E. Noriega-Álvarez , A. Moreno-Ballesteros , M. Velasco Nuño , J.M. Cordero García , J.J. Rosales Castillo , U.V. Schmülling , E. López Rodríguez , A. Rigabert Sánchez-Junco , B. Rodríguez Alfonso
{"title":"National survey on nuclear imaging in infectious bone pathology: Results and diagnostic recommendations of the Musculoskeletal Pathology Working Group (MSP-WG)","authors":"E. Noriega-Álvarez , A. Moreno-Ballesteros , M. Velasco Nuño , J.M. Cordero García , J.J. Rosales Castillo , U.V. Schmülling , E. López Rodríguez , A. Rigabert Sánchez-Junco , B. Rodríguez Alfonso","doi":"10.1016/j.remnie.2025.500165","DOIUrl":"10.1016/j.remnie.2025.500165","url":null,"abstract":"<div><div>The continued increase in demand for diagnosis and monitoring of infectious bone diseases, along with the introduction of new equipment, radiopharmaceuticals, and techniques for this purpose, has made it necessary to dynamically update the existing protocols and recommendations. Therefore, the MSP-WG conducted a survey for spanish hospitals to complete and develop recommendations in the form of algorithms, in an attempt to combine existing scientific evidence with the reality of national clinical practice.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 5","pages":"Article 500165"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Inal, C Soydal, B Demir, M Araz, Y Urun, S Baltacı, E Suer, N O Kucuk
{"title":"Comparative evaluation of the performance of <sup>18</sup>F-PSMA-1007 PET/CT and <sup>68</sup>Ga-PSMA-11 PET/CT in prostate cancer patients with biochemical recurrence.","authors":"G Inal, C Soydal, B Demir, M Araz, Y Urun, S Baltacı, E Suer, N O Kucuk","doi":"10.1016/j.remnie.2025.500178","DOIUrl":"10.1016/j.remnie.2025.500178","url":null,"abstract":"<p><strong>Aim: </strong>In this study, we aimed to evaluate the diagnostic performance of <sup>18</sup>F-PSMA-1007 PET/CT compared to <sup>68</sup>Ga-PSMA-11 PET/CT, which is more commonly used in routine practice, for detecting prostate cancer recurrence in prostate cancer patients with biochemical recurrence.</p><p><strong>Materials and methods: </strong>Forty-one prostate cancer patients with biochemical recurrence were prospectively included in the study. Additionally, images from 46 patients in our institution's database, who had undergone <sup>68</sup>Ga-PSMA-11 PET/CT imaging for biochemical recurrence, were retrospectively re-evaluated to compare the detection rates with those of <sup>18</sup>F-PSMA-1007 PET/CT. SUVmax, total tumor PSMA, PSMA total tumor volume were calculated for local recurrence, lymph node metastasis, and organ metastasis. The diagnostic performances of the two imaging methods were then compared.</p><p><strong>Results: </strong>The mean age, Gleason scores, ISUP scores, serum PSA levels at diagnosis and at the time of imaging, and PSA doubling times were similar across the <sup>18</sup>F-PSMA-1007 and <sup>68</sup>Ga-PSMA-11 groups. Pathological uptake was observed in the prostatic bed in 16 patients (39.0%), lymph nodes in 22 patients (46.3%), and bones in 11 patients (26.8%) with <sup>18</sup>F-PSMA-1007 PET/CT. <sup>18</sup>F-PSMA-1007 PET/CT showed statistically significant superiority over <sup>68</sup>Ga-PSMA-11 PET/CT in detecting lymph node metastases (41.6% vs. 25.4%; P=.028). There was no significant difference between the two imaging protocols in the detection rates of local recurrence (P=.067) and bone metastasis (P=.580).</p><p><strong>Conclusion: </strong>Although the study included a small sample size, the results revealed that <sup>18</sup>F-PSMA-1007 PET/CT had a higher detection rate than <sup>68</sup>Ga-PSMA-11 PET/CT in patients with biochemically recurrent prostate carcinoma, particularly for lymph node metastases.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500178"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"May it be a new parameter of 18F-FDG PET/CT for differentiating between benign and malignant adrenal lesions: \"Adrenal Densitometabolic Index (ADMI)\".","authors":"E Ciftci, T Y Erdil, B Karaşah Erkek, B Akovali","doi":"10.1016/j.remnie.2025.500185","DOIUrl":"10.1016/j.remnie.2025.500185","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the diagnostic importance of a new parameter consisting of the densitometric and metabolic properties of the lesion measured by 18F-FDG PET/CT in differentiating between benign and malignant adrenal lesions in cancer patients.