Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"False lymph node recurrence image in PET/CT with [68Ga]Ga-PSMA-11. Importance of the acquisition protocol","authors":"Carolina Castillo-Arias , Daniel Vas , Erick García , Katherine Quintero , Marta Tormo , Pilar Paredes","doi":"10.1016/j.remnie.2024.500077","DOIUrl":"10.1016/j.remnie.2024.500077","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 2","pages":"Article 500077"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioactive seed localization technique with 125-I in inguinal endometriosis","authors":"L. Rodríguez-Díaz , E. García , C. de Guirior , R. Salvador , J. Ribera-Perianes , S. Vidal-Sicart","doi":"10.1016/j.remnie.2024.500069","DOIUrl":"10.1016/j.remnie.2024.500069","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 2","pages":"Article 500069"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of staging using [68Ga]Ga-PSMA-11 PET/CT and histopathological results in intermediate- and high-risk prostate cancer patients treated with radical prostatectomy and pelvic lymph node dissection","authors":"J.J. Rosales ,&nbsp;V. Betech Antar ,&nbsp;F. Mínguez ,&nbsp;F. Pareja ,&nbsp;F. Guillén ,&nbsp;E. Prieto ,&nbsp;G. Quincoces ,&nbsp;F.D. Caballero ,&nbsp;B. Miñana ,&nbsp;J.L. Pérez-Gracia ,&nbsp;M. Rodríguez-Fraile","doi":"10.1016/j.remnie.2024.500076","DOIUrl":"10.1016/j.remnie.2024.500076","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the diagnostic accuracy of [⁶⁸Ga]Ga-PSMA-11 PET/CT (PET-PSMA) in local and loco-regional nodal staging compared with histopathological results in intermediate- and high-risk prostate cancer patients treated with radical prostatectomy (RP) and pelvic lymph node dissection (PLND).</div></div><div><h3>Materials y methods</h3><div>A total of 122 intermediate- and high-risk prostate cancer (PCa) patients staged with PET-PSMA and treated with RP (36/122) and RP plus PLND (86/122) from December 2018 to December 2023 were included. Visual and semiquantitative analysis findings using the SUVmax of the molecular imaging were correlated with histopathological results.</div></div><div><h3>Results</h3><div>The primary tumor was visible by PET-PSMA in 96.7% of the patients. A positive correlation was found between PSA levels and SUVmax (Spearman’s r: 0.303, p &lt; 0.001). PET-PSMA detected nodal involvement in 25/89 patients (28.08%). The sensitivity, specificity, and diagnostic accuracy of PET-PSMA for detecting nodal involvement were 75%, 82.2%, and 80.9%, respectively. Patients with PSA levels &gt;20 ng/mL, Gleason score ≥7b, ISUP grade &gt;2, and extracapsular extension showed significantly higher SUVmax values. No differences were observed in SUVmax between risk groups or in other histopathological variables.</div></div><div><h3>Conclusions</h3><div>PET-PSMA is an effective tool for the initial staging of intermediate- and high-risk PCa. SUVmax values were significantly higher in patients with unfavorable clinical features.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 2","pages":"Article 500076"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of 18F-FDG PET/CT in the diagnosis and grading of incidental colorectal adenomas","authors":"Z. Qi ,&nbsp;K. Tang ,&nbsp;X. Lu ,&nbsp;Y. Zhu ,&nbsp;N. Xu","doi":"10.1016/j.remnie.2024.500075","DOIUrl":"10.1016/j.remnie.2024.500075","url":null,"abstract":"<div><h3>Purpose</h3><div>Colorectal adenomas (CRAs) are at a higher risk of progressing to colorectal cancer (CRC) as their histological grade increases. Herein, this study investigated the relationship between the maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography-computed tomography (¹⁸F-FDG PET/CT) and the histological grades of CRAs and constructed the optimal regression model for distinguishing between different histological grades.