Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Tuberculous lymphadenitis mimicking dedifferentiation on dual [⁶⁸Ga]Ga-DOTA-TOC and [¹⁸F]FDG PET/CT in a neuroendocrine tumor.","authors":"Y Delisau, M Velasco-Nuño, M Calls-Calahorro, M Rodríguez-Fontán, G Arís-Cuadras, A Flotats","doi":"10.1016/j.remnie.2026.500346","DOIUrl":"10.1016/j.remnie.2026.500346","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500346"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent fibroblast-related tissue activity in long COVID after moderate-to-severe acute COVID-19 assessed by [⁶⁸Ga]Ga-FAPI PET/CT.","authors":"Ö Hasan, K Abidin, Ö Halil, D Z Didem, Y Burcu, E Dilek, E Recai, T Baykal, E Orhan Önder, Y Farise, K G Gonca, K Fikret","doi":"10.1016/j.remnie.2026.500348","DOIUrl":"10.1016/j.remnie.2026.500348","url":null,"abstract":"<p><strong>Purpose: </strong>Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms. Fibroblast activation protein (FAP), expressed on activated fibroblasts during tissue remodeling, can be visualized with [⁶⁸Ga]Ga-FAPI PET/CT. This study investigated lung and muscle fibroblastic activity in patients with post-acute sequelae of COVID-19 (PASC) following moderate-to-severe COVID-19 pneumonia more than two years after the acute infection, using [⁶⁸Ga]Ga-FAPI PET/CT.</p><p><strong>Methods: </strong>In this pilot prospective observational study, we enrolled patients with PASC following severe acute COVID-19 requiring high-flow nasal cannula or mechanical ventilation and age- and sex-matched controls without pulmonary pathology between September 2023 and February 2024. PASC patients underwent high-resolution CT (HRCT), pulmonary function tests (PFTs), and [⁶⁸Ga]Ga-FAPI PET/CT. SUVmax and SUVmean were measured for each lung lobe. HRCT abnormalities were scored using a semi-quantitative scale (0-20) and categorized as ground-glass opacities, reticulations, parenchymal bands, traction bronchiectasis, or subpleural cysts. These findings were statistically compared and correlated with PET parameters, PFTs, and clinical symptoms. In addition, [⁶⁸Ga]Ga-FAPI uptake in the paravertebral muscles was assessed at the level of the L3 vertebra.</p><p><strong>Results: </strong>Twenty patients with PASC and 10 control subjects were included (median ages: 64 and 58.5 years, respectively). The mean interval between hospitalization for acute COVID-19 and study imaging was 25 ± 4.5 months. PASC patients exhibited significantly increased [⁶⁸Ga]Ga-FAPI uptake in the lungs compared with controls. Lung [⁶⁸Ga]Ga-FAPI uptake was markedly increased in patients with traction bronchiectasis. No correlations were observed between lung [⁶⁸Ga]Ga-FAPI SUVmax and PFTs or symptom burden. However, lung [⁶⁸Ga]Ga-FAPI SUVmean demonstrated moderate inverse correlation with DLCO (r = -0.455, p = 0.044). In addition, [⁶⁸Ga]Ga-FAPI SUVmax in muscle was significantly higher in PASC patients than in controls, with particularly elevated uptake observed in patients with a history of mechanical ventilation.</p><p><strong>Conclusions: </strong>[⁶⁸Ga]Ga-FAPI PET/CT demonstrated increased lung tracer uptake in patients with PASC more than two years after moderate to severe COVID-19, supporting persistent fibroblast-related tissue activity. Limited associations between lung SUVmean and DLCO suggest a potential link between tracer uptake and functional impairment. Increased muscle [⁶⁸Ga]Ga-FAPI uptake was also observed as an exploratory finding requiring further functional and histopathological validation.