Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Metastatic retroperitoneal paraganglioma: Insights from somatostatin receptor versus FAPI imaging","authors":"M.H. Samadi , P. Sahafi , M. Ahmadi , A. Taghizadeh , A. Aghaee","doi":"10.1016/j.remnie.2025.500266","DOIUrl":"10.1016/j.remnie.2025.500266","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500266"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of visual assessment, centiloid quantification, and clinical follow-up in patients with suspected Alzheimer’s disease with [18F]Florbetaben PET imaging","authors":"J.A. Lojo-Ramírez ,&nbsp;C.A. Rodríguez-Vergara ,&nbsp;P. Fernández-Rodríguez ,&nbsp;M. Guerra-Gómez ,&nbsp;A.M. Marín Cabañas ,&nbsp;J.M. Jiménez-Hoyuela García ,&nbsp;E. Franco-Macías ,&nbsp;D. García-Solís","doi":"10.1016/j.remnie.2025.500274","DOIUrl":"10.1016/j.remnie.2025.500274","url":null,"abstract":"<div><h3>Objetive</h3><div>The detection of amyloid deposition has become a pivotal element in the diagnostic workup of Alzheimer's disease (AD). Among the available PET radiotracers, [¹⁸F]Florbetaben has proven to be a reliable tool for identifying amyloid-beta plaques, validated through both clinical assessments and histopathological correlation. This study aimed to assess the diagnostic accuracy and reliability of two key imaging methods: visual interpretation and semi-quantitative analysis using the Centiloid (CL) scale.</div></div><div><h3>Methods</h3><div>We included 208 patients who were attended at the outpatient Memory Clinic of a tertiary hospital, with mild cognitive impairment or mild dementia, suspected of AD. We performed receiver-operating-characteristic (ROC) analyses to compare the discriminative power of visual and quantification between AD and non-AD patients, characterized through the previously established standard of truth (SoT) as clinical follow-up.</div></div><div><h3>Results</h3><div>A total of 198 cases (95.0%) demonstrated concordance between both diagnostic methods (visual and CL-based quantification) and the SoT, with a weighted kappa coefficient k = 0.903 (<em>p</em> &lt; 0.001), indicating almost perfect agreement. When comparing visual diagnosis to the SoT, the sensitivity was 96.8%, specificity was 96.5%, and diagnostic accuracy was 96.6%. Both approaches exhibited excellent diagnostic performance, effectively correlating with the final clinical diagnoses.</div></div><div><h3>Conclusion</h3><div>Our findings highlight that both visual assessment and semi quantitative analysis are reliable tools for the detection and monitoring of amyloid deposition in AD, particularly for early diagnosis and disease progression tracking.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500274"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulocyte-colony stimulating factor-associated aortitis on 18F-FDG PET/CT","authors":"R. Jordà-Sánchez ,&nbsp;M. Ortiz-Fernández ,&nbsp;I.A. Hernández ,&nbsp;Á. Muxi ,&nbsp;S. Prieto-González","doi":"10.1016/j.remnie.2025.500256","DOIUrl":"10.1016/j.remnie.2025.500256","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500256"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the era of personalized dosimetry in hepatic radioembolization coming to an end?","authors":"J. Orcajo Rincón ,&nbsp;L. Reguera Berenguer ,&nbsp;A.M. Matilla Peña ,&nbsp;M. González Leyte ,&nbsp;J. Ardila Mantilla ,&nbsp;S. Salcedo Cortés ,&nbsp;V. Pérez Aradas ,&nbsp;J.C. Alonso Farto","doi":"10.1016/j.remnie.2026.500273","DOIUrl":"10.1016/j.remnie.2026.500273","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500273"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of absolute myocardial blood blow with a dedicated CZT cardiac gamma camera: Methods and potential pitfalls","authors":"A. Palomar-Muñoz ,&nbsp;A. Cardozo-Saavedra ,&nbsp;M.J. Díez-Castro ,&nbsp;M.C. López Arribas ,&nbsp;M.N. Pizzi ,&nbsp;A. Roque-Pérez ,&nbsp;S. Aguadé-Bruix ,&nbsp;D. Sánchez-Artuñedo ,&nbsp;C. Gámez-Cenzano","doi":"10.1016/j.remnie.2026.500271","DOIUrl":"10.1016/j.remnie.2026.500271","url":null,"abstract":"<div><div>Non-invasive techniques for the evaluation of myocardial perfusion provide key functional information for the diagnosis of coronary disease and the stratification of risk in ischemic cardiopathy. Nonetheless, despite their adequate diagnostic performance, the myocardial perfusion images present limitations in the detection of balanced ischemia due to multivessel disease and in the assessment of microvascular pathology. Evaluation of the parameters of myocardial blood flow (MBF) and myocardial flow reserve may be useful in cases in which the technique is limited due to balanced coronary disease or in patients with healthy coronary arteries and suspicion of microvascular involvement.