Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Semi-quantitative MIBG scores in relapsed/refractory neuroblastoma: Prognostic insights from post-131I-MIBG treatment scans and impact of SPECT-CT imaging.","authors":"M E Mavi, P Özgen-Kıratlı, A Varan, B Volkan-Salancı","doi":"10.1016/j.remnie.2025.500133","DOIUrl":"10.1016/j.remnie.2025.500133","url":null,"abstract":"<p><strong>Objectives: </strong>Neuroblastoma often demonstrates high uptake of MIBG, which is used for imaging and therapy. This retrospective observational study aimed to assess the prognostic significance of modified Curie scores (mCS) and SIOPEN scores (SS) derived from post-treatment ¹³¹I-MIBG scans in relapsed/refractory neuroblastoma. Additionally, the impact of SPECT-CT imaging on these scores was investigated as a secondary goal.</p><p><strong>Material and methods: </strong>Pediatric patients with relapsed/refractory neuroblastoma, who underwent ¹³¹I-MIBG treatment, were included (n=35). mCS and SS were calculated from planar images of post-treatment ¹³¹I-MIBG scans. Patients were then categorized based on the cut-off values obtained from these scans, and survival analysis was conducted. To investigate the impact of SPECT-CT imaging on scores, mCS and SS were also calculated from both planar and SPECT-CT images of diagnostic ¹²³I-MIBG scans separately.</p><p><strong>Results: </strong>Patients with mCS>12 or SS>23 on post-treatment ¹³¹I-MIBG scans had significantly worse overall survival. mCS and SS from SPECT-CT were significantly higher than planar images in pre- and post-treatment diagnostic ¹²³I-MIBG scans. SPECT-CT caused changes in mCS for 61% and SS for 55% of patients, predominantly in axial and appendicular skeleton regions.</p><p><strong>Conclusions: </strong>Both mCS and SS from post-treatment ¹³¹I-MIBG planar scans correlated significantly with overall survival in relapsed/refractory neuroblastoma. Patients with mCS>12 or SS>23 had poorer survival. SPECT-CT imaging influenced scores for a substantial portion of patients, emphasizing its value alongside planar imaging. Larger, comprehensive studies are warranted to validate these findings and refine prognostic cut-offs. Incorporating SPECT-CT in relevant body regions is recommended for improved disease assessment.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500133"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of perinodal infiltration on recurrence in papillary thyroid cancer.","authors":"C Alev, T U Mert, O Kursat, D N Aydinbelge, E Aysenur, A B Bedi, G P Akkus, O Murat, C Derya, A Engin, I Semra","doi":"10.1016/j.remnie.2025.500182","DOIUrl":"10.1016/j.remnie.2025.500182","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Locoregional recurrence occurs in up to 28% of patients with papillary thyroid cancer (PTC). Several risk factors contribute to this metastatic process. The latest of them is perinodal infiltration (PNI). PNI refers to the pathological extension of tumor cells through the lymph node (LN) capsule into the perinodal fibroadipose tissue. It has been accepted as a poor predictive variable. This study aimed to evaluate the prognostic significance of PNI in recurrence of PTC and identify predictive parameters associated with the recurrence in PNI (+) patients.</p><p><strong>Material and methods: </strong>The study included 680 PTC patients with initial LN metastasis (ILNM). Study population was selected from them according to presence or absence of PNI. Eventually, 102 PNI (+) and 122 PNI (-) patients remained eligible for the study. Patients were statistically compared according to demographic, clinicopathologic features both between PNI (+) and PNI (-) groups and within the PNI (+) group over recurrence status.</p><p><strong>Results: </strong>The recurrence rates were 40% and 15% in PNI (+) and PNI (-) patients, respectively (p < 0.001). The independent predictive factors associated with recurrence were central ILNM (p = 0.005), combined central and lateral ILNM (p = 0.003), ILNM > 5 (p = 0.023), stage III-IV (p = 0.025 and p < 0.001), tumor size (TS) (p < 0.001), ILNM size (p < 0.001), stimulated thyroglobulin (sTg) (p = 0.039). PNI (p = 0.05), central ILNM (p = 0.035) and TS (p = 0.027) remained prognostic variables after multivariate analysis.