Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Re: Evaluating the role of sarcopenia and [18F]FDG PET/CT parameters in prognosis of pancreatic ductal adenocarcinoma","authors":"D. Mut Surmeli","doi":"10.1016/j.remnie.2025.500125","DOIUrl":"10.1016/j.remnie.2025.500125","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500125"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare imaging features of adult chronic recurrent multifocal osteomyelitis on PET/CT","authors":"R. Luo , W. Zhang , A. Kuang, Y. Li","doi":"10.1016/j.remnie.2025.500121","DOIUrl":"10.1016/j.remnie.2025.500121","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500121"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of the art and future perspectives of new radionuclides in Nuclear Medicine. Part II","authors":"L. Sancho ,&nbsp;A. Roteta ,&nbsp;I. Torres ,&nbsp;M. de Arcocha ,&nbsp;R. Ramos ,&nbsp;M.L. Domínguez ,&nbsp;J.J. Rosales ,&nbsp;E. Prieto ,&nbsp;G. Quincoces ,&nbsp;en nombre del Grupo de Oncología de la SEMNim","doi":"10.1016/j.remnie.2025.500128","DOIUrl":"10.1016/j.remnie.2025.500128","url":null,"abstract":"<div><div>The state of the art and future perspectives of new radionuclides in Nuclear Medicine continue to evolve, driven by the development of isotopes with innovative applications in theragnostics.</div><div>In this second part of the continuing education series, the clinical and therapeutic applications of terbium, actinium, and bismuth are analyzed in depth. The use of the four terbium isotopes (terbium-149, terbium-152, terbium-155, and terbium-161) is described, offering a versatile system for both diagnosis and treatment due to their chemical similarity to lutetium-177, along with the challenges related to their production and availability. Additionally, actinium-225, a powerful alpha-emitting radionuclide, is reviewed for its growing role in Targeted Alpha Therapy (TAT), particularly in prostate cancer and neuroendocrine tumors. Finally, bismuth-213, derived from actinium-225, is analyzed for its short half-life, making it a viable option for localized and selective therapies.</div><div>Despite technical and production challenges, these radionuclides are driving the evolution of precision medicine, expanding therapeutic and diagnostic possibilities in Nuclear Medicine.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500128"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of dosimetry and clinical variables in treatments of neuroendocrine tumours with [177Lu]Lu-DOTA-TATE","authors":"P. Mínguez Gabiña ,&nbsp;T. Monserrat Fuertes ,&nbsp;B. Santos Zorrozua ,&nbsp;A. Esteban Figueruelo ,&nbsp;M.A. Astudillo Sarmiento ,&nbsp;A. Peña Fuentes ,&nbsp;I. Vinagre Pérez ,&nbsp;E. Rodeño Ortiz de Zarate ,&nbsp;I.L. Fernández Tercero","doi":"10.1016/j.remnie.2024.500089","DOIUrl":"10.1016/j.remnie.2024.500089","url":null,"abstract":"<div><h3>Purpose</h3><div>The main objectives were to study differences between the first and the fourth cycle in dosimetry variables in patients treated for neuroendocrine tumours with four cycles of [¹⁷⁷Lu]Lu-DOTA-TATE, as well as to look for absorbed dose–effect correlations aiming to help individualise and optimise this therapy for future patients.</div></div><div><h3>Material and methods</h3><div>SPECT/CT based dosimetry of tumour lesions and kidneys was performed in the first and the fourth cycles of the [¹⁷⁷Lu]Lu-DOTA-TATE treatments for 17 patients from 2020 to 2023. Clinical variables of interest were collected in order to look for correlations with some dosimetry variables. Statistical analysis was performed using the R software.</div></div><div><h3>Results</h3><div>Regarding dosimetry variables, for lesions a significant decrease in absorbed dose, mass and initial activity between the first and fourth cycles was observed. For kidneys, a significant increase in absorbed dose was observed. Effective decay constants did not significantly change neither for lesions nor for kidneys. The relative decrease in lesion masses correlated with their total absorbed dose. Total absorbed doses to kidneys were well below the toxicity limits mostly used in this therapy. Relative decrease in lesion absorbed doses was significantly lower for tumour primary sites in ileum and jejunum compared to those in pancreas. Moreover, radiological response correlated with clinical response.