Revista espanola de medicina nuclear e imagen molecular最新文献

{"title":"Macrophage activation syndrome in a pediatric patient: Findings on PET/CT with 18F-FDG","authors":"J.P. Suárez Fernández, M. Luz Domínguez Grande, C. Vigil Díaz, B.F. Llana, N. Martín Fernández, F. Manuel González García","doi":"10.1016/j.remnie.2025.500183","DOIUrl":"10.1016/j.remnie.2025.500183","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 4","pages":"Article 500183"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between HER2 status acquired from pathological data and metabolic parameters from pre-treatment [18F]FDG PET/CT in gastric adenocarcinomas","authors":"M.N. Acar Tayyar ,&nbsp;M.Ö. Tamam ,&nbsp;G.B. Babacan ,&nbsp;M.C. Şahin ,&nbsp;H. Özçevik ,&nbsp;S. Şengiz Erhan ,&nbsp;A.E. Öztürk","doi":"10.1016/j.remnie.2024.500080","DOIUrl":"10.1016/j.remnie.2024.500080","url":null,"abstract":"<div><h3>Objective</h3><div>Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is thought to be more aggressive in gastric cancer. This study aimed to evaluate the predictability of HER2 status and other prognostic pathologic parameters using [¹⁸F]FDG PET/CT and to investigate its impact on survival.</div></div><div><h3>Methods</h3><div>Pretreatment metabolic parameters measured by [¹⁸F]FDG PET/CT as a prognostic factor were retrospectively evaluated in 117 HER2-analysed patients. The relationship between pathological data, tumor metabolic characteristics, and distant metastases was examined, and the effect on survival was investigated.</div></div><div><h3>Results</h3><div>Among the 117 patients, 17.1% were HER2-positive (HER2+), and 82.9% were HER2-negative (HER2-). There was no significant association between PET/CT parameters in the HER2+ and HER2- patient groups. HER2+ patients had higher 1- and 3-year survival expectations than HER2- patients (80%-%37.9; %47.5-%20; respectively). There was no statistically significant difference in overall survival. In Cox-regression analysis, while the presence of vascular invasion, local invasion, and distant metastasis were poor prognostic factors, HER2 was not a prognostic factor. Vascular invasion and local invasion (T3/T4) were also associated with higher SUVmax values. Patients with distant metastases had significantly higher SUVmax, SUVmean, and TLG.</div></div><div><h3>Conclusion</h3><div>This study showed no association between HER2 expression and [¹⁸F]FDG PET/CT metabolic parameters. However, regardless of HER2 status, the results indicated distant metastasis, local invasion, and vascular invasion could be associated with primary tumor metabolism. PET/CT parameters predict tumor aggressiveness and disease prognosis better than HER2 status.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 4","pages":"Article 500080"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of the art and future perspectives of new radinuclides in Nuclear Medicine: Part III","authors":"I. Torres ,&nbsp;R. Ramos ,&nbsp;M.L. Domínguez ,&nbsp;J.J. Rosales ,&nbsp;A. Roteta ,&nbsp;E. Prieto ,&nbsp;L. Sancho ,&nbsp;M. de Arcocha ,&nbsp;G. Quincoces ,&nbsp;en nombre del Grupo de Oncología de la SEMNIM","doi":"10.1016/j.remnie.2025.500161","DOIUrl":"10.1016/j.remnie.2025.500161","url":null,"abstract":"<div><div>In this third installment of the continuing education series, the clinical and therapeutic applications of zirconium, astatine and thorium are analyzed in depth. Although they are not described as theragnostic pairs, each of these radionuclides plays a fundamental role in precision medicine, which is rapidly advancing within Nuclear Medicine.</div><div>We begin by analyzing zirconium-89, a positron emitter whose long half-life makes it particularly suitable for labeling large molecules with slow kinetics, such as antibodies, playing a crucial role in immunotherapy. The use of astatine-211, an alpha-emitting radionuclide with a simple decay scheme and chemical behavior similar to iodine, is also discussed. Its main challenge lies in its production, as it requires cyclotrons capable of generating highly energetic alpha particle beams. Furthermore, thorium-227, a 100% alpha emitter, is reviewed. This radionuclide exhibits excellent chelation properties, enabling its conjugation with tumor-targeting molecules to produce thorium-labeled conjugates. While this technique is yielding promising preclinical results, the use of thorium faces challenges, including the potential separation of radium-223 from the molecule and the dependence of activity measurements on the time of production. Since it takes 100 days to reach equilibrium, activity assessment is based on photons emitted by its daughter radionuclides.