The American journal of Chinese medicine最新文献_第4页

Mast Cells in Acupoint Sensitization: Mechanisms and Research Advances. 肥大细胞在穴位致敏中的作用机制及研究进展。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-08 DOI: 10.1142/S0192415X25500491

Ran Li, Miao Liu, Yueming Lv, Fujie Jing

{"title":"Mast Cells in Acupoint Sensitization: Mechanisms and Research Advances.","authors":"Ran Li, Miao Liu, Yueming Lv, Fujie Jing","doi":"10.1142/S0192415X25500491","DOIUrl":"10.1142/S0192415X25500491","url":null,"abstract":"Acupoint sensitization is characterized by a dynamic transition from a \"resting state\" to an \"activated state\". Research in this area holds significant implications not only for clinical acupoint selection but also for disease diagnosis. However, the biological mechanisms and material basis underlying this process require further investigation. In recent years, mast cells have been recognized as a key cellular foundation and an objective indicator of acupoint sensitization. When mechanical signals are transmitted to the subcutaneous tissue, mast cell aggregation and degranulation are induced. This leads to subsequent effects on the surrounding tissues, including blood vessels, muscles, and nerve endings, and thereby mediates the acupuncture effect. Evidence suggests that mast cells not only initiate acupuncture effects but also, through their released substances, reflect the dynamic and functional characteristics of acupoint sensitization. These cells also contribute to both central and peripheral sensitization processes. Despite recent advancements, several challenges remain in the study of acupoint sensitization, including the lack of dynamic monitoring methods, inconsistent indicators for measuring sensitization intensity, and an uncertainty regarding the potential of neurotransmitter-independent sensitization processes. This study provides an overview of mast cells and their role in the mechanism of acupoint sensitization, thereby aiming to establish a comprehensive network linking the central and peripheral systems to the neuroendocrine-immune system. The study aims to offer insights that will facilitate further exploration of the biological significance of acupoint sensitization and promote more in-depth research.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1265-1284"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chinese Medicine for Non-Alcoholic Fatty Liver Disease: Targeting Key Signaling Pathways. 中医药治疗非酒精性脂肪肝：针对关键信号通路

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-18 DOI: 10.1142/S0192415X25500533

Shihao Zheng, Xinyue Shi, Chengyuan Xue, Qiuyue Wang, Wenying Qi, Xiaoke Li, Hongbo Du, Size Li, Xiaobin Zao, Peng Zhang, Yongan Ye

{"title":"Chinese Medicine for Non-Alcoholic Fatty Liver Disease: Targeting Key Signaling Pathways.","authors":"Shihao Zheng, Xinyue Shi, Chengyuan Xue, Qiuyue Wang, Wenying Qi, Xiaoke Li, Hongbo Du, Size Li, Xiaobin Zao, Peng Zhang, Yongan Ye","doi":"10.1142/S0192415X25500533","DOIUrl":"https://doi.org/10.1142/S0192415X25500533","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatocellular injury, inflammation and fibrosis, which result from the accumulation of hepatic lipids. As one of the most prevalent chronic liver diseases globally, its pathogenesis remains complex. With the improvement in living standards, the incidence of NAFLD is expected to rise, drawing increasing attention to its development, prevention, and treatment from researchers worldwide. Currently, the therapeutic progress achieved by Western medicine in treating NAFLD remains limited, and its clinical efficacy is unsatisfactory. In contrast, Chinese medicine has a long history in the treatment of NAFLD, and possesses such advantages as fewer side effects, and multi-component, multi-target, and multi-pathway therapeutic actions. In recent years, several studies have demonstrated that Chinese medicine can modulate the progression of NAFLD by regulating relevant signaling pathways both in vivo and in vitro. However, comprehensive reviews on this topic remain scarce. Therefore, in this paper, a literature search was conducted using PubMed and Web of Science to summarize key signaling pathways implicated in Chinese medicine-mediated interventions in NAFLD, including AMPK, mTOR, PI3K/Akt, Toll-like receptor, NF-[Formula: see text]B, and MAPK pathways. Furthermore, the specific anti-NAFLD mechanisms of these pathways were elaborated. The objective of this paper is to provide an overview of the effective therapeutic pathways and mechanisms associated with Chinese medicine in the treatment of NAFLD, and to thereby offer a theoretical foundation and innovative perspectives for future research and clinical applications.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 5","pages":"1379-1410"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnomedicine, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Rhizoma Corydalis: A Systematic Review. 杨连的民族医学、植物学、植物化学、药理学、药代动力学和毒性研究综述。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-18 DOI: 10.1142/S0192415X25500557