</div></div><div><h3>Conclusions</h3><div>The results seem to indicate that the current treatment scheme could be optimised in order to obtain better treatment outcomes.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500089"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of [99mTc]Tc-DPD gated-SPECT-CT in the assessment of myocardial uptake patterns in transthyretin amyloidosis (TTR-CA)","authors":"F. Sebastián Palacid ,&nbsp;N. Álvarez Mena ,&nbsp;M. García Aragón ,&nbsp;R.d.C. Zambrano Infantino ,&nbsp;B.M. Jaramillo López ,&nbsp;J. Gómez Hidalgo ,&nbsp;B. Pérez López ,&nbsp;M.P. Redondo del Río ,&nbsp;R. Ruano Pérez","doi":"10.1016/j.remnie.2025.500081","DOIUrl":"10.1016/j.remnie.2025.500081","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the feasibility of identifying various distribution patterns of [^99mTc]Tc-DPD in patients with cardiac transthyretin amyloidosis using gated SPECT-CT.</div></div><div><h3>Materials and methods</h3><div>Gated SPECT-CT was performed in patients with a positive scintigraphy result for cardiac amyloidosis due to transthyretin (TTR-CA). Patients were categorized into several groups based on sex, degree of radiopharmaceutical uptake according to the Perugini’s visual scale and ventricular ejection fraction (LVEF). Cardiac polar maps were obtained using <em>Emory Cardiac Toolbox</em>™ software and scored by segments according to radiopharmaceutical uptake on a scale from 0 (no uptake) to 4 (very high uptake intensity). The Mann-Whitney U and Pearson's Chi-square statistical tests were employed to identify significant differences in distribution patterns according to the different variables under study.</div></div><div><h3>Results</h3><div>65 patients were evaluated. The gender variable determined the main statistically significant differences, highlighting distinct distribution patterns of the radiopharmaceutical at the cardiac level: while women showed lower accumulation of [^99mTc]Tc-DPD in the middle anterior (<em>p</em> <!-->=<!--> <!-->0.035) and basal anterior (<em>p</em> <!-->=<!--> <!-->0.001) segments, whereas men demonstrated higher accumulation in the basal anteroseptal (<em>p</em> <!-->=<!--> <!-->0.009) and basal inferoseptal (<em>p</em> <!-->=<!--> <!-->0.009) segments, and lower scores in the lateroapical segment (<em>p</em> <!-->=<!--> <!-->0.039).</div></div><div><h3>Conclusions</h3><div>Gated SPECT-CT is an essential tool for assessing the distribution pattern of [^99mTc]Tc-DPD of patients with TTR-CA, offering valuable insights into the pathophysiology of the disease.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500081"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical application of multimodality imaging for cardio-oncology in Latin America","authors":"Saurabh Malhotra ,&nbsp;Amalia Peix ,&nbsp;Claudia Gutierrez-Villamil ,&nbsp;Manuel Bazan ,&nbsp;Raffaele Giubbini ,&nbsp;Carla Cueva ,&nbsp;Enrique Estrada ,&nbsp;Diana Paez","doi":"10.1016/j.remnie.2024.500086","DOIUrl":"10.1016/j.remnie.2024.500086","url":null,"abstract":"<div><div>Latin America (LA) is one of the regions in the world with the highest levels of overweight, dyslipidemia, and diabetes mellitus, which, together with smoking and high blood pressure, are common risk factors for cardiovascular and oncological diseases. Chemotherapy (CT) and Radiotherapy (RT) have become two of the mainstays of treatment for several types of cancer. One of the most worrisome side effects generated by CT and RT is cardiotoxicity. There are several imaging techniques in cardiology that can inform the presence of underlying disease, but they differ in their availability and access to the masses, their accuracy and repeatability, all of which are important determinants of the applicability of these techniques in routine clinical practice. Thus, it is mandatory to promote a clinically effective and a cost-effective multimodality approach for risk stratification, diagnosis and management of cardiovascular diseases in oncologic patients. The purpose of this review is to inform cardiologists, oncologists, cardio-oncologists and imaging cardiologists on the cardiac imaging modalities that can be applied in patients with cancer, the differences among imaging techniques and recommendations on how to apply them in LA.