Stomatologija最新文献

Multinucleated giant cells: Do they have an impact on prognosis and overall survival in oral squamous cell carcinoma? 多核巨细胞：它们对口腔鳞状细胞癌的预后和总体生存有影响吗？

Stomatologija Pub Date : 2026-01-01

Kuldeep Singh, Priya Kumar, Aadithya B Urs

{"title":"Multinucleated giant cells: Do they have an impact on prognosis and overall survival in oral squamous cell carcinoma?","authors":"Kuldeep Singh, Priya Kumar, Aadithya B Urs","doi":"","DOIUrl":"","url":null,"abstract":"Background: Multinucleated Giant Cells (MGCs) are akin to immune cells that play a crucial role in the tumor microenvironment. MGCs have been shown to have both tumor-promoting and tumor-suppressing effects. This study explores the role of MGCs in OSCC and their prognostic value.Material and methods: 100 proven cases of OSCC were retrieved with complete clinicopathological data. Haematoxylin-eosin sections were reviewed independently by three pathologists and grouped into two, with and without MGCs. The distribution, and average number of MGCs per 5 high-power fields per case were examined. All clinicopathological parameters and prognosis based on Bryne's grading were compared between groups. The overall survival with follow-up period of >36 months was analysed.Results: 34 cases with MGCs were found, out of which 21 patients are alive. Cases with MGCs had pTNM stage III whereas majority of cases without MGC's had stage IV. Signifi cant correlation was found for lympho-vascular invasion only. Cases with MGC's showed good prognostic score according to Bryne's grading, while without MGC's showed moderate to poor prognostic score. Cases of alveolar mucosa, including gingiva and ridge SCC with MGCs, showed poor survival.Conclusions: This study highlights the potential role of MGCs in OSCC, suggesting an association with earlier tumor stages and favorable prognostic scores. Further research is needed to assess their prognostic and therapeutic relevance.","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"28 2","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The management dilemma of alveolar bone fracture: Case report and narrative review. 牙槽骨骨折的治疗困境：个案报告及叙述回顾。

Stomatologija Pub Date : 2026-01-01

Oumayma El Yacoubi, Akram Belmehdi, Bassima Chami

{"title":"The management dilemma of alveolar bone fracture: Case report and narrative review.","authors":"Oumayma El Yacoubi, Akram Belmehdi, Bassima Chami","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Alveolar process fracture is a common injury in dental practice that has a signifi cant impact on patient's aesthetics and functionality, necessitating prompt and appropriate management. The purpose of this article is to present a clinical case of a comminuted alveolar fracture managed through open reduction and fi xation using a wire composite splint. Additionally, it will provide a narrative review of the different treatment options for alveolar bone fractures, discussing the controversies and challenges in their management. This comparative analysis of therapeutic approaches aims to identify best practices to optimize clinical outcomes for patients with this injury.Case report: The clinical case involves a 25-year-old patient with a dentoalveolar fracture extending from the 33 to 44, caused by a workplace accident and treated with open reduction and wire splint placement.Discussion: The initial management of bone fracture based on reduction and fi xation of the fractured segment plays a critical role in determining the ultimate outcome. Various techniques have been documented in current literature, and selecting the right technique is determined by a clinical assessment and a comprehensive evaluation of the unique aspects of each clinical case.Conclusion: It is essential for healthcare professionals to closely monitor the evolution of clinical guidelines and research studies in this fi eld in order to provide patients with adapted treatment.","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"28 2","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The formation of epithelial orbital cysts secondary to orbital implants and reconstruction with computer-assisted manufactured patient-specific implant: A two-part case series. 眼眶植入物继发上皮性眼眶囊肿的形成和计算机辅助制造的患者特异性植入物的重建：两部分病例系列。

Stomatologija Pub Date : 2026-01-01

Fiona L Guan, Paul Hankinson, Sachin M Salvi, Nicholas J Lee

引用次数: 0

Focal reactive gingival overgrowth: Diagnosis, histopathological evaluation and management. 局灶性反应性牙龈过度生长：诊断、组织病理学评估和处理。

Stomatologija Pub Date : 2026-01-01

Meenu Taneja Bhasin, Karuna Joshi, Gunjan Gupta, C S Baiju, Shefali Malik, Sunny Mavi

引用次数: 0

Diagnosis of secretory carcinoma of the upper lip: A rare case report and literature review. 上唇分泌性癌的诊断：罕见病例报告及文献复习。