</div></div><div><h3>Methods</h3><div>This study retrospectively analyzed the data of 153 patients with CRAs who had colorectal ¹⁸F-FDG uptake incidentally found on PET/CT. The patients were categorized into low-grade intraepithelial neoplasia (LGIN) and high-grade intraepithelial neoplasia (HGIN) groups based on their histological grade. After the analysis of the relationship between SUVmax measured on preoperative ¹⁸F-FDG PET/CT scans and histological grades, receiver-operating characteristic (ROC) curves were analyzed to determine the optimal cut-off values for distinguishing between the two groups. Common clinical and pathological factors were included and subjected to univariate and multivariate logistic regression analyses to identify independent risk factors. A diagnostic model integrating SUVmax and several risk factors was developed with the multivariate logistic regression analysis.</div></div><div><h3>Results</h3><div>SUVmax was significantly different between the two groups (<em>P</em> &lt; 0.001) and increased with an elevation in the malignancy degree. The area under the ROC curve (AUC) for identifying LGIN and HGIN was 0.796, and the AUC of the combination model was 0.822. Furthermore, SUVmax was an independent risk factor for distinguishing between different histological grades in pairwise comparisons.</div></div><div><h3>Conclusion</h3><div>The regression model involving SUVmax on ¹⁸F-FDG PET/CT can distinguish between histological grades of CRAs, which therefore can be used as a noninvasive tool for the accurate diagnosis of CRAs and assist in developing patient-specific treatment strategies before surgery.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 2","pages":"Article 500075"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role and applications of [18F]FDG PET/CT in the assessment of osteoarticular infection and inflammation — Part II","authors":"E. Noriega-Álvarez ,&nbsp;B. Rodríguez Alfonso ,&nbsp;J.J. Rosales Castillo ,&nbsp;A. Moreno Ballesteros ,&nbsp;E. López Rodríguez ,&nbsp;S. Sanz Viedma ,&nbsp;M.P. Orduña Diez ,&nbsp;L. Domínguez Gadea","doi":"10.1016/j.remnie.2025.500102","DOIUrl":"10.1016/j.remnie.2025.500102","url":null,"abstract":"<div><div>[¹⁸F]FDG PET/TC is an emerging tool in the evaluation of inflammatory arthropathies, characterised by their insidious course and clinical overlap. It allows detection of subclinical inflammation, assessment of systemic involvement and quantification of metabolic parameters useful in early diagnosis and therapeutic monitoring. In rheumatoid arthritis, it correlates with clinical indices (<em>Disease Activity Score</em>), serological markers (CRP, anti-citrullinated protein antibodies) and ultrasound findings, and facilitates the identification of complications such as cardiovascular and pulmonary involvement. In spondyloarthritis, its ability to identify enthesitis and peripheral synovitis is promising, although less studied. In addition, [¹⁸F]FDG PET/TC evaluates the response to biological treatments, helping to optimise therapeutic decisions. However, its implementation faces challenges such as lack of standardised indications, incidental findings and technical artefacts. Although not routinely recommended, its usefulness in specific settings underlines the need for further studies to consolidate its role in the management of these diseases. In this manuscript, we present a brief review providing general and practical information about the role of [¹⁸F]FDG PET/TC in inflammatory osteoarticular pathology, while “Role and applications of [¹⁸F]FDG PET/CT in the assessment of osteoarticular infection and inflammation — Part I” has addressed its role in infectious osteoarticular disease.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 2","pages":"Article 500102"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome and incidence of hypothyroidism in low-dose radioactive iodine treatment for hyperthyroidism","authors":"Ku-Hung Lin ,&nbsp;Jiun-Chang Wu ,&nbsp;Ming-Che Wu","doi":"10.1016/j.remnie.2024.500056","DOIUrl":"10.1016/j.remnie.2024.500056","url":null,"abstract":"<div><h3>Objective</h3><div>The study aimed to analyze the outcome of low-dose radioactive iodine (RAI) treatment for hyperthyroidism, disclose whether age and gender influence the outcome and determine the incidence and onset time of hypothyroidism following low-dose RAI.