</div><div>Despite these challenges, these radionuclides are driving the evolution of precision medicine, expanding therapeutic and diagnostic possibilities within Nuclear Medicine.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 4","pages":"Article 500161"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining preoperative imaging-based localization of adenomas in primary hyperparathyroidism patients candidates for minimally invasive surgery","authors":"Sebastián Casanueva-Eliceiry ,&nbsp;Marti Manyalich-Blasi ,&nbsp;Arnau Farré-Melero ,&nbsp;Aida Niñerola-Baizán ,&nbsp;David Saavedra ,&nbsp;Mireia Mora-Porta ,&nbsp;Felicia A. Hanzu ,&nbsp;Aida Orois ,&nbsp;Mattia Squarcia ,&nbsp;Maite Rodrigo-Calvo ,&nbsp;Marta Tormo-Ratera ,&nbsp;Katherine Quintero-Martinez ,&nbsp;David Fuster-Pelfort ,&nbsp;Oscar Vidal-Pérez ,&nbsp;Sergi Vidal-Sicart","doi":"10.1016/j.remnie.2025.500091","DOIUrl":"10.1016/j.remnie.2025.500091","url":null,"abstract":"<div><h3>Background and objectives</h3><div>To compare the diagnostic accuracy of [¹⁸F]-Fluorocholine (FCH) PET/CT with conventional [⁹⁹mTc]Tc-MIBI scintigraphy and cervical ultrasound (USG) for the preoperative localization of hyperfunctioning parathyroid tissue (HFPT) in patients with primary hyperparathyroidism (PHPT).</div></div><div><h3>Materials and methods</h3><div>This prospective study included 90 patients diagnosed with PHPT who underwent [¹⁸F]F-CH PET/CT, [⁹⁹mTc]Tc-MIBI SPECT/CT and Neck USG. The diagnostic accuracy of each imaging modality was assessed using intraoperative findings and histopathological confirmation as the gold standard. The localization accuracy was evaluated based on specific quadrant detection, laterality, and ectopic gland identification. The study also explored the correlation between imaging findings and biochemical parameters, including preoperative and postoperative PTH and calcium levels.</div></div><div><h3>Results</h3><div>[¹⁸F]F-CH PET/CT demonstrated superior accuracy in detecting pathological parathyroid glands compared to [^99mTc]Tc-MIBI SPECT/CT and USG. [¹⁸F]F-CH PET/CT correctly identified 98.9% of patients with pathological glands, with a specific location accuracy of 93.2%, 65.9% and 38.8% for [¹⁸F]F-CH PET/CT, [^99mTc]Tc-MIBI SPECT/CT and USG, respectively.</div><div>For ectopic adenomas, FCH PET/CT achieved an accuracy of 100% (4/4), while MIBI and neck ultrasound identified these in 50% (2/4) and 0% (0/4) of cases, respectively.</div><div>There were two cases of multiglandular disease, [¹⁸F]F-CH PET/CT and [99mTc]Tc-MIBI each detected one gland in one case (50%) while USG detected none; in the other case, [¹⁸F]F-CH PET/CT and USG identified both glands (100%), and [99mTc]Tc-MIBI detected none.</div><div>Significant correlations were observed between SUVmax values from [¹⁸F]F-CH PET/CT and gland size, weight, and preoperative PTH levels.</div></div><div><h3>Conclusions</h3><div>[¹⁸F]F-CH PET/CT outperformed conventional imaging modalities in the preoperative localization of HFPT, particularly in challenging cases such ectopic or multiglandular disease. These findings support its potential as an effective and reliable imaging tool for the management of primary hyperparathyroidism.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 4","pages":"Article 500091"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procedure update and interpretation guide for the brain 18F-FDG PET study","authors":"C. Vigil Díaz ,&nbsp;P. Paredes Rodríguez ,&nbsp;A. Perissinotti ,&nbsp;E. Fernando Guillén ,&nbsp;D.A. Diego Alfonso ,&nbsp;J.A. Lojo Ramírez ,&nbsp;P. Aguiar Fernández ,&nbsp;V. Camacho ,&nbsp;M. Nieves Cabrera-Martín ,&nbsp;por el grupo de Trabajo de Neuroimagen de la SEMNIM","doi":"10.1016/j.remnie.2025.500159","DOIUrl":"10.1016/j.remnie.2025.500159","url":null,"abstract":"<div><div>The increase in the prevalence of dementia in our clinical setting poses a diagnostic challenge for the Nuclear Medicine specialist. The aim of this study is to review the modifications in the procedure and to describe the usefulness of the use of brain PET with ¹⁸F-FDG in different clinical indications, both classic and emerging ones. The SEMNIM Neuroimaging working group has considered it appropriate to update the procedures available in Spanish in order to optimize the quality of this technique and the interpretation of its findings, both for the specialist in Nuclear Medicine and the rest of the professionals involved in the diagnosis and treatment of neurodegenerative diseases.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 4","pages":"Article 500159"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of cardiac angiosarcoma using [18F]FDG PET/CT","authors":"B. Hervás-Sanz ,&nbsp;N. Ruiz-Roig ,&nbsp;L. Rodríguez-Bel ,&nbsp;L.M. Gràcia-Sánchez ,&nbsp;M. Cortés-Romera ,&nbsp;P.C. Notta","doi":"10.1016/j.remnie.2025.500131","DOIUrl":"10.1016/j.remnie.2025.500131","url":null,"abstract":"","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 4","pages":"Article 500131"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National survey on nuclear imaging in infectious bone pathology: Results and diagnostic recommendations of the Musculoskeletal Pathology Working Group (MSP-WG)","authors":"E. Noriega-Álvarez ,&nbsp;A. Moreno-Ballesteros ,&nbsp;M. Velasco Nuño ,&nbsp;J.M. Cordero García ,&nbsp;J.J. Rosales Castillo ,&nbsp;U.V. Schmülling ,&nbsp;E. López Rodríguez ,&nbsp;A. Rigabert Sánchez-Junco ,&nbsp;B. Rodríguez Alfonso","doi":"10.1016/j.remnie.2025.500165","DOIUrl":"10.1016/j.remnie.2025.500165","url":null,"abstract":"<div><div>The continued increase in demand for diagnosis and monitoring of infectious bone diseases, along with the introduction of new equipment, radiopharmaceuticals, and techniques for this purpose, has made it necessary to dynamically update the existing protocols and recommendations. Therefore, the MSP-WG conducted a survey for spanish hospitals to complete and develop recommendations in the form of algorithms, in an attempt to combine existing scientific evidence with the reality of national clinical practice.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"44 5","pages":"Article 500165"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the performance of ¹⁸F-PSMA-1007 PET/CT and ⁶⁸Ga-PSMA-11 PET/CT in prostate cancer patients with biochemical recurrence.","authors":"G Inal, C Soydal, B Demir, M Araz, Y Urun, S Baltacı, E Suer, N O Kucuk","doi":"10.1016/j.remnie.2025.500178","DOIUrl":"10.1016/j.remnie.2025.500178","url":null,"abstract":"<p><strong>Aim: </strong>In this study, we aimed to evaluate the diagnostic performance of ¹⁸F-PSMA-1007 PET/CT compared to ⁶⁸Ga-PSMA-11 PET/CT, which is more commonly used in routine practice, for detecting prostate cancer recurrence in prostate cancer patients with biochemical recurrence.</p><p><strong>Materials and methods: </strong>Forty-one prostate cancer patients with biochemical recurrence were prospectively included in the study. Additionally, images from 46 patients in our institution's database, who had undergone ⁶⁸Ga-PSMA-11 PET/CT imaging for biochemical recurrence, were retrospectively re-evaluated to compare the detection rates with those of ¹⁸F-PSMA-1007 PET/CT. SUVmax, total tumor PSMA, PSMA total tumor volume were calculated for local recurrence, lymph node metastasis, and organ metastasis. The diagnostic performances of the two imaging methods were then compared.</p><p><strong>Results: </strong>The mean age, Gleason scores, ISUP scores, serum PSA levels at diagnosis and at the time of imaging, and PSA doubling times were similar across the ¹⁸F-PSMA-1007 and ⁶⁸Ga-PSMA-11 groups. Pathological uptake was observed in the prostatic bed in 16 patients (39.0%), lymph nodes in 22 patients (46.3%), and bones in 11 patients (26.8%) with ¹⁸F-PSMA-1007 PET/CT. ¹⁸F-PSMA-1007 PET/CT showed statistically significant superiority over ⁶⁸Ga-PSMA-11 PET/CT in detecting lymph node metastases (41.6% vs. 25.4%; P=.028). There was no significant difference between the two imaging protocols in the detection rates of local recurrence (P=.067) and bone metastasis (P=.580).</p><p><strong>Conclusion: </strong>Although the study included a small sample size, the results revealed that ¹⁸F-PSMA-1007 PET/CT had a higher detection rate than ⁶⁸Ga-PSMA-11 PET/CT in patients with biochemically recurrent prostate carcinoma, particularly for lymph node metastases.