The American journal of Chinese medicine最新文献_第4页

Tanshinone IIA Inhibits NADPH Oxidase 4 Expression by Regulating Sestrin2-Mediated AMPK/mTOR Signaling Pathway to Alleviate Myofibroblast Activation in Pulmonary Fibrosis. 丹参酮IIA通过调节sestrin2介导的AMPK/mTOR信号通路抑制NADPH氧化酶4的表达，减轻肺纤维化中肌成纤维细胞的活化。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-08-14 DOI: 10.1142/S0192415X25500685

Congying Guo, Sheng Ai, Mingyu Wu, Rao Zhai, Jun Chen

{"title":"Tanshinone IIA Inhibits NADPH Oxidase 4 Expression by Regulating Sestrin2-Mediated AMPK/mTOR Signaling Pathway to Alleviate Myofibroblast Activation in Pulmonary Fibrosis.","authors":"Congying Guo, Sheng Ai, Mingyu Wu, Rao Zhai, Jun Chen","doi":"10.1142/S0192415X25500685","DOIUrl":"https://doi.org/10.1142/S0192415X25500685","url":null,"abstract":"Oxidative stress serves as a driving force for myofibroblast activation in pulmonary fibrosis (PF). As a main enzymatic source of reactive oxygen species (ROS), NADPH oxidase 4 (Nox4) plays a critical role in modulating myofibroblast activation, and has thus emerged as a potential therapeutic target for PF. Tanshinone IIA (Tan-IIA), the most abundant fat-soluble component found in the root and rhizome of Salvia miltiorrhiza Bge., has been demonstrated to suppress ROS-mediated myofibroblast activation by inhibiting Nox4, and thereby ameliorating PF. However, the mechanism through which Tan-IIA regulates Nox4 to prevent myofibroblast activation remains unclear. This study aimed to investigate the protective effects of Tan-IIA against myofibroblast activation in PF, and to elucidate the upstream molecular mechanisms involved in Nox4 regulation. Tan-IIA inhibited myofibroblast activation by reducing extracellular matrix deposition in a mouse model of bleomycin-induced PF. Furthermore, Tan-IIA enhanced the expression of Sestrin2 (Sesn2), while concurrently suppressing Nox4 expression. This effect was verified using an in vitro model of transforming growth factor beta 1 (TGF-β1)-stimulated myofibroblast activation. We further demonstrated that Sesn2 was required for Tan-IIA to act against TGF-β1-induced myofibroblast activation by inhibiting Nox4-mediated oxidative stress. Additionally, both in vitro and in vivo studies revealed that Tan-IIA activates AMP-activated protein kinase (AMPK) and inhibits mammalian target of rapamycin (mTOR) via the upregulation of Sesn2. The findings indicate that Tan-IIA suppresses Nox4 by regulating the Sesn2/AMPK/mTOR signaling pathway, which highlights the crucial effect Sesn2 has in modulating Nox4 expression to prevent myofibroblast activation during PF.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 6","pages":"1845-1863"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Traditional Chinese Medicine in Alzheimer's Disease Treatment: A Focus on the Wnt/[Formula: see text]-Catenin Pathway. 中医药在阿尔茨海默病治疗中的应用：以Wnt/[方式：见正文]-Catenin通路为重点。

IF 5.5

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-08-01 DOI: 10.1142/S0192415X25500624

Chunmiao Ying, Yuxuan He, Yingshu Guo, Feiyan Fan, Boqiao Wang, Jing Gao, Yiwen Li, Yunke Zhang

