M S Casallas Cepeda, S Salcedo Córtes, I Gómez Fernández, J Orcajo Rincón, L Reguera Berenguer, E J Ardila Manjarrez, J J Ardila Mantilla, V Castillo Morales, J Gúzman Cruz, D Zamudio Rodríguez, A Marí Hualde, J E Montalvá Pastor, S Álvarez Lara, J C Alonso Farto
{"title":"在深吸气时使用 [18F]-FDG PET/CT 评估肺结节。","authors":"M S Casallas Cepeda, S Salcedo Córtes, I Gómez Fernández, J Orcajo Rincón, L Reguera Berenguer, E J Ardila Manjarrez, J J Ardila Mantilla, V Castillo Morales, J Gúzman Cruz, D Zamudio Rodríguez, A Marí Hualde, J E Montalvá Pastor, S Álvarez Lara, J C Alonso Farto","doi":"10.1016/j.remnie.2024.500074","DOIUrl":null,"url":null,"abstract":"<p><p>The characterization of pulmonary nodules (PN) is a primary indication for [<sup>18</sup>F]-FDG PET/CT. However, respiratory movements hinder this characterization, especially for PN located in the lower lobes. Various methods have been developed to improve image resolution.</p><p><strong>Objective: </strong>Our objective was to compare the diagnostic efficacy of [<sup>18</sup>F]-FDG PET/CT in deep inspiration breath-hold (DIBH) versus free-breathing corrected by software, in the evaluation of PN.</p><p><strong>Methods: </strong>We prospectively analyzed 51 patients to assess PN using [<sup>18</sup>F]-FDG PET/CT in DIBH and free-breathing corrected by software. A total of 84 nodules with an average size of 10 mm were analyzed, with pathological anatomy or medical treatment decide by a multidisciplinary tumor board used as reference.</p><p><strong>Results: </strong>A total of 84 PN were evaluated, comparing those in DIBH versus free-breathing, finding statistically significant differences in SUVmax values P(< 0.05) (mean SUVmax 3.7 in free-breathing vs. 5.33 in DIBH). When analyzed by location in lobes, we did not find statistically significant differences, though there was a trend towards higher SUVmax values in the lower lobes. [<sup>18</sup>F]-FDG PET/CT in DIBH showed high sensitivity (95%) and negative predictive value (NPV) (92%), indicating it may be a promising tool for PN characterization.</p><p><strong>Conclusions: </strong>The acquisition of [<sup>18</sup>F]-FDG PET/CT in DIBH significantly improves the sensitivity and diagnostic efficacy in the assessment of PN. Although no statistically significant differences were found based on location, there is a potential benefit for the lower lobes. These findings could support its use in clinical practice.</p>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":" ","pages":"500074"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessment of pulmonary nodules using [<sup>18</sup>F]-FDG PET/CT in deep inspiration breath-hold.\",\"authors\":\"M S Casallas Cepeda, S Salcedo Córtes, I Gómez Fernández, J Orcajo Rincón, L Reguera Berenguer, E J Ardila Manjarrez, J J Ardila Mantilla, V Castillo Morales, J Gúzman Cruz, D Zamudio Rodríguez, A Marí Hualde, J E Montalvá Pastor, S Álvarez Lara, J C Alonso Farto\",\"doi\":\"10.1016/j.remnie.2024.500074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The characterization of pulmonary nodules (PN) is a primary indication for [<sup>18</sup>F]-FDG PET/CT. However, respiratory movements hinder this characterization, especially for PN located in the lower lobes. Various methods have been developed to improve image resolution.</p><p><strong>Objective: </strong>Our objective was to compare the diagnostic efficacy of [<sup>18</sup>F]-FDG PET/CT in deep inspiration breath-hold (DIBH) versus free-breathing corrected by software, in the evaluation of PN.</p><p><strong>Methods: </strong>We prospectively analyzed 51 patients to assess PN using [<sup>18</sup>F]-FDG PET/CT in DIBH and free-breathing corrected by software. A total of 84 nodules with an average size of 10 mm were analyzed, with pathological anatomy or medical treatment decide by a multidisciplinary tumor board used as reference.</p><p><strong>Results: </strong>A total of 84 PN were evaluated, comparing those in DIBH versus free-breathing, finding statistically significant differences in SUVmax values P(< 0.05) (mean SUVmax 3.7 in free-breathing vs. 5.33 in DIBH). When analyzed by location in lobes, we did not find statistically significant differences, though there was a trend towards higher SUVmax values in the lower lobes. [<sup>18</sup>F]-FDG PET/CT in DIBH showed high sensitivity (95%) and negative predictive value (NPV) (92%), indicating it may be a promising tool for PN characterization.</p><p><strong>Conclusions: </strong>The acquisition of [<sup>18</sup>F]-FDG PET/CT in DIBH significantly improves the sensitivity and diagnostic efficacy in the assessment of PN. Although no statistically significant differences were found based on location, there is a potential benefit for the lower lobes. These findings could support its use in clinical practice.</p>\",\"PeriodicalId\":94197,\"journal\":{\"name\":\"Revista espanola de medicina nuclear e imagen molecular\",\"volume\":\" \",\"pages\":\"500074\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista espanola de medicina nuclear e imagen molecular\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.remnie.2024.500074\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista espanola de medicina nuclear e imagen molecular","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.remnie.2024.500074","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Assessment of pulmonary nodules using [18F]-FDG PET/CT in deep inspiration breath-hold.
The characterization of pulmonary nodules (PN) is a primary indication for [18F]-FDG PET/CT. However, respiratory movements hinder this characterization, especially for PN located in the lower lobes. Various methods have been developed to improve image resolution.
Objective: Our objective was to compare the diagnostic efficacy of [18F]-FDG PET/CT in deep inspiration breath-hold (DIBH) versus free-breathing corrected by software, in the evaluation of PN.
Methods: We prospectively analyzed 51 patients to assess PN using [18F]-FDG PET/CT in DIBH and free-breathing corrected by software. A total of 84 nodules with an average size of 10 mm were analyzed, with pathological anatomy or medical treatment decide by a multidisciplinary tumor board used as reference.
Results: A total of 84 PN were evaluated, comparing those in DIBH versus free-breathing, finding statistically significant differences in SUVmax values P(< 0.05) (mean SUVmax 3.7 in free-breathing vs. 5.33 in DIBH). When analyzed by location in lobes, we did not find statistically significant differences, though there was a trend towards higher SUVmax values in the lower lobes. [18F]-FDG PET/CT in DIBH showed high sensitivity (95%) and negative predictive value (NPV) (92%), indicating it may be a promising tool for PN characterization.
Conclusions: The acquisition of [18F]-FDG PET/CT in DIBH significantly improves the sensitivity and diagnostic efficacy in the assessment of PN. Although no statistically significant differences were found based on location, there is a potential benefit for the lower lobes. These findings could support its use in clinical practice.
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