Xu Wu, Shiyuan Tang, Xiaohui Bian, Zihan Ma, Xinyi Zhang, Zhangli Jiang, Hui Zhang, Heshui Yu, Zhiying Dou

{"title":"Ethnomedicine, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Rhizoma Corydalis: A Systematic Review.","authors":"Xu Wu, Shiyuan Tang, Xiaohui Bian, Zihan Ma, Xinyi Zhang, Zhangli Jiang, Hui Zhang, Heshui Yu, Zhiying Dou","doi":"10.1142/S0192415X25500557","DOIUrl":"https://doi.org/10.1142/S0192415X25500557","url":null,"abstract":"Rhizoma Corydalis (RC) is a traditional Chinese herbal medicine (TCM) known as Yan Hu Suo or Yuan Hu in China. This plant is a limited resource distributed in Zhe Jiang, Shaan Xi, Jiang Su, and other places of China. The aim of this paper is to provide a systematic review on the traditional uses, botany, phytochemistry, pharmacology, and pharmacokinetics of this plant. Furthermore, the potential development and perspectives for upcoming research on RC are also discussed. At present, over 160 compounds have been isolated and identified from RC, including alkaloids, anthraquinone, amino acids, organic acids, essential oils and microelements. RC was demonstrated to possess wide-reaching pharmacological properties, including effects on the nervous system, cardiovascular system, analgesic properties, sedative and anti-epileptic effects, antidepressive and anti-anxiety effects, antimyocardial ischemia/reperfusion (MIR) injury activities, anticerebral ischemia/reperfusion (CIR) injury activities, gastro-protective effects, and anticancer effects. In TCM clinical treatments, Angelicae Sinensis Radix, Myrrha, Cinnamomi Ramulus, and Paeoniae Radix Rubra were compatible with RC and frequently used to treat chest pain, lumbago, and abdominal pain. However, further research elucidating the signaling pathways between chemical compounds and targets in order to better understand the mechanism by which RC might be treated, and to optimize for quality control in processing products of RC is necessary.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 5","pages":"1441-1476"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hepatic Oxidative Metabolite of Palmatine Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization Through AMPK/NF-κB Pathway. 巴马汀肝氧化代谢物通过AMPK/NF-κB通路调节巨噬细胞极化改善dss诱导的溃疡性结肠炎

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1142/S0192415X25500119

Qi-Ting Huang, Xing-Dong Ma, Jia-Na Zhang, Wei-Xiong Lin, Xue-Xia Shen, Zhuo-Wen Huang, Xia Zhang, Xiao-Yan Wu, Yao-Xing Dou, Zi-Ren Su, Ji-Yan Su, Yu-Cui Li, Yu-Hong Liu, You-Liang Xie, Rong-Feng Lin, Hai-Yang Huang, Qi-Hui Zhang, Xiao-Qi Huang

{"title":"A Hepatic Oxidative Metabolite of Palmatine Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization Through AMPK/NF-κB Pathway.","authors":"Qi-Ting Huang, Xing-Dong Ma, Jia-Na Zhang, Wei-Xiong Lin, Xue-Xia Shen, Zhuo-Wen Huang, Xia Zhang, Xiao-Yan Wu, Yao-Xing Dou, Zi-Ren Su, Ji-Yan Su, Yu-Cui Li, Yu-Hong Liu, You-Liang Xie, Rong-Feng Lin, Hai-Yang Huang, Qi-Hui Zhang, Xiao-Qi Huang","doi":"10.1142/S0192415X25500119","DOIUrl":"10.1142/S0192415X25500119","url":null,"abstract":"Palmatine (PAL) and berberine are both classified as protoberberine alkaloids, derived from several traditional Chinese herbs such as Coptis chinensis Franch. and Phellodendron chinense Schneid. These compounds are extensively used in treating dysentery and colitis. PAL is one of the crucial quality markers for these plants in the Chinese Pharmacopoeia. A key metabolite of PAL, 8-Oxypalmatine (OPAL), shows favorable anti-inflammatory activity and better safety compared to PAL, though its mechanisms in ulcerative colitis (UC) are not fully understood. This study used a dextran sodium sulfate-induced colitis mouse model to explore OPAL's effects. The results indicated that OPAL provided superior therapeutic effects to those of PAL, alleviating colitis symptoms and reducing colon inflammation by modulating pro-inflammatory (tumor necrosis factor-α, interleukin-1β, and interleukin-6) and anti-inflammatory (transforming growth factor-β and interleukin-10) cytokines. Additionally, OPAL helped rebuild the mucus barrier and upregulated tight junction proteins, thereby restoring intestinal integrity. Notably, OPAL inhibited the M1 macrophages infiltration while promoting M2 macrophage distribution in the colon. Its role in fostering M2 polarization and modulating the inflammatory cytokine profile was further confirmed in vitro. Importantly, the anti-inflammatory effects were primarily linked to AMP-activated protein kinase activation, which subsequently inhibited the nuclear factor-kappa B pathway. These findings highlight OPAL as a crucial active metabolite responsible for the therapeutic effects of PAL against UC, emphasizing its potential as a novel treatment for this condition.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"285-307"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rg6 Improves Cisplatin Resistance in Epithelial Ovarian Cancer Cells via Suppressing Fucosylation and Inducing Autophagy. 人参皂苷Rg6通过抑制聚焦和诱导自噬提高卵巢癌上皮细胞对顺铂的耐药性。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-03-27 DOI: 10.1142/S0192415X25500247