{"title":"Application of Traditional Chinese Medicine in Alzheimer's Disease Treatment: A Focus on the Wnt/[Formula: see text]-Catenin Pathway.","authors":"Chunmiao Ying, Yuxuan He, Yingshu Guo, Feiyan Fan, Boqiao Wang, Jing Gao, Yiwen Li, Yunke Zhang","doi":"10.1142/S0192415X25500624","DOIUrl":"10.1142/S0192415X25500624","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily characterized by cognitive decline. Its etiology and pathogenesis are complex and multifactorial, with neurotoxicity induced by the abnormal aggregation of amyloid-beta (A[Formula: see text]) protein widely recognized as a central pathological hallmark. Current pharmacological treatments provide only limited symptomatic relief and are often associated with dose-dependent adverse effects. In contrast, Traditional Chinese Medicine (TCM) has garnered growing attention due to its distinctive therapeutic profile, and in particular, its multi-target and multi-pathway synergistic mechanisms. The Wnt/[Formula: see text]-catenin signaling pathway plays a crucial role in intracellular signal transduction and is closely associated with several key pathological processes involved in AD. This review provides a comprehensive analysis of the molecular interplay between the Wnt/[Formula: see text]-catenin signaling pathway and the pathogenesis of AD, as well as a specific focus on how natural compounds, herbal monomers, and classical TCM formulations modulate this pathway. Accumulating evidence suggests that TCM exerts neuroprotective effects by regulating Wnt/[Formula: see text]-catenin signaling to thereby suppress A[Formula: see text] deposition, preserve synaptic structure and tissue homeostasis, modulate cell proliferation and apoptosis, and maintain metabolic and redox homeostasis. Additionally, the review discusses key challenges, such as improving blood-brain barrier permeability and enhancing bioavailability, and outlines future directions involving advanced delivery systems and optimized administration routes. These insights provide a robust scientific foundation for the development of Wnt/[Formula: see text]-catenin-targeted therapies and highlight the potential of TCM in the clinical treatment of AD.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1641-1683"},"PeriodicalIF":5.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticancer Potential of [Formula: see text]-Sitosterol: A Comprehensive Exploration of Mechanisms and Therapeutic Prospects. [配方：见正文]-谷甾醇的抗癌潜力：机制和治疗前景的综合探索。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-06-17 DOI: 10.1142/S0192415X2550048X

Yuzhe Zhang, Chunjiao Yang, Junhan Guo, Lirong Yan, Yanke Li, Ye Zhang

{"title":"Anticancer Potential of [Formula: see text]-Sitosterol: A Comprehensive Exploration of Mechanisms and Therapeutic Prospects.","authors":"Yuzhe Zhang, Chunjiao Yang, Junhan Guo, Lirong Yan, Yanke Li, Ye Zhang","doi":"10.1142/S0192415X2550048X","DOIUrl":"https://doi.org/10.1142/S0192415X2550048X","url":null,"abstract":"This paper comprehensively examines the anticancer mechanisms and therapeutic potential of β-sitosterol, a naturally occurring phytosterol found in various plants. β-Sitosterol has shown significant efficacy in inhibiting tumor growth and metastasis through various biological pathways, including inducing apoptosis, arresting cell cycle progression, and suppressing cell proliferation, invasion, and migration. We highlight the key mechanisms by which β-sitosterol exerts its effects, such as modulating apoptosis-related signaling pathways like those of the Bcl-2 family proteins and reactive oxygen species production. Furthermore, β-sitosterol's role in disrupting the epithelial-mesenchymal transition and its impact on tumor metabolism, particularly in cholesterol and glucose regulation, are discussed. The article also explores the potential of β-sitosterol to enhance chemotherapy sensitivity, making it a promising adjunct in cancer treatment. Additionally, we incorporate a bibliometric analysis and network pharmacology approach to identify potential therapeutic targets and pathways influenced by β-sitosterol, providing new insights into its multifaceted anticancer activities. These findings underscore the potential of β-sitosterol as a novel anticancer agent, warranting further research and clinical investigation to optimize its future therapeutic application.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 4","pages":"1241-1263"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total Saponins of Panax notoginseng Leaves Alleviate Vascular Dementia via the Gut-Brain Axis. 三七叶总皂苷通过肠脑轴缓解血管性痴呆。

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X25500430

Yu Ren, Yi Sun, Lan Sun, Jin-Ling Chen, Yu-Han Chen, Shi-Yu Yan, Ling Cheng, Jia-Li Yuan, Xiao-Ya Li

