Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Bilateral lacrimal gland MALT lymphoma incidentally detected on 68Ga-DOTATATE PET/CT: an unusual but noticeable finding","authors":"C. Kucuker, S. Akin, D.P. Baran, E. Gumeler, A. Uner, P. Kiratli","doi":"10.1016/j.remnie.2025.500202","DOIUrl":"10.1016/j.remnie.2025.500202","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500202"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PSMA-PET as an emerging tool for response assessment in metastatic prostate cancer (mPC): Revolution and necessary evolution","authors":"N. Álvarez Mena,&nbsp;J. Gómez Hidalgo,&nbsp;M.P. Fierro Alanis,&nbsp;P. García-Talavera San Miguel,&nbsp;A. Roteta Unceta Barrenechea,&nbsp;S. Menéndez Sánchez,&nbsp;J.E. Montalvá Pastor,&nbsp;J.A. Badell Martínez,&nbsp;A.C. Peñaherrera Cepeda,&nbsp;D. Carrera Salazar,&nbsp;G. Quincoces Fernández,&nbsp;M. Rodríguez-Fraile,&nbsp;en nombre del Grupo de Oncología de la SEMNIM","doi":"10.1016/j.remnie.2026.500285","DOIUrl":"10.1016/j.remnie.2026.500285","url":null,"abstract":"<div><div>This article critically reviews the available evidence on the role of PSMA-PET in evaluating therapeutic response in metastatic prostate cancer (mPC), comparing it with conventional criteria —serum PSA levels, Response Evaluation Criteria in Solid Tumours (RECIST 1.1), Prostate Cancer Working Group 3 (PCWG3)— and analyzing its integration into clinical practice. It addresses the biological basis of PSMA and how different treatments —androgen deprivation therapy (ADT), androgen receptor pathway inhibitors (ARPI), taxanes, [¹⁷⁷Lu]Lu-PSMA-617, [²²³Ra], stereotactic body radiotherapy (SBRT)— modulate its expression, which influences image interpretation and phenomena such as flare.</div><div>This work describes specific assessment systems for PSMA-PET, including PSMA PET Progression Criteria (PPP), Response Evaluation Criteria in PSMA (RECIP 1.0), and EAU/EANM criteria, highlighting their superior prognostic value compared to RECIST and PCWG3, especially in metastatic castration-resistant prostate cancer (mCRPC). RECIP 1.0, initially validated for [¹⁷⁷Lu]Lu-PSMA-617, has demonstrated robust correlation with overall survival and interobserver reproducibility, improving risk stratification when combined with PSA. Quantitative parameters such as PSMA-VOL and TLP, key biomarkers for monitoring response and predicting outcomes, are analyzed.</div><div>Furthermore, the evidence is reviewed by therapeutic modality, proposing practical recommendations on the optimal timing for PSMA-PET (baseline, intermediate, or delayed depending on treatment) and the need for standardized reporting (PROMISE, E-PSMA). The article also identifies current limitations: variability among radiopharmaceuticals, a lack of universal criteria, a scarcity of prospective studies, and challenges in multimodal integration with PSA and other biomarkers.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500285"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDG PET/CT reveals solitary hepatic metastasis from urachal adenocarcinoma mimicking a hepatic pseudolesion on contrast-enhanced CT","authors":"D. Huang,&nbsp;C. Jiang,&nbsp;Z. He,&nbsp;Y. Chen","doi":"10.1016/j.remnie.2025.500259","DOIUrl":"10.1016/j.remnie.2025.500259","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500259"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of axillary staging in breast cancer: Efficacy of sentinel lymph node biopsy and targeted axillary dissection post-chemotherapy","authors":"A. García-Ruiz,&nbsp;I. Martínez-Rodríguez,&nbsp;N. Martínez-Amador,&nbsp;F.J. Gómez-de la Fuente,&nbsp;A. Sánchez-Salmón,&nbsp;J. Jiménez-Bonilla,&nbsp;M. de Arcocha-Torres,&nbsp;V. Mendi Barcina,&nbsp;F. Rodríguez-Izquierdo,&nbsp;N.V. Carvalho-Duarte,&nbsp;M.P. Botanch-Domingo,&nbsp;L. Cabrera-Portillo,&nbsp;P.D. Andrade-Mejía,&nbsp;A. Clavijo-Umbarila,&nbsp;R. Quirce","doi":"10.1016/j.remnie.2025.500134","DOIUrl":"10.1016/j.remnie.2025.500134","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the contribution of sentinel node biopsy using lymphoscintigraphy in breast cancer (BC) with clip-marked lymph node involvement and neoadjuvant chemotherapy (NACT) in axillary staging and reduction of potential false negatives from exclusively radiological localization.