The American journal of Chinese medicine最新文献_第5页

Chinese Medicine in Regulating Immune Balance for the Treatment of Autoimmune Diseases. 中医药调节免疫平衡治疗自身免疫性疾病

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-31 DOI: 10.1142/S0192415X25500612

Min Zhou, Bin Wu

{"title":"Chinese Medicine in Regulating Immune Balance for the Treatment of Autoimmune Diseases.","authors":"Min Zhou, Bin Wu","doi":"10.1142/S0192415X25500612","DOIUrl":"10.1142/S0192415X25500612","url":null,"abstract":"The normal immune system maintains a dynamic equilibrium of immune regulation. When natural immune tolerance is disrupted, aberrant immune activation occurs, which leads to tissue damage and the onset of autoimmune diseases (AIDs). Pathological damage in AIDs stems from abnormal immune responses triggered by a systemic imbalance, and modern medicine has yet to find a definitive cure. The advantages of Chinese medicine (CM), which targets the fundamental pathogenesis of \"immune imbalance\" by regulating immune homeostasis and restoring a healthy Yin-Yang equilibrium state, are increasingly being demonstrated. CM promotes immune balance by modulating CD4[Formula: see text] T cell subset imbalances, dysfunctional immune cells (e.g., B cells, dendritic cells, and macrophages), and their associated cytokines and transcription factors. Although CM shows therapeutic potential for AIDs via immune homeostasis modulation, comprehensive reviews analyzing this approach through the lens of AIDs' shared mechanism - immune imbalance - remain scarce. Thus, this paper first elucidates immune imbalance in AIDs from the perspectives of immune cells, cytokines, and transcription factors. Then, leveraging CM's strengths in immune regulation, we systematically review current research on bioactive components extracted from Chinese herbs, such as Paeoniflorin-6'-O-benzene sulfonate (from Paeonia lactiflora) and Artesunate (from Artemisia annua), as well as herbal formulas like Zengye Runzao decoction and Er Miao San, to focus on their immunomodulatory effects in AIDs treatment. This synthesis provides valuable insights into the scientific rationale of CM for restoring immune balance in the treatment of AIDs.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1615-1640"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hepatic Oxidative Metabolite of Palmatine Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization Through AMPK/NF-κB Pathway. 巴马汀肝氧化代谢物通过AMPK/NF-κB通路调节巨噬细胞极化改善dss诱导的溃疡性结肠炎

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1142/S0192415X25500119

Qi-Ting Huang, Xing-Dong Ma, Jia-Na Zhang, Wei-Xiong Lin, Xue-Xia Shen, Zhuo-Wen Huang, Xia Zhang, Xiao-Yan Wu, Yao-Xing Dou, Zi-Ren Su, Ji-Yan Su, Yu-Cui Li, Yu-Hong Liu, You-Liang Xie, Rong-Feng Lin, Hai-Yang Huang, Qi-Hui Zhang, Xiao-Qi Huang

{"title":"A Hepatic Oxidative Metabolite of Palmatine Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization Through AMPK/NF-κB Pathway.","authors":"Qi-Ting Huang, Xing-Dong Ma, Jia-Na Zhang, Wei-Xiong Lin, Xue-Xia Shen, Zhuo-Wen Huang, Xia Zhang, Xiao-Yan Wu, Yao-Xing Dou, Zi-Ren Su, Ji-Yan Su, Yu-Cui Li, Yu-Hong Liu, You-Liang Xie, Rong-Feng Lin, Hai-Yang Huang, Qi-Hui Zhang, Xiao-Qi Huang","doi":"10.1142/S0192415X25500119","DOIUrl":"10.1142/S0192415X25500119","url":null,"abstract":"Palmatine (PAL) and berberine are both classified as protoberberine alkaloids, derived from several traditional Chinese herbs such as Coptis chinensis Franch. and Phellodendron chinense Schneid. These compounds are extensively used in treating dysentery and colitis. PAL is one of the crucial quality markers for these plants in the Chinese Pharmacopoeia. A key metabolite of PAL, 8-Oxypalmatine (OPAL), shows favorable anti-inflammatory activity and better safety compared to PAL, though its mechanisms in ulcerative colitis (UC) are not fully understood. This study used a dextran sodium sulfate-induced colitis mouse model to explore OPAL's effects. The results indicated that OPAL provided superior therapeutic effects to those of PAL, alleviating colitis symptoms and reducing colon inflammation by modulating pro-inflammatory (tumor necrosis factor-α, interleukin-1β, and interleukin-6) and anti-inflammatory (transforming growth factor-β and interleukin-10) cytokines. Additionally, OPAL helped rebuild the mucus barrier and upregulated tight junction proteins, thereby restoring intestinal integrity. Notably, OPAL inhibited the M1 macrophages infiltration while promoting M2 macrophage distribution in the colon. Its role in fostering M2 polarization and modulating the inflammatory cytokine profile was further confirmed in vitro. Importantly, the anti-inflammatory effects were primarily linked to AMP-activated protein kinase activation, which subsequently inhibited the nuclear factor-kappa B pathway. These findings highlight OPAL as a crucial active metabolite responsible for the therapeutic effects of PAL against UC, emphasizing its potential as a novel treatment for this condition.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"285-307"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rg6 Improves Cisplatin Resistance in Epithelial Ovarian Cancer Cells via Suppressing Fucosylation and Inducing Autophagy. 人参皂苷Rg6通过抑制聚焦和诱导自噬提高卵巢癌上皮细胞对顺铂的耐药性。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-03-27 DOI: 10.1142/S0192415X25500247