{"title":"Total Saponins of Panax notoginseng Leaves Alleviate Vascular Dementia via the Gut-Brain Axis.","authors":"Yu Ren, Yi Sun, Lan Sun, Jin-Ling Chen, Yu-Han Chen, Shi-Yu Yan, Ling Cheng, Jia-Li Yuan, Xiao-Ya Li","doi":"10.1142/S0192415X25500430","DOIUrl":"https://doi.org/10.1142/S0192415X25500430","url":null,"abstract":"Vascular dementia (VD) is the second most common type of dementia after Alzheimer's disease (AD), and chronic cerebral hypoperfusion (CCH) is the main causative factor of VD. Previous reports have confirmed that there is a relationship between VD and gut microbiota, and that some plant-based foods can improve VD through the gut-brain axis (GBA). Panax notoginseng leaves are a specialty food in Yunnan, China, and saponin is its main bioactive component. In this study, we investigated the effects of the total saponins of Panax notoginseng leaves (TSPNL) on CCH-induced VD and their potential mechanisms. In this experiment, the model was replicated using bilateral common carotid artery occlusion (BCCAO) and divided into Sham, Model, TSPNL-L, TSPNL-H and Positive drug control. At the end of the treatment, behavior, brain-derived neurotrophic factor (BDNF), hypothalamic-pituitary-adrenal (HPA) axis-related indices, neuronal apoptosis-related indices, gut microbiota composition, and colon and brain pathology were tested. The results showed that TSPNL attenuated CCH-induced VD, promoted BDNF synthesis, and inhibited neuronal apoptosis. Predictions of network pharmacology and experiments demonstrated that these beneficial effects are mediated in part through BDNF-TrKB-PI3K/Akt signaling. In addition, TSPNL prevented intestinal dysbiosis by increasing the abundance of the probiotic Ligilactobacillus and decreasing the abundance of the deleterious bacterium Clostridia_ UCG_014_unclassified relative to the model group. TSPNL was also able to partially reverse intestinal barrier disruption and inhibit intestinal inflammation and the hyperactivation of the HPA axis. The results of this study support the conclusion that TSPNL has potential in the prevention of CCH-induced VD and warrants further investigation.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 4","pages":"1155-1179"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1-NRF2 Pathway. 天然产物在慢性疾病治疗中的作用：调控KEAP1-NRF2通路的作用

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1142/S0192415X25500041

Yaling Li, Xijia Wang, Shuyue Li, Lei Wang, Ningning Ding, Yali She, Changtian Li

{"title":"Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1-NRF2 Pathway.","authors":"Yaling Li, Xijia Wang, Shuyue Li, Lei Wang, Ningning Ding, Yali She, Changtian Li","doi":"10.1142/S0192415X25500041","DOIUrl":"10.1142/S0192415X25500041","url":null,"abstract":"Oxidative stress represents a pivotal mechanism in the pathogenesis of numerous chronic diseases. The Kelch-like ECH-associated protein 1-transcription factor NF-E2 p45-related factor 2 (KEAP1-NRF2) pathway plays a crucial role in maintaining redox homeostasis and regulating a multitude of biological processes such as inflammation, protein homeostasis, and metabolic homeostasis. In this paper, we present the findings of recent studies on the KEAP1-NRF2 pathway, which have revealed that it is aberrantly regulated and induces oxidative stress injury in a variety of diseases such as neurodegenerative diseases, cardiovascular diseases, metabolic diseases, respiratory diseases, digestive diseases, and cancer. Given this evidence, targeting KEAP1-NRF2 represents a highly promising avenue for developing therapeutic strategies for chronic diseases, and thus the development of appropriate therapeutic strategies based on the targeting of the NRF2 pathway has emerged as a significant area of research interest. This paper highlights an overview of current strategies to modulate KEAP1-NRF2, as well as recent advances in the use of natural compounds and traditional Chinese medicine, with a view to providing meaningful guidelines for drug discovery and development targeting KEAP1-NRF2. Additionally, it discusses the challenges associated with harnessing NRF2 as a therapeutic target.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"67-96"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Pharmacological Research on Icaritin: A Comprehensive Review. 淫羊藿苷药理研究进展综述。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1142/S0192415X25500089

