Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia最新文献

{"title":"[Relevance of genetic polymorphisms in voriconazole neurotoxicity: case report in a pediatric patient].","authors":"Alicia Martín-Roldán, Alejandra Merino-Pardo, Esther Algarra-Sánchez, Margarita Cuervas-Mons Vendrell","doi":"10.37201/req/112.2024","DOIUrl":"10.37201/req/112.2024","url":null,"abstract":"","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"145-147"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Emergent presence of slow-growing microorganisms in urine cultures. Clinical and microbiological analysis].","authors":"Leticia Castellano-Sánchez, Antonio Rosales-Castillo, María Carmen Olvera-Porcel, José María Navarro-Marí, José Gutiérrez-Fernández","doi":"10.37201/req/101.2024","DOIUrl":"10.37201/req/101.2024","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence, clinical characteristics, and antibiotic susceptibility of the slow-growing microorganisms <i>Corynebacterium urealyticum, Corynebacterium glucuronolyticum, Lactobacillus delbrueckii</i>, and <i>Aerococcus</i> spp. in urine cultures are analyzed.</p><p><strong>Material and methods: </strong>Descriptive and retrospective cross-sectional study carried out in a Regional Hospital. Reports of clinical episodes with single isolation of the aforementioned microorganisms were selected between January 2016 and December 2023.</p><p><strong>Results: </strong>A total of 186 single-isolation episodes were included, corresponding to 0.44% of the total. The most frequently isolated species was <i>Aerococcus urinae</i>. Overall, the risk factors were the presence of an indwelling bladder catheter (24.73%), immunosuppression (24.19%), health care (35.48%), diabetes mellitus (19.89%), nephrourological disorders (31.18%) and previous antibiotherapy (35.48%). Urinary tract infections due to <i>Aerococcus</i> spp. predominated in elderly patients, with nephrourological disorders and a history of antibiotic therapy in the previous 3 months. <i>C. glucuronolyticum, C. urealyticum</i> and <i>L. delbrueckii</i> were associated with immunosuppression, healthcare contact and previous antibiotherapy. <i>C. urealyticum</i> was also associated with the presence of an indwelling bladder catheter.</p><p><strong>Conclusions: </strong>Slow-growing opportunistic emerging microorganisms represent a small percentage of the aetiological agents in urinary tract infections, although of important and growing clinical interest given their pathogenic role in the presence of certain circumstances and risk factors, as well as the challenges they pose for laboratory diagnosis. It is essential to perform antibiograms for an adequate targeted treatment.</p>","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"75-83"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-COVID-19 tuberculosis in southeastern Spain: incidence, risk factors and the role of latent tuberculosis infection screening.","authors":"José Antonio Peregrina-Rivas, Daniel Fernández-Reyes, Adolfo de Salazar-González, Fernando García-García, Miguel Ángel Montero-Alonso, José Hernández-Quero, Emilio Guirao-Arrabal","doi":"10.37201/req/111.2024","DOIUrl":"10.37201/req/111.2024","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of coinfections and superinfections following SARS-CoV-2 pneumonia has garnered increasing attention, with complications arising from various pathogens, including viruses, bacteria, and fungi. Nevertheless, the relationship between COVID-19 and tuberculosis (TB) is not fully understood. This study investigates the incidence and risk factors for post-COVID-19 pulmonary TB in a low TB prevalence area in southeastern Spain, alongside the influence of COVID-19 on indeterminate results in the Quantiferon-TB Gold Plus (QFT-Plus) test and its prognostic role.</p><p><strong>Material and methods: </strong>A retrospective cohort study was conducted involving 475 hospitalized COVID-19 from March 2020 to March 2022, all of them with a QFT-Plus performed.</p><p><strong>Results: </strong>The study found three cases of pulmonary TB in the post-COVID-19 period, yielding an incidence density of 3.56 cases per 1000 patient-years, all associated with chronic systemic corticosteroid therapy. Notably, the percentage of indeterminate QFT-Plus results during COVID-19 was significantly higher than when it was performed before the disease (16.82% vs. 3.37%). Patients with indeterminate results exhibited elevated inflammatory markers and a greater need for invasive mechanical ventilation, correlating with more severe disease, although without statistical significance.</p><p><strong>Conclusions: </strong>The findings suggest that prolonged systemic corticosteroid therapy is a common risk factor for pulmonary TB development and that systematic LTBI screening may not be necessary for all COVID-19 patients unless prolonged corticosteroid treatment is foreseen. This study highlights the need for further research to clarify the relationship between COVID-19 and post-COVID-19 pulmonary TB, as well as the prognostic implications of QFT-Plus results.</p>","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"108-114"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Infective endocarditis caused by <i>Aggregatibacter actinomycetemcomitans</i>].","authors":"Catalina Jesús Ramírez-Estupiñán, Margarita Bolaños-Rivero, Michele Hernández-Cabrera, Isabel de Miguel Martínez","doi":"10.37201/req/109.2024","DOIUrl":"10.37201/req/109.2024","url":null,"abstract":"","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"142-144"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Distribution of diarrheagenic <i>Escherichia coli</i> pathotypes in the pediatric population and antibiotic susceptibility profile in the Valladolid Oeste health area (ASVAO)].","authors":"Yully Paulín Martínez-Oliveros, Laura Rita-Iotti, Belén Francisca Sánchez, José M Eiros, Mónica de Frutos","doi":"10.37201/req/092.2024","DOIUrl":"10.37201/req/092.2024","url":null,"abstract":"","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"129-132"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic absorption of liposomal inhaled