Kai Xue, Yun Bai, Yufei Han, Chuanxiang Yao, Zhenzhe Zhao, Dongyang Liang, Feiyu Lu, Yinping Jin, Jiazhe Song

{"title":"Ginsenoside Rg6 Improves Cisplatin Resistance in Epithelial Ovarian Cancer Cells via Suppressing Fucosylation and Inducing Autophagy.","authors":"Kai Xue, Yun Bai, Yufei Han, Chuanxiang Yao, Zhenzhe Zhao, Dongyang Liang, Feiyu Lu, Yinping Jin, Jiazhe Song","doi":"10.1142/S0192415X25500247","DOIUrl":"10.1142/S0192415X25500247","url":null,"abstract":"Platinum-based chemotherapy remains a mainstay of clinical practice in the standard treatment of epithelial ovarian cancer (EOC). Most patients who receive this treatment, however, develop relapse and drug resistance. Ginsenoside Rg6 (G-Rg6), one of the anticarcinogenic active components in the American ginseng berry, may hold promise in the adjuvant chemotherapy of EOC. In this study, the correlation between fucosylation and cisplatin (cDDP) resistance in EOC cells was validated by gene expression profile analysis and lectin blot. We found that G-Rg6 derived from the American ginseng berry inhibits the cell viability and protein fucosylation of cDDP-resistant EOC cells. G-Rg6-induced G2/M-cell cycle arrest was proven to result from the autophagy of cDDP-resistant EOC cells. In addition, we observed that G-Rg6 initiates autophagy in cDDP-resistant EOC cells by inhibiting the GRB2-ERK1/2-mTOR axis, and that high concentration of G-Rg6 treatment leads to cell apoptosis. G-Rg6 also enhances cDDP uptake in A2780CP cells by promoting CTR1 expression and suppressing its core fucosylation. Therapies combining cDDP and G-Rg6 display higher efficacy in inhibiting the cDDP-resistant EOC cells in comparison with the sole application of cDDP, exhibiting strong potential for clinical application. G-Rg6 derived from the American ginseng berry can improve cDDP resistance in EOC cells via suppressing fucosylation and inducing autophagy, suggesting its potential in the adjuvant chemotherapy of EOC patients.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"621-646"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in the Research of Astragalus membranaceus for the Treatment of Colorectal Cancer. 黄芪治疗大肠癌的研究进展。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1142/S0192415X25500065