Kai Xue, Yun Bai, Yufei Han, Chuanxiang Yao, Zhenzhe Zhao, Dongyang Liang, Feiyu Lu, Yinping Jin, Jiazhe Song

{"title":"Ginsenoside Rg6 Improves Cisplatin Resistance in Epithelial Ovarian Cancer Cells via Suppressing Fucosylation and Inducing Autophagy.","authors":"Kai Xue, Yun Bai, Yufei Han, Chuanxiang Yao, Zhenzhe Zhao, Dongyang Liang, Feiyu Lu, Yinping Jin, Jiazhe Song","doi":"10.1142/S0192415X25500247","DOIUrl":"10.1142/S0192415X25500247","url":null,"abstract":"Platinum-based chemotherapy remains a mainstay of clinical practice in the standard treatment of epithelial ovarian cancer (EOC). Most patients who receive this treatment, however, develop relapse and drug resistance. Ginsenoside Rg6 (G-Rg6), one of the anticarcinogenic active components in the American ginseng berry, may hold promise in the adjuvant chemotherapy of EOC. In this study, the correlation between fucosylation and cisplatin (cDDP) resistance in EOC cells was validated by gene expression profile analysis and lectin blot. We found that G-Rg6 derived from the American ginseng berry inhibits the cell viability and protein fucosylation of cDDP-resistant EOC cells. G-Rg6-induced G2/M-cell cycle arrest was proven to result from the autophagy of cDDP-resistant EOC cells. In addition, we observed that G-Rg6 initiates autophagy in cDDP-resistant EOC cells by inhibiting the GRB2-ERK1/2-mTOR axis, and that high concentration of G-Rg6 treatment leads to cell apoptosis. G-Rg6 also enhances cDDP uptake in A2780CP cells by promoting CTR1 expression and suppressing its core fucosylation. Therapies combining cDDP and G-Rg6 display higher efficacy in inhibiting the cDDP-resistant EOC cells in comparison with the sole application of cDDP, exhibiting strong potential for clinical application. G-Rg6 derived from the American ginseng berry can improve cDDP resistance in EOC cells via suppressing fucosylation and inducing autophagy, suggesting its potential in the adjuvant chemotherapy of EOC patients.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"621-646"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in the Research of Astragalus membranaceus for the Treatment of Colorectal Cancer. 黄芪治疗大肠癌的研究进展。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1142/S0192415X25500065