</div></div><div><h3>Material and methods</h3><div>A total of 158 patients who received doses less than 370 Mbq RAI were enrolled in the study. Treatment outcome and incidence of hypothyroidism were compared between different gender (45 male vs.113 female), age (77 patients ≥45 years old vs. 81 patients &lt;45 years old) and dose (39 patients receiving higher doses RAI vs. 119 receiving lower dose with a cutoff of 222 MBq) groups. Treatment outcomes were categorized into post-treatment hypothyroidism, treatment failure (persistent hyperthyroidism), and euthyroidism. In those becoming hypothyroid, time to develop hypothyroidism was calculated for cumulative incidences over time.</div></div><div><h3>Results</h3><div>Out of 158 patients, 47 (29.7%) developed hypothyroidism, 101 (63.9%) had treatment failure, and 10 (6.3%) remained euthyroid after treatment. Response rates (33.6% vs. 43.5%, p = 0.260) and hypothyroidism incidences (26.9% vs. 38.5%, p = 0.170) did not differ significantly between lower and higher dose groups, neither between lower and higher age groups (p = 0.69 in response rates and p = 0.75 in hypothyroidism incidence). Females exhibited higher response rates (42.5% vs. 20.0%, p = 0.008) and hypothyroidism incidence (46.3% vs. 13.3%, p = 0.004) compared to males. Hypothyroidism onset occurred at a mean of 24.0 ± 29.2 months, and the cumulative incidences over time were 47% and 60% in six and twelve months, respectively.</div></div><div><h3>Conclusions</h3><div>Low-dose RAI has a low response rate for treating hyperthyroidism. Although there may be a lower incidence of hypothyroidism following low-dose RAI compared to high-dose RAI, hypothyroidism may occur early after treatment. Besides, females have higher response rates but more incidence of hypothyroidism. The balance between the risks and benefits of using low-dose RAI should be taken into deliberate consideration.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 2","pages":"Article 500056"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of [^99mTc]Tc-DPD gated-SPECT-CT in the assessment of myocardial uptake patterns in transthyretin amyloidosis (TTR-CA).","authors":"F Sebastián Palacid, N Álvarez Mena, M García Aragón, R D C Zambrano Infantino, B M Jaramillo López, J Gómez Hidalgo, B Pérez López, M P Redondo Del Río, R Ruano Pérez","doi":"10.1016/j.remnie.2025.500081","DOIUrl":"10.1016/j.remnie.2025.500081","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the feasibility of identifying various distribution patterns of [^99mTc]Tc-DPD in patients with cardiac transthyretin amyloidosis using gated SPECT-CT.</p><p><strong>Materials and methods: </strong>Gated SPECT-CT was performed in patients with a positive scintigraphy result for cardiac amyloidosis due to transthyretin (TTR-CA). Patients were categorized into several groups based on sex, degree of radiopharmaceutical uptake according to the Perugini's visual scale and ventricular ejection fraction (LVEF). Cardiac polar maps were obtained using Emory Cardiac Toolbox™ software and scored by segments according to radiopharmaceutical uptake on a scale from 0 (no uptake) to 4 (very high uptake intensity). The Mann-Whitney U and Pearson's Chi-square statistical tests were employed to identify significant differences in distribution patterns according to the different variables under study.</p><p><strong>Results: </strong>65 patients were evaluated. The gender variable determined the main statistically significant differences, highlighting distinct distribution patterns of the radiopharmaceutical at the cardiac level: while women showed lower accumulation of [^99mTc]Tc-DPD in the middle anterior (p=0.035) and basal anterior (p=0.001) segments, whereas men demonstrated higher accumulation in the basal anteroseptal (p=0.009) and basal inferoseptal (p=0.009) segments, and lower scores in the lateroapical segment (p=0.039).</p><p><strong>Conclusions: </strong>Gated SPECT-CT is an essential tool for assessing the distribution pattern of [^99mTc]Tc-DPD of patients with TTR-CA, offering valuable insights into the pathophysiology of the disease.