Stomatologija Pub Date : 2026-01-01

Caroline Alfaia-Silva, Túlio Silva Rosa, Paulo Victor Mendes Penafort, Larissa Tinô de Carvalho Silva, Amanda Almeida Leite, Renata Andrada Tenório Almeida Silva, Catarina Rodrigues Rosa Oliveira, Sonia Maria Soares Ferreira, Ricardo Luiz Cavalcanti Albuquerque-Júnior

{"title":"Diagnosis of secretory carcinoma of the upper lip: A rare case report and literature review.","authors":"Caroline Alfaia-Silva, Túlio Silva Rosa, Paulo Victor Mendes Penafort, Larissa Tinô de Carvalho Silva, Amanda Almeida Leite, Renata Andrada Tenório Almeida Silva, Catarina Rodrigues Rosa Oliveira, Sonia Maria Soares Ferreira, Ricardo Luiz Cavalcanti Albuquerque-Júnior","doi":"","DOIUrl":"","url":null,"abstract":"Secretory carcinoma (SC) is a rare malignant neoplasm of the salivary glands, first recognized in 2010 due to its resemblance to secretory breast carcinoma. Although classified as a low-grade tumor with generally favorable outcomes, some cases may exhibit high-grade features, including lymph node metastasis and aggressive histological architecture. The defining characteristic of SC is the ETV6-NTRK3 gene fusion; however, diagnosis can also rely on histopathological and immunohistochemical criteria when this fusion is absent. SC typically requires complete surgical excision with negative margins, with adjuvant radiotherapy considered in selected cases. Occurrence of SC in the upper lip is extremely rare, particularly in female patients, making accurate diagnosis essential. A 50-year-old woman with a history of sinusitis, arthritis, hypercholesterolemia, and thyroid nodules presented with a slow-growing, painless nodule on the upper labial mucosa. Clinically, the lesion resembled a benign mucocele. Histopathological analysis revealed a fibrous capsule surrounding proliferating cells with eosinophilic cytoplasm and a predominantly microcystic pattern with some papillary features. Immunohistochemistry confirmed SC, with strong positivity for CK7, S100, and mammaglobin, and negativity for CK14 and p63. Complete surgical excision was performed, and no residual tumor was found. Follow-up over nine months showed no recurrence. This case highlights the importance of recognizing SC in atypical locations, such as the upper lip. Given its clinical similarity to benign conditions like mucocele, thorough histopathological and immunohistochemical analyses are crucial. Early identification and complete excision are key to achieving favorable outcomes.","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"28 1","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relation of gubernacular canal and permanent dentition by Nolla stage: Cone-beam computed tomography analysis. 颊根管与恒牙列的关系：锥束ct分析。

Stomatologija Pub Date : 2026-01-01

Ana Luisa Marques Bemquerer, Larissa Marques Bemquerer, Lucas Guimarães Abreu, Cláudia Borges Brasileiro

{"title":"Relation of gubernacular canal and permanent dentition by Nolla stage: Cone-beam computed tomography analysis.","authors":"Ana Luisa Marques Bemquerer, Larissa Marques Bemquerer, Lucas Guimarães Abreu, Cláudia Borges Brasileiro","doi":"","DOIUrl":"","url":null,"abstract":"Background: The aim of the study was to evaluate an association between the stages of permanent dentition development, based on Nolla stages, and the characteristics of the gubernacular canal (GC), and to investigate the correlation between eruption process failures and the GC.Material and methods: This observational, cross-sectional, and retrospective study analyzed tomographic scans from 164 patients, encompassing 244 included teeth. The teeth were categorized into ten and three stages according to Nolla stages and were evaluated the position of the GC relative to the dental follicle, the alignment of the GC relative to the tooth and the direction of the GC relative to the bone cortices. The teeth were also classifi ed as: normal impacted, normal non-impacted, delayed impacted, and delayed non-impacted.Results: Of the total sample, 162 exhibited GC (71.1%). Statistical signifi cance was noted when exploring the association between Nolla stage, categorized into ten and three stages, and the position of GC in relation to the follicle (p=0.023 and p=0.005, respectively). Furthermore, an association was identifi ed between teeth with delayed (Nolla stage equal to or greater than 8) and impacted eruption and the position of GC in relation to the follicle (p=0.004) showing a shifting of the canal's position as the root develops, from the occlusal position to other positions.Conclusions: The fi ndings of this study suggest that displacement of the GC from its typical occlusal position to other directions may be associated with tooth impaction or delayed eruption and highlight the potential of GC position as an early radiographic marker for eruption disturbances.","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"28 2","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of menopausal estrogen deficiency on dentin formation: A comparative analysis of mineralization front and predentin thickness in pre and postmenopausal women. 绝经期雌激素缺乏对牙本质形成的影响：绝经前和绝经后妇女牙本质矿化面和牙本质厚度的比较分析。

Stomatologija Pub Date : 2026-01-01

Andamuthu Yamunadevi, D B Nandini, Mandana Donogh, Praveen S Basandi, Manickam Selvamani, G S Madhushankari

{"title":"Effect of menopausal estrogen deficiency on dentin formation: A comparative analysis of mineralization front and predentin thickness in pre and postmenopausal women.","authors":"Andamuthu Yamunadevi, D B Nandini, Mandana Donogh, Praveen S Basandi, Manickam Selvamani, G S Madhushankari","doi":"","DOIUrl":"","url":null,"abstract":"Objective: The effects of menopausal estrogen deficiency on dentin and its uncalcified organic matrix, termed predentin, in humans have not been documented so far in the literature. Thus, the present study was conducted to study the effects of menopause on dentin by analyzing the mineralization front in predentin and measuring the predentin thickness in teeth of pre and post-menopausal women.Material and methods: 80 freshly extracted teeth, collected from pre and postmenopausal women (40 from each group), between 30-60 years of age group, were decalcified and predentin thickness was measured and compared at the cuspal tip, middle third and apical third. Age-wise inter and intragroup comparison was done to know the influence of aging on predentin thickness. Wider metadentin zone, indicative of delay in mineralization process was observed and analyzed by grading them. Unpaired 't' test was employed for the statistical analysis.Results: There was no difference in predentin thickness between pre and post-menopausal women at all three sites. With advancing age, the predentin thickness decreased in both the study groups. Within the same age range (41-50 years), the predentin thickness slightly increased in postmenopausal women than premenopausal women. The presence of metadentin zone was more frequent (p<0.001) in the postmenopausal women.Conclusions: Estrogen deficiency during menopause affects the dentin by causing delay in mineralization process and manifests as wider metadentin zone. Further studies on a larger scale including pre and postmenopausal women of 41-50 years are suggested for knowing the effect of menopause on predentin thickness.","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"28 1","pages":"10-16"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lag screw vs miniplate fixation in treatment of condylar neck fractures: A systematic review. 拉力螺钉与微型钢板固定治疗髁突颈骨折：系统回顾。

Stomatologija Pub Date : 2026-01-01

Augustinas Buškus, Jan Pavel Rokicki, Simas Steponaitis

{"title":"Lag screw vs miniplate fixation in treatment of condylar neck fractures: A systematic review.","authors":"Augustinas Buškus, Jan Pavel Rokicki, Simas Steponaitis","doi":"","DOIUrl":"","url":null,"abstract":"Background: Fractures of the mandibular condyle region, particularly high condylar neck and condylar process fractures can lead to tremendous functional and aesthetic impairments and are challenging to treat. A conservative approach is the treatment of choice in non-displaced cases. However, fractures with signifi cant displacement pose considerable diffi culty as they require surgical intervention. Various techniques, including lag screws and miniplates, are currently available. This review aimed to assess the usage patterns and outcomes of lag screw and miniplate fi xation techniques in cases of mandibular condyle region fractures.Material and methods: This review was conducted following the PRISMA guidelines. A comprehensive search of Science Direct, Springer Link and PubMed databases was performed, supplemented by a manual internet search. Keywords \"lag screw\", \"miniplate\", \"condylar fracture\", \"high condylar neck fracture\", \"fi xation\" were utilized. This review included human subject studies and in vitro studies published in the previous ten years.Results: A total of eight studies were included in the qualitative analysis. Four studies assessed miniplate fi xation while the other four examined fi xation with lag screws. Five out of six in vivo studies assessed mouth opening, healing of the surgical site, occlusion during follow-up, and patient satisfaction. All studies showed satisfactory results in functional restoration. In-vitro studies indicated that either two lag screws or two parallel plain plates provide adequate fi xation for high condylar neck fractures.Conclusion: Current clinical research biases lag screw usage more towards condylar process - high condylar neck fractures while miniplates are more commonly used in high condylar neck fractures. There is a severe lack of published studies regarding treatment outcomes of high condylar neck fractures.","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"28 2","pages":"35-39"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the prevention and management of bisphosphonate-related osteonecrosis of the jaw: A literature review. 预防和治疗双膦酸盐相关性颌骨骨坏死的研究进展：文献综述。

