Gut Microbes.","authors":"Wen-Wen Cheng, Bao-Hong Liu, Xiao-Ting Hou, Huan Meng, Dan Wang, Cheng-Hao Zhang, Shuo Yuan, Qing-Gao Zhang","doi":"10.1142/S0192415X24500514","DOIUrl":"10.1142/S0192415X24500514","url":null,"abstract":"Inflammatory bowel disease (IBD) refers to long-term medical conditions that involve inflammation of the digestive tract, and the global incidence and prevalence of IBD are on the rise. Gut microbes play an important role in maintaining the intestinal health of the host, and the occurrence, development, and therapeutic effects of IBD are closely related to the structural and functional changes of gut microbes. Published studies have shown that the natural products from traditional Chinese medicine have direct or indirect regulatory impacts on the composition and metabolism of the gut microbes. In this review, we summarize the research progress of several groups of natural products, i.e., flavonoids, alkaloids, saponins, polysaccharides, polyphenols, and terpenoids, for the therapeutic activities in relieving IBD symptoms. The role of gut microbes and their intestinal metabolites in managing the IBD is presented, with focusing on the mechanism of action of those natural products. Traditional Chinese medicine alleviated IBD symptoms by regulating gut microbes, providing important theoretical and practical basis for the treatment of variable inflammatory intestinal diseases.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1275-1301"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota. 人参皂苷 Rg2 通过抑制 Caspase 8 介导的细胞凋亡和调节肠道微生物群减轻衰老诱导的肝损伤

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-08-28 DOI: 10.1142/S0192415X24500563

Xu-Fei Gao, Bao-Yu Ji, Jun-Jie Zhang, Zi Wang, Shuang Jiang, Jun-Nan Hu, Xiao-Jie Gong, Jing-Tian Zhang, Ivan Stève Nguepi Tsopmejio, Wei Li

{"title":"Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.","authors":"Xu-Fei Gao, Bao-Yu Ji, Jun-Jie Zhang, Zi Wang, Shuang Jiang, Jun-Nan Hu, Xiao-Jie Gong, Jing-Tian Zhang, Ivan Stève Nguepi Tsopmejio, Wei Li","doi":"10.1142/S0192415X24500563","DOIUrl":"10.1142/S0192415X24500563","url":null,"abstract":"Aging is an irresistible natural law of the progressive decline of body molecules, organs, and overall function with the passage of time, resulting in eventual death. World Health Organization data show that aging is correlated with a wide range of common chronic diseases in the elderly, and is an essential driver of many diseases. Panax Ginseng C.A Meyer is an ancient herbal medicine, which has an effect of \"long service, light weight, and longevity\" recorded in the ancient Chinese medicine book \"Compendium of Materia Medica.\" Ginsenoside Rg2, the main active ingredient of ginseng, also exerts a marked effect on the treatment of liver injury. However, it remains unclear whether Rg2 has the potential to ameliorate aging-induced liver injury. Hence, exploring the hepatoprotective properties of Rg2 and its possible molecular mechanism by Senescence Accelerate Mouse Prone 8 (SAMP8) and gut microbiota. Our study demonstrated that Rg2 can inhibit pyroptosis and apoptosis through caspase 8, and regulate the gut-liver axis to alleviate liver inflammation by changing the composition of gut microbiota, thus improving aging-induced liver injury. These findings provide theoretical support for the pharmacological effects of ginsenosides in delaying aging-induced liver injury.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1427-1449"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer Pain Management with Traditional Chinese Medicine: Current Status and Future Perspectives. 中医药治疗癌症疼痛：现状与未来展望

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-01-26 DOI: 10.1142/S0192415X24500058

Jiafu Ji, Jingxuan Guo, Yongliang Chi, Fan Su

{"title":"Cancer Pain Management with Traditional Chinese Medicine: Current Status and Future Perspectives.","authors":"Jiafu Ji, Jingxuan Guo, Yongliang Chi, Fan Su","doi":"10.1142/S0192415X24500058","DOIUrl":"10.1142/S0192415X24500058","url":null,"abstract":"Cancer pain, especially the moderate-to-severe pain experienced by patients with advanced cancer, is still one of the most challenging clinical problems. The current mainstream pharmacological treatment for cancer pain involves applying opioid medications and other pain-killing drugs. However, analgesic drugs have many adverse effects such as addiction, tolerance, and other formidable clinical and social issues. Thus, finding a new therapeutic approach to treat cancer pain is essential. Traditional Chinese medicine (TCM) has been increasingly applied in clinical practice because of its good efficacy and few side effects. However, its mechanisms of action in treating pain are still under investigation. The most important mechanism of cancer pain is that a large amount of pain-causing substances are secreted from cancer cells and promote their growth and invasion. The physical and chemical stimulations of these substances exist along with the cancer growth, leading to constantly increased pain sensation. Whether cancer pain can be alleviated by inhibiting cancer cells from releasing the substances and changing the microenvironment around the cancer mass, or even by eliminating pain-causing substances, is largely unknown. Based on TCM theory, this study reported that the aforementioned approach could effectively manage different cancer pains by tonifying qi, clearing and activating channels and meridians, and strengthening body resistance. The TCM therapies activate blood circulation, remove blood stasis, and nourish the heart. Commonly used Chinese herbal drugs include Corydalis yanhusuo, Angelica dahurica, and Ligusticum chuanxiong. Instead of using conventional analgesics to reduce pain, we should focus on using TCM modalities to alleviate cancer pain and increase the quality of life in patients suffering from cancer pain. TCM should provide us with a new strategy for managing cancer pain.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"123-135"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on the Antitumor Molecular Mechanism of Ginsenoside Rh2. 人参皂苷 Rh2 的抗肿瘤分子机制研究进展。

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-01-31 DOI: 10.1142/S0192415X24500095

Lan Yang, Jenny Jie Chen, Brian Sheng-Xian Teo, Jiong Zhang, Mingqiang Jiang

{"title":"Research Progress on the Antitumor Molecular Mechanism of Ginsenoside Rh2.","authors":"Lan Yang, Jenny Jie Chen, Brian Sheng-Xian Teo, Jiong Zhang, Mingqiang Jiang","doi":"10.1142/S0192415X24500095","DOIUrl":"10.1142/S0192415X24500095","url":null,"abstract":"Cancer has evolved into a substantial public health concern as the second-leading cause of mortality globally. Radiotherapy and chemotherapy have been the two most widely used cancer therapies in recent years; however, both have drawbacks. Therefore, the focus has shifted to the creation of herbal medicines, the extraction of active ingredients, replacement therapy, and the adverse effects of these medications. Ginsenoside Rh2, which is extracted from ginseng, has been identified in many cancer cells. The immune system of the body is strengthened by ginsenoside Rh2, which can also cause the proliferation, death, and differentiation of tumor cells through various pathways. For instance, it inhibits the expression of the NF-[Formula: see text]B signaling pathway and induces cell apoptosis, affects the expression levels of mitochondrial apoptosis proteins Bcl-2 and Bax, and cooperates with the PD-1 blockade to reactivate T cells to promote an antitumor immune response. Furthermore, ginsenosides Rh2 has the effect of reversing the toxic effect of chemotherapy drugs on normal cells, reducing myocardial damage, and relieving bone marrow function suppression. For clinical applications, it is mainly used as an adjuvant drug for preoperative neoadjuvant chemotherapy, postoperative adjuvant chemotherapy, and rescue treatment of advanced cancer. This paper summarizes the pharmacological action and mechanism of ginsenosides Rh2 in all kinds of cancer and looks forward to its future development and application.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"217-230"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Berberine Metabolites Stimulate GLP-1 Secretion by Alleviating Oxidative Stress and Mitochondrial Dysfunction. 小檗碱代谢物通过缓解氧化应激和线粒体功能障碍刺激 GLP-1 分泌

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-02-08 DOI: 10.1142/S0192415X24500113

Wei-Li Yang, Chen-Yang Zhang, Wen-Yi Ji, Li-Li Zhao, Fang-Yuan Yang, Lin Zhang, Xi Cao

{"title":"Berberine Metabolites Stimulate GLP-1 Secretion by Alleviating Oxidative Stress and Mitochondrial Dysfunction.","authors":"Wei-Li Yang, Chen-Yang Zhang, Wen-Yi Ji, Li-Li Zhao, Fang-Yuan Yang, Lin Zhang, Xi Cao","doi":"10.1142/S0192415X24500113","DOIUrl":"10.1142/S0192415X24500113","url":null,"abstract":"Berberine (BBR) is a principal component of Rhizoma coptidis known for its therapeutic potential in treating diseases such as type 2 diabetes mellitus (T2DM) and obesity. Despite the trace levels of BBR in plasma, it's believed that its metabolites play a pivotal role in its biological activities. While BBR is recognized to promote GLP-1 production in intestinal L cells, the cytoprotective effects of its metabolites on these cells are yet to be explored. The present study investigates the effects of BBR metabolites on GLP-1 secretion and the underlying mechanisms. Our results revealed that, out of six BBR metabolites, berberrubine (BBB) and palmatine (PMT) significantly increased the production and glucose-stimulated secretion of GLP-1 in GLUTag cells. Notably, both BBB and PMT could facilitate GLP-1 and insulin secretion and enhance glucose tolerance in standard mice. Moreover, a single dose of PMT could markedly increase plasma GLP-1 and improve glucose tolerance in mice with obesity induced by a high-fat diet. In palmitic acid or TNF[Formula: see text]-treated GLUTag cells, BBB and PMT alleviated cell death, oxidative stress, and mitochondrial dysfunction. Furthermore, they could effectively reverse inflammation-induced inhibition of the Akt signaling pathway. In general, these insights suggest that the beneficial effects of orally administered BBR on GLP-1 secretion are largely attributed to the pharmacological activity of BBB and PMT by their above cytoprotective effects on L cells, which provide important ideas for stimulating GLP-1 secretion and the treatment of T2DM.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"253-274"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma. 槲皮素通过黑色素瘤中的 PDK1/CD47 轴限制肿瘤免疫逃逸