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500086"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical muscle metastatic dissemination detected by [18F]FDG PET/CT in high-grade retroperitoneal leiomyosarcoma","authors":"R. Valverde-Jorge ,&nbsp;M. Díez-García ,&nbsp;I. Vinagre-Pérez ,&nbsp;L. Mosteiro-González ,&nbsp;I. Ratón-Zulueta ,&nbsp;I. Fernández-Tercero","doi":"10.1016/j.remnie.2025.500094","DOIUrl":"10.1016/j.remnie.2025.500094","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500094"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between metabolic response determined with [18F]FDG PET/CT and pathological response after neoadjuvant treatment and surgery in patients with esophageal cancer","authors":"J.R. Infante ,&nbsp;J. Quirós ,&nbsp;R. Barco ,&nbsp;C. Bejarano ,&nbsp;E. Agudo ,&nbsp;J. Fernández ,&nbsp;A. Baena ,&nbsp;A. Utrera ,&nbsp;A. Martínez ,&nbsp;C. Durán ,&nbsp;J. Serrano","doi":"10.1016/j.remnie.2025.500088","DOIUrl":"10.1016/j.remnie.2025.500088","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the correlation between the result of the PET/CT study with [¹⁸F]FDG and the histological outcome in patients with esophageal cancer undergoing chemoradiotherapy and subsequent surgery.</div></div><div><h3>Material and methods</h3><div>41 patients (35 men) diagnosed with esophageal cancer during a 10-year interval were retrospectively evaluated. PERCIST criteria and SULpeak (ΔSULpeak) variation between pre- and post-treatment PET/CT studies were used. After neoadjuvant treatment and subsequent surgery, histological response and patient survival were determined, correlating the findings with the result of the metabolic study. Different parameters related to patient and tumors lesion characteristics were compared with respect to histologic response. ROC curves and the Kaplan-Meier method were applied for the analysis of prognostic factors and survival curves.</div></div><div><h3>Results</h3><div>The mean follow-up was 34.9 months, with 21 relapses-progressions and 25 deaths. Significant differences were demonstrated between histologic responses regarding PERCIST criteria and ΔSULpeak. Both showed adequate sensitivity and moderate specificity in relation to their histological correlation. No significant differences were found with respect to other parameters studied. Survival analysis showed significantly different progression-free survival curves for the ΔSULpeak and histologic outcome.</div></div><div><h3>Conclusion</h3><div>PERCIST criteria and ΔSULpeak differentiated between patients with and without histological response. ΔSULpeak and histological results proved to be prognostic factors. The results could help to personalize treatment and, together with other determinations, allow an active surveillance approach could be contemplated.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500088"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the diagnostic performances of CT attenuation corrected and non-attenuation corrected SPECT myocardial perfusion scintigraphy in coronary artery disease","authors":"G. Kara Gedik ,&nbsp;A. Volkan Çelik ,&nbsp;M.U. Yalçın ,&nbsp;M. Koplay ,&nbsp;F. Yılmaz ,&nbsp;H. Önner","doi":"10.1016/j.remnie.2024.500085","DOIUrl":"10.1016/j.remnie.2024.500085","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).</div></div><div><h3>Materials and methods</h3><div>Eightysix patients in whom NAC, AC and prone images were obtained with SPECT, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied. Myocardial perfusion scintigraphy was performed using SPECT/CT dual-headed gamma camera. Images were evaluated qualitatively and semi-quantitatively using 20-segment model. Analyzes of global myocardium and LAD, RCA, Cx vascular areas as regional analysis were performed. In qualitative evaluation, if SPECT study was abnormal, relevant coronary artery area was recorded. Quantitative Perfusion SPECT (QPS) program was used in semi-quantitative analysis; SSS (Summed Stress Score) ≥ 4 was accepted for presence of CAD in per-patient analysis. In regional analysis SSS ≥ 2 was taken into account. Coronary angiography/CT coronary angiography was used as gold standard. Threshold value was determined as ≥50% and above luminal diameter narrowing. While AC and NAC methods were compared for per-patient analysis and each vascular area; 3 imaging methods including prone acqusition, were compared for the RCA area. Diagnostic performances of the methods were evaluated by comparing the areas under the curve with ROC analysis.