Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Superior vena cava syndrome as a manifestation of primary atypical carcinoid tumor of mediastinum by [68Ga]Ga-DOTA-TATE PET/CT","authors":"M. Daşar, A. Akbulut, S. Özdemir, K. Demirel, G. Koca, M. Korkmaz","doi":"10.1016/j.remnie.2025.500278","DOIUrl":"10.1016/j.remnie.2025.500278","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500278"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of transperineal prostate biopsy guided by fusion of [18F]F-PSMA-1007 PET/MRI with real-time transrectal ultrasound. Prostate cancer classification using imaging biomarkers and radiomics in PIRADS 3 lesions","authors":"J.R. Garcia ,&nbsp;N. Garrido ,&nbsp;P. Bassa ,&nbsp;A. Compte ,&nbsp;L. Pinilla ,&nbsp;J.R. Romero ,&nbsp;L. Mont-Castro ,&nbsp;J. Garcia-Magro ,&nbsp;S. Ruiz ,&nbsp;S. Mourelo ,&nbsp;J.M. Santabárbara ,&nbsp;E. Riera","doi":"10.1016/j.remnie.2025.500263","DOIUrl":"10.1016/j.remnie.2025.500263","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the diagnostic feasibility of transperineal biopsy guided by fusion of PET/MRI with [18F]F-PSMA-1007 and real-time transrectal ultrasound (BP PET/MR PSMA + TRUS) in patients with PIRADS 3 lesions.</div><div>To analyze imaging biomarkers and radiomic features for differentiating between patients with negative biopsy, clinically non-significant prostate cancer (cnsPCa), and clinically significant prostate cancer (csPCa).</div></div><div><h3>Methods</h3><div>A prospective study was conducted in 20 patients with PIRADS 3 lesions and PSA ≥ 4 ng/mL, with no concurrent suspicious lesions.</div><div>All patients underwent a PET/MRI with [18F]F-PSMA-1007, followed by targeted biopsy using real-time ultrasound fusion.</div><div>Diagnostic accuracy for prostate cancer (PCa) and the proportion of csPCa and cnsPCa diagnoses were calculated.</div><div>Imaging biomarkers and machine learning models based on radiomic features were analyzed.</div></div><div><h3>Results</h3><div>The technique was feasible in 100% of cases.</div><div>The overall detection rate of PCa was 80%, with 100% sensitivity and 36% specificity for csPCa.</div><div>SUVpeak was the only biomarker that showed significant differences between patients with negative histology and PCa (AUC 0.81; sensitivity 75%; specificity 80%; cutoff value 3.5). No biomarker successfully differentiated between csPCa and cnsPCa.</div><div>Both supervised classification models demonstrated high diagnostic performance (AUC &gt; 0.95): Multimodal regression performed slightly better for binary classification (negative vs. PCa). Random Forest outperformed in three-class classification (negative vs. cnsPCa vs. csPCa).</div></div><div><h3>Conclusions</h3><div>BP PET/MRI PSMA + TRUS is a feasible, safe, and potentially superior technique compared to MRI-only targeted biopsy, especially in PIRADS 3 lesions.</div><div>Radiomic analysis improves discriminative ability over conventional imaging biomarkers, particularly for distinguishing between cnsPCa and csPCa.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500263"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative prediction of lymph node metastasis and prognosis in gastric cancer patients: A machine learning model based on 18F-FDG metabolic parameters","authors":"D. Chen,&nbsp;W. Chen,&nbsp;X. Pan,&nbsp;Q. Lyu,&nbsp;J. Zhang,&nbsp;D. Lin,&nbsp;D. Liu","doi":"10.1016/j.remnie.2025.500277","DOIUrl":"10.1016/j.remnie.2025.500277","url":null,"abstract":"<div><h3>Objective</h3><div>To construct and validate a model for predicting lymph node metastasis (LNMs) of gastric cancer (GC) based on 18F-FDG PET/CT multi-parameter data and multiple machine learning (ML) algorithms.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of clinical records and 18F-FDG PET/CT images from 167 GC patients treated with radical gastrectomy. The dataset was randomly divided into two cohorts (training and validation cohort) with a ratio of 7:3. Seven machine learning algorithms were used to develop models. The model's performance was evaluated using metrics such as the receiver operating characteristic curve (ROC), sensitivity, specificity, accuracy, negative and positive predictive value, F1 score, calibration curve, and decision curve. Shapley Additive Explanations (SHAP) analysis was conducted to determine feature importance and enhance model interpretability. Additionally, Kaplan-Meier analysis was used to evaluate the prognosis of GC patients.