Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Imaging characteristics of an atypical spinal angiolipoma on PET/CT and MRI","authors":"","doi":"10.1016/j.remnie.2024.500015","DOIUrl":"10.1016/j.remnie.2024.500015","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 4","pages":"Article 500015"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radio theranostics in paragangliomas and pheochromocytomas","authors":"","doi":"10.1016/j.remnie.2024.500017","DOIUrl":"10.1016/j.remnie.2024.500017","url":null,"abstract":"<div><p><span><span>This continuing education aims to present in a clear and easy-to-understand manner the biology of paragangliomas and </span>pheochromocytomas (PPGLs), the functional imaging studies available for their diagnosis and therapeutic planning, the requirements necessary to administer </span>radioligand<span> therapy (RLT) and the characteristics of these treatments (inclusion criteria, administration protocols, adverse effects and future perspectives).</span></p><p>In this pathology we have two RLT options: [¹³¹I]MIBG and [¹⁷⁷Lu]Lu-DOTA-TATE. The indication for treatment is determined by the expression of its therapeutic target in functional imaging studies, allowing precision and personalized medicine.</p><p>Although most of the results we have for both treatments have as origin small retrospective series, RLT is presented as a safe and well-tolerated therapeutic option in PPGLs with slow-moderate progression or with uncontrollable symptoms, obtaining high disease control rates.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 4","pages":"Article 500017"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent sinonasal meningioma: insights from somatostatin receptor imaging","authors":"","doi":"10.1016/j.remnie.2024.500014","DOIUrl":"10.1016/j.remnie.2024.500014","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 4","pages":"Article 500014"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on radiation protection of the thyroid gland","authors":"","doi":"10.1016/j.remnie.2024.500026","DOIUrl":"10.1016/j.remnie.2024.500026","url":null,"abstract":"<div><p>In recent years, concern about the effects of ionizing radiation<span><span> on exposed individuals has led to the need to regulate and quantify the use of diagnostic and therapeutic techniques. Geopolitical events in recent times have also increased the population's perception of insecurity regarding ionizing radiation, and we increasingly face patients reluctant to undergo certain types of scans in our </span>nuclear medicine<span> services and, albeit less frequently, in radiology<span> services. This article aims to summarise the extent to which ionizing radiation is present in our daily lives and how diagnostic and therapeutic procedures can affect our health, particularly from the perspective of their effects on the thyroid gland, one of the body's most radiation-sensitive organs.</span></span></span></p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 4","pages":"Article 500026"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of incidental cardiac uptake in bone scintigraphy across Spain: The ECCINGO study","authors":"","doi":"10.1016/j.remnie.2024.500020","DOIUrl":"10.1016/j.remnie.2024.500020","url":null,"abstract":"<div><h3>Aim</h3><p>Myocardial uptake on bone scintigraphy has become useful for the detection of transthyretin cardiac amyloidosis (ATTR-CA). This study aimed to assess the prevalence of myocardial uptake in patients over 18 years of age with no clinical suspicion of cardiac amyloidosis (CA) who had undergone bone scintigraphy.</p></div><div><h3>Methods and results</h3><p>This was an observational, retrospective, multicenter study across 21 Spanish hospitals (September–November 2019). Of the 9864 scans analyzed (locally and centrally), incidental cardiac uptake was observed in 71 patients (0.72%), a prevalence that increased with age. A previous diagnosis of heart failure was found in 16.9% of patients with positive uptake, with &gt;50% in NYHA II. ATTR-CA was diagnosed in 10 patients, with a mean delay of 10.4 months (95% CI: 5.1–15.7). All were &gt;70 years old, primarily male, and had greater left ventricular hypertrophy than patients without a confirmed diagnosis (<em>p</em> <!-->&lt;<!--> <!-->0.0001). ATTR-CA patients had higher rates of orthostatic hypotension (30.0% vs. 3.8% in non-ATTR-CA; <em>p</em> <!-->=<!--> <!-->0.025).</p></div><div><h3>Conclusions</h3><p>This is the first retrospective, national, multicenter study evaluating the prevalence of incidental cardiac uptake in bone scintigraphy performed for non-cardiac reasons, showing a prevalence of 0.72% in this population. Referral of these patients may facilitate early diagnosis of CA with a resulting benefit for patients.