Ran Guo, Zhiping Yan, Rui Wang, Tongxuan Guo, Hao Li, Minyu Kong, Wenzhi Guo

{"title":"Advances in Pharmacological Research on Icaritin: A Comprehensive Review.","authors":"Ran Guo, Zhiping Yan, Rui Wang, Tongxuan Guo, Hao Li, Minyu Kong, Wenzhi Guo","doi":"10.1142/S0192415X25500089","DOIUrl":"10.1142/S0192415X25500089","url":null,"abstract":"Epimedium has been widely used in traditional Chinese medicine for several thousands of years. This plant is known for tonifying kidney Yang, strengthening muscles and bones, and dispelling wind and dampness. It is worth noting that icaritin, a prenylated flavonoid isolated from Epimedium, has received increasing attention in recent years due to its wide range of pharmacological activities. Icaritin exhibits significant therapeutic potential against various diseases, such as osteoporosis, tumors (hepatocellular carcinoma, stomach cancer, breast cancer, and glioblastoma), cerebral ischemia skin injury, thrombocytopenia, and systemic lupus erythematosus. We review the pharmacological activities of icaritin and its potential molecular mechanisms for the treatment of related diseases. The data suggest that icaritin can have the pharmacological effects of mediating Wnt/[Formula: see text]-catenin, IL-6/JAK2/STAT3, AMPK/mTOR, PTEN/AKT, MAPK, NF-[Formula: see text]B, and other signaling pathways. This paper also discusses the progress of clinical trials of icaritin. Icaritin was approved by the State Food and Drug Administration in January 2022 for the treatment of advanced HCC, and has various clinical drug prospects. Although it has some disadvantages, including poor solubility, and low bioavailability, icaritin is still a prospective candidate for the development of naturally derived drugs, especially in the treatment of tumors and inflammatory diseases. This review aims to update and deepen the understanding of icaritin, and provide a theoretical basis for its further study.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"179-203"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rg2 Alleviates HFD/STZ-Induced Diabetic Nephropathy by Inhibiting Pyroptosis via NF-κB/NLRP3 Signaling Pathways. 人参皂苷Rg2通过NF-κB/NLRP3信号通路抑制焦亡减轻HFD/ stz诱导的糖尿病肾病

The American journal of Chinese medicine Pub Date : 2025-01-01 DOI: 10.1142/S0192415X2550034X

Ke Li, Ya-Jun Wang, Kun Wei, Wen-Lin Li, Yong-Bo Liu, Jun-Nan Hu, Wen-Guang Chang, Wen-Xuan Zhang, Long Chen, Wei Li

