Resuscitation plus最新文献

{"title":"Use of personal protective equipment and cognitive load during cardiopulmonary resuscitation – A randomized cross-over simulation-based study","authors":"Johannes Heymer ,&nbsp;Daniel Räpple ,&nbsp;Matthias Ott ,&nbsp;Florian Dengler ,&nbsp;Christina Jaki ,&nbsp;Daniel Bent ,&nbsp;Anna Hegar","doi":"10.1016/j.resplu.2025.100936","DOIUrl":"10.1016/j.resplu.2025.100936","url":null,"abstract":"<div><h3>Background</h3><div>The use of personal protective equipment (PPE) is essential during cardiopulmonary resuscitation (CPR) to prevent disease transmission, but its impact on rescuer fatigue and CPR quality remains debated.</div></div><div><h3>Aim</h3><div>To simultaneously evaluate the effect of PPE on cognitive load and resuscitation quality.</div></div><div><h3>Methods</h3><div>In a simulation-based trial at a German tertiary care hospital, 31 healthcare workers performed two 2-minute chest compression (CC) cycles on a manikin, once with PPE and once without. Compression quality (rate, depth, hand position, chest recoil) was assessed. Cognitive load was measured post-task using NASA- and Simulation Task Load Index (NASA- and SIM-TLX). Primary outcome was the difference in cognitive load with and without PPE, and secondary outcomes included differences in CC quality parameters.</div></div><div><h3>Results</h3><div>SIM-TLX identified a significant impact of PPE on task complexity and perceptual strain, while situational stress, distractions, task control, and NASA-TLX parameters (mental, physical, temporal demand, frustration, effort, performance) showed no significant differences. No significant differences were found in compression rate (113 bpm without PPE vs. 109 bpm with PPE), depth (61 mm without vs. 62 mm with PPE), correct hand position (81% without vs. 78% with PPE), and complete chest recoil (94% without vs. 84% with PPE). However not significant, PPE use showed more negative outliers in hand position and chest recoil.</div></div><div><h3>Conclusion</h3><div>PPE increases values on two subscales of the SIM-TLX (task complexity and perceptual strain), but does not significantly impact chest compression quality in CPR simulations.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100936"},"PeriodicalIF":2.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postresuscitation pleth variability index-guided hemodynamic management of out-of-hospital cardiac arrest survivors: A randomised controlled trial","authors":"Stefano Malinverni ,&nbsp;Paul Dumay ,&nbsp;Pierre Domont ,&nbsp;Marc Claus ,&nbsp;Antoine Herpain ,&nbsp;Jolan Grignard ,&nbsp;Silvia Matta ,&nbsp;Fatima Zohra Bouazza ,&nbsp;Queitan Ochogavia","doi":"10.1016/j.resplu.2025.100933","DOIUrl":"10.1016/j.resplu.2025.100933","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Hypotension and shock after return of spontaneous circulation is harmful. Goal-directed post-resuscitation care aims at maintaining adequate perfusion pressure, but evidence.</div><div>on strategies to achieve this goal is limited. This study aimed to compare outