Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Diagnostic accuracy of thyroid/background ratio in distinguishing Graves' disease from subacute thyroiditis: A comparative study.","authors":"G Silov, F Bati, N Biçakçi, B Kirtiloğlu, M Yilmaz","doi":"10.1016/j.remnie.2025.500199","DOIUrl":"10.1016/j.remnie.2025.500199","url":null,"abstract":"<p><strong>Background and objective: </strong>Thyrotoxicosis is a common clinical condition in endocrinology, with Graves' disease (GD) and subacute thyroiditis (SAT) as its predominant causes. These disorders often share overlapping clinical and biochemical features, making differential diagnosis challenging. This study evaluates the diagnostic efficacy of the thyroid/background ratio (TBR) as a semiquantitative method for differentiating GD from SAT and compares multiple diagnostic parameters.</p><p><strong>Materials and methods: </strong>This was a retrospective analysis of 106 consecutive patients newly diagnosed with thyrotoxicosis. All participants underwent assessment of free tri-iodothyronine (fT3), free thyroxine (fT4), TSH, thyroid-stimulating immunoglobulin (TSI), Anti-TPO, Anti-Tg, CRP, erythrocyte sedimentation rate (ESR), 99mTc thyroid scintigraphy (TS), and ultrasonography (USG). TBR was calculated from TS. Each patient was followed for at least six months, with final diagnoses of GD or SAT made by an endocrinologist.</p><p><strong>Results: </strong>Sixty-eight and 38 patients were diagnosed with GD and SAT, respectively. The analysis of thyroid-associated laboratory markers and inflammatory indices revealed characteristic differences between GD and SAT. Multivariable logistic regression analysis revealed three independent predictors of SAT: diminished TSI (OR = 0.04; P = .039), reduced fT3/fT4 ratio (OR = 0.05, P = .019), and lower TBR (OR = 0.20, P = .001). TSI demonstrated high diagnostic accuracy area under the curve (AUC): 0.923, optimal cut-off: ≤1.05 IU/L, sensitivity: 100%, specificity: 85.9%). The TBR yielded the highest AUC (0.990) in distinguishing GD from SAT (cut-off: ≤3.6 IU/L, sensitivity: 97.4%, specificity: 98.5%). According to USG findings, the cases showed two different patterns as diffuse thyroiditis pattern (DTP) and nodular thyroiditis pattern (NTP). On USG a DTP was more frequent in GD group than in SAT group (80.9% vs. 55.3%, P = .007). In both GD and SAT, demographic and clinical findings were similar between patients with DTP and patients with NTP. However, symptom duration, TSI, fT3, fT3/fT4 ratio, anti-TPO, thyroid ROI and TBR levels were higher in GD patients with DTP or NTP than in SAT patients with DTP or NTP. In contrast, background ROI, ESR and CRP levels were lower. Among patients with DTP, a TBR cut-off value of ≤3.7 yielded a sensitivity of 95.2% and a specificity of 98.2% in distinguishing SAT from GD. In this cohort, TBR demonstrated superior diagnostic performance compared to TSI. The optimal TBR threshold for differentiating SAT from GD among patients with NTP was <2.3, exhibiting 100% sensitivity and 100% specificity. However, the diagnostic performance was not significantly different from that of TSI. A positive thyroglossal duct activity finding was present only in GD, in 45.5% of the patients.</p><p><strong>Conclusion: </strong>The fT3/fT4 ratio demonstrates limited efficacy as a diagnost","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500199"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of synchronous bilateral ciliary body adenocarcinoma on [¹⁸F]FDG PET/CT and [⁶⁸Ga]Ga-PSMA PET/CT.","authors":"N Aydinbelge Dizdar, E Tatci, O Ozmen","doi":"10.1016/j.remnie.2025.500181","DOIUrl":"10.1016/j.remnie.2025.500181","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500181"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioimmunoblastic T-Cell lymphoma involved thyroid on ¹⁸F-FDG PET/CT.","authors":"Y Li, X Zhang, Z-X He","doi":"10.1016/j.remnie.2025.500177","DOIUrl":"10.1016/j.remnie.2025.500177","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500177"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ^99mTc-HYNIC-PSMA-11, bone scan and post radioligand therapy images in mCRPC