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500081"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Time-Point ¹⁸F-FDG PET/CT in a case of primary hepatic Extranodal Marginal Zone Lymphoma of Mucosa-associated Lymphoid Tissue.","authors":"Runjun Yang, Zhe Zheng, Yu Lin, Hongcheng Shi","doi":"10.1016/j.remnie.2025.500105","DOIUrl":"10.1016/j.remnie.2025.500105","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500105"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: The role of baseline volumetric 18F-FDG PET/CT parameters and inflammatory markers.","authors":"Gokmen Umut Erdem, Ozge Vural Topuz, Esranur Acar, Tanju Kapagan, Esma Yetim, Aykut Ozmen, Simay Gurocak, Gamze Usul, Sercan Yuksel, Aytul Hande Yardimci, Nilufer Bulut","doi":"10.1016/j.remnie.2025.500113","DOIUrl":"10.1016/j.remnie.2025.500113","url":null,"abstract":"<p><strong>Objectives: </strong>We evaluated the influence of baseline volumetric 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) parameters and inflammatory prognostic markers on complete response (CR) in patients with locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT).</p><p><strong>Materials and methods: </strong>In total, 90 patients with LARC, including those with and without CR, were evaluated based on baseline volumetric PET/CT parameters, such as maximum standard uptake value, metabolic tumor volume (MTV), tumor lesion glycolysis, and inflammatory prognostic markers, including the lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio.</p><p><strong>Results: </strong>Of the 90 patients, 62 (68.9%) were male and 28 (31.1%) were female. The median age was 61 (31-81) years. A complete response was observed in 20 (22%) patients following nCRT. Of these, 5 demonstrated a clinical complete response, whereas 15 exhibited a complete response after surgery. A low pretreatment PLR, low MTV levels, and stage 2 disease were identified as significant predictors of complete response. The optimal cutoff values were 16.5 for MTV (sensitivity 80%, specificity 62%) and 121 for PLR (sensitivity 73%, specificity 65%).</p><p><strong>Conclusion: </strong>Our findings suggest that stage 2 disease, low pretreatment MTV, and low PLR levels may be predictive of a CR to nCRT in patients with LARC.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500113"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of normalized distance from maximum standardized uptake value to tumor centroid on [¹⁸F]FDG PET/CT in head and neck squamous cell carcinoma.","authors":"Sun-Pyo Hong, Sang Mi Lee, Ik Dong Yoo, In Young Jo, Yong Kyun Won, Min-Su Kim, Hye Jeong Choi, Jeong Won Lee, Su Jin Jang","doi":"10.1016/j.remnie.2025.500103","DOIUrl":"10.1016/j.remnie.2025.500103","url":null,"abstract":"<p><strong>Objective: </strong>The maximum [¹⁸F]FDG uptake of a cancer lesion has been found to relocate from the center to the periphery during progression. This behavior suggests that the normalized distances from the hotspot of radiotracer uptake to the tumor centroid (NHOC) and to the tumor perimeter (NHOP) could serve as novel geometric PET parameters indicative of tumor aggressiveness. This study aimed to explore the prognostic relevance of NHOC and NHOP in [¹⁸F]FDG PET/CT for predicting the response to concurrent chemoradiotherapy (CCRT) and progression-free survival (PFS) in patients with head and neck squamous cell carcinoma (HNSCC).</p><p><strong>Materials and methods: </strong>We retrospectively reviewed 116 HNSCC patients who received CCRT and were assessed with pre-treatment (PET1) and three months post-treatment PET/CT (PET2). Along with conventional PET parameters, NHOC and NHOP for primary tumors on PET1 and the percent changes in NHOC and NHOP between PET1 and PET2 were measured.</p><p><strong>Results: </strong>Of all the PET1 parameters assessed, NHOC was the most effective in predicting the CCRT response, achieving an area under the receiver operating characteristic curve of 0.645. In multivariate logistic regression and survival analysis, NHOC identified as an independent predictor for both complete metabolic response (P = .028) and PFS (P = .006). In a subgroup of 46 patients exhibiting residual primary tumors on PET2, both the percent changes in NHOC (P = .048) and NHOP (P = .041) were significantly associated with PFS.</p><p><strong>Conclusions: </strong>NHOC and the percent changes in NHOC and NHOP following CCRT may serve as effective [¹⁸F]FDG PET/CT parameters for predicting clinical outcomes in HNSCC patients.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500103"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}