</p><p><strong>Conclusion: </strong>PNI positivity is a poor prognostic factor for PTC recurrence. PNI, especially with large TS and central ILNM, should be taken into account when planning RAI therapy in PTC patients.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500182"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPECT/CT with 99mTc-sestamibi in the diagnosis of renal masses.","authors":"L Pinilla, E Riera, J R García, L I Mont-Castro, M Soria, E Valls","doi":"10.1016/j.remnie.2025.500197","DOIUrl":"10.1016/j.remnie.2025.500197","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500197"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical course and features of thyroid oncocytic (Hurthle cell) cancer: Comparison with thyroid follicular cancer.","authors":"O Kursat, T U Mert, G P Akkus, O Murat, D N Aydinbelge, C Alev, S Mehmet, S P Oguz, Z R Deniz, G N Ersoz, I Semra","doi":"10.1016/j.remnie.2025.500158","DOIUrl":"10.1016/j.remnie.2025.500158","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Although, oncocytic (Hurthle cell) carcinoma (OTC) resembles to follicular thyroid carcinoma (FTC), they are different tumors derived from thyroid follicular cells. OTC comprises 3-5% of all differentiated thyroid carcinomas and has more aggressive behaviour than FTC. Clinicians discuss about the treatment and prognosis of OTC. We evaluated its clinicopathological features and clinical course.</p><p><strong>Material and methods: </strong>We examined and followed up 169 patients with OTC (126 minimally invasive, 43 widely invasive) and 837 patients with FTC (640 minimally invasive, 197 widely invasive). OTC and FTC were compared according to prognostic variables, recurrence rate (Rec) and outcome. The predictor factors impacting on recurrence in OTC were also determined.</p><p><strong>Results: </strong>There were statistically significant differences between OTC and FTC in age, sex, capsule invasion (CI), tumor size (TS), total administered [131I]NaI dose (TID), stimulated thyroglobulin (sTg), Rec and stage (p < 0.001, p = 0.032, p < 0.001, p < 0.001, p = 0.004, p = 0.026, p = 0.017, p = 0.044, respectively). Age, CI, extrathyroidal extension (ETE), TS, initial lymph node metastasis (ILNM), sTg and stage (p = 0.01, p = 0.016, p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively) were the predictors for recurrence in OTC. Metastasis incidence was 19.5% for OTC and 12% for FTC. The cause of death was cancer in 25 patients with FTC (2.8%) and 11 patients with OTC (6.5%).</p><p><strong>Conclusion: </strong>The prognosis of minimally invasive OTC is quite favorable. However the prognosis of widely invasive OTC is unfavorable. RAI may be administered to these tumors, but it is in vain to insist on RAI after the first adjuvant therapy if it does not respond.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500158"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of synchronous bilateral ciliary body adenocarcinoma on [¹⁸F]FDG PET/CT and [⁶⁸Ga]Ga-PSMA PET/CT.","authors":"N A Dizdar, E Tatci, O Ozmen","doi":"10.1016/j.remnie.2025.500181","DOIUrl":"10.1016/j.remnie.2025.500181","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500181"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of thyroid/background ratio in distinguishing Graves' disease from subacute thyroiditis: A comparative study.","authors":"G Silov, F Bati, N Biçakçi, B Kirtiloğlu, M Yilmaz","doi":"10.1016/j.remnie.2025.500199","DOIUrl":"10.1016/j.remnie.2025.500199","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and objective: &lt;/strong&gt;Thyrotoxicosis is a common clinical condition in endocrinology, with Graves' disease (GD) and subacute thyroiditis (SAT) as its predominant causes. These disorders often share overlapping clinical and biochemical features, making differential diagnosis challenging. This study evaluates the diagnostic efficacy of the thyroid/background ratio (TBR) as a semiquantitative method for differentiating GD from SAT and compares multiple diagnostic parameters.