Qiwen Lu, Jiaxin Jiang, Xi Wang, Rongling Wang, Xuan Han

{"title":"Advancements in the Research of Astragalus membranaceus for the Treatment of Colorectal Cancer.","authors":"Qiwen Lu, Jiaxin Jiang, Xi Wang, Rongling Wang, Xuan Han","doi":"10.1142/S0192415X25500065","DOIUrl":"10.1142/S0192415X25500065","url":null,"abstract":"Colorectal cancer, characterized by its high incidence, concealed early symptoms, and poor prognosis at advanced stages, ranks as the third leading cause of cancer-related deaths worldwide. Astragalus membranaceus (AM) refers to the dried roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao and Astragalus membranaceus (Fisch.) Bge. In the theory of Traditional Chinese Medicine (TCM), it is believed to have the functions of tonifying qi and lifting yang, as well as generating body fluids and nourishing blood. It can effectively treat cancer caused by the deficiency of vital energy and susceptibility to external diseases. Modern research has confirmed that the active components of AM, including Astragalus polysaccharides, flavonoids (formononetin and calycosin), Astragalus saponins (Astragaloside I and Astragaloside III), and Astragalus nanovesicles, are effective in the treatment of colorectal cancer. The mechanisms mainly involve inducing apoptosis, inhibiting tumor angiogenesis and the metastasis of cancer cells, regulating the cell cycle and tumor microenvironment, and reversing drug resistance. Moreover, it offers a synergistic enhancement when used in combination with chemotherapy, radiotherapy, targeted therapy, or surgical treatment. AM also has great potential in treating colorectal cancer when combined with other herbs. This review summarizes the relevant research findings on the treatment of colorectal cancer with AM, as well as its main pharmacological effects and molecular mechanisms, aiming to provide guidance for the development of new drugs, and offer direction for the conduct of more related research and promoting the development and application of AM.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"119-146"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of NLRP3 Inflammasome: Advantages of Chinese Herbal Medicine in Treating Myocardial Ischemia/Reperfusion Injury. 调节NLRP3炎性体：中药治疗心肌缺血/再灌注损伤的优势。

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X25500284

Yihang Du, Chenglin Duan, Xiaohan Zhang, Shuqing Shi, Xueping Zhu, Meng Lyu, Yi Wei, Yuanhui Hu

{"title":"Modulation of NLRP3 Inflammasome: Advantages of Chinese Herbal Medicine in Treating Myocardial Ischemia/Reperfusion Injury.","authors":"Yihang Du, Chenglin Duan, Xiaohan Zhang, Shuqing Shi, Xueping Zhu, Meng Lyu, Yi Wei, Yuanhui Hu","doi":"10.1142/S0192415X25500284","DOIUrl":"https://doi.org/10.1142/S0192415X25500284","url":null,"abstract":"Myocardial ischemia/reperfusion (I/R) injury is characterized by severe inflammation and oxidative stress, and involves the recruitment and activation of immune cells, the release of pro-inflammatory cytokines, and the generation of reactive oxygen species (ROS). The NOD-like receptor protein 3 (NLRP3) inflammasome, a multiprotein complex, is activated when exposed to different danger signals like excessive ROS, changes in ionic flux, and mitochondrial dysfunction. Once the NLRP3 inflammasome is activated, it promotes the maturation and release of pro-inflammatory cytokines such as interleukin-1β and interleukin-18, which contributes to the inflammatory storm in myocardial I/R injury. This inflammatory cascade not only leads to adverse cardiac remodeling but also impairs cardiac function, ultimately exacerbating the clinical outcomes of myocardial infarction. Despite the critical role of the NLRP3 inflammasome in myocardial I/R injury, there is a significant absence of effective therapeutic strategies to address it in clinical practice. In recent years, Chinese herbal medicine has emerged as a promising candidate in the therapeutic landscape of myocardial I/R injury. Chinese herbal medicine exerts its cardioprotective effects through various mechanisms of inhibiting NLRP3 inflammasomes, including enhancing mitochondrial function, reducing ROS generation, inhibiting the release of pro-inflammatory cytokines, and suppressing pyroptosis. This review emphasizes the therapeutic potential of Chinese herbal medicine and its extracts to inhibit NLRP3 inflammasomes in an effort to develop effective treatments for myocardial I/R injury. It likewise summarizes the research results of Chinese herbal medicine interventions for myocardial I/R injury by the mechanism of regulating the NLRP3 inflammasome, providing insights for the development of effective treatments for myocardial I/R injury.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 3","pages":"737-769"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Natural Products on Wnt/β-Catenin Signaling Pathway in Diseases. 天然产物对Wnt/β-Catenin信号通路的调控

