A Aghaee, Z Bakhshi, V Roshanravan, N Norouzbeigi, H Dadgar, E Askari, K Aryana, S Shafiei, S Soltani, S Sadeghpour
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The imaging results were analysed for lesion count, type, localisation, and maximum standardised uptake values.</p><p><strong>Results: </strong>57.97% exhibited positive findings for pathologic prostatic lesions in the standard PET scans (SUV<sub>max</sub>: 10.24). In contrast, early PET imaging detected lesions in 58.01% of patients (SUV<sub>max</sub> of 5.86), while delayed scans revealed lesions suggestive of malignancy in 55.45% of patients (SUV<sub>max</sub> of 12.79). The analysis demonstrated a statistically significant difference in SUV<sub>max</sub> values across the time points (P < .001). Pathologic lymph nodes on images 60 min p.i. were revealed by an SUV max 60 min p.i.: 15.78; this number for the first 4 min and after 3 h were 7.36, 19.19, respectively. Metastatic bone lesions on WB were found in 38 patients, more than the ESI (n = 37) and DI (n = 24). In comparison, urinary bladder activity assessment was detectable with the WB imaging SUV<sub>max</sub> 60 min 11.07. Even though the SUV max for ESI and DI were 6.95 and 31.97, respectively. In the statistical analysis, pathologic radiotracer uptake in tumour lesions was statistically higher in ESI and WB than in urinary bladder activity.</p><p><strong>Conclusions: </strong>The findings indicate that neither early [68 Ga]Ga-PSMA-11 PET/CT nor delayed imaging significantly enhanced the overall detection rate of malignant lesions in prostate cancer patients. However, the early 4-minute post-injection acquisition of PET images proved beneficial for distinguishing local bladder invasion more effectively.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500184"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Beyond the standard: Enhancing prostate bed and regional lymph node detection in prostate cancer patients with early and delayed imaging in [68 Ga]Ga-PSMA-11 PET/CT.\",\"authors\":\"A Aghaee, Z Bakhshi, V Roshanravan, N Norouzbeigi, H Dadgar, E Askari, K Aryana, S Shafiei, S Soltani, S Sadeghpour\",\"doi\":\"10.1016/j.remnie.2025.500184\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aims to evaluate the diagnostic value of early static and delayed imaging in conjunction with standard 68Ga-PSMA-11 PET/CT scans to detect prostate malignant lesions in prostate cancer patients.</p><p><strong>Methods: </strong>One hundred and thirty-eight prostate cancer patients underwent routine [68 Ga]Ga-PSMA-11 PET/CT imaging, 4-minute static acquisition post-injection, and delayed imaging 3 h post-injection. The imaging results were analysed for lesion count, type, localisation, and maximum standardised uptake values.</p><p><strong>Results: </strong>57.97% exhibited positive findings for pathologic prostatic lesions in the standard PET scans (SUV<sub>max</sub>: 10.24). In contrast, early PET imaging detected lesions in 58.01% of patients (SUV<sub>max</sub> of 5.86), while delayed scans revealed lesions suggestive of malignancy in 55.45% of patients (SUV<sub>max</sub> of 12.79). The analysis demonstrated a statistically significant difference in SUV<sub>max</sub> values across the time points (P < .001). Pathologic lymph nodes on images 60 min p.i. were revealed by an SUV max 60 min p.i.: 15.78; this number for the first 4 min and after 3 h were 7.36, 19.19, respectively. Metastatic bone lesions on WB were found in 38 patients, more than the ESI (n = 37) and DI (n = 24). In comparison, urinary bladder activity assessment was detectable with the WB imaging SUV<sub>max</sub> 60 min 11.07. Even though the SUV max for ESI and DI were 6.95 and 31.97, respectively. In the statistical analysis, pathologic radiotracer uptake in tumour lesions was statistically higher in ESI and WB than in urinary bladder activity.</p><p><strong>Conclusions: </strong>The findings indicate that neither early [68 Ga]Ga-PSMA-11 PET/CT nor delayed imaging significantly enhanced the overall detection rate of malignant lesions in prostate cancer patients. 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引用次数: 0
摘要
目的：本研究旨在评价早期静态和延迟成像结合标准68Ga-PSMA-11 PET/CT扫描对前列腺癌患者前列腺恶性病变的诊断价值。方法：138例前列腺癌患者行常规[68 Ga]Ga- psma -11 PET/CT成像，注射后4分钟静态采集，注射后3小时延迟成像。影像学结果分析病变计数、类型、定位和最大标准化摄取值。结果：57.97%的患者在标准PET扫描中表现为前列腺病理性病变阳性（SUVmax: 10.24）。相比之下，58.01%的患者（SUVmax为5.86）在早期PET成像中发现病变，而55.45%的患者（SUVmax为12.79）在延迟扫描中发现提示恶性病变。分析表明，SUVmax值在不同时间点有统计学意义差异（p max 60 min 11.07）。尽管ESI和DI的SUV max分别为6.95和31.97。在统计分析中，病理放射性示踪剂在肿瘤病变中的摄取在ESI和WB中高于膀胱活动。结论：研究结果表明，早期[68 Ga]Ga- psma -11 PET/CT和延迟显像均未显著提高前列腺癌患者恶性病变的整体检出率。然而，注射后早期4分钟的PET图像采集有助于更有效地识别局部膀胱侵犯。
Beyond the standard: Enhancing prostate bed and regional lymph node detection in prostate cancer patients with early and delayed imaging in [68 Ga]Ga-PSMA-11 PET/CT.
Objectives: This study aims to evaluate the diagnostic value of early static and delayed imaging in conjunction with standard 68Ga-PSMA-11 PET/CT scans to detect prostate malignant lesions in prostate cancer patients.
Methods: One hundred and thirty-eight prostate cancer patients underwent routine [68 Ga]Ga-PSMA-11 PET/CT imaging, 4-minute static acquisition post-injection, and delayed imaging 3 h post-injection. The imaging results were analysed for lesion count, type, localisation, and maximum standardised uptake values.
Results: 57.97% exhibited positive findings for pathologic prostatic lesions in the standard PET scans (SUVmax: 10.24). In contrast, early PET imaging detected lesions in 58.01% of patients (SUVmax of 5.86), while delayed scans revealed lesions suggestive of malignancy in 55.45% of patients (SUVmax of 12.79). The analysis demonstrated a statistically significant difference in SUVmax values across the time points (P < .001). Pathologic lymph nodes on images 60 min p.i. were revealed by an SUV max 60 min p.i.: 15.78; this number for the first 4 min and after 3 h were 7.36, 19.19, respectively. Metastatic bone lesions on WB were found in 38 patients, more than the ESI (n = 37) and DI (n = 24). In comparison, urinary bladder activity assessment was detectable with the WB imaging SUVmax 60 min 11.07. Even though the SUV max for ESI and DI were 6.95 and 31.97, respectively. In the statistical analysis, pathologic radiotracer uptake in tumour lesions was statistically higher in ESI and WB than in urinary bladder activity.
Conclusions: The findings indicate that neither early [68 Ga]Ga-PSMA-11 PET/CT nor delayed imaging significantly enhanced the overall detection rate of malignant lesions in prostate cancer patients. However, the early 4-minute post-injection acquisition of PET images proved beneficial for distinguishing local bladder invasion more effectively.
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