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;This was a retrospective analysis of 106 consecutive patients newly diagnosed with thyrotoxicosis. All participants underwent assessment of free tri-iodothyronine (fT3), free thyroxine (fT4), TSH, thyroid-stimulating immunoglobulin (TSI), Anti-TPO, Anti-Tg, CRP, erythrocyte sedimentation rate (ESR), 99mTc thyroid scintigraphy (TS), and ultrasonography (USG). TBR was calculated from TS. Each patient was followed for at least six months, with final diagnoses of GD or SAT made by an endocrinologist.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Sixty-eight and 38 patients were diagnosed with GD and SAT, respectively. The analysis of thyroid-associated laboratory markers and inflammatory indices revealed characteristic differences between GD and SAT. Multivariable logistic regression analysis revealed three independent predictors of SAT: diminished TSI (OR = 0.04; P = .039), reduced fT3/fT4 ratio (OR = 0.05, P = .019), and lower TBR (OR = 0.20, P = .001). TSI demonstrated high diagnostic accuracy area under the curve (AUC): 0.923, optimal cut-off: ≤1.05 IU/L, sensitivity: 100%, specificity: 85.9%). The TBR yielded the highest AUC (0.990) in distinguishing GD from SAT (cut-off: ≤3.6 IU/L, sensitivity: 97.4%, specificity: 98.5%). According to USG findings, the cases showed two different patterns as diffuse thyroiditis pattern (DTP) and nodular thyroiditis pattern (NTP). On USG a DTP was more frequent in GD group than in SAT group (80.9% vs. 55.3%, P = .007). In both GD and SAT, demographic and clinical findings were similar between patients with DTP and patients with NTP. However, symptom duration, TSI, fT3, fT3/fT4 ratio, anti-TPO, thyroid ROI and TBR levels were higher in GD patients with DTP or NTP than in SAT patients with DTP or NTP. In contrast, background ROI, ESR and CRP levels were lower. Among patients with DTP, a TBR cut-off value of ≤3.7 yielded a sensitivity of 95.2% and a specificity of 98.2% in distinguishing SAT from GD. In this cohort, TBR demonstrated superior diagnostic performance compared to TSI. The optimal TBR threshold for differentiating SAT from GD among patients with NTP was &lt;2.3, exhibiting 100% sensitivity and 100% specificity. However, the diagnostic performance was not significantly different from that of TSI. A positive thyroglossal duct activity finding was present only in GD, in 45.5% of the patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The fT3/fT4 ratio demonstrates limited efficacy as a diagnost","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500199"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioimmunoblastic T-Cell lymphoma involved thyroid on ¹⁸F-FDG PET/CT.","authors":"Y Li, X Zhang, Z-X He","doi":"10.1016/j.remnie.2025.500177","DOIUrl":"10.1016/j.remnie.2025.500177","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500177"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ^99mTc-HYNIC-PSMA-11, bone scan and post radioligand therapy images in mCRPC patients: A single center experience.","authors":"K Aryana, A Aghaee, E Askari, Y Fakhar, N Raeisi, M Mottaghi, M Emadzadeh, H Ghorbani, S Barashki","doi":"10.1016/j.remnie.2025.500157","DOIUrl":"10.1016/j.remnie.2025.500157","url":null,"abstract":"<p><strong>Background: </strong>Prostate-Specific Membrane Antigen is overexpressed in primary and metastatic prostate cancer tissues. While PSMA PET agents have gained their role in the prostate cancer guidelines, Technetium-based PSMA agents have left behind. Given the novelty of ^99mTc-HYNIC-PSMA-11, we conducted this study to compare its detection rate in tracing skeletal metastases in comparison to bone scans and also compared the number of metastatic lesions which showed PSMA uptake in the diagnostic scan with those detected in post-treatment scans after radioligand therapy (RLT) with ¹⁷⁷Lu-PSMA-617-617.