Shasha Kong, Qian Liao, Yuling Liu, Yuting Luo, Sai Fu, Longfei Lin, Hui Li
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引用次数: 0
摘要
洋槐被广泛用于传统中药已有 1700 多年的历史。这种植物具有清热、燥湿、杀虫和利尿的功效。植物化学研究发现，前炔类黄酮是 S. flavescens 中一类独特的生物活性化合物。最近的药理学研究表明，S. flavescens 的前炔化黄酮类化合物（PFS）具有很强的抗肿瘤、抗炎和调节糖脂代谢的活性，对多种疾病有显著的治疗效果。然而，目前尚未对 PFS 的药代动力学和毒理学特征进行系统研究。尽管前炔类黄酮化合物对类似疾病具有多种生物效应，但其结构与活性之间的关系尚未完全明了。本综述旨在总结有关 S. flavescens 中前酰基黄酮类化合物的化学成分、药物代谢、药理特性、毒性和结构-活性关系的最新发现。旨在强调其临床应用潜力，并提出未来相关研究的方向。
Prenylated Flavonoids in Sophora flavescens: A Systematic Review of Their Phytochemistry and Pharmacology.
Sophora flavescens has been widely used in traditional Chinese medicine for over 1700 years. This plant is known for its heat-clearing, damp-drying, insecticidal, and diuretic properties. Phytochemical research has identified prenylated flavonoids as a unique class of bioactive compounds in S. flavescens. Recent pharmacological studies reveal that the prenylated flavonoids from S. flavescens (PFS) exhibit potent antitumor, anti-inflammatory, and glycolipid metabolism-regulating activities, offering significant therapeutic benefits for various diseases. However, the pharmacokinetics and toxicological profiles of PFS have not been systematically studied. Despite the diverse biological effects of prenylated flavonoid compounds against similar diseases, their structure-activity relationship is not yet fully understood. This review aims to summarize the latest findings regarding the chemical composition, drug metabolism, pharmacological properties, toxicity, and structure-activity relationship of prenylated flavonoids from S. flavescens. It seeks to highlight their potential for clinical use and suggest directions for future related studies.
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