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-03-16 DOI: 10.1142/S0192415X2450023X

Xin Li, Xue He, Bing Lin, Li Li, Qifeng Deng, Chengzhi Wang, Jing Zhang, Ying Chen, Jingyi Zhao, Xinrui Li, Yan Li, Qing Xi, Rongxin Zhang

{"title":"Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma.","authors":"Xin Li, Xue He, Bing Lin, Li Li, Qifeng Deng, Chengzhi Wang, Jing Zhang, Ying Chen, Jingyi Zhao, Xinrui Li, Yan Li, Qing Xi, Rongxin Zhang","doi":"10.1142/S0192415X2450023X","DOIUrl":"10.1142/S0192415X2450023X","url":null,"abstract":"Quercetin (3,3[Formula: see text],4[Formula: see text],5,7-pentahydroxyflavone) is a bioactive plant-derived flavonoid, abundant in fruits and vegetables, that can effectively inhibit the growth of many types of tumors without toxicity. Nevertheless, the effect of quercetin on melanoma immunology has yet to be determined. This study aimed to investigate the role and mechanism of the antitumor immunity action of quercetin in melanoma through both in vivo and in vitro methods. Our research revealed that quercetin has the ability to boost antitumor immunity by modulating the tumor immune microenvironment through increasing the percentages of M1 macrophages, CD8[Formula: see text] T lymphocytes, and CD4[Formula: see text] T lymphocytes and promoting the secretion of IL-2 and IFN-[Formula: see text] from CD8[Formula: see text] T cells, consequently suppressing the growth of melanoma. Furthermore, we revealed that quercetin can inhibit cell proliferation and migration of B16 cells in a dose-dependent manner. In addition, down-regulating PDK1 can inhibit the mRNA and protein expression levels of CD47. In the rescue experiment, we overexpressed PDK1 and found that the protein and mRNA expression levels of CD47 increased correspondingly, while the addition of quercetin reversed this effect. Moreover, quercetin could stimulate the proliferation and enhance the function of CD8[Formula: see text] T cells. Therefore, our results identified a novel mechanism through which CD47 is regulated by quercetin to promote phagocytosis, and elucidated the regulation of quercetin on macrophages and CD8[Formula: see text] T cells in the tumor immune microenvironment. The use of quercetin as a therapeutic drug holds potential benefits for immunotherapy, enhancing the efficacy of existing treatments for melanoma.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"541-563"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Application of Traditional Chinese Medicine Using AI Machine Learning and Deep Learning Strategies. 利用人工智能机器学习和深度学习策略开发和应用传统中医药。

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-05-08 DOI: 10.1142/S0192415X24500265

Danping Pan, Yilei Guo, Yongfu Fan, Haitong Wan

{"title":"Development and Application of Traditional Chinese Medicine Using AI Machine Learning and Deep Learning Strategies.","authors":"Danping Pan, Yilei Guo, Yongfu Fan, Haitong Wan","doi":"10.1142/S0192415X24500265","DOIUrl":"10.1142/S0192415X24500265","url":null,"abstract":"Traditional Chinese medicine (TCM) has been used for thousands of years and has been proven to be effective at treating many complicated illnesses with minimal side effects. The application and advancement of TCM are, however, constrained by the absence of objective measuring standards due to its relatively abstract diagnostic methods and syndrome differentiation theories. Ongoing developments in machine learning (ML) and deep learning (DL), specifically in computer vision (CV) and natural language processing (NLP), offer novel opportunities to modernize TCM by exploring the profound connotations of its theory. This review begins with an overview of the ML and DL methods employed in TCM; this is followed by practical instances of these applications. Furthermore, extensive discussions emphasize the mature integration of ML and DL in TCM, such as tongue diagnosis, pulse diagnosis, and syndrome differentiation treatment, highlighting their early successful application in the TCM field. Finally, this study validates the accomplishments and addresses the problems and challenges posed by the application and development of TCM powered by ML and DL. As ML and DL techniques continue to evolve, modern technology will spark new advances in TCM.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"605-623"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0