{"title":"Massive subcutaneous emphysema and complete resorption images detected on [<sup>18</sup>F]-FDG PET/CT.","authors":"M T Tatoğlu, H Uslu","doi":"10.1016/j.remnie.2025.500180","DOIUrl":"10.1016/j.remnie.2025.500180","url":null,"abstract":"<p><p>Subcutaneous emphysema may occur iatrogenically, spontaneously, or post-traumatically as a result of free air passage under the skin from the respiratory tract or gastrointestinal tract. In this case, we present the typical appearance of a case of massive subcutaneous emphysema observed on [18F]-FDG PET/CT for metabolic characterization due to a massive lesion in the lung and the images of complete resorption after seven months.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500180"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multifocal bone tuberculosis with adrenal involvement mimicking malignant tumors with multiple metastases on PET/CT.","authors":"W Zhang, Y Xing, A Kuang, Y Li","doi":"10.1016/j.remnie.2025.500141","DOIUrl":"10.1016/j.remnie.2025.500141","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500141"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G A Divband, E Askari, H R Amini, A R Noferesti, P Sahafi
{"title":"<sup>68</sup>Ga-FAPI and <sup>18</sup>F-FDG PET/CT: Complementary imaging modalities for detecting unusual metastasis in a patient with osteosarcoma.","authors":"G A Divband, E Askari, H R Amini, A R Noferesti, P Sahafi","doi":"10.1016/j.remnie.2025.500137","DOIUrl":"10.1016/j.remnie.2025.500137","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500137"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Aghaee, Z Bakhshi, V Roshanravan, N Norouzbeigi, H Dadgar, E Askari, K Aryana, S Shafiei, S Soltani, S Sadeghpour
{"title":"Beyond the standard: Enhancing prostate bed and regional lymph node detection in prostate cancer patients with early and delayed imaging in [68 Ga]Ga-PSMA-11 PET/CT.","authors":"A Aghaee, Z Bakhshi, V Roshanravan, N Norouzbeigi, H Dadgar, E Askari, K Aryana, S Shafiei, S Soltani, S Sadeghpour","doi":"10.1016/j.remnie.2025.500184","DOIUrl":"10.1016/j.remnie.2025.500184","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the diagnostic value of early static and delayed imaging in conjunction with standard 68Ga-PSMA-11 PET/CT scans to detect prostate malignant lesions in prostate cancer patients.</p><p><strong>Methods: </strong>One hundred and thirty-eight prostate cancer patients underwent routine [68 Ga]Ga-PSMA-11 PET/CT imaging, 4-minute static acquisition post-injection, and delayed imaging 3 h post-injection. The imaging results were analysed for lesion count, type, localisation, and maximum standardised uptake values.</p><p><strong>Results: </strong>57.97% exhibited positive findings for pathologic prostatic lesions in the standard PET scans (SUV<sub>max</sub>: 10.24). In contrast, early PET imaging detected lesions in 58.01% of patients (SUV<sub>max</sub> of 5.86), while delayed scans revealed lesions suggestive of malignancy in 55.45% of patients (SUV<sub>max</sub> of 12.79). The analysis demonstrated a statistically significant difference in SUV<sub>max</sub> values across the time points (P < .001). Pathologic lymph nodes on images 60 min p.i. were revealed by an SUV max 60 min p.i.: 15.78; this number for the first 4 min and after 3 h were 7.36, 19.19, respectively. Metastatic bone lesions on WB were found in 38 patients, more than the ESI (n = 37) and DI (n = 24). In comparison, urinary bladder activity assessment was detectable with the WB imaging SUV<sub>max</sub> 60 min 11.07. Even though the SUV max for ESI and DI were 6.95 and 31.97, respectively. In the statistical analysis, pathologic radiotracer uptake in tumour lesions was statistically higher in ESI and WB than in urinary bladder activity.</p><p><strong>Conclusions: </strong>The findings indicate that neither early [68 Ga]Ga-PSMA-11 PET/CT nor delayed imaging significantly enhanced the overall detection rate of malignant lesions in prostate cancer patients. However, the early 4-minute post-injection acquisition of PET images proved beneficial for distinguishing local bladder invasion more effectively.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500184"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidental detection of bone metastases from gastric cancer on [99mTc]Tc-DTPA renal dynamic scintigraphy.","authors":"C Nong, Y Xing, L Jiang, Z Zhao","doi":"10.1016/j.remnie.2025.500196","DOIUrl":"10.1016/j.remnie.2025.500196","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500196"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M E Mavi, P Özgen-Kıratlı, A Varan, B Volkan-Salancı