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500348"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalised dosimetry in hepatic radiomebolization: Time to optimise, not to abandon.","authors":"I Torres Espallardo, G Reynés Llompart, J J Martín Marcuartu, P Mínguez Gabiña, V Morán Velasco, D Pérez Enguix, M Lam","doi":"10.1016/j.remnie.2026.500354","DOIUrl":"10.1016/j.remnie.2026.500354","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500354"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense ¹⁸F-FDG uptake on PET/CT in a patient with active polyarticular tophaceous gout.","authors":"A De-Bonilla Damiá, D Prieto Cebollero, I Acevedo Báñez, J M Jimenez-Hoyuela García","doi":"10.1016/j.remnie.2026.500349","DOIUrl":"10.1016/j.remnie.2026.500349","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500349"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[¹⁸F]FDG PET/CT showing intense uptake in a scalp mass as the initial presentation of grade 3 neuroendocrine neoplasm.","authors":"L N Panqueva Giraldo, G A Montaño Rozo, A C Munive Gnecco, S V Á Ramírez Aguirre, J G Rojas Camacho","doi":"10.1016/j.remnie.2026.500343","DOIUrl":"10.1016/j.remnie.2026.500343","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500343"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive multisystem sarcoidosis with skeletal muscle involvement: tiger-man pattern. The added value of [¹⁸F] FDG PET/TC in diagnosis and treatment response assessment.","authors":"C Ramos-Font, F M Ramos-Pleguezuelos, T Rudolphi-Solero, A C Villena-García, L Cagua-Ruiz, R Sanchez-Sanchez","doi":"10.1016/j.remnie.2026.500342","DOIUrl":"10.1016/j.remnie.2026.500342","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500342"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of multimodal imaging to the metabolic characterization of gliomatosis cerebri in adult type diffuse glioma.","authors":"J Villena-Salinas, M I Morales-Lozano, G A Jiménez-Londoño, F Pérez-Ángel, M Gallego-Peinado","doi":"10.1016/j.remnie.2026.500350","DOIUrl":"10.1016/j.remnie.2026.500350","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500350"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed model to facilitate the surgical localization of the sentinel lymph node in gynecological tumors.","authors":"D Tercero Garrido, M V Guiote Moreno, M D Albalá González, S A Tejerina Tejerina, A J Rodríguez Llamas, J A Vallejo Casas","doi":"10.1016/j.remnie.2026.500334","DOIUrl":"10.1016/j.remnie.2026.500334","url":null,"abstract":"<p><strong>Objective: </strong>To propose a model to facilitate the surgical localization and excision of the sentinel lymph node in gynecological tumors.</p><p><strong>Methodology: </strong>This was an observational, cross-sectional, retrospective, and descriptive study incorporating data from patients who underwent sentinel lymph node biopsy for gynecological tumors between May 2020 and August 2025.</p><p><strong>Results: </strong>The assumptions of linearity, normality, independence, and homoscedasticity of residuals were verified. Subsequently, a simple linear regression analysis model was performed, yielding a predictive equation for surgical count rates: Y = 26.918 + 0.056 × SPECT/CT Counts (R² = 0.925). This equation demonstrated applicability in a small sample of patients.</p><p><strong>Conclusions: </strong>The SPECT/CT counts helps estimate the surgical count rate using a predictive equation. However, studies with larger sample sizes are needed to obtain a more precise equation with greater clinical applicability.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500334"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148858002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of [¹⁸F]PSMA-1007 PET/CT in staging of prostate cancer: Influence of bone uptake and relationship with D'Amico risk classification.","authors":"S S Medina-Ornelas, J E Vargas-Ahumada, R Hernandez-Ramirez, P Chavez-Torres, N Ramirez-Pedraza, A Leon-Alvarez, A Barrientos-Priego","doi":"10.1016/j.remnie.2026.500325","DOIUrl":"10.1016/j.remnie.2026.500325","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer represents a significant global health challenge, particularly in Mexico where it ranks as the leading cause of cancer-related mortality among men. The introduction of Prostate-Specific Membrane Antigen labeled with fluoride [¹⁸F]F-PSMA-1007 PET/CT has revolutionized diagnostics, enabling identification of metastases not visible on conventional imaging, although it presents unspecific bone uptake (UBU) in up to 72% of patients.