amikacin in the treatment of resistant <i>Mycobacterium avium</i>: beyond expectations.","authors":"Belén Sánchez-Pascual, Juan Emilio Losa-García, Sira Sanz-Márquez, Irene Salvador-Llana, Ana Vegas-Serrano, Montserrat Pérez-Encinas","doi":"10.37201/req/115.2024","DOIUrl":"10.37201/req/115.2024","url":null,"abstract":"","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"148-151"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Suspected serotonergic syndrome associated with tedizolid: a case report].","authors":"Álvaro González-Gómez, Alfonso Peñaroya-Rodríguez, José Manuel Caro-Teller, Carmen García-Muñoz, María Del Carmen Moreno-de la Santa, José Miguel Ferrari-Piquero","doi":"10.37201/req/071.2024","DOIUrl":"10.37201/req/071.2024","url":null,"abstract":"","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"126-128"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline survey of doravirine resistance among pregnant women with HIV.","authors":"Javier Alejandro Sfalcin, Diego Cecchini, Ines Zapiola, Alan Gómez, Silvina Fernández-Giuliano, Claudia Rodríguez, Lilia Mammana, Analia Seravalle, Fabián Fay, María Belén-Bouzas","doi":"10.37201/req/107.2024","DOIUrl":"10.37201/req/107.2024","url":null,"abstract":"","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"139-141"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics of antimicrobial use in Primary Care in Spain: a nationwide study.","authors":"Héctor Sánchez-Herrero, Álvaro Solaz-García, Alejandro Pinilla-González, Elena Vanessa Martínez-Sánchez, Patricia Santágueda-Balader, María Cernada-Badía","doi":"10.37201/req/120.2024","DOIUrl":"10.37201/req/120.2024","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to describe antimicrobial use in primary care across Spain by analyzing the prescriptions dispensed in pharmacies. Antimicrobials were categorized into therapeutic action groups based on the ATC-2 classification: antibacterials (J01), antimycotics (J02), antimycobacterials (J04), and antivirals (J05). Additionally, the study explores epidemiological patterns of use.</p><p><strong>Methods: </strong>A retrospective observational study was conducted using data from the Primary Care Clinical Database (BDCAP) for 2023. The analysis focused on defined daily doses (DDD) per 1,000 persons/day (DHD), and the number of individuals with at least one antimicrobial prescription in primary care. Data were stratified by age, sex, municipality size, income level, country of birth, and employment status. Changes in prescriptions percentages in 2017 and 2023, as well as variations by age group and sex were compared.</p><p><strong>Results: </strong>An overall upward temporal trend in the antimicrobial DHD was observed from 2017 to 2023 (increase of 20.2%), with a decrease in usage during 2020 and 2021. Women exhibited higher DHD for antibacterials, antimycotics, and antivirals, whereas men demonstrated higher DHD for antimycobacterials. Notably, antimycobacterial agents had higher DHD in municipalities with populations exceeding 100,000 inhabitants and among foreign-born individuals. Out of 46,762,487 people assigned to primary care, 14,056,450 received prescribed antimicrobials in 2023.</p><p><strong>Conclusions: </strong>These findings indicate a rising trend in antimicrobial use in primary care, underscoring the need for targeted interventions to encourage the rational use of antimicrobials, particularly in high-use groups.</p>","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"115-125"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of the COVID-19 pneumonia in a group of hospitals from Madrid-Spain during the full period of the State of Alarm HM cohort.","authors":"José Barberán, María Ramos, Julio Villanueva, Paula Villares, Mercedes Villareal, María Vivas, Susana Orche, María Tejera-Gonzalez, Justo M Menéndez, Lenin Tolentino Hinojosa, Cristina Almirall, Leonor Antolin, Lady Martinez, Silvia Mendoza, Adrián Pelaez, María Segarra-Cañamares, José E Guerrero, Jesús Pelaez, Pablo Cardinal-Fernández","doi":"10.37201/req/110.2024","DOIUrl":"10.37201/req/110.2024","url":null,"abstract":"<p><strong>Introduction: </strong>To describe the epidemiology pattern of the COVID-19 pandemic during all Spanish State of Alarm.</p><p><strong>Methods: </strong>Retrospective, observational, cohort and multicenter study. Inclusion criteria: age ≥18 years old, admitted for COVID-19 pneumonia in any of the centers of the HM Hospitals Group. Exclusion criteria: voluntary discharge, death in the emergency department, transfer to centers outside the HM group or incomplete data. State of Alarm period: 31/01/2020 to 05/07/2023. Predominant COVID-19 variant was defined when it exceeded 50% of the total isolates.</p><p><strong>Results: </strong>During the study period, 2,992 patients were admitted due to a COVID-19 pneumonia, 295 patients (9.86%) non-survive. Survivors and non-survivors were different in age and comorbidities. However, both cohorts presented a similar net of interaction between comorbidities. Hospital admissions per week showed an evolution in \"peaks\" with \"troughs\". A total of 197 (6.48%) patients were admitted to the ICU, of whom 52 (26.39%) non-survive; this subgroup stood out for having a higher proportion of septic shock, orotracheal intubation and acute renal failure, as well as a lower proportion of pulmonary thromboembolism and delirium. Concerning the viral variants, the incidence for the original variant was 4.05 cases/day, for the alpha variant 3.82 cases/day, for the delta variant 1.16 cases/day and for the omicron variant 1.35 cases/day.</p><p><strong>Conclusion: </strong>Almost 1 of 10 patients with COVID-19 pneumonia death, a proportion that increased to 1 of 4 in case of being admitted to the ICU. Unexpectedly, interaction between comorbidities did not differ between survivors and non-survivors patients. Predominant variants were associated with different hospital admission rates but not influence the presence of peak-troughs evolution of the pandemic.</p>","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":"38 2","pages":"97-107"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}