Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Analysis of dosimetry and clinical variables in treatments of neuroendocrine tumours with [¹⁷⁷Lu]Lu-DOTA-TATE.","authors":"P Mínguez Gabiña, T Monserrat Fuertes, B Santos Zorrozua, A Esteban Figueruelo, M A Astudillo Sarmiento, A Peña Fuentes, I Vinagre Pérez, E Rodeño Ortiz de Zarate, I L Fernández Tercero","doi":"10.1016/j.remnie.2024.500089","DOIUrl":"https://doi.org/10.1016/j.remnie.2024.500089","url":null,"abstract":"<p><strong>Purpose: </strong>The main objectives were to study differences between the first and the fourth cycle in dosimetry variables in patients treated for neuroendocrine tumours with four cycles of [¹⁷⁷Lu]Lu-DOTA-TATE, as well as to look for absorbed dose-effect correlations aiming to help individualise and optimise this therapy for future patients.</p><p><strong>Material and methods: </strong>SPECT based dosimetry of tumour lesions and kidneys was performed in the first and the fourth cycles of the [¹⁷⁷Lu]Lu-DOTA-TATE treatments for 17 patients from 2020 to 2023. Clinical variables of interest were collected in order to look for correlations with some dosimetry variables. Statistical analysis was performed using the R software.</p><p><strong>Results: </strong>Regarding dosimetry variables, for lesions a significant decrease in absorbed dose, mass and initial activity between the first and fourth cycles was observed. For kidneys, a significant increase in absorbed dose was observed. Effective decay constants did not significantly change neither for lesions nor for kidneys. The relative decrease in lesion masses correlated with their total absorbed dose. Total absorbed doses to kidneys were well below the toxicity limits mostly used in this therapy. Relative decrease in lesion absorbed doses was significantly lower for tumour primary sites in ileum and jejunum compared to those in pancreas. Moreover, radiological response correlated with clinical response.</p><p><strong>Conclusions: </strong>The results seem to indicate that the current treatment scheme could be optimised in order to obtain better treatment outcomes.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500089"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the diagnostic performances of ct attenuation corrected and non-attenuation corrected spect myocardial perfusion scintigraphy in coronary artery disease.","authors":"G Kara Gedik, A Volkan Çelik, M U Yalçın, M Koplay, F Yılmaz, H Önner","doi":"10.1016/j.remnie.2024.500085","DOIUrl":"https://doi.org/10.1016/j.remnie.2024.500085","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).</p><p><strong>Materials and methods: </strong>Eightysix patients in whom NAC, AC and prone images were obtained with SPECT at Selcuk University Faculty of Medicine, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied. Myocardial perfusion scintigraphy was performed using SPECT/CT dual-headed gamma camera. Images were evaluated qualitatively and semi-quantitatively using 20-segment model. Analyzes of global myocardium and LAD, RCA, Cx vascular areas as regional analysis were performed. In qualitative evaluation, if SPECT study was abnormal, relevant coronary artery area was recorded. Quantitative Perfusion SPECT (QPS) program was used in semi-quantitative analysis; SSS ≥ 4 was accepted for presence of CAD in per-patient analysis. In regional analysis SSS ≥ 2 was taken into account. Coronary angiography/CT coronary angiography was used as gold standard. Threshold value was determined as ≥50% and above luminal diameter narrowing. While AC and NAC methods were compared for per-patient analysis and each vascular area; 3 imaging methods including prone acqusition, were compared for the RCA area. Diagnostic performances of the methods were evaluated by comparing the areas under the curve with ROC analysis.</p><p><strong>Results: </strong>In visual evaluation, sensitivity of AC was significantly lower than NAC in analyzes of per-patient, RCA and Cx areas (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%, respectively; p < 0.05 ). Sensitivity of prone imaging was significantly higher than AC in analysis of the RCA area (76.09% vs 60.87%, respectively; p < 0.05) Specificity values ​​were higher in analyzes of global, RCA and Cx areas in AC than in NAC method; this difference was significant in RCA and Cx areas (RCA 70% vs 42.50%, Cx 85.11% vs 70.21%, respectively; p < 0.05). In semi-quantitative evaluation, AC and NAC had similar sensitivity and specificity in global and regional analyzes; in RCA area, no significant difference was detected between the 3 methods. In ROC analysis, no significant difference was detected between methods in per-patient and regional analyzes both in visual and semi-quantitative evaluation.</p><p><strong>Conclusions: </strong>CT-based attenuation correction increases specificity, but reduces sensitivity in the diagnosis of CAD in regional areas of RCA and Cx. Prone imaging remains important in evaluation of RCA area.