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 4","pages":"Article 500020"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2253808924000363/pdfft?md5=75a7fd39af35c157e9b416aacf8f86c9&pid=1-s2.0-S2253808924000363-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk management of radioiodine treatment in differentiated thyroid cancer","authors":"J. Villena-Salinas ,&nbsp;M.A. Sempere Alcocer ,&nbsp;M. Gallego Peinado","doi":"10.1016/j.remnie.2024.500029","DOIUrl":"10.1016/j.remnie.2024.500029","url":null,"abstract":"<div><h3>Introduction</h3><p>Patient safety is paramount in providing quality healthcare and constitutes a global concern for healthcare systems. Radioiodine treatment to patients with well-differentiated thyroid cancer is not without risks. The aim of this study is to identify, evaluate and mitigate the risks associated with this procedure.</p></div><div><h3>Materials and methods</h3><p>A single-centre descriptive study was conducted in which risk management was carried out by establishing a risk map using FMEA methodology.</p></div><div><h3>Results</h3><p>Based on the process map 6 sub-processes and 23 failure modes in the three phases of the treatment process were analysed. According to risk priority number (RPN), the sub-process with the highest risk was administrative management (RPN 82), followed by treatment per se and post-treatment imaging (both with RPN 70). An overall process RPN of 300 (156 pre-treatment, 74 treatment and 70 post-treatment) was obtained. Failures directly related to the patient pose a high risk. The implementation of verification systems, performing tasks earlier and providing quality medical information are the most relevant preventive measures to be implemented.</p></div><div><h3>Conclusions</h3><p>The application of the FMEA methodology in the risk management for radioiodine treatment is a valuable tool for improving the quality and safety of this process. The risk map has been able to identify failures at different stages, assess their causes and effects, prioritise the risks identified and implement preventive and corrective measures that can be monitored, ensuring the effectiveness of the actions taken.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 4","pages":"Article 500029"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A serial image analysis architecture with positron emission tomography using machine learning combined for the detection of lung cancer","authors":"S. Guzmán Ortiz ,&nbsp;R. Hurtado Ortiz ,&nbsp;A. Jara Gavilanes ,&nbsp;R. Ávila Faican ,&nbsp;B. Parra Zambrano","doi":"10.1016/j.remnie.2024.500003","DOIUrl":"10.1016/j.remnie.2024.500003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Lung cancer is the second type of cancer with the second highest incidence rate and the first with the highest mortality rate in the world. Machine learning through the analysis of imaging tests such as positron emission tomography/computed tomography (PET/CT) has become a fundamental tool for the early and accurate detection of cancer. The objective of this study was to propose an image analysis architecture (PET/CT) ordered in phases through the application of ensemble or combined machine learning methods for the early detection of lung cancer by analyzing PET/CT images.</p></div><div><h3>Material and methods</h3><p>A retrospective observational study was conducted utilizing a public dataset entitled “A large-scale CT and PET/CT dataset for lung cancer diagnosis.” Various imaging modalities, including CT, PET, and fused PET/CT images, were employed. The architecture or framework of this study comprised the following phases: 1. Image loading or collection, 2. Image selection, 3. Image transformation, and 4. Balancing the frequency distribution of image classes. Predictive models for lung cancer detection using PET/CT images included: a) the Stacking model, which used Random Forest and Support Vector Machine (SVM) as base models and complemented them with a logistic regression model, and b) the Boosting model, which employed the <em>Adaptive Boosting</em> (<em>AdaBoost</em>) model for comparison with the Stacking model. Quality metrics used for evaluation included accuracy, precision, recall, and F1-score.</p></div><div><h3>Results</h3><p>This study showed a general performance of 94% with the Stacking method and a general performance of 77% with the Boosting method.</p></div><div><h3>Conclusions</h3><p>The Stacking method proved to be a model with high performance and quality for lung cancer detection when analyzing PET/CT images.