Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia最新文献_第10页

[Defining new therapeutic scenarios for oritavancin: severe bacteremic Staphylococcus aureus skin and soft tissue infection in a severely immunocompromised oncology patient]. [确定oritavancin的新治疗方案：免疫功能严重受损的肿瘤患者的严重细菌性金黄色葡萄球菌皮肤和软组织感染]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-10-11 DOI: 10.37201/req/055.2023

J Moreno Izarra, A Brunst, J A Carmona Álvarez, F Aranda, J M Mártir Alario

引用次数: 0

[Bacterial coinfection in the critically-ill COVID-19 patient: incidence, impact and need for antimicrobial therapy]. [危重新冠肺炎患者的细菌合并感染：发病率、影响和抗菌治疗的需要]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-09-25 DOI: 10.37201/req/060.2023

P Vidal-Cortés, J Nieto Del Olmo, A I Tizón Varela, E Seoane Fernández, F Eiras Abalde, J Blanco Chapela, L Larrañaga Sigwald, D E Suárez Fernández, P Fernández Ugidos, L Del Río Carbajo

{"title":"[Bacterial coinfection in the critically-ill COVID-19 patient: incidence, impact and need for antimicrobial therapy].","authors":"P Vidal-Cortés, J Nieto Del Olmo, A I Tizón Varela, E Seoane Fernández, F Eiras Abalde, J Blanco Chapela, L Larrañaga Sigwald, D E Suárez Fernández, P Fernández Ugidos, L Del Río Carbajo","doi":"10.37201/req/060.2023","DOIUrl":"10.37201/req/060.2023","url":null,"abstract":"Objective: To assess the frequency of bacterial coinfection upon ICU admission in SARS-CoV-2 pneumonia patients, its microbiology, and impact on prognosis.The secondary objective was to identify risk factors for coinfection on admission.Methods: Retrospective study, including patients with SARS-CoV-2 pneumonia admitted to the ICU.We defined bacterial coinfection by respiratory symptoms, radiological data, positive and clinically significant microbiological results in samples obtained in the first 48 h of admission and/or a determination of procalcitonin ≥ 0.5 ng/mL in the first 48 h.We evaluated demographic variables, comorbidities, SARS-CoV-2 infection data, severity scores, treatments received, need for respiratory support and outcomes (ICU and hospital mortality).Results: A total of 182 patients were analyzed, 62 (34.1%) with bacterial coinfection.The most frequent microbiology was S. pneumoniae and M. pneumoniae. 96.1% of the patients received antibiotic therapy on admission, 98.9% corticosteroids, 27.5% tocilizumab, and 7.7% remdesivir.85.7% required invasive mechanical ventilation.The SOFA score (OR: 1.315, 95% CI1.116-1.548) and the delay in ICU admission (OR: 0.899, 95% CI 0.831-0.972) were related to the risk of coinfection. Bacterial coinfection increases the risk of death in hospital (OR 2.283; 95% CI 1.011.5.151; p=0.047).Conclusions: Bacterial coinfection is common in COVID patients admitted to the ICU and increases the risk of death. It is not possible to identify with certainty, at the time of admission, which patients do not benefit from antibiotic treatment.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"612-620"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Uveitis complicated by Scedosporium apiospermum sensu stricto: relevance of early diagnosis and its multidisciplinary management]. [严格意义上的尖端细孢子虫并发葡萄膜炎：早期诊断及其多学科治疗的相关性]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-10-02 DOI: 10.37201/req/064.2023

S Hernández Egido, B Benito-Pascual, P Hernández Calvo, L Vizuete-Rodríguez, O M Muñoz Clemente, M S Cuétara

引用次数: 0

[Skin infection by Bacillus licheniformis]. [地衣芽孢杆菌引起的皮肤感染]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-10-02 DOI: 10.37201/req/040.2023

L R Iotti, L Puente-Fuertes, M de Frutos, A Gonzalez-Lopez, J M Eiros

引用次数: 0

Wound infection caused by Pasteurella canis and Neisseria animaloris after a dog bite. 犬咬伤后由犬巴氏杆菌和动物奈瑟菌引起的伤口感染。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-09-29 DOI: 10.37201/req/035.2023

D Fernández Vecilla, C Aspichueta Vivanco, E Ugalde Zárraga, J L Díaz de Tuesta Del Arco

引用次数: 0

[Temporal evolution of antiretroviral therapy (2017-2021): analysis of treatment change and its economic impact]. [抗逆转录病毒疗法的时间演变（2017-2021）：治疗变化及其经济影响的分析]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-09-21 DOI: 10.37201/req/047.2023