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500085"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG and ¹¹C-PIB PET/TC findings in status epilepticus in the setting of a patient with mild cognitive impairment.","authors":"M Pombo-López, A Bota-Bota, I Martínez-Rodríguez, F Gómez-de la Fuente, J Jiménez-Bonilla, R Quirce","doi":"10.1016/j.remnie.2024.500079","DOIUrl":"https://doi.org/10.1016/j.remnie.2024.500079","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500079"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"False Lymph Node Recurrence Image in PET/CT with [68Ga]Ga-PSMA-11. Importance of the Acquisition Protocol.","authors":"C Castillo, D Vas, E García, K Quintero, M Tormo, P Paredes","doi":"10.1016/j.remnie.2024.500077","DOIUrl":"https://doi.org/10.1016/j.remnie.2024.500077","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500077"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between [18F]-FDG PET/CT findings and pathological subtypes of lung adenocarcinoma presenting as ground-glass opacity.","authors":"H Ji, S Jiang, C Sun, T Liu, G Yang, L Zhang, J Sun, J Wu","doi":"10.1016/j.remnie.2024.500087","DOIUrl":"https://doi.org/10.1016/j.remnie.2024.500087","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to analyze the correlation between [18F]-FDG PET/CT (positron emission tomography/computed tomography) findings and pathological subtypes of lung adenocarcinoma with ground-glass opacity (GGO).</p><p><strong>Materials and methods: </strong>88 patients were included in this study, which underwent [18F]-FDG PET/CT and were finally diagnosed with lung adenocarcinoma. A total of 90 GGO lesions were analyzed. The size and SUV_max of all lesions were measured, the proportion of solid components of GGO in lesions was calculated, and quantitative classification was performed. The above GGO lesions were divided into three groups based on the 2011 IASLC/ATS/ERS lung adenocarcinoma pathological classification, namely good prognosis group, relatively good prognosis group and poor prognosis group. Chi-square test, independent sample t test, and analysis of variance were used for statistical analysis.</p><p><strong>Results: </strong>There was a negative correlation between the SUV_max and quantitative classification value (r = -0.638, P < 0.001). Atypical adenomatous hyperplasia (AAH), acinar predominant adenocarcinoma (APA), lepidic predominant adenocarcinoma (LPA), papillary predominant adenocarcinoma (PPA), and solid predominant adenocarcinoma (SPA) had significant differences in GGO lesion size, SUV_max, and quantitative classification value (F = 3.849, P = 0.019; F = 27.420, P < 0.001; F = 4.353, P = 0.002). There were significant differences in GGO lesion size, SUV_max, and quantitative classification value among the good prognosis group, relatively good prognosis group, and poor prognosis group (F = 5.626, P = 0.011; F = 37.587, P < 0.001; F = 5.119, P = 0.008).</p><p><strong>Conclusion: </strong>GGO lesion size, SUV_max, and quantitative classification value are correlated with different pathological subtypes and can be used toevaluate the prognosis of lung adenocarcinoma with GGO.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500087"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between HER2 Status Acquired From Pathological Data and Metabolic Parameters From Pre-treatment [¹⁸F]FDG PET/CT in Gastric Adenocarcinomas.","authors":"M N Acar Tayyar, M Ö Tamam, G B Babacan, M Can Şahin, H Özçevik, S Şengiz Erhan, A E Öztürk","doi":"10.1016/j.remnie.2024.500080","DOIUrl":"https://doi.org/10.1016/j.remnie.2024.500080","url":null,"abstract":"<p><strong>Objective: </strong>Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is thought to be more aggressive in gastric cancer. This study aimed to evaluate the predictability of HER2 status and other prognostic pathologic parameters using [¹⁸F]FDG PET/CT and to investigate its impact on survival.</p><p><strong>Methods: </strong>Pretreatment metabolic parameters measured by [¹⁸F]FDG PET/CT as a prognostic factor were retrospectively evaluated in 117 HER2-analysed patients. The relationship between pathological data, tumor metabolic characteristics, and distant metastases was examined, and the effect on survival was investigated.</p><p><strong>Results: </strong>Among the 117 patients, 17.1% were HER2-positive (HER2+), and 82.9% were HER2-negative (HER2-). There was no significant association between PET/CT parameters in the HER2+ and HER2- patient groups. HER2+ patients had higher 1- and 3-year survival expectations than HER2- patients (80%-%37.9; %47.5-%20; respectively). There was no statistically significant difference in overall survival. In Cox-regression analysis, while the presence of vascular invasion, local invasion, and distant metastasis were poor prognostic factors, HER2 was not a prognostic factor. Vascular invasion and local invasion (T3/T4) were also associated with higher SUVmax values. Patients with distant metastases had significantly higher SUVmax, SUVmean, and TLG.