patients: A single center experience.","authors":"K Aryana, A Aghaee, E Askari, Y Fakhar, N Raeisi, M Mottaghi, M Emadzadeh, H Ghorbani, S Barashki","doi":"10.1016/j.remnie.2025.500157","DOIUrl":"10.1016/j.remnie.2025.500157","url":null,"abstract":"<p><strong>Background: </strong>Prostate-Specific Membrane Antigen is overexpressed in primary and metastatic prostate cancer tissues. While PSMA PET agents have gained their role in the prostate cancer guidelines, Technetium-based PSMA agents have left behind. Given the novelty of ^99mTc-HYNIC-PSMA-11, we conducted this study to compare its detection rate in tracing skeletal metastases in comparison to bone scans and also compared the number of metastatic lesions which showed PSMA uptake in the diagnostic scan with those detected in post-treatment scans after radioligand therapy (RLT) with ¹⁷⁷Lu-PSMA-617-617.</p><p><strong>Methods: </strong>Bone and ^99mTc-HYNIC-PSMA-11 scans with a maximum interval of 90 days were performed in thirty-nine patients with widespread bone metastases. If the PSMA scan was positive, patients were treated with ¹⁷⁷Lu-PSMA-617 and post treatment scan was also obtained. For negative PSMA results, ⁶⁸Ga-PSMA PET/CT was performed to compare its results with the bone scan. In patients with PSMA expression, detection of metastatic lesions in three consecutive whole-body scans in different regions were compared (^99mTc-HYNIC-PSMA-11 with bone and post treatment scans, separately).</p><p><strong>Results: </strong>37 (94.9%) showed adequate ^99mTc-HYNIC-PSMA-11 uptake in the metastatic regions. Compared to bone scan, ^99mTc-HYNIC-PSMA-11 showed additional lesions in 13 (35.1%) participants which were mostly located in the appendicular skeleton and pelvic bones. Inversely, the bone scan detected more lesions in 12 (32.4%) patients. Both scans in 12 (32.4%) patients showed the exact same results. Comparison between the ^99mTc-HYNIC-PSMA-11 scan and ¹⁷⁷Lu-PSMA-617 showed completely similar results in 29 (78.4%) patients; however, ¹⁷⁷Lu-PSMA-617 detected more lesions in eight (21.6%) participants.</p><p><strong>Conclusion: </strong>The ^99mTc-HYNIC-PSMA-11 scan demonstrates comparable results to bone scans in evaluating skeletal metastases in prostate cancer patients. It serves as a cost-effective modality for identifying suitable candidates for radioligand therapy, particularly beneficial in resource-limited countries.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500157"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staging in nasopharynx cancers prognostic value of volumetric parameters in [¹⁸F]FDG PET/CT imaging.","authors":"Ç Erol, Ö Şahin, G Kanyılmaz, S Erol","doi":"10.1016/j.remnie.2025.500160","DOIUrl":"10.1016/j.remnie.2025.500160","url":null,"abstract":"<p><strong>Objective: </strong>The aim of our study was to determine whether volumetric parameters measured from the primary lesion and metastatic lymph node (LN) using [¹⁸F]FDG PET/CT imaging affect prognosis and survival in nasopharyngeal cancer (NPC) patients.</p><p><strong>Material and methods: </strong>Our study included 62 patients diagnosed with NPC who underwent [¹⁸F]FDG PET/CT imaging for pre-treatment staging. SUVmax, SUVmean, MTV and TLG values were measured from the primary tumor and LN. Lymph node/primary tumor SUV ratio (NTR) was calculated. The relationships between volumetric parameters and overall survival (OS), locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS) and progression-free survival (PFS) were evaluated.</p><p><strong>Results: </strong>LN SUVmax and LN SUVmean values were significantly higher in patients with distant metastases (p = 0.002 and p = 0.016, respectively). NTR values were significantly higher in patients with distant metastases (p = 0.047). The ideal LN SUVmax and SUVmean cut-off values for predicting distant metastasis in patients with LN metastasis were 16.45 and 6.5, respectively. There was a statistically significant difference between the DMFSs of the two groups when the NTR cut-off value was 0.8 (p = 0.047). Multivariate analysis showed that LN SUVmax, LN SUVmean and NTR were associated with DMFS (P = 0.003, 0.05 and 0.014, respectively), while primary tumor TLG and MTV values were associated with LRRFS (P = 0.035 and 0.03, respectively).