</p><p><strong>Material and methods: </strong>We evaluated PET/CT parameters of adrenal lesions of patients between 2017 and 2019. A new parameter, \"Adrenal Dansitometabolic index (ADMI),\" was investigated. Additionally, SUVmax, tumor-to-liver ratio (T/LR), Hounsfield Units (HU), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of adrenal lesions were analyzed. Logistic regression analyses were conducted to identify the most predictive parameter for malignant lesions.</p><p><strong>Results: </strong>Two hundred and four adrenal lesions underwent PET/CT for tumor evaluation. Based on ROC analysis, ADMI > 9.5, a SUVmax > 4.15, a T/L SUVmax ratio > 1.7, an attenuation value > 21.75 HU, a TLG > 14.61 and a MTV > 4.5 were chosen as the optimal cut-off values for differentiating malignant from benign lesions. ADMI, SUVmax, and T/L ratio demonstrated similarly high diagnostic performance (AUC values: 0.993, 0.992 and 0.988 (P = .000), respectively). ADMI exhibited the highest sensitivity and negative predictive value. A multivariate logistic regression analysis revealed that both ADMI and T/L ratio serve as independent prognostic factors for malignancy (P = .001 and P = .003, respectively).</p><p><strong>Conclusion: </strong>ADMI, effectively distinguishes benign from malignant. This technique may facilitate investigations of the adrenal lesions to clinical outcomes but needs further large series studies.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500185"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pretreatment <sup>18</sup>F-FDG PET/CT in predicting the survival of patients with hepatic neuroendocrine tumors.","authors":"Y Zhang, G Liu, L Zhong, B Li, Y Zhang","doi":"10.1016/j.remnie.2025.500198","DOIUrl":"10.1016/j.remnie.2025.500198","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prognostic value of pretreatment 2-[<sup>18</sup>F]-fluoro-2-deoxy-d-glucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with hepatic neuroendocrine tumors (HNET).</p><p><strong>Methods: </strong>In total, 41 patients were included in this study. PET-derived metabolic parameters, including maximum and mean standardized uptake values (SUV<sub>max</sub> and SUV<sub>mean</sub>, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), of the tumors were measured. Meanwhile, clinical data, including tumor pathological findings such as the Ki-67 index were also assessed. Progression-free survival (PFS) and overall survival (OS) were evaluated. Univariate and multivariate analyses were performed to predict the prognostic value of clinical variables and PET-derived metabolic parameters in HNET patients. Correlation between PET-derived metabolic parameters and Ki-67 was estimated.</p><p><strong>Results: </strong>Univariate analyses revealed that among PET-derived metabolic parameters, SUV<sub>max</sub>, SUV<sub>mean</sub>, and TLG were significant prognostic factors for OS (P < .05). Among clinical variables, the Ki-67 index and radical surgical resection were significant factors for both PFS and OS (P < .05). In multivariate analyses, only Ki-67 index was an independent prognostic factor for both PFS and OS (P < .05). Ki-67 index presented correlates with SUV<sub>max</sub> and SUV<sub>mean</sub> (R = 0.566, P < .001, R = 0.493, P = .001, respectively).</p><p><strong>Conclusions: </strong>In patients with HNET, the Ki-67 index was an independent prognostic factor for both PFS and OS, while SUV<sub>max</sub>, SUV<sub>mean</sub>, and TLG measured on pretreatment <sup>18</sup>F-FDG PET/CT scans were prognostic factors for predicting OS. Ki-67 index also presented correlates with SUV<sub>max</sub> and SUV<sub>mean</sub>. <sup>18</sup>F-FDG-PET may be useful as quantitative predicting prognostic imaging biomarkers, especially in poorly differentiated HNET.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500198"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Massive subcutaneous emphysema and complete resorption images detected on [<sup>18</sup>F]-FDG PET/CT.","authors":"M T Tatoğlu, H Uslu","doi":"10.1016/j.remnie.2025.500180","DOIUrl":"10.1016/j.remnie.2025.500180","url":null,"abstract":"<p><p>Subcutaneous emphysema may occur iatrogenically, spontaneously, or post-traumatically as a result of free air passage under the skin from the respiratory tract or gastrointestinal tract. In this case, we present the typical appearance of a case of massive subcutaneous emphysema observed on [18F]-FDG PET/CT for metabolic characterization due to a massive lesion in the lung and the images of complete resorption after seven months.