{"title":"Ginsenoside Rg2 Alleviates HFD/STZ-Induced Diabetic Nephropathy by Inhibiting Pyroptosis via NF-κB/NLRP3 Signaling Pathways.","authors":"Ke Li, Ya-Jun Wang, Kun Wei, Wen-Lin Li, Yong-Bo Liu, Jun-Nan Hu, Wen-Guang Chang, Wen-Xuan Zhang, Long Chen, Wei Li","doi":"10.1142/S0192415X2550034X","DOIUrl":"https://doi.org/10.1142/S0192415X2550034X","url":null,"abstract":"Diabetes mellitus (DM) is considered to be the most widespread epidemic worldwide, and diabetic nephropathy (DN) is one of the most serious diabetic complications. Its complex pathogenesis makes treatment of DN an ongoing medical challenge. Ginseng (Panax ginseng. C. A Meyer) is a valuable medicinal herb with a long medicinal and culinary history. Ginsenoside Rg2 (Rg2), an important active component in ginseng, has effective inhibitory effects on lipogenesis and hepatic glucose production. However, the potential effect and mechanism of Rg2 on DN remain unclear. In this study, we investigated the effect of Rg2 on DN in high fat diet/streptozotocin (HFD/STZ)-induced type 2 diabetic mice and high glucose (HG)-induced human kidney 2 (HK-2) cells. The results demonstrated that Rg2 significantly improved the levels of FBG, dyslipidemia and impaired kidney function in DN mice. Additionally, Rg2 decreased the phosphorylation levels of IKKβ, IκBα, and NF-κB p65, inhibited the activation of NLRP3 inflammasomes (NLRP3, ASC, and Caspase 1), and restrained release of inflammatory factors (IL-18 and IL-1[Formula: see text]. In HG-induced HK-2 cells, Rg2 showed similar inhibitory effects on pyroptosis via NF-κB/NLRP3 signaling pathways. Moreover, the effect of Rg2 on inhibiting the activation of NF-κB/NLRP3 signaling pathways may have a relationship to reducing the overproduction of reactive oxygen species (ROS), which is further supported by the ROS inhibitor N-acetylcysteine (NAC). In conclusion, our findings clearly indicated that Rg2 could prevent the progress of DN by inhibiting the activation of pyroptosis-related NF-κB/NLRP3 signaling pathways in vivo and in vitro, suggesting that Rg2 may be a novel and promising therapeutic agent in the treatment of DN.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 3","pages":"909-930"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chinese Medicine for Non-Alcoholic Fatty Liver Disease: Targeting Key Signaling Pathways. 中医药治疗非酒精性脂肪肝：针对关键信号通路

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-18 DOI: 10.1142/S0192415X25500533

Shihao Zheng, Xinyue Shi, Chengyuan Xue, Qiuyue Wang, Wenying Qi, Xiaoke Li, Hongbo Du, Size Li, Xiaobin Zao, Peng Zhang, Yongan Ye

{"title":"Chinese Medicine for Non-Alcoholic Fatty Liver Disease: Targeting Key Signaling Pathways.","authors":"Shihao Zheng, Xinyue Shi, Chengyuan Xue, Qiuyue Wang, Wenying Qi, Xiaoke Li, Hongbo Du, Size Li, Xiaobin Zao, Peng Zhang, Yongan Ye","doi":"10.1142/S0192415X25500533","DOIUrl":"https://doi.org/10.1142/S0192415X25500533","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatocellular injury, inflammation and fibrosis, which result from the accumulation of hepatic lipids. As one of the most prevalent chronic liver diseases globally, its pathogenesis remains complex. With the improvement in living standards, the incidence of NAFLD is expected to rise, drawing increasing attention to its development, prevention, and treatment from researchers worldwide. Currently, the therapeutic progress achieved by Western medicine in treating NAFLD remains limited, and its clinical efficacy is unsatisfactory. In contrast, Chinese medicine has a long history in the treatment of NAFLD, and possesses such advantages as fewer side effects, and multi-component, multi-target, and multi-pathway therapeutic actions. In recent years, several studies have demonstrated that Chinese medicine can modulate the progression of NAFLD by regulating relevant signaling pathways both in vivo and in vitro. However, comprehensive reviews on this topic remain scarce. Therefore, in this paper, a literature search was conducted using PubMed and Web of Science to summarize key signaling pathways implicated in Chinese medicine-mediated interventions in NAFLD, including AMPK, mTOR, PI3K/Akt, Toll-like receptor, NF-[Formula: see text]B, and MAPK pathways. Furthermore, the specific anti-NAFLD mechanisms of these pathways were elaborated. The objective of this paper is to provide an overview of the effective therapeutic pathways and mechanisms associated with Chinese medicine in the treatment of NAFLD, and to thereby offer a theoretical foundation and innovative perspectives for future research and clinical applications.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 5","pages":"1379-1410"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnomedicine, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Rhizoma Corydalis: A Systematic Review. 杨连的民族医学、植物学、植物化学、药理学、药代动力学和毒性研究综述。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-18 DOI: 10.1142/S0192415X25500557

Xu Wu, Shiyuan Tang, Xiaohui Bian, Zihan Ma, Xinyi Zhang, Zhangli Jiang, Hui Zhang, Heshui Yu, Zhiying Dou