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 3","pages":"Article 500003"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an alternative procedure for quantitative quality control analysis of 99mTc-radiopharmaceuticals using a Geiger Müller counter","authors":"M.M. Gonzalez ,&nbsp;A.L. Poma ,&nbsp;N. Cuello ,&nbsp;A.L. Soldati","doi":"10.1016/j.remnie.2024.500006","DOIUrl":"10.1016/j.remnie.2024.500006","url":null,"abstract":"<div><h3>Background and objectives</h3><p>In a hospital radiopharmacy with 2a operational level, including the preparation of radiopharmaceuticals from prepared and approved reagent kits, it is common to have a single activimeter or dose calibrator for labeling and fractionation, and to perform the quality controls of the ^99mTc-radiopharmaceuticals. In certain cases, the accumulation of radioactive material or accidental contamination of the work area causes the background to exceed the limits to carry out the radiochemical purity analyses and it is necessary to look for viable alternatives. In this work, a Geiger Müller detector (equipped with a probe for measuring surface contamination) frequently used for radioprotection purposes, was validated as an alternative and its performance was compared against the activimeter for ^99mTc-radiopharmaceuticals.</p></div><div><h3>Materials and methods</h3><p>Using [^99mTc]pertechnetate, systematic studies of error analyses and detector response to activity concentration, activity and measurement time were carried out in liquid matrices and in paper. The results were compared against an activimeter calibrated for [^99mTc]Tc.</p></div><div><h3>Results</h3><p>The developed method was used to determine the radiochemical purity of the compounds [^99mTc]Tc-MDP and [^99mTc]Tc-MIBI by ascending paper chromatography tests, obtaining comparable values to those measured with an activimeter in the same system (within 1% uncertainty) and using the method of vial partitioning in a dedicated equipment.</p></div><div><h3>Conclusions</h3><p>This work demonstrates that a Geiger Müller detector with a probe for measuring surface contamination can be adequately used to replace other equipment in the control of radiochemical purity in the hospital radiopharmacy.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 3","pages":"Article 500006"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of bone gammagraphy as a reflection of the patient’s nutritional status, a case of scurvy","authors":"Julio Alberto Vázquez Gómez ,&nbsp;Myriam Salvá Arteaga ,&nbsp;Inés Roncero Sánchez-Cano ,&nbsp;Ana Fernández Marín ,&nbsp;María del Puy Garrastachu Zumarán ,&nbsp;María Yolanda Ruiz del Prado","doi":"10.1016/j.remnie.2024.500012","DOIUrl":"10.1016/j.remnie.2024.500012","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 3","pages":"Article 500012"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional imaging in neuroendocrine tumors: assessment of molecular heterogeneity using [68Ga]Ga-DOTA-TOC and [18F]FDG PET/CT","authors":"Z. Nogareda Seoane ,&nbsp;M.C. Mallón Araújo ,&nbsp;A. Calatayud Cubes ,&nbsp;C. Barberán Corral ,&nbsp;Y. Domínguez Novoa ,&nbsp;A. Cousillas Castiñeira ,&nbsp;N. Martínez Lago ,&nbsp;J.M. de Matías Leralta ,&nbsp;V. Pubul Nuñez","doi":"10.1016/j.remnie.2024.500011","DOIUrl":"10.1016/j.remnie.2024.500011","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of the study was evaluate the diagnostic performance of [⁶⁸Ga]Ga-DOTA-TOC and [¹⁸F]FDG PET/CT in patients with histologically proven neuroendocrine tumors (NETs), as well as the correlation of the visualized findings with the tumor grade.</p></div><div><h3>Material and methods</h3><p>We included 50 patients with NETs who underwent both [⁶⁸Ga]Ga-DOTA-TOC and [¹⁸F]FDG PET/TC. The pooled sensitivity of both scans was compared, as well as [⁶⁸Ga]Ga-DOTA-TOC and [¹⁸F]FDG for each tumor grade (grade 1/G1, grade 2/G2 and grade 3/G3). Also, the sensitivity of [⁶⁸Ga]Ga-DOTA-TOC and [¹⁸F]FDG as a function of the continuous variable Ki-67 was investigated. Finally, the number of lesions detected by both PET radiopharmaceuticals for each tumor grade was compared.</p></div><div><h3>Results</h3><p>The pooled sensitivity of both PET/CT (96%) was higher than [68Ga]Ga-DOTA-TOC (84%) and [¹⁸F]FDG (44%) separately, with statistically significant differences. The sensitivity of [⁶⁸Ga]Ga-DOTA-TOC was higher than [¹⁸F]FDG in both G1 (p = 0.004) and G2 (p &lt; 0.001). In G3 the performance of both scans detected disease in 100% of this subgroup. The sensitivity of [⁶⁸Ga]Ga-DOTA-TOC and [¹⁸F]FDG PET/CT correlated significantly with the Ki-67 proliferative index. In G2 patients the number of lesions detected with [⁶⁸Ga]Ga-DOTA-TOC was higher than [¹⁸F]FDG.</p></div><div><h3>Conclusions</h3><p>The performance of both PET/CT, particularly in G2 and G3, demonstrates the molecular heterogeneity of metastatic NETs and contributes to the selection of a more appropriate treatment, particularly in those high-grade patients who may benefit from radionuclide therapy (PRRT).</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 3","pages":"Article 500011"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140771217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}