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500180"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multifocal bone tuberculosis with adrenal involvement mimicking malignant tumors with multiple metastases on PET/CT.","authors":"W Zhang, Y Xing, A Kuang, Y Li","doi":"10.1016/j.remnie.2025.500141","DOIUrl":"10.1016/j.remnie.2025.500141","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500141"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G A Divband, E Askari, H R Amini, A R Noferesti, P Sahafi
{"title":"<sup>68</sup>Ga-FAPI and <sup>18</sup>F-FDG PET/CT: Complementary imaging modalities for detecting unusual metastasis in a patient with osteosarcoma.","authors":"G A Divband, E Askari, H R Amini, A R Noferesti, P Sahafi","doi":"10.1016/j.remnie.2025.500137","DOIUrl":"10.1016/j.remnie.2025.500137","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500137"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Aghaee, Z Bakhshi, V Roshanravan, N Norouzbeigi, H Dadgar, E Askari, K Aryana, S Shafiei, S Soltani, S Sadeghpour
{"title":"Beyond the standard: Enhancing prostate bed and regional lymph node detection in prostate cancer patients with early and delayed imaging in [68 Ga]Ga-PSMA-11 PET/CT.","authors":"A Aghaee, Z Bakhshi, V Roshanravan, N Norouzbeigi, H Dadgar, E Askari, K Aryana, S Shafiei, S Soltani, S Sadeghpour","doi":"10.1016/j.remnie.2025.500184","DOIUrl":"10.1016/j.remnie.2025.500184","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the diagnostic value of early static and delayed imaging in conjunction with standard 68Ga-PSMA-11 PET/CT scans to detect prostate malignant lesions in prostate cancer patients.</p><p><strong>Methods: </strong>One hundred and thirty-eight prostate cancer patients underwent routine [68 Ga]Ga-PSMA-11 PET/CT imaging, 4-minute static acquisition post-injection, and delayed imaging 3 h post-injection. The imaging results were analysed for lesion count, type, localisation, and maximum standardised uptake values.</p><p><strong>Results: </strong>57.97% exhibited positive findings for pathologic prostatic lesions in the standard PET scans (SUV<sub>max</sub>: 10.24). In contrast, early PET imaging detected lesions in 58.01% of patients (SUV<sub>max</sub> of 5.86), while delayed scans revealed lesions suggestive of malignancy in 55.45% of patients (SUV<sub>max</sub> of 12.79). The analysis demonstrated a statistically significant difference in SUV<sub>max</sub> values across the time points (P < .001). Pathologic lymph nodes on images 60 min p.i. were revealed by an SUV max 60 min p.i.: 15.78; this number for the first 4 min and after 3 h were 7.36, 19.19, respectively. Metastatic bone lesions on WB were found in 38 patients, more than the ESI (n = 37) and DI (n = 24). In comparison, urinary bladder activity assessment was detectable with the WB imaging SUV<sub>max</sub> 60 min 11.07. Even though the SUV max for ESI and DI were 6.95 and 31.97, respectively. In the statistical analysis, pathologic radiotracer uptake in tumour lesions was statistically higher in ESI and WB than in urinary bladder activity.</p><p><strong>Conclusions: </strong>The findings indicate that neither early [68 Ga]Ga-PSMA-11 PET/CT nor delayed imaging significantly enhanced the overall detection rate of malignant lesions in prostate cancer patients. However, the early 4-minute post-injection acquisition of PET images proved beneficial for distinguishing local bladder invasion more effectively.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500184"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidental detection of bone metastases from gastric cancer on [99mTc]Tc-DTPA renal dynamic scintigraphy.","authors":"C Nong, Y Xing, L Jiang, Z Zhao","doi":"10.1016/j.remnie.2025.500196","DOIUrl":"10.1016/j.remnie.2025.500196","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500196"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}