</div></div><div><h3>Material and methods</h3><div>A retrospective study of 20 women with BC and nodal involvement marked with clip and NACT. Lymphoscintigraphy was complemented with SPECT/CT in 12 patients. The correlation between lymphoscintigraphic sentinel lymph node (SLN) and the clip-marked node was analyzed.</div></div><div><h3>Results</h3><div>Lymphoscintigraphy detected 34 axillary SLNs. SPECT/CT showed uptake in 10 of 16 clip-marked nodes (62.5%). During surgery, 39 nodes were removed; 33 (84.6%) were SLNs, 18 with clip, and 15 without clip. One SLN was not located surgically. Six clip-marked nodes (15.3%) showed no uptake. In 8 of 20 patients (40%), drainage to a single SLN was detected; this corresponded to the clip-marked node in 5 cases (non-metastatic) and non-clip-marked nodes in 3 cases (1 metastatic). In 12 of 20 patients (60%), lymphoscintigraphy showed drainage to more than one SLN. A total of 26 SLNs were detected: 13 SLNs with clip (5 metastatic) and 13 without clip (4 metastatic). Lymphoscintigraphy detected 5 SLNs in 4 of 20 patients (20%) that did not match the clip-marked node and were metastatic.</div><div>The detection and removal rate of GCL was 97% and false negative rate was 16,67%.</div></div><div><h3>Conclusion</h3><div>Lymphoscintigraphy in BC with positive axilla before NACT detected metastases in a significant percentage of patients not identified with clip, being an essential tool for accurate axillary staging.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500134"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of synchronous multicentric paragangliomas detected using [⁶⁸Ga]Ga-DOTATATE PET/CT","authors":"N. Aydinbelge Dizdar,&nbsp;A. Dursun,&nbsp;M. Samsum,&nbsp;O. Ozmen","doi":"10.1016/j.remnie.2025.500233","DOIUrl":"10.1016/j.remnie.2025.500233","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500233"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic impact of 18F-PSMA-1007 PET/MRI in staging intermediate/high-risk prostate cancer patients: Imaging biomarkers and radiomic analysis associated with tumor aggressiveness","authors":"J.R. Garcia,&nbsp;L. Pinilla,&nbsp;A. Compte,&nbsp;N. Garrido,&nbsp;L.L. Mont-Castro,&nbsp;S. Ruiz,&nbsp;J. Garcia Magro,&nbsp;J.M. Santabárbara,&nbsp;D. Tovar,&nbsp;S. Mourelo,&nbsp;M. Soria,&nbsp;E. Riera","doi":"10.1016/j.remnie.2026.500309","DOIUrl":"10.1016/j.remnie.2026.500309","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of initial staging in prostate cancer patients using 18F-PSMA PET/MR and to analyze the prognostic value of pre-treatment PET/MRI imaging biomarkers.</div></div><div><h3>Methods</h3><div>Prospective study of 50 consecutive patients diagnosed with intermediate/high-risk prostate cancer.</div><div>Simultaneous acquisition on PET/MR (SIGNA GE) 1 h after intravenous administration of 370 ± 10% MBq of 18F-PSMA-1007:</div><div> <!-->- Prostate (20 min): PET emission + mpMRI sequences: DIXON, T1, T2, DWI, DCE.</div><div> <!-->- Whole-body (30 min): PET emission + MR sequences: DIXON, T1, T2, DWI, STIR.</div><div>Consensus between nuclear medicine physician and radiologist for T, nodal, and metastatic staging. Visual interpretation. Treatment selection by multidisciplinary tumor board.</div><div>SUV and ADC values were calculated. Pearson correlation analysis was performed. Radiomic analysis included extraction of 93 features: first-order and texture-based. Significant differentiation was assessed using ANOVA between two prognostic groups: (1) TxN0M0 or TxN1M0; (2) TxN1M1a or M1b.</div></div><div><h3>Results</h3><div>PET/MRI enabled comprehensive staging in a single session, classifying 28% of patients as T3b and detecting extraprostatic disease in 44% (28% oligometastatic, 16% polymetastatic).