</p><p><strong>Conclusion: </strong>In conclusion, we believe that LN SUVmax, SUVmean and NTR may be prognostic indicators for distant metastasis, and MTV and TLG for locoregional recurrence.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500160"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive ductal carcinoma presented with bilateral breast superscan on [¹⁸F]FDG PET/CT.","authors":"Ahmed S Abdlkadir, Enrique Estrada-Lobato, Kamal Al-Rabi, Akram Al-Ibraheem","doi":"10.1016/j.remnie.2025.500163","DOIUrl":"10.1016/j.remnie.2025.500163","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500163"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse large B-cell lymphoma mimicking as Erdheim-Chester disease on ¹⁸F-FDG PET/CT.","authors":"L Yang, P Dong, L Li, M Su","doi":"10.1016/j.remnie.2025.500156","DOIUrl":"10.1016/j.remnie.2025.500156","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500156"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental detection of thyroid carcinoma and parathyroid adenoma with 18F-Fluorocholine PET/CT","authors":"G. Cuesta Domingo ,&nbsp;C. Rodríguez Rey ,&nbsp;A. Ortega Candil ,&nbsp;P. Nespral Torres ,&nbsp;S. Ochagavía Cámara ,&nbsp;M.N. Cabrera Martín","doi":"10.1016/j.remnie.2025.500136","DOIUrl":"10.1016/j.remnie.2025.500136","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 5","pages":"Article 500136"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse reactions mediated by ^99mTc-tetrofosmin: Literature review and analysis of post-marketing reports.","authors":"S Martins, S Costa, M Sousa, F Moreira, A Martín-Suaréz, Â Jesus","doi":"10.1016/j.remnie.2025.500166","DOIUrl":"10.1016/j.remnie.2025.500166","url":null,"abstract":"<p><strong>Introduction: </strong>^99mTc-tetrofosmin is a diagnostic radiopharmaceutical used to evaluate cardiac pathologies. Despite the lower incidence of reactions compared to other drugs, radiopharmaceuticals can still cause adverse reactions. For this reason, pharmacovigilance plays a crucial role in detecting, understanding, evaluating and preventing them.</p><p><strong>Objective: </strong>This study aims to review the available literature,on the safety of ^99mTc-tetrofosmin, and to analyze spontaneous adverse drug reaction reports from the European EudraVigilance database.</p><p><strong>Methods: </strong>A literature review was conducted according to PRISMA methodology. An analysis of spontaneous notifications was carried out in EudraVigilance, until 2022.</p><p><strong>Results: </strong>The review identified a selection of 7 articles. The most reported adverse reactions were skin irritation, strange taste in the mouth and nausea. Regarding the EudraVigilance analysis, 220 notifications were identified, accounting for 477 adverse reactions. The majority belong to males (51%), between 18-64 years (45%). Health professionals were the main reporters (84%). The most prevalent System Organ Class was \"general disorders and administration site conditions\" (21%) and the most reported adverse reaction was pruritus (10%). Approximately 67% of reactions were considered serious, with 6 fatal cases recorded.</p><p><strong>Conclusion: </strong>The results demonstrated that adverse reactions associated with ^99mTc-tetrofosmin do occur and should not be minimized. Over a period of 17 years, only 220 notifications were recorded, which may highlight potential challenges in pharmacovigilance for radiopharmaceuticals. Therefore, raising awareness about the importance of reporting adverse reactions is crucial.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500166"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striking pattern on [18F]FDG PET/CT in anti-NMDA receptor encephalitis","authors":"D.A. López-Mora ,&nbsp;L. Lozano Murgas ,&nbsp;M. Hervas Pujol ,&nbsp;A.A. Rodríguez Revuelto","doi":"10.1016/j.remnie.2025.500084","DOIUrl":"10.1016/j.remnie.2025.500084","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 5","pages":"Article 500084"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}