{"title":"Semi-quantitative MIBG scores in relapsed/refractory neuroblastoma: Prognostic insights from post-131I-MIBG treatment scans and impact of SPECT-CT imaging.","authors":"M E Mavi, P Özgen-Kıratlı, A Varan, B Volkan-Salancı","doi":"10.1016/j.remnie.2025.500133","DOIUrl":"10.1016/j.remnie.2025.500133","url":null,"abstract":"<p><strong>Objectives: </strong>Neuroblastoma often demonstrates high uptake of MIBG, which is used for imaging and therapy. This retrospective observational study aimed to assess the prognostic significance of modified Curie scores (mCS) and SIOPEN scores (SS) derived from post-treatment <sup>131</sup>I-MIBG scans in relapsed/refractory neuroblastoma. Additionally, the impact of SPECT-CT imaging on these scores was investigated as a secondary goal.</p><p><strong>Material and methods: </strong>Pediatric patients with relapsed/refractory neuroblastoma, who underwent <sup>131</sup>I-MIBG treatment, were included (n=35). mCS and SS were calculated from planar images of post-treatment <sup>131</sup>I-MIBG scans. Patients were then categorized based on the cut-off values obtained from these scans, and survival analysis was conducted. To investigate the impact of SPECT-CT imaging on scores, mCS and SS were also calculated from both planar and SPECT-CT images of diagnostic <sup>123</sup>I-MIBG scans separately.</p><p><strong>Results: </strong>Patients with mCS>12 or SS>23 on post-treatment <sup>131</sup>I-MIBG scans had significantly worse overall survival. mCS and SS from SPECT-CT were significantly higher than planar images in pre- and post-treatment diagnostic <sup>123</sup>I-MIBG scans. SPECT-CT caused changes in mCS for 61% and SS for 55% of patients, predominantly in axial and appendicular skeleton regions.</p><p><strong>Conclusions: </strong>Both mCS and SS from post-treatment <sup>131</sup>I-MIBG planar scans correlated significantly with overall survival in relapsed/refractory neuroblastoma. Patients with mCS>12 or SS>23 had poorer survival. SPECT-CT imaging influenced scores for a substantial portion of patients, emphasizing its value alongside planar imaging. Larger, comprehensive studies are warranted to validate these findings and refine prognostic cut-offs. Incorporating SPECT-CT in relevant body regions is recommended for improved disease assessment.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500133"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Delgado Niño, J Romero Martínez, F Martín Ordoñez
{"title":"Contribution of 123-I in Peritoneal Strumosis.","authors":"L Delgado Niño, J Romero Martínez, F Martín Ordoñez","doi":"10.1016/j.remnie.2025.500200","DOIUrl":"10.1016/j.remnie.2025.500200","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500200"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Cinar, U M Turan, K Okuyucu, N Aydinbelge Dizdar, A Erol, B Bedi Alpay, P Akkus Gunduz, M Ozkara, D Cayir, E Alagoz, S Ince
{"title":"Impact of perinodal infiltration on recurrence in papillary thyroid cancer.","authors":"A Cinar, U M Turan, K Okuyucu, N Aydinbelge Dizdar, A Erol, B Bedi Alpay, P Akkus Gunduz, M Ozkara, D Cayir, E Alagoz, S Ince","doi":"10.1016/j.remnie.2025.500182","DOIUrl":"10.1016/j.remnie.2025.500182","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Locoregional recurrence occurs in up to 28% of patients with papillary thyroid cancer (PTC). Several risk factors contribute to this metastatic process. The latest of them is perinodal infiltration (PNI). PNI refers to the pathological extension of tumor cells through the lymph node (LN) capsule into the perinodal fibroadipose tissue. It has been accepted as a poor predictive variable. This study aimed to evaluate the prognostic significance of PNI in recurrence of PTC and identify predictive parameters associated with the recurrence in PNI (+) patients.