</div><div>PET/MRI concordance for extracapsular extension and seminal vesicle infiltration was high in T3b (85.7%) but markedly lower in T3a (25%).</div><div>SUVmax/ADC correlation was inverse and significant (<em>P</em> &lt; .05). Texture features showed superior discriminative ability compared to conventional parameters, achieving an AUC of 0.79 for differentiating advanced T stages.</div><div>Following PET/MR, 66% of patients underwent radical prostatectomy (with targeted lymphadenectomy in N1), 18% received image-guided radiotherapy, and 16% systemic therapy, without performing surgery in cases with extracapsular extension or metastatic disease.</div></div><div><h3>Conclusion</h3><div>PET/MRI with [18F]F-PSMA-1007 is a feasible and effective technique for initial staging of intermediate/high-risk prostate cancer, acting as a comprehensive “one-stop” diagnostic procedure.</div><div>Its high sensitivity for nodal and bone disease, combined with integration of radiomic biomarkers, provides prognostic value and enables optimization of personalized therapeutic decisions.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500309"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal and Hematologic Toxicity Profile of [177] Lu-labeled PSMA-targeted radioligand-therapy (177Lu-PSMA-RLT): A Retrospective Cohort Study","authors":"M. Yalçınkaya,&nbsp;F. Demir,&nbsp;S. Karaçavuş,&nbsp;M. Demir","doi":"10.1016/j.remnie.2026.500306","DOIUrl":"10.1016/j.remnie.2026.500306","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to retrospectively evaluate the renal and hematologic toxicity profile of ¹⁷⁷Lu-PSMA-RLT in patients with metastatic castration-resistant prostate cancer.</div></div><div><h3>Methods</h3><div>Renal function (GFR, BUN, and creatinine) and hematological parameters (hemoglobin, leukocyte, platelet) before and after treatment were examined in 41 patients who received ¹⁷⁷Lu-PSMA-RLT at our clinic, and changes along with toxicity grades were determined. Additionally, pre-treatment PSMA PET/CT findings and other demographic and clinical data were assessed.</div></div><div><h3>Results</h3><div>In terms of renal toxicity, G0-G1 level toxicity was observed in 97.6% of cases, while G2 toxicity was observed in only one patient. This patient already had a low GFR before treatment and experienced only a 2-unit decrease. Regarding hematological toxicity, the rates of G3–4 toxicity were as follows: leukocytes 7.3%, hemoglobin 9.8%, platelets 7.3%.</div></div><div><h3>Conclusion</h3><div>No clinically significant nephrotoxicity was observed with ¹⁷⁷Lu-PSMA-RLT. Hematologic toxicity is significant but manageable, and severe side effects are rare and within predictable limits.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500306"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter regarding “Redefining preoperative imaging-based localization of adenomas in primary hyperparathyroidism candidates for minimally invasive surgery”","authors":"Sebastián Casanueva Eliceiry,&nbsp;Katherine Quintero Martinez,&nbsp;David Fuster Pelfort","doi":"10.1016/j.remnie.2025.500257","DOIUrl":"10.1016/j.remnie.2025.500257","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500257"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining preoperative imaging-based localization of adenomas in primary hyperparathyroidism patients candidates for minimally invasive surgery","authors":"P. Aphale,&nbsp;S. Dokania,&nbsp;H. Shekhar","doi":"10.1016/j.remnie.2025.500227","DOIUrl":"10.1016/j.remnie.2025.500227","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500227"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible cortical hypometabolism in prolonged migraine aura: findings on 18[F]FDG PET/CT","authors":"Diego Alfonso López-Mora,&nbsp;Lucia Lozano Murgas,&nbsp;Antoni Mestre-Fusco,&nbsp;Maria Isabel Santisteban Gutierrez,&nbsp;Ato Antonio Rodriguez Revuelto","doi":"10.1016/j.remnie.2026.500279","DOIUrl":"10.1016/j.remnie.2026.500279","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 5","pages":"Article 500279"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}