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500178"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"May it be a new parameter of 18F-FDG PET/CT for differentiating between benign and malignant adrenal lesions: \"Adrenal Densitometabolic Index (ADMI)\".","authors":"E Ciftci, T Y Erdil, B Karaşah Erkek, B Akovali","doi":"10.1016/j.remnie.2025.500185","DOIUrl":"10.1016/j.remnie.2025.500185","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the diagnostic importance of a new parameter consisting of the densitometric and metabolic properties of the lesion measured by 18F-FDG PET/CT in differentiating between benign and malignant adrenal lesions in cancer patients.</p><p><strong>Material and methods: </strong>We evaluated PET/CT parameters of adrenal lesions of patients between 2017 and 2019. A new parameter, \"Adrenal Dansitometabolic index (ADMI),\" was investigated. Additionally, SUVmax, tumor-to-liver ratio (T/LR), Hounsfield Units (HU), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of adrenal lesions were analyzed. Logistic regression analyses were conducted to identify the most predictive parameter for malignant lesions.</p><p><strong>Results: </strong>Two hundred and four adrenal lesions underwent PET/CT for tumor evaluation. Based on ROC analysis, ADMI > 9.5, a SUVmax > 4.15, a T/L SUVmax ratio > 1.7, an attenuation value > 21.75 HU, a TLG > 14.61 and a MTV > 4.5 were chosen as the optimal cut-off values for differentiating malignant from benign lesions. ADMI, SUVmax, and T/L ratio demonstrated similarly high diagnostic performance (AUC values: 0.993, 0.992 and 0.988 (P = .000), respectively). ADMI exhibited the highest sensitivity and negative predictive value. A multivariate logistic regression analysis revealed that both ADMI and T/L ratio serve as independent prognostic factors for malignancy (P = .001 and P = .003, respectively).</p><p><strong>Conclusion: </strong>ADMI, effectively distinguishes benign from malignant. This technique may facilitate investigations of the adrenal lesions to clinical outcomes but needs further large series studies.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500185"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretreatment ¹⁸F-FDG PET/CT in predicting the survival of patients with hepatic neuroendocrine tumors.","authors":"Y Zhang, G Liu, L Zhong, B Li, Y Zhang","doi":"10.1016/j.remnie.2025.500198","DOIUrl":"10.1016/j.remnie.2025.500198","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prognostic value of pretreatment 2-[¹⁸F]-fluoro-2-deoxy-d-glucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with hepatic neuroendocrine tumors (HNET).</p><p><strong>Methods: </strong>In total, 41 patients were included in this study. PET-derived metabolic parameters, including maximum and mean standardized uptake values (SUV_max and SUV_mean, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), of the tumors were measured. Meanwhile, clinical data, including tumor pathological findings such as the Ki-67 index were also assessed. Progression-free survival (PFS) and overall survival (OS) were evaluated. Univariate and multivariate analyses were performed to predict the prognostic value of clinical variables and PET-derived metabolic parameters in HNET patients. Correlation between PET-derived metabolic parameters and Ki-67 was estimated.</p><p><strong>Results: </strong>Univariate analyses revealed that among PET-derived metabolic parameters, SUV_max, SUV_mean, and TLG were significant prognostic factors for OS (P < .05). Among clinical variables, the Ki-67 index and radical surgical resection were significant factors for both PFS and OS (P < .05). In multivariate analyses, only Ki-67 index was an independent prognostic factor for both PFS and OS (P < .05). Ki-67 index presented correlates with SUV_max and SUV_mean (R = 0.566, P < .001, R = 0.493, P = .001, respectively).</p><p><strong>Conclusions: </strong>In patients with HNET, the Ki-67 index was an independent prognostic factor for both PFS and OS, while SUV_max, SUV_mean, and TLG measured on pretreatment ¹⁸F-FDG PET/CT scans were prognostic factors for predicting OS. Ki-67 index also presented correlates with SUV_max and SUV_mean. ¹⁸F-FDG-PET may be useful as quantitative predicting prognostic imaging biomarkers, especially in poorly differentiated HNET.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500198"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}