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X25500272

Genggeng Zheng, Shuoqi Lin, Shijie Wang, Yuxiang Yan, Dali Zheng

{"title":"Regulation of Natural Products on Wnt/β-Catenin Signaling Pathway in Diseases.","authors":"Genggeng Zheng, Shuoqi Lin, Shijie Wang, Yuxiang Yan, Dali Zheng","doi":"10.1142/S0192415X25500272","DOIUrl":"https://doi.org/10.1142/S0192415X25500272","url":null,"abstract":"The Wnt/β-catenin signaling pathway plays a crucial role in both physiological and pathological conditions. Targeting molecules associated with the Wnt/β-catenin signaling pathway presents a promising approach for disease treatment. The use of natural products in treating various diseases is widespread due to their favorable biocompatibility, low toxicity, and high biological activity. Research has shown that natural products such as curcumin and resveratrol can regulate multiple signaling pathways under disease conditions, including the Wnt/β-catenin signaling pathway. However, the regulatory mechanisms of natural products remain incompletely understood. This review aims to explore the regulatory effects of natural products on the Wnt/β-catenin signaling pathway in certain diseases, especially in the process of tumor progression. It outlines the composition and mechanisms of the Wnt/β-catenin signaling pathway. Furthermore, we predicted the potential binding sites of these natural products to this pathway, summarized the effects of diverse natural products on this signaling pathway, and conducted a preliminary exploration ofd the mechanisms of the effects of natural products. In addition, we considered and discussed the limitations of natural products, such as potential side effects from long-term use and the precision in targeting the Wnt/β-catenin signaling pathway. This review provides a theoretical basis for the targeted strategy of the Wnt/β-catenin signaling pathway.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 3","pages":"709-735"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin Alleviates Folic Acid-Induced Renal Fibrosis by Inhibiting Tubular Epithelial Cell Ferroptosis via EGFR/ACSL4 Pathway. 槲皮素通过EGFR/ACSL4途径抑制小管上皮细胞铁下垂减轻叶酸诱导的肾纤维化

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-08-07 DOI: 10.1142/S0192415X25500715

Xian-Li Gao, Ting Chen, Shao-Ling Lin, Cai-Yun Guo, Wen-Jun Li, Wen-Jun Ning, Xiao-Ying Zhan, Huan Jing, You-Ling Fan, Hong-Tao Chen, Jun Zhou

{"title":"Quercetin Alleviates Folic Acid-Induced Renal Fibrosis by Inhibiting Tubular Epithelial Cell Ferroptosis via EGFR/ACSL4 Pathway.","authors":"Xian-Li Gao, Ting Chen, Shao-Ling Lin, Cai-Yun Guo, Wen-Jun Li, Wen-Jun Ning, Xiao-Ying Zhan, Huan Jing, You-Ling Fan, Hong-Tao Chen, Jun Zhou","doi":"10.1142/S0192415X25500715","DOIUrl":"10.1142/S0192415X25500715","url":null,"abstract":"Ferroptosis has emerged as a critical contributor to the pathogenesis of chronic kidney disease (CKD). Quercetin, a promising therapeutic agent and flavonoid with potential antiferroptotic properties, has demonstrated renoprotective effects. However, its molecular mechanisms remain unclear. This study integrated bioinformatics, network pharmacology, and molecular docking to identify the epithelial growth factor receptor (EGFR) as a key target of quercetin. In folic acid (FA)-induced CKD mice, quercetin decreased renal fibrosis (reducing [Formula: see text]-SMA, collagen I, and fibronectin), suppressed ferroptosis markers (including iron accumulation, malondialdehyde [MDA] levels, and acyl-CoA synthetase long-chain family member 4 [ACSL4] expression), and downregulated EGFR. In FA-stimulated HK-2 cells, quercetin inhibited epithelial-mesenchymal transition (by decreasing N-cadherin and fibronectin) and ferroptosis (by lowering iron, MDA, and ACSL4) while suppressing EGFR expression. Pharmacological inhibition and genetic knockout of EGFR in HK-2 cells confirmed that EGFR blockade alleviated FA-induced renal fibrosis and ferroptosis. These findings demonstrate that quercetin mitigates FA-induced renal fibrosis by inhibiting tubular epithelial ferroptosis via the EGFR/ACSL4 signaling axis, and thus highlights its therapeutic potential in CKD.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1913-1931"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platycodin D Improves Early Atherosclerosis in Type 2 Diabetes Mellitus by Regulating Endothelial Inflammation and Apoptosis. 桔梗素D通过调节内皮炎症和细胞凋亡改善2型糖尿病早期动脉粥样硬化。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-29 DOI: 10.1142/S0192415X25500703

Zi Wang, Yu Dong, Yu-Ying Bai, Jing-Tian Zhang, Le-Qi Wang, Shen Ren, Xin-Dian Li, Jun-Nan Hu, Wei Li