</p><p><strong>Methods: </strong>Bone and ^99mTc-HYNIC-PSMA-11 scans with a maximum interval of 90 days were performed in thirty-nine patients with widespread bone metastases. If the PSMA scan was positive, patients were treated with ¹⁷⁷Lu-PSMA-617 and post treatment scan was also obtained. For negative PSMA results, ⁶⁸Ga-PSMA PET/CT was performed to compare its results with the bone scan. In patients with PSMA expression, detection of metastatic lesions in three consecutive whole-body scans in different regions were compared (^99mTc-HYNIC-PSMA-11 with bone and post treatment scans, separately).</p><p><strong>Results: </strong>37 (94.9%) showed adequate ^99mTc-HYNIC-PSMA-11 uptake in the metastatic regions. Compared to bone scan, ^99mTc-HYNIC-PSMA-11 showed additional lesions in 13 (35.1%) participants which were mostly located in the appendicular skeleton and pelvic bones. Inversely, the bone scan detected more lesions in 12 (32.4%) patients. Both scans in 12 (32.4%) patients showed the exact same results. Comparison between the ^99mTc-HYNIC-PSMA-11 scan and ¹⁷⁷Lu-PSMA-617 showed completely similar results in 29 (78.4%) patients; however, ¹⁷⁷Lu-PSMA-617 detected more lesions in eight (21.6%) participants.</p><p><strong>Conclusion: </strong>The ^99mTc-HYNIC-PSMA-11 scan demonstrates comparable results to bone scans in evaluating skeletal metastases in prostate cancer patients. It serves as a cost-effective modality for identifying suitable candidates for radioligand therapy, particularly beneficial in resource-limited countries.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500157"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staging in nasopharynx cancers prognostic value of volumetric parameters in [¹⁸F]FDG PET/CT imaging.","authors":"Ç Erol, Ö Şahin, G Kanyılmaz, S Erol","doi":"10.1016/j.remnie.2025.500160","DOIUrl":"10.1016/j.remnie.2025.500160","url":null,"abstract":"<p><strong>Objective: </strong>The aim of our study was to determine whether volumetric parameters measured from the primary lesion and metastatic lymph node (LN) using [¹⁸F]FDG PET/CT imaging affect prognosis and survival in nasopharyngeal cancer (NPC) patients.</p><p><strong>Material and methods: </strong>Our study included 62 patients diagnosed with NPC who underwent [¹⁸F]FDG PET/CT imaging for pre-treatment staging. SUVmax, SUVmean, MTV and TLG values were measured from the primary tumor and LN. Lymph node/primary tumor SUV ratio (NTR) was calculated. The relationships between volumetric parameters and overall survival (OS), locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS) and progression-free survival (PFS) were evaluated.</p><p><strong>Results: </strong>LN SUVmax and LN SUVmean values were significantly higher in patients with distant metastases (p = 0.002 and p = 0.016, respectively). NTR values were significantly higher in patients with distant metastases (p = 0.047). The ideal LN SUVmax and SUVmean cut-off values for predicting distant metastasis in patients with LN metastasis were 16.45 and 6.5, respectively. There was a statistically significant difference between the DMFSs of the two groups when the NTR cut-off value was 0.8 (p = 0.047). Multivariate analysis showed that LN SUVmax, LN SUVmean and NTR were associated with DMFS (P = 0.003, 0.05 and 0.014, respectively), while primary tumor TLG and MTV values were associated with LRRFS (P = 0.035 and 0.03, respectively).</p><p><strong>Conclusion: </strong>In conclusion, we believe that LN SUVmax, SUVmean and NTR may be prognostic indicators for distant metastasis, and MTV and TLG for locoregional recurrence.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500160"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive ductal carcinoma presented with bilateral breast superscan on [¹⁸F]FDG PET/CT.","authors":"Ahmed S Abdlkadir, Enrique Estrada-Lobato, Kamal Al-Rabi, Akram Al-Ibraheem","doi":"10.1016/j.remnie.2025.500163","DOIUrl":"10.1016/j.remnie.2025.500163","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500163"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}