Qiwen Lu, Jiaxin Jiang, Xi Wang, Rongling Wang, Xuan Han

{"title":"Advancements in the Research of Astragalus membranaceus for the Treatment of Colorectal Cancer.","authors":"Qiwen Lu, Jiaxin Jiang, Xi Wang, Rongling Wang, Xuan Han","doi":"10.1142/S0192415X25500065","DOIUrl":"10.1142/S0192415X25500065","url":null,"abstract":"Colorectal cancer, characterized by its high incidence, concealed early symptoms, and poor prognosis at advanced stages, ranks as the third leading cause of cancer-related deaths worldwide. Astragalus membranaceus (AM) refers to the dried roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao and Astragalus membranaceus (Fisch.) Bge. In the theory of Traditional Chinese Medicine (TCM), it is believed to have the functions of tonifying qi and lifting yang, as well as generating body fluids and nourishing blood. It can effectively treat cancer caused by the deficiency of vital energy and susceptibility to external diseases. Modern research has confirmed that the active components of AM, including Astragalus polysaccharides, flavonoids (formononetin and calycosin), Astragalus saponins (Astragaloside I and Astragaloside III), and Astragalus nanovesicles, are effective in the treatment of colorectal cancer. The mechanisms mainly involve inducing apoptosis, inhibiting tumor angiogenesis and the metastasis of cancer cells, regulating the cell cycle and tumor microenvironment, and reversing drug resistance. Moreover, it offers a synergistic enhancement when used in combination with chemotherapy, radiotherapy, targeted therapy, or surgical treatment. AM also has great potential in treating colorectal cancer when combined with other herbs. This review summarizes the relevant research findings on the treatment of colorectal cancer with AM, as well as its main pharmacological effects and molecular mechanisms, aiming to provide guidance for the development of new drugs, and offer direction for the conduct of more related research and promoting the development and application of AM.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"119-146"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of NLRP3 Inflammasome: Advantages of Chinese Herbal Medicine in Treating Myocardial Ischemia/Reperfusion Injury. 调节NLRP3炎性体：中药治疗心肌缺血/再灌注损伤的优势。

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X25500284

Yihang Du, Chenglin Duan, Xiaohan Zhang, Shuqing Shi, Xueping Zhu, Meng Lyu, Yi Wei, Yuanhui Hu

{"title":"Modulation of NLRP3 Inflammasome: Advantages of Chinese Herbal Medicine in Treating Myocardial Ischemia/Reperfusion Injury.","authors":"Yihang Du, Chenglin Duan, Xiaohan Zhang, Shuqing Shi, Xueping Zhu, Meng Lyu, Yi Wei, Yuanhui Hu","doi":"10.1142/S0192415X25500284","DOIUrl":"https://doi.org/10.1142/S0192415X25500284","url":null,"abstract":"Myocardial ischemia/reperfusion (I/R) injury is characterized by severe inflammation and oxidative stress, and involves the recruitment and activation of immune cells, the release of pro-inflammatory cytokines, and the generation of reactive oxygen species (ROS). The NOD-like receptor protein 3 (NLRP3) inflammasome, a multiprotein complex, is activated when exposed to different danger signals like excessive ROS, changes in ionic flux, and mitochondrial dysfunction. Once the NLRP3 inflammasome is activated, it promotes the maturation and release of pro-inflammatory cytokines such as interleukin-1β and interleukin-18, which contributes to the inflammatory storm in myocardial I/R injury. This inflammatory cascade not only leads to adverse cardiac remodeling but also impairs cardiac function, ultimately exacerbating the clinical outcomes of myocardial infarction. Despite the critical role of the NLRP3 inflammasome in myocardial I/R injury, there is a significant absence of effective therapeutic strategies to address it in clinical practice. In recent years, Chinese herbal medicine has emerged as a promising candidate in the therapeutic landscape of myocardial I/R injury. Chinese herbal medicine exerts its cardioprotective effects through various mechanisms of inhibiting NLRP3 inflammasomes, including enhancing mitochondrial function, reducing ROS generation, inhibiting the release of pro-inflammatory cytokines, and suppressing pyroptosis. This review emphasizes the therapeutic potential of Chinese herbal medicine and its extracts to inhibit NLRP3 inflammasomes in an effort to develop effective treatments for myocardial I/R injury. It likewise summarizes the research results of Chinese herbal medicine interventions for myocardial I/R injury by the mechanism of regulating the NLRP3 inflammasome, providing insights for the development of effective treatments for myocardial I/R injury.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 3","pages":"737-769"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Natural Products on Wnt/β-Catenin Signaling Pathway in Diseases. 天然产物对Wnt/β-Catenin信号通路的调控