</div><div>The greater spatial resolution and energy and greater sensitivity of the new generation cadmium-zinc-telluride gamma cameras compared to conventional equipment allow isotopic evaluation by single photon emission computed tomography of microvascular disease, which, previously, was mainly evaluated with the gold standard technique of positron emission tomography.</div><div>The aim of this article of collaboration is to describe the protocol for the quantification of MBF developed by the Department of Nuclear Medicine of the Hospital Vall d’Hebron using a cardio-dedicated gamma camera (MyoSPECT™- GE HealthCare), highlighting the particularities of the acquisition of post-processing of the images as well as the possible artifacts.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500271"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical presentation of angiosarcoma detected by 18F-FDG PET/CT as a solitary mediastinal lesion","authors":"N. Hou,&nbsp;H. Dai,&nbsp;R. Huang,&nbsp;M. Su","doi":"10.1016/j.remnie.2025.500275","DOIUrl":"10.1016/j.remnie.2025.500275","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500275"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-depth clinical and dosimetric analysis of 166Ho-radioembolization in patients with liver cancer: An observational study","authors":"R. Sá e Silva ,&nbsp;J. André Oliveira ,&nbsp;J. Santos ,&nbsp;R. Albergueiro ,&nbsp;P. Pereira ,&nbsp;L. Costa","doi":"10.1016/j.remnie.2025.500269","DOIUrl":"10.1016/j.remnie.2025.500269","url":null,"abstract":"<div><h3>Introduction</h3><div>Transarterial radioembolization (TARE) using holmium-166 (¹⁶⁶Ho) microspheres is a treatment for unresectable primary and secondary liver malignancies. The pre-therapeutic simulation procedure using a scout dose is critical to predict microsphere distribution and exclude extrahepatic leakage. This single-center observational study aimed to evaluate the dosimetric agreement between ¹⁶⁶Ho-scout and ¹⁶⁶Ho-therapy, and to correlate tumor-absorbed dose with treatment response at both tumor and patient levels.</div></div><div><h3>Methods</h3><div>Prospective, observational study included patients with BCLC 2022 stage A/B hepatocellular carcinoma or oligometastatic liver disease undergoing ¹⁶⁶Ho-TARE were included. Voxel-based dosimetry was performed using Q-suite. Contrast-enhanced CT was acquired 3 months post-treatment. Treatment response was assessed by RECIST/mRECIST criteria.</div></div><div><h3>Results</h3><div>Twenty patients underwent the pre-treatment procedure; 18 proceeded to therapy. No significant differences were observed between scout and therapy procedures in whole-liver (<em>P</em> <!-->=<!--> <!-->.331) and tumor doses (<em>P</em> <!-->=<!--> <!-->.063), indicating reliable pre-therapeutic evaluation. Fourteen patients with 16 treated lesions were included in the dose-response analysis (median volume: 22,1 [10,5–80,3]<!--> <!-->mL; dose: 22,1 [10,5–80,3]<!--> <!-->Gy). The objective tumor response rate at 3 months was 94%. However, no significant differences were found in absorbed dose metrics (<em>P</em> <!-->=<!--> <!-->.315) or dose-volume histogram values (D50, D70, D85) between responsive and non-responsive (NR) lesions. Patient-level analysis showed a 29% progression rate, with NR patients more likely to have secondary liver tumors (<em>P</em> <!-->=<!--> <!-->.011).</div></div><div><h3>Conclusion</h3><div>This study including a Portuguese cohort treated with ¹⁶⁶Ho-TARE showed a high tumor response rate. However, the limited sample size reduces the robustness of the conclusions. Further data from ongoing follow-up are awaited.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500269"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on quantitative assessment of renal tubular function based on renal dynamic imaging","authors":"W. Liu,&nbsp;G. Yao,&nbsp;Y. Gao,&nbsp;C. Wang","doi":"10.1016/j.remnie.2025.500268","DOIUrl":"10.1016/j.remnie.2025.500268","url":null,"abstract":"<div><h3>Objective</h3><div>To establish a renal tubular uptake rate (RTUR) model based on renal dynamic imaging (RDI) for detecting early tubular injury and to explore its clinical application value.</div></div><div><h3>Materials and methods</h3><div>RDI data collected from August 2020 to June 2025 were analyzed. A total of 292 eligible cases (441 kidneys) were included. Participants were categorized into: - Control group: 56 cases (112 kidneys) - Renal insufficiency group: 93 cases (186 kidneys) - Fully compensated group: 62 cases (62 kidneys) - Partially compensated group: 35 cases (35 kidneys) - Decompensated group: 46 cases (46 kidneys).</div></div><div><h3>RTUR calculation formula</h3><div>RTUR = (Ascent slope of renal scintigraphy/Total injected radioactive drug activity) × 10⁵ × 100%.</div></div><div><h3>Analysis content</h3><div>Distribution of RTUR values across five groups; correlation between GFR and RTUR in 441 kidneys. Differences in RTUR between the control group and other four groups; diagnostic efficacy and clinical value of RTUR.