</p><p><strong>Material and methods: </strong>The study included 680 PTC patients with initial LN metastasis (ILNM). Study population was selected from them according to presence or absence of PNI. Eventually, 102 PNI (+) and 122 PNI (-) patients remained eligible for the study. Patients were statistically compared according to demographic, clinicopathologic features both between PNI (+) and PNI (-) groups and within the PNI (+) group over recurrence status.</p><p><strong>Results: </strong>The recurrence rates were 40% and 15% in PNI (+) and PNI (-) patients, respectively (p < 0.001). The independent predictive factors associated with recurrence were central ILNM (p = 0.005), combined central and lateral ILNM (p = 0.003), ILNM > 5 (p = 0.023), stage III-IV (p = 0.025 and p < 0.001), tumor size (TS) (p < 0.001), ILNM size (p < 0.001), stimulated thyroglobulin (sTg) (p = 0.039). PNI (p = 0.05), central ILNM (p = 0.035) and TS (p = 0.027) remained prognostic variables after multivariate analysis.</p><p><strong>Conclusion: </strong>PNI positivity is a poor prognostic factor for PTC recurrence. PNI, especially with large TS and central ILNM, should be taken into account when planning RAI therapy in PTC patients.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500182"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Pinilla, E Riera, J R García, L I Mont-Castro, M Soria, E Valls
{"title":"SPECT/CT with 99mTc-sestamibi in the diagnosis of renal masses.","authors":"L Pinilla, E Riera, J R García, L I Mont-Castro, M Soria, E Valls","doi":"10.1016/j.remnie.2025.500197","DOIUrl":"10.1016/j.remnie.2025.500197","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500197"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Okuyucu, U M Turan, P Akkus Gunduz, M Ozkara, N Aydinbelge Dizdar, A Cinar, M Samsum, P Sahin Oguz, R D Zeyrek, N Ersoz Gulcelik, S Ince
{"title":"Clinical course and features of thyroid oncocytic (Hurthle cell) cancer: Comparison with thyroid follicular cancer.","authors":"K Okuyucu, U M Turan, P Akkus Gunduz, M Ozkara, N Aydinbelge Dizdar, A Cinar, M Samsum, P Sahin Oguz, R D Zeyrek, N Ersoz Gulcelik, S Ince","doi":"10.1016/j.remnie.2025.500158","DOIUrl":"10.1016/j.remnie.2025.500158","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Although, oncocytic (Hurthle cell) carcinoma (OTC) resembles to follicular thyroid carcinoma (FTC), they are different tumors derived from thyroid follicular cells. OTC comprises 3-5% of all differentiated thyroid carcinomas and has more aggressive behaviour than FTC. Clinicians discuss about the treatment and prognosis of OTC. We evaluated its clinicopathological features and clinical course.</p><p><strong>Material and methods: </strong>We examined and followed up 169 patients with OTC (126 minimally invasive, 43 widely invasive) and 837 patients with FTC (640 minimally invasive, 197 widely invasive). OTC and FTC were compared according to prognostic variables, recurrence rate (Rec) and outcome. The predictor factors impacting on recurrence in OTC were also determined.</p><p><strong>Results: </strong>There were statistically significant differences between OTC and FTC in age, sex, capsule invasion (CI), tumor size (TS), total administered [131I]NaI dose (TID), stimulated thyroglobulin (sTg), Rec and stage (p<0.001, p=0.032, p<0.001, p<0.001, p=0.004, p=0.026, p=0.017, p=0.044, respectively). Age, CI, extrathyroidal extension (ETE), TS, initial lymph node metastasis (ILNM), sTg and stage (p=0.01, p=0.016, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, respectively) were the predictors for recurrence in OTC. Metastasis incidence was 19.5% for OTC and 12% for FTC. The cause of death was cancer in 25 patients with FTC (2.8%) and 11 patients with OTC (6.5%).</p><p><strong>Conclusion: </strong>The prognosis of minimally invasive OTC is quite favorable. However the prognosis of widely invasive OTC is unfavorable. RAI may be administered to these tumors, but it is in vain to insist on RAI after the first adjuvant therapy if it does not respond.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500158"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}