</p><p><strong>Conclusion: </strong>This study showed no association between HER2 expression and [¹⁸F]FDG PET/CT metabolic parameters. However, regardless of HER2 status, the results indicated distant metastasis, local invasion, and vascular invasion could be associated with primary tumor metabolism. PET/CT parameters predict tumor aggressiveness and disease prognosis better than HER2 status.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500080"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role and applications of ¹⁸F-FDG PET/CT in the assessment of osteoarticular infection and inflammation - Part I.","authors":"E Noriega-Álvarez, B Rodríguez Alfonso, J J Rosales Castillo, A Moreno Ballesteros, E López Rodríguez, S Sanz Viedma, M Del P Orduña Diez, L Domínguez Gadea","doi":"10.1016/j.remnie.2024.500073","DOIUrl":"10.1016/j.remnie.2024.500073","url":null,"abstract":"<p><p>¹⁸F-FDG PET/CT has been positioned over time as a useful tool in the evaluation of osteoarticular infections, overcoming conventional explorations like MRI or bone scintigraphy in some indications. Its ability to provide functional and anatomical images simultaneously and its excellent resolution contributes to a more precise and personalised approach in the treatment of osteoarticular diseases such as spondylodiscitis. In addition, it has proven valuable in patients with suspected infection that is complex to diagnose or treat, improving detection in subclinical stages. However, some limitations have been identified, such as difficulty in the differential diagnosis of infection vs. inflammation (as in diabetic foot) or in the interpretation of patients with osteosynthesis materials. In this manuscript, we present a brief review providing general and practical information about the role of ¹⁸F-FDG PET/CT in infectious osteoarticular pathology, while part 2 discusses the role of ¹⁸F-FDG PET/CT in osteoarticular inflammation.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500073"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of ¹⁸F-FDG PET/CT in the diagnosis and grading of incidental colorectal adenomas.","authors":"Z Qi, K Tang, X Lu, Y Zhu, N Xu","doi":"10.1016/j.remnie.2024.500075","DOIUrl":"10.1016/j.remnie.2024.500075","url":null,"abstract":"<p><strong>Purpose: </strong>Colorectal adenomas (CRAs) are at a higher risk of progressing to colorectal cancer (CRC) as their histological grade increases. Herein, this study investigated the relationship between the maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography-computed tomography (¹⁸F-FDG PET/CT) and the histological grades of CRAs and constructed the optimal regression model for distinguishing between different histological grades.</p><p><strong>Methods: </strong>This study retrospectively analyzed the data of 153 patients with CRAs who had colorectal ¹⁸F-FDG uptake incidentally found on PET/CT. The patients were categorized into low-grade intraepithelial neoplasia (LGIN) and high-grade intraepithelial neoplasia (HGIN) groups based on their histological grade. After the analysis of the relationship between SUVmax measured on preoperative ¹⁸F-FDG PET/CT scans and histological grades, receiver-operating characteristic (ROC) curves were analyzed to determine the optimal cut-off values for distinguishing between the two groups. Common clinical and pathological factors were included and subjected to univariate and multivariate logistic regression analyses to identify independent risk factors. A diagnostic model integrating SUVmax and several risk factors was developed with the multivariate logistic regression analysis.</p><p><strong>Results: </strong>SUVmax was significantly different between the two groups (P < 0.001) and increased with an elevation in the malignancy degree. The area under the ROC curve (AUC) for identifying LGIN and HGIN was 0.796, and the AUC of the combination model was 0.822. Furthermore, SUVmax was an independent risk factor for distinguishing between different histological grades in pairwise comparisons.</p><p><strong>Conclusion: </strong>The regression model involving SUVmax on ¹⁸F-FDG PET/CT can distinguish between histological grades of CRAs, which therefore can be used as a noninvasive tool for the accurate diagnosis of CRAs and assist in developing patient-specific treatment strategies before surgery.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500075"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of sarcopenia and [18F]FDG PET/CT parameters in prognosis of pancreatic ductal adenocarcinoma","authors":"Önner H.,&nbsp;Calderon Tobar M.N.,&nbsp;Perktaş L.,&nbsp;Yilmaz F.,&nbsp;Kara Gedik G.","doi":"10.1016/j.remnie.2024.500046","DOIUrl":"10.1016/j.remnie.2024.500046","url":null,"abstract":"<div><div>This study investigates the relationship between ¹⁸F-fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters, clinicopathological characteristics, and sarcopenia in patients with pancreatic ductal adenocarcinoma (PDAC) and evaluates their prognostic roles.