E Herranz-Bayo, H Navarro-Aznárez, A Pinilla-Rello, C I Díaz-Calderón-Horcada

{"title":"[Temporal evolution of antiretroviral therapy (2017-2021): analysis of treatment change and its economic impact].","authors":"E Herranz-Bayo, H Navarro-Aznárez, A Pinilla-Rello, C I Díaz-Calderón-Horcada","doi":"10.37201/req/047.2023","DOIUrl":"10.37201/req/047.2023","url":null,"abstract":"Objective: To analyze the modifications of antiretroviral therapy (ART) and their economic impact on daily clinical practice.Methods: Observational, retrospective study of patients who started ART between 01/2017-12/2021 (follow-up until 12/2022). Variables collected: prescribed ART, duration, the reason for the change, and treatment costs.Results: A total of 280 patients initiated ART therapy. The median durability of 1st line was: 19.9 months in 2017 (95%CI 13.9-25.9), 12.2 months in 2018 (95%CI 4.7-19.7), 27.4 months in 2019 (95%CI 6.8-48.1) and the median was not reached for the years 2020 and 2021 (p<0.001). Triple therapy with protease inhibitors was changed in 63.8% (81/127) of cases, followed by integrase inhibitors 52.1% (159/305), while dual therapy (DTG/3TC) only in 8.3% (7/84). The main cause of discontinuation was simplification/optimization 47.5% (124/261), followed by adverse effects 21.8% (57/261), with 2017 being the only year where simplification/optimization was at the same level as adverse effects. The economic impact of ART changes resulted in an average cost reduction of 34.0€ [-391.4 to +431.4] per month per patient. The year 2019 stands out as the only year where these changes were associated with an increase in mean additional cost (23.4€ [-358.3 to +431.4]).Conclusions: Optimization/simplification accounts for almost half of the reasons for TAR change, with an economic impact that, despite the inflection point of 2019, each year manages to exceed the previous one, achieving a progressive cost reduction maintained over time.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"604-611"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comparative study of different methods of detection of Monkeypox: antigen versus PCR]. [猴痘不同检测方法的比较研究：抗原与聚合酶链式反应]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-10-06 DOI: 10.37201/req/057.2023

M García González, J A Pérez-García, E Culebras López, B Baza Caraciolo, E Orviz García, M Vera García, A Delgado-Iribarren García

引用次数: 0

[Evaluation of two phenotypic techniques and a commercial multiplex molecular panel for the detection of different carbapenemases]. [用于检测不同碳青霉烯酶的两种表型技术和商业多重分子组的评估]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-10-03 DOI: 10.37201/req/049.2023

N Hernando Parreño, A Sampere Martínez

{"title":"[Evaluation of two phenotypic techniques and a commercial multiplex molecular panel for the detection of different carbapenemases].","authors":"N Hernando Parreño, A Sampere Martínez","doi":"10.37201/req/049.2023","DOIUrl":"10.37201/req/049.2023","url":null,"abstract":"Objective: The prevalence of carbapenemase-producing Enterobacterales has increased in recent years and is considered an important public health problem.Methods: A total of 106 clinical samples were analyzed by different carbapenemase detection techniques: inhibition discs (ID), immunochromatographic test (ICT) and a genotypic method, comparing them with a multiplex RT-PCR as a reference method.Results: Overall, all 3 techniques exceeded 90% sensitivity, although with differences in the performance of some of them by carbapenemase type. DI had low specificity (62%) for OXA-48, while with TIC the sensitivity for NDM-type metallo-beta-lactamase (93%) was slightly lower than for OXA-48 (95%). The best results were obtained with the genotypic technique (100% overall performance).Conclusions: Despite the lower sensitivity of TICs (especially in NDM carbapenemases) compared to molecular techniques, with the modification of the protocol we managed to increase this sensitivity and, together with the lower price, simplicity and speed, it makes this technique a good screening option.","PeriodicalId":94198,"journal":{"name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","volume":" ","pages":"621-624"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prosthesis joint infection due to Clostridioides difficile and literature review]. [艰难梭菌引起的人工关节感染及文献综述]。

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-10-10 DOI: 10.37201/req/037.2023

S Astor Molero, N Vázquez-Temprano, P Camacho Zamora, X Sola Mallo, P Álvarez García, J C Rodríguez García

引用次数: 0

Is Mycobacterium shimoidei an under-recognized cause of tuberculosis-like disease? 岛分枝杆菌是一种未被充分认识的结核病样疾病的病因吗？

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Pub Date : 2023-12-01 Epub Date: 2023-10-02 DOI: 10.37201/req/054.2023

L Alonso Acero, I Quiles-Melero, M J Jaras-Hernández, C Toro

引用次数: 0