</p><p><strong>Methods: </strong>Eighty-one patients with newly diagnosed prostate cancer who underwent [¹⁸F]F-PSMA-1007 PET/CT for staging were retrospectively analyzed. Patients were categorized according to D'Amico risk classification. The prevalence of PSMA-positive lesions in various anatomical sites was assessed, defining unspecific bone uptake as focal uptake without meeting PROMISE criteria for osseous metastases.</p><p><strong>Results: </strong>Metastatic disease, specifically defined by the presence of miN1 and/or miM1a-c lesions, was detected in a substantial majority of the patients, totaling 61 individuals, which corresponds to 75% of the entire cohort. Abnormal bone uptake was identified in 58% of cases, distributed equally across D'Amico risk groups. No significant association was found between bone uptake frequency and antigen prostatic specific (PSA) levels or Gleason score (p = 0.24). However, SUVmax was independently associated with metastasis (adjusted OR 1.67 per 5 units increase, 95% CI 1.31-2.14; p < 0.001). Definite bone metastases were confirmed in 44% of patients with bone uptake using an SUVmax ≥ 10 threshold.</p><p><strong>Conclusions: </strong>[¹⁸F]F-PSMA-1007 PET/CT significantly enhances primary staging accuracy in prostate cancer, refining the D'Amico risk classification. The SUVmax ≥ 10 threshold allows differentiation between true bone metastases and unspecific bone uptake. Initial PSA levels significantly predict nodal metastases presence, optimizing treatment strategies and patient outcomes.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500325"},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"May it be a new parameter of 18F-FDG PET/CT for differentiating between benign and malignant adrenal lesions: “Adrenal Densitometabolic Index (ADMI)”","authors":"E. Ciftci,&nbsp;T.Y. Erdil,&nbsp;B. Karaşah Erkek,&nbsp;B. Akovali","doi":"10.1016/j.remnie.2025.500185","DOIUrl":"10.1016/j.remnie.2025.500185","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluates the diagnostic importance of a new parameter consisting of the densitometric and metabolic properties of the lesion measured by 18F-FDG PET/CT in differentiating between benign and malignant adrenal lesions in cancer patients.</div></div><div><h3>Material and methods</h3><div>We evaluated PET/CT parameters of adrenal lesions of patients between 2017 and 2019. A new parameter, “Adrenal Dansitometabolic index (ADMI),” was investigated. Additionally, SUVmax, tumor-to-liver ratio (T/LR), Hounsfield Units (HU), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of adrenal lesions were analyzed. Logistic regression analyses were conducted to identify the most predictive parameter for malignant lesions.</div></div><div><h3>Results</h3><div><span>Two hundred and four adrenal lesions underwent PET/CT for tumor evaluation. Based on ROC analysis, ADMI &gt; 9.5, a SUVmax &gt; 4.15, a T/L SUVmax ratio &gt; 1.7, an attenuation value &gt; 21.75 HU, a TLG &gt; 14.61 and a MTV &gt; 4.5 were chosen as the optimal cut-off values for differentiating malignant from benign lesions. ADMI, SUVmax, and T/L ratio demonstrated similarly high diagnostic performance (AUC values: 0.993, 0.992 and 0.988 (</span><em>P</em><span><span> = .000), respectively). ADMI exhibited the highest sensitivity and negative predictive value. A multivariate logistic regression analysis revealed that both ADMI and T/L ratio serve as independent </span>prognostic factors<span> for malignancy (</span></span><em>P</em> = .001 and <em>P</em> = .003, respectively).</div></div><div><h3>Conclusion</h3><div>ADMI, effectively distinguishes benign from malignant. This technique may facilitate investigations of the adrenal lesions to clinical outcomes but needs further large series studies.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 4","pages":"Article 500185"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}