{"title":"Platycodin D Improves Early Atherosclerosis in Type 2 Diabetes Mellitus by Regulating Endothelial Inflammation and Apoptosis.","authors":"Zi Wang, Yu Dong, Yu-Ying Bai, Jing-Tian Zhang, Le-Qi Wang, Shen Ren, Xin-Dian Li, Jun-Nan Hu, Wei Li","doi":"10.1142/S0192415X25500703","DOIUrl":"10.1142/S0192415X25500703","url":null,"abstract":"Atherosclerosis (AS) is a risk factor for cardiovascular complications, induced by Type 2 diabetes mellitus (T2DM), which greatly increases the mortality of patients. Previous studies explored the potential molecular mechanism of Platycodin D (PD) in its capacity as a treatment of AS through network pharmacology, and obtained the potential targets of PD treatment of AS. Therefore, this paper conducted a more in-depth study on the anti-Type 2 diabetes mellitus-Atherosclerosis (T2DM-AS) activity of PD. By establishing a T2DM-AS mice model induced by high-fat diet (HFD) combined with streptozotocin (STZ), and human umbilical vein endothelial cell (HUVEC) injury models induced by lipopolysaccharide (LPS), both the NLRP3 inflammatory body and endoplasmic reticulum stress (ERS) were studied. This study focused on ERS activation to explore the regulatory effect and mechanism of PD on the inflammation and apoptosis of aorta and endothelial cells. It was found that PD (2.5[Formula: see text]mg/kg) could improve early AS inflammation and lipid translocation deposition in T2DM mice. PD could also alleviate the LPS-induced apoptosis of HUVECs at concentrations of 0.5, 1, and 2[Formula: see text][Formula: see text]M by regulating the PI3K/AKT pathway, and ameliorate inflammation by inhibiting the activation of the NLRP3 inflammasome and the NF-[Formula: see text]B pathway. Both in vivo and in vitro experiments showed that PD could regulate the activation of NLRP3 inflammasome, inhibit endothelial cell inflammation and cell apoptosis caused by ERS, and improve AS inflammation and lipid deposition in the early stage of T2DM by restoring damaged cell function. This study provided a theoretical reference for its clinical treatment and the development and application of health care products.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1887-1912"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on Traditional Uses, Chemical Composition, Pharmacological Actions, and Clinical Applications of Ginseng-Containing Sijunzi Decoction. 含人参四君子汤的传统用途、化学成分、药理作用及临床应用研究进展

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-08-01 DOI: 10.1142/S0192415X25500636

Yihan Li, Changgang Sun, Xiaoqing Guan

{"title":"Research Progress on Traditional Uses, Chemical Composition, Pharmacological Actions, and Clinical Applications of Ginseng-Containing Sijunzi Decoction.","authors":"Yihan Li, Changgang Sun, Xiaoqing Guan","doi":"10.1142/S0192415X25500636","DOIUrl":"10.1142/S0192415X25500636","url":null,"abstract":"Sijunzi Decoction (SJZD), a classic traditional Chinese medicine formula, is primarily composed of Panax ginseng, Atractylodes macrocephala, Poria cocos, and Glycyrrhiza uralensis. This review aimed to provide a comprehensive overview of SJZD's traditional uses, chemical composition, pharmacological actions, and clinical applications, with a particular emphasis on its potential role in cancer therapy. The review also aims to identify the gaps in current knowledge and suggest directions for future research on SJZD. Research shows that this formula contains various chemical compounds, including saponins, flavonoids, and polysaccharides, which have significant pharmacological effects such as enhanced immune function, antitumor activity, and inhibition of tumor cell invasion and metastasis. Clinically, SJZD has evolved from its traditional gastrointestinal applications to demonstrate chemo-adjuvant potential by virtue of its characteristic detoxification-potentiation duality. Studies have revealed its ability to enhance patients' quality of life through immune modulation and the mitigation of chemotherapy-induced toxicity effects (e.g., myelosuppression and gastrointestinal reactions), while preclinical evidence suggests potential efficacy-enhancing synergies with conventional antitumor agents. However, further research on SJZD, and in particular, comprehensive studies of its chemical composition, large-scale clinical trials, and interdisciplinary collaboration, is needed. Future research is expected to reveal the underlying mechanisms of action, and provide new ideas and methods for cancer treatment.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1685-1710"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum - Gardenia jasminoides Extract GJ-4 Aleviates Memory Defciency of Vascular Dementia in Rats through PERK-Mediated Endoplasmic Reticulum Stress Pathway. 更正：栀子提取物GJ-4通过perk介导的内质网应激途径减轻血管性痴呆大鼠的记忆缺陷。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-08 DOI: 10.1142/S0192415X25920016

Fang-Yu Yuan, Cheng Ju, Cai-Xia Zang, Hui Liu, Mei-Yu Shang, Jing-Wen Ning, Yang Yang, Jing-Wei Ma, Gen Li, Yang Yu, Xin-Sheng Yao, Xiu-Qi Bao, Dan Zhang

引用次数: 0