{"title":"Ethnomedicine, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Rhizoma Corydalis: A Systematic Review.","authors":"Xu Wu, Shiyuan Tang, Xiaohui Bian, Zihan Ma, Xinyi Zhang, Zhangli Jiang, Hui Zhang, Heshui Yu, Zhiying Dou","doi":"10.1142/S0192415X25500557","DOIUrl":"https://doi.org/10.1142/S0192415X25500557","url":null,"abstract":"Rhizoma Corydalis (RC) is a traditional Chinese herbal medicine (TCM) known as Yan Hu Suo or Yuan Hu in China. This plant is a limited resource distributed in Zhe Jiang, Shaan Xi, Jiang Su, and other places of China. The aim of this paper is to provide a systematic review on the traditional uses, botany, phytochemistry, pharmacology, and pharmacokinetics of this plant. Furthermore, the potential development and perspectives for upcoming research on RC are also discussed. At present, over 160 compounds have been isolated and identified from RC, including alkaloids, anthraquinone, amino acids, organic acids, essential oils and microelements. RC was demonstrated to possess wide-reaching pharmacological properties, including effects on the nervous system, cardiovascular system, analgesic properties, sedative and anti-epileptic effects, antidepressive and anti-anxiety effects, antimyocardial ischemia/reperfusion (MIR) injury activities, anticerebral ischemia/reperfusion (CIR) injury activities, gastro-protective effects, and anticancer effects. In TCM clinical treatments, Angelicae Sinensis Radix, Myrrha, Cinnamomi Ramulus, and Paeoniae Radix Rubra were compatible with RC and frequently used to treat chest pain, lumbago, and abdominal pain. However, further research elucidating the signaling pathways between chemical compounds and targets in order to better understand the mechanism by which RC might be treated, and to optimize for quality control in processing products of RC is necessary.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":"53 5","pages":"1441-1476"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mast Cells in Acupoint Sensitization: Mechanisms and Research Advances. 肥大细胞在穴位致敏中的作用机制及研究进展。

The American journal of Chinese medicine Pub Date : 2025-01-01 Epub Date: 2025-07-08 DOI: 10.1142/S0192415X25500491

Ran Li, Miao Liu, Yueming Lv, Fujie Jing

{"title":"Mast Cells in Acupoint Sensitization: Mechanisms and Research Advances.","authors":"Ran Li, Miao Liu, Yueming Lv, Fujie Jing","doi":"10.1142/S0192415X25500491","DOIUrl":"10.1142/S0192415X25500491","url":null,"abstract":"Acupoint sensitization is characterized by a dynamic transition from a \"resting state\" to an \"activated state\". Research in this area holds significant implications not only for clinical acupoint selection but also for disease diagnosis. However, the biological mechanisms and material basis underlying this process require further investigation. In recent years, mast cells have been recognized as a key cellular foundation and an objective indicator of acupoint sensitization. When mechanical signals are transmitted to the subcutaneous tissue, mast cell aggregation and degranulation are induced. This leads to subsequent effects on the surrounding tissues, including blood vessels, muscles, and nerve endings, and thereby mediates the acupuncture effect. Evidence suggests that mast cells not only initiate acupuncture effects but also, through their released substances, reflect the dynamic and functional characteristics of acupoint sensitization. These cells also contribute to both central and peripheral sensitization processes. Despite recent advancements, several challenges remain in the study of acupoint sensitization, including the lack of dynamic monitoring methods, inconsistent indicators for measuring sensitization intensity, and an uncertainty regarding the potential of neurotransmitter-independent sensitization processes. This study provides an overview of mast cells and their role in the mechanism of acupoint sensitization, thereby aiming to establish a comprehensive network linking the central and peripheral systems to the neuroendocrine-immune system. The study aims to offer insights that will facilitate further exploration of the biological significance of acupoint sensitization and promote more in-depth research.","PeriodicalId":94221,"journal":{"name":"The American journal of Chinese medicine","volume":" ","pages":"1265-1284"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0