</div></div><div><h3>Results</h3><div>The Artificial Neural Network algorithm(ANN)model outperformed other algorithms in the validation set, with an AUC of 0.814 (95% CI: 0.707−0.921), a sensitivity of 0.872, a specificity of 0.500 and an accuracy of 0.784. Both calibration and decision curve analyses demonstrated excellent calibrated ability and favorable clinical applicability. Through SHAP method, tumor invasion depth (clinical T stage), platelet count (PLT), and total lesion glycolysis (TLG) emerged as the most influential predictors in the ML model. Furthermore, the model exhibited robust risk stratification capability for overall survival (OS).</div></div><div><h3>Conclusion</h3><div>The ML model utilizing 18F-FDG PET/CT metabolic parameters showed good efficacy and reliability in predicting LNS preoperatively in GC patients.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500277"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic retroperitoneal paraganglioma: Insights from somatostatin receptor versus FAPI imaging","authors":"M.H. Samadi ,&nbsp;P. Sahafi ,&nbsp;M. Ahmadi ,&nbsp;A. Taghizadeh ,&nbsp;A. Aghaee","doi":"10.1016/j.remnie.2025.500266","DOIUrl":"10.1016/j.remnie.2025.500266","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500266"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of visual assessment, centiloid quantification, and clinical follow-up in patients with suspected Alzheimer’s disease with [18F]Florbetaben PET imaging","authors":"J.A. Lojo-Ramírez ,&nbsp;C.A. Rodríguez-Vergara ,&nbsp;P. Fernández-Rodríguez ,&nbsp;M. Guerra-Gómez ,&nbsp;A.M. Marín Cabañas ,&nbsp;J.M. Jiménez-Hoyuela García ,&nbsp;E. Franco-Macías ,&nbsp;D. García-Solís","doi":"10.1016/j.remnie.2025.500274","DOIUrl":"10.1016/j.remnie.2025.500274","url":null,"abstract":"<div><h3>Objetive</h3><div>The detection of amyloid deposition has become a pivotal element in the diagnostic workup of Alzheimer's disease (AD). Among the available PET radiotracers, [¹⁸F]Florbetaben has proven to be a reliable tool for identifying amyloid-beta plaques, validated through both clinical assessments and histopathological correlation. This study aimed to assess the diagnostic accuracy and reliability of two key imaging methods: visual interpretation and semi-quantitative analysis using the Centiloid (CL) scale.</div></div><div><h3>Methods</h3><div>We included 208 patients who were attended at the outpatient Memory Clinic of a tertiary hospital, with mild cognitive impairment or mild dementia, suspected of AD. We performed receiver-operating-characteristic (ROC) analyses to compare the discriminative power of visual and quantification between AD and non-AD patients, characterized through the previously established standard of truth (SoT) as clinical follow-up.</div></div><div><h3>Results</h3><div>A total of 198 cases (95.0%) demonstrated concordance between both diagnostic methods (visual and CL-based quantification) and the SoT, with a weighted kappa coefficient k = 0.903 (<em>p</em> &lt; 0.001), indicating almost perfect agreement. When comparing visual diagnosis to the SoT, the sensitivity was 96.8%, specificity was 96.5%, and diagnostic accuracy was 96.6%. Both approaches exhibited excellent diagnostic performance, effectively correlating with the final clinical diagnoses.</div></div><div><h3>Conclusion</h3><div>Our findings highlight that both visual assessment and semi quantitative analysis are reliable tools for the detection and monitoring of amyloid deposition in AD, particularly for early diagnosis and disease progression tracking.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500274"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulocyte-colony stimulating factor-associated aortitis on 18F-FDG PET/CT","authors":"R. Jordà-Sánchez ,&nbsp;M. Ortiz-Fernández ,&nbsp;I.A. Hernández ,&nbsp;Á. Muxi ,&nbsp;S. Prieto-González","doi":"10.1016/j.remnie.2025.500256","DOIUrl":"10.1016/j.remnie.2025.500256","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500256"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the era of personalized dosimetry in hepatic radioembolization coming to an end?","authors":"J. Orcajo Rincón ,&nbsp;L. Reguera Berenguer ,&nbsp;A.M. Matilla Peña ,&nbsp;M. González Leyte ,&nbsp;J. Ardila Mantilla ,&nbsp;S. Salcedo Cortés ,&nbsp;V. Pérez Aradas ,&nbsp;J.C. Alonso Farto","doi":"10.1016/j.remnie.2026.500273","DOIUrl":"10.1016/j.remnie.2026.500273","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500273"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of absolute myocardial blood blow with a dedicated CZT cardiac gamma camera: Methods and potential pitfalls","authors":"A. Palomar-Muñoz ,&nbsp;A. Cardozo-Saavedra ,&nbsp;M.J. Díez-Castro ,&nbsp;M.C. López Arribas ,&nbsp;M.N. Pizzi ,&nbsp;A. Roque-Pérez ,&nbsp;S. Aguadé-Bruix ,&nbsp;D. Sánchez-Artuñedo ,&nbsp;C. Gámez-Cenzano","doi":"10.1016/j.remnie.2026.500271","DOIUrl":"10.1016/j.remnie.2026.500271","url":null,"abstract":"<div><div>Non-invasive techniques for the evaluation of myocardial perfusion provide key functional information for the diagnosis of coronary disease and the stratification of risk in ischemic cardiopathy. Nonetheless, despite their adequate diagnostic performance, the myocardial perfusion images present limitations in the detection of balanced ischemia due to multivessel disease and in the assessment of microvascular pathology. Evaluation of the parameters of myocardial blood flow (MBF) and myocardial flow reserve may be useful in cases in which the technique is limited due to balanced coronary disease or in patients with healthy coronary arteries and suspicion of microvascular involvement.</div><div>The greater spatial resolution and energy and greater sensitivity of the new generation cadmium-zinc-telluride gamma cameras compared to conventional equipment allow isotopic evaluation by single photon emission computed tomography of microvascular disease, which, previously, was mainly evaluated with the gold standard technique of positron emission tomography.</div><div>The aim of this article of collaboration is to describe the protocol for the quantification of MBF developed by the Department of Nuclear Medicine of the Hospital Vall d’Hebron using a cardio-dedicated gamma camera (MyoSPECT™- GE HealthCare), highlighting the particularities of the acquisition of post-processing of the images as well as the possible artifacts.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500271"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical presentation of angiosarcoma detected by 18F-FDG PET/CT as a solitary mediastinal lesion","authors":"N. Hou,&nbsp;H. Dai,&nbsp;R. Huang,&nbsp;M. Su","doi":"10.1016/j.remnie.2025.500275","DOIUrl":"10.1016/j.remnie.2025.500275","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500275"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-depth clinical and dosimetric analysis of 166Ho-radioembolization in patients with liver cancer: An observational study","authors":"R. Sá e Silva ,&nbsp;J. André Oliveira ,&nbsp;J. Santos ,&nbsp;R. Albergueiro ,&nbsp;P. Pereira ,&nbsp;L. Costa","doi":"10.1016/j.remnie.2025.500269","DOIUrl":"10.1016/j.remnie.2025.500269","url":null,"abstract":"<div><h3>Introduction</h3><div>Transarterial radioembolization (TARE) using holmium-166 (¹⁶⁶Ho) microspheres is a treatment for unresectable primary and secondary liver malignancies. The pre-therapeutic simulation procedure using a scout dose is critical to predict microsphere distribution and exclude extrahepatic leakage. This single-center observational study aimed to evaluate the dosimetric agreement between ¹⁶⁶Ho-scout and ¹⁶⁶Ho-therapy, and to correlate tumor-absorbed dose with treatment response at both tumor and patient levels.</div></div><div><h3>Methods</h3><div>Prospective, observational study included patients with BCLC 2022 stage A/B hepatocellular carcinoma or oligometastatic liver disease undergoing ¹⁶⁶Ho-TARE were included. Voxel-based dosimetry was performed using Q-suite. Contrast-enhanced CT was acquired 3 months post-treatment. Treatment response was assessed by RECIST/mRECIST criteria.</div></div><div><h3>Results</h3><div>Twenty patients underwent the pre-treatment procedure; 18 proceeded to therapy. No significant differences were observed between scout and therapy procedures in whole-liver (<em>P</em> <!-->=<!--> <!-->.331) and tumor doses (<em>P</em> <!-->=<!--> <!-->.063), indicating reliable pre-therapeutic evaluation. Fourteen patients with 16 treated lesions were included in the dose-response analysis (median volume: 22,1 [10,5–80,3]<!--> <!-->mL; dose: 22,1 [10,5–80,3]<!--> <!-->Gy). The objective tumor response rate at 3 months was 94%. However, no significant differences were found in absorbed dose metrics (<em>P</em> <!-->=<!--> <!-->.315) or dose-volume histogram values (D50, D70, D85) between responsive and non-responsive (NR) lesions. Patient-level analysis showed a 29% progression rate, with NR patients more likely to have secondary liver tumors (<em>P</em> <!-->=<!--> <!-->.011).</div></div><div><h3>Conclusion</h3><div>This study including a Portuguese cohort treated with ¹⁶⁶Ho-TARE showed a high tumor response rate. However, the limited sample size reduces the robustness of the conclusions. Further data from ongoing follow-up are awaited.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500269"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}