</div></div><div><h3>Results</h3><div>Compared with the control group, significant differences in RTUR were observed in the renal insufficiency group, fully compensated group, and decompensated group (<em>P</em> &lt; .01). GFR in 441 kidneys showed a strong positive correlation with RTUR (r = 0.739, <em>P</em> &lt; .001). ROC analysis indicated that RTUR ≤ 5.225% identified renal insufficiency (sensitivity 77.7%, specificity 70.4%), while RTUR ≥ 9.135% diagnosed complete renal compensation with 82.3% sensitivity.</div></div><div><h3>Conclusion</h3><div>The RTUR model enables stable quantitative assessment of renal tubular reabsorption rate, facilitating diagnosis of renal insufficiency and complete renal compensation. It holds promise as a novel quantitative indicator for evaluating tubular function. Renal GFR exhibits a strong correlation with RTUR.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500268"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between metabolic parameters and asphericity derived from 18F-FDG PET/CT and stage in small cell lung cancer","authors":"K. Şeker ,&nbsp;Ö. Ulaş ,&nbsp;Z. Hasbek","doi":"10.1016/j.remnie.2025.500276","DOIUrl":"10.1016/j.remnie.2025.500276","url":null,"abstract":"<div><h3>Purpose</h3><div>This study retrospectively evaluated the relationship between disease stage and metabolic parameters, along with asphericity, derived from ¹⁸F-FDG PET/CT images in patients with Small Cell Lung Cancer (SCLC).</div></div><div><h3>Methods</h3><div>We analyzed primary tumor metabolic parameters, including maximum and mean standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), as well as Asphericity (ASP). Disease staging was determined from ¹⁸F-FDG PET/CT images as either limited-stage (LS) or extensive-stage (ES). Statistical analyses assessed the correlation among these metabolic parameters and ASP, their relationship with disease stage, their ability to predict disease stage.</div></div><div><h3>Results</h3><div>The study included 134 SCLC patients (mean age: 62.3; 112 males, 22 females). Of these, 61.2% had ES and 38.8% had LS disease. MTV, TLG, and ASP values were significantly higher in the ES group than in the LS group (<em>p</em> &lt; 0.001). In the multivariate binary logistic regression analysis, Age (<em>p</em> = 0.025), Gender (<em>p</em> = 0.033), and ASP (<em>p</em> = 0.001) were identified as independent predictors of disease stage. Notably, a one-unit increase in ASP was associated with a 6.35-fold increase in the likelihood of Extensive-Stage disease (OR = 6.350). In ROC analysis, MTV, TLG, and ASP significantly distinguished disease stages (<em>p</em> &lt; 0.001) with optimal cut-off values of 45.05, 382.81, and 0.536, respectively.</div></div><div><h3>Conclusion</h3><div>Relying solely on SUVmax for SCLC patient evaluation may be insufficient. Incorporating other metabolic parameters like MTV and TLG, in addition to ASP, which was identified as a strong independent predictor, may enhance the understanding of tumor behavior during staging. These additional parameters can significantly aid in comprehensive patient assessment.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500276"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic salivary gland scintigraphy in rheumatoid arthritis: Association with disease activity.","authors":"A Jiang, Y Gao, Y Zhu, L Xu, H Huang","doi":"10.1016/j.remnie.2026.500313","DOIUrl":"10.1016/j.remnie.2026.500313","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate salivary gland function in patients with rheumatoid arthritis (RA) and to assess its association with disease activity and systemic inflammatory markers.</p><p><strong>Methods: </strong>In this retrospective study, 90 patients with RA and 50 age- and sex-matched healthy controls underwent ⁹⁹ᵐTcO₄^- dynamic planar salivary gland scintigraphy. No SPECT or CT acquisition was performed. Maximum accumulation rate (MAR) and maximum secretion rate (MSR) were calculated for the parotid and submandibular glands. Associations with DAS28-CRP, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and anti-cyclic citrullinated peptide antibodies (anti-CCP) were assessed using Spearman correlation analysis.</p><p><strong>Results: </strong>RA patients showed significantly lower MAR and MSR compared with healthy controls (both P < 0.001). Salivary gland function declined progressively with increasing disease activity. MAR and MSR were negatively correlated with CRP, ESR, RF, and anti-CCP levels.</p><p><strong>Conclusion: </strong>Salivary gland dysfunction is common in RA patients without Sjögren's syndrome and is associated with disease activity and systemic inflammation. Dynamic planar salivary gland scintigraphy provides a non-invasive quantitative method for evaluating glandular function in RA. Prospective studies are warranted to further define its clinical role.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500313"},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}