</div></div><div><h3>Results</h3><div>In visual evaluation, sensitivity of AC was significantly lower than NAC in analyzes of per-patient, RCA and Cx areas (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%, respectively; <em>p</em> &lt; 0.05). Sensitivity of prone imaging was significantly higher than AC in analysis of the RCA area (76.09% vs 60.87%, respectively; <em>p</em> &lt; 0.05) Specificity values ​​were higher in analyzes of global, RCA and Cx areas in AC than in NAC method; this difference was significant in RCA and Cx areas (RCA 70% vs 42.50%, Cx 85.11% vs 70.21%, respectively; <em>p</em> &lt; 0.05). In semi-quantitative evaluation, AC and NAC had similar sensitivity and specificity in global and regional analyzes; in RCA area, no significant difference was detected between the 3 methods. In ROC analysis, no significant difference was detected between methods in per-patient and regional analyzes both in visual and semi-quantitative evaluation.</div></div><div><h3>Conclusions</h3><div>CT-based attenuation correction increases specificity, but reduces sensitivity in the diagnosis of CAD in regional areas of RCA and Cx. Prone imaging remains important in evaluation of RCA area.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500085"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between [18F]-FDG PET/CT findings and pathological subtypes of lung adenocarcinoma presenting as ground-glass opacity","authors":"H. Ji ,&nbsp;S. Jiang ,&nbsp;C. Sun ,&nbsp;T. Liu ,&nbsp;G. Yang ,&nbsp;L. Zhang ,&nbsp;J. Sun ,&nbsp;J. Wu","doi":"10.1016/j.remnie.2024.500087","DOIUrl":"10.1016/j.remnie.2024.500087","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to analyze the correlation between [18F]-FDG PET/CT (positron emission tomography/computed tomography) findings and pathological subtypes of lung adenocarcinoma with ground-glass opacity (GGO).</div></div><div><h3>Materials and methods</h3><div>88 patients were included in this study, which underwent [18F]-FDG PET/CT and were finally diagnosed with lung adenocarcinoma. A total of 90 GGO lesions were analyzed. The size and SUV_max of all lesions were measured, the proportion of solid components of GGO in lesions was calculated, and quantitative classification was performed. The above GGO lesions were divided into three groups based on the 2011 IASLC/ATS/ERS lung adenocarcinoma pathological classification, namely good prognosis group, relatively good prognosis group and poor prognosis group. Chi-square test, independent sample t test, and analysis of variance were used for statistical analysis.</div></div><div><h3>Results</h3><div>There was a negative correlation between the SUV_max and quantitative classification value (<em>r</em> = −0.638, <em>P</em> &lt; 0.001). Atypical adenomatous hyperplasia (AAH), acinar predominant adenocarcinoma (APA), lepidic predominant adenocarcinoma (LPA), papillary predominant adenocarcinoma (PPA), and solid predominant adenocarcinoma (SPA) had significant differences in GGO lesion size, SUV_max, and quantitative classification value (<em>F</em> = 3.849, <em>P</em> = 0.019; <em>F</em> = 27.420, <em>P</em> &lt; 0.001; <em>F</em> = 4.353, <em>P</em> = 0.002). There were significant differences in GGO lesion size, SUV_max, and quantitative classification value among the good prognosis group, relatively good prognosis group, and poor prognosis group (<em>F</em> = 5.626, <em>P</em> = 0.011; <em>F</em> = 37.587, <em>P</em> &lt; 0.001; <em>F</em> = 5.119, <em>P</em> = 0.008).</div></div><div><h3>Conclusion</h3><div>GGO lesion size, SUV_max, and quantitative classification value are correlated with different pathological subtypes and can be used toevaluate the prognosis of lung adenocarcinoma with GGO.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 3","pages":"Article 500087"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}