Stomatologija Pub Date : 2026-01-01

Benas Ilekis, Salma Varoneckaitė, Juozas Žilinskas

{"title":"Advances in the prevention and management of bisphosphonate-related osteonecrosis of the jaw: A literature review.","authors":"Benas Ilekis, Salma Varoneckaitė, Juozas Žilinskas","doi":"","DOIUrl":"","url":null,"abstract":"Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) emerges as a serious side effect of bisphosphonate treatment worldwide, significantly impairing patients' oral health and overall quality of life. Ongoing research shows emerging treatment modalities such as a combination of pentoxifylline and tocopherol, teriparatide, and platelet concentrates that enhances the prospects of BRONJ treatment. However, the need for more accurate and predictable treatment options still remains. The aim of this review is to summarize and ascertain the current prevention and treatment strategies of BRONJ.Materials and methods: A narrative literature review was conducted using the PubMed, Wiley Online Library, ScienceDirect, and Springer databases using the Medical Subject Headings (MeSH) terms including \"Osteonecrosis of the Jaw,\" \"Disphosphonates,\" \"Teriparatide,\" \"Platelet-Rich Plasma,\" and \"Pentoxifylline\". Inclusion criteria comprised clinical studies involving human subjects that evaluated prevention or treatment strategies for bisphosphonate-related osteonecrosis of the jaw. Randomized controlled trials, prospective and retrospective cohort studies, and clinical comparative studies published in English between 2015 and 2025. The literature search was conducted in January 2025.Results: Emerging prevention and treatment strategies, including teriparatide and the combination of pentoxifylline and tocopherol, show potential in improving clinical outcomes and reducing disease progression.Conclusions: Although emerging treatment methods show promising results, BRONJ continues to pose significant clinical challenges.","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"28 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of aligners with mandibular advancement in treatment of Class II malocclusions compared to conventional functional appliances: A systematic review. 与传统的功能矫治器相比，下颌前移矫正器治疗II类错颌的临床疗效：一项系统综述。

Stomatologija Pub Date : 2026-01-01

Deimantė Kuzminskaitė, Jurga Liatukienė, Juozas Žilinskas

{"title":"Clinical efficacy of aligners with mandibular advancement in treatment of Class II malocclusions compared to conventional functional appliances: A systematic review.","authors":"Deimantė Kuzminskaitė, Jurga Liatukienė, Juozas Žilinskas","doi":"","DOIUrl":"","url":null,"abstract":"Background and objectives: Clear aligners were initially limited to the treatment of mild malocclusions. Recent advancements have expanded their use to skeletal Class II correction through mandibular advancement features designed to mimic conventional functional appliances. However, evidence regarding their clinical effectiveness, particularly compared with traditional functional appliances, remains limited. The aim of this systematic review is to evaluate the clinical effectiveness of clear aligners with mandibular advancement in the management of Class II malocclusion, in comparison with conventional functional orthopedic appliances.Material and methods: The protocol of the systematic review is in line with the PRISMA requirements, papers published in English language between 2020 and 2025 were searched in PubMed, ScienceDirect, The Cochrane Library and Google Scholar databases using the PICO framework. The ROBINS-I tool was used to assess the risk of bias.Results: A total of 726 articles were identified. After eliminating duplicates and applying eligibility criteria, nine studies involving 412 patients were included, primarily using cephalometric analyses to evaluate skeletal and dental changes before and after treatment. Despite variability in the parameters assessed and methodologies used, both aligners with mandibular advancement and conventional functional appliances showed similar skeletal and dental correction. Consistent reductions in overbite and overjet, increases in SNB as well as decreases in ANB and Wits appraisal.Conclusion: Aligners with mandibular advancement appear to be an effective option for treating Class II malocclusions in growing patients, demonstrating similar dentoalveolar and skeletal effects to conventional functional appliances. However, methodological limitations and heterogeneity among studies restrict the strength of the evidence.","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"28 1","pages":"2-9"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0