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X25500272

Genggeng Zheng, Shuoqi Lin, Shijie Wang, Yuxiang Yan, Dali Zheng

{"title":"Regulation of Natural Products on Wnt/β-Catenin Signaling Pathway in Diseases.","authors":"Genggeng Zheng, Shuoqi Lin, Shijie Wang, Yuxiang Yan, Dali Zheng","doi":"10.1142/S0192415X25500272","DOIUrl":"https://doi.org/10.1142/S0192415X25500272","url":null,"abstract":"The Wnt/β-catenin signaling pathway plays a crucial role in both physiological and pathological conditions. Targeting molecules associated with the Wnt/β-catenin signaling pathway presents a promising approach for disease treatment. The use of natural products in treating various diseases is widespread due to their favorable biocompatibility, low toxicity, and high biological activity. Research has shown that natural products such as curcumin and resveratrol can regulate multiple signaling pathways under disease conditions, including the Wnt/β-catenin signaling pathway. However, the regulatory mechanisms of natural products remain incompletely understood. This review aims to explore the regulatory effects of natural products on the Wnt/β-catenin signaling pathway in certain diseases, especially in the process of tumor progression. It outlines the composition and mechanisms of the Wnt/β-catenin signaling pathway. Furthermore, we predicted the potential binding sites of these natural products to this pathway, summarized the effects of diverse natural products on this signaling pathway, and conducted a preliminary exploration ofd the mechanisms of the effects of natural products. In addition, we considered and discussed the limitations of natural products, such as potential side effects from long-term use and the precision in targeting the Wnt/β-catenin signaling pathway. This review provides a theoretical basis for the targeted strategy of the Wnt/β-catenin signaling pathway.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 3","pages":"709-735"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celastrol Alleviates Intestinal Epithelial Permeability by Inhibiting Ferroptosis through PI3K/Akt/FOXO1/HO-1 Signaling Pathway. Celastrol通过PI3K/Akt/FOXO1/HO-1信号通路抑制铁下垂，减轻肠上皮通透性

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X25500466

Dan Wu, Ping Shi, Lian-Hua Tang, Xiao-Mei Song, Juan Deng, Hong Guo, Fei Yin

{"title":"Celastrol Alleviates Intestinal Epithelial Permeability by Inhibiting Ferroptosis through PI3K/Akt/FOXO1/HO-1 Signaling Pathway.","authors":"Dan Wu, Ping Shi, Lian-Hua Tang, Xiao-Mei Song, Juan Deng, Hong Guo, Fei Yin","doi":"10.1142/S0192415X25500466","DOIUrl":"https://doi.org/10.1142/S0192415X25500466","url":null,"abstract":"Ulcerative colitis (UC) is a recurrent inflammatory intestinal disorder characterized by systemic inflammatory response, abnormal intestinal epithelial cell death, and damage to the intestinal mucosal barrier. This study aimed to explore the role of celastrol in ferroptosis and intestinal epithelial barrier permeability. The results demonstrated that celastrol significantly inhibited ferroptosis in RSL3-induced intestinal epithelial cells by regulating the expression of ferroptosis-related proteins. Concurrently, celastrol dramatically improved the permeability of the intestinal epithelial monolayer by increasing the expression of tight junction proteins including ZO-1, occludin, and claudin-1. Moreover, celastrol markedly attenuated the effect of RSL3 on the phosphorylation of Akt and FOXO1. LY294002, a PI3K inhibitor, significantly inhibited the role of celastrol in the expression of ferroptosis-related and intestinal tight junction proteins. In vivo, celastrol administration not only significantly ameliorated dextran sulfate sodium (DSS)-induced colitis by preventing neutrophil infiltration, but also ameliorated intestinal mucosa damage, and colon shortening. Celastrol administration was also found to reduce the expression of ferroptosis-related proteins prevent the infiltration of fluorescein isothiocyanate-dextran (FITC-dextran) and increase the levels of tight junction proteins. Collectively, these findings suggest that due to its effects on ferroptosis and tight junctions in intestinal epithelial cells, celastrol may be a compound with significant promise in the prevention and treatment of UC.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 4","pages":"1207-1224"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum - Gardenia jasminoides Extract GJ-4 Aleviates Memory Defciency of Vascular Dementia in Rats through PERK-Mediated Endoplasmic Reticulum Stress Pathway. 更正：栀子提取物GJ-4通过perk介导的内质网应激途径减轻血管性痴呆大鼠的记忆缺陷。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-08 DOI: 10.1142/S0192415X25920016

Fang-Yu Yuan, Cheng Ju, Cai-Xia Zang, Hui Liu, Mei-Yu Shang, Jing-Wen Ning, Yang Yang, Jing-Wei Ma, Gen Li, Yang Yu, Xin-Sheng Yao, Xiu-Qi Bao, Dan Zhang

引用次数: 0