</div></div><div><h3>Material and methods</h3><div>The primary tumor's maximum standard uptake (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) values, as well as clinicopathological factors, were evaluated retrospectively. Computed tomography (CT) was used to assess the skeletal muscle index (SMI). Sarcopenia was defined based on SMI calculated at the third lumbar vertebra (L3). SMI cut-off values ​​for sarcopenia were accepted as 44.77 cm²/m² for men and 32.50 cm²/m² for women. The primary endpoint was the overall survival (OS). OS data were analyzed by the Kaplan-Meier method and compared using the log-rank test. To identify predictive factors for sarcopenia, multivariable logistic regression was used following univariable logistic regression. Cox proportional hazards regression analyses were used to find predictors of OS.</div></div><div><h3>Results</h3><div>Of the 86 patients included in the study, 37 (43%) were diagnosed with sarcopenia. Compared with non-sarcopenic patients, sarcopenia was observed in older patients (P<!--> <!-->=<!--> <!-->0,028) and patients with lower body mass index (BMI) (p<!--> <!-->=<!--> <!-->0,001). Age and BMI independently predicted sarcopenia. Univariate analysis identified sarcopenia, advanced stage, and higher primary tumor TLG as significant predictors of overall survival. Multivariate Cox regression analysis revealed that the advanced tumor stage (p<!--> <!-->=<!--> <!-->0.017) and higher TLG (p<!--> <!-->=<!--> <!-->0,042) independently predicted OS. The median OS was 9.4 months in non-sarcopenic patients and 5.0 months in sarcopenic patients (p<!--> <!-->=<!--> <!-->0,021).</div></div><div><h3>Conclusion</h3><div>In this study cohort, advanced-stage disease and higher primary tumor TLG were identified as independent predictors of OS in patients with PDAC. Additionally, we emphasize the importance of incorporating [¹⁸F]FDG PET/CT-derived sarcopenia assessments into the prognostic evaluation and clinical management of PDAC patients. While sarcopenia was associated with shorter OS in univariate analysis, it was not an independent predictor in multivariate analysis.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 6","pages":"Article 500046"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiosynoviorthesis with [90Y] Yttrium citrate in refractory synovitis of the knee: Experience of 2 reference hospitals","authors":"I. Bolívar Roldán ,&nbsp;Ana Moreno Ballesteros ,&nbsp;C. Martínez Chinchilla ,&nbsp;A. Jiménez-Heffernan ,&nbsp;M.C. Calvo Morón","doi":"10.1016/j.remnie.2024.500052","DOIUrl":"10.1016/j.remnie.2024.500052","url":null,"abstract":"<div><h3>Introduction</h3><div>To describe the therapeutic efficacy of radiosynoviorthesis with [⁹⁰Y]Yttrium citrate (⁹⁰Y), in patients with chronic knee synovitis refractory to systemic treatments and/or infiltrations, correlating the results with the different etiologies and degenerative changes that they showed, in order to optimize the indication of the technique.</div></div><div><h3>Material and methods</h3><div>Observational retrospective study with 32 patients (22 men and 10 women) and 34 knees, with refractory chronic knee synovitis, who underwent radiosynoviorthesis between January 2013 and December 2022. Its efficacy was described and analyzed by the subjective improvement referred by the patients and its relationship with the existing etiologies and radiological degenerative changes, expressed by the Kellgren-Lawrence (K-L) scale.</div></div><div><h3>Results</h3><div>A statistically significant subjective improvement was observed in 70.6% of the cases (<em>p</em> &lt; 0.001). There were 92.3% of cases with absent, doubtful or mild degenerative changes (K-L 0-2) who improved, while only 50% with moderate or severe changes (K-L 3-4) improved, showing statistically significant differences (<em>p</em> = 0.03). Among patients with chronic inflammatory origin of synovitis (spondyloarthropathies and rheumatoid arthritis), 80% improved, while in those with osteoarthritis (degenerative) origin, only 25% improved with statistically significant differences (p = 0.006).</div></div><div><h3>Conclusions</h3><div>Radiosynoviorthesis with ⁹⁰Y is an effective treatment in patients with knee refractory chronic synovitis, especially in the presence of mil degenerative joint changes and chronic inflammatory origin. We must ensure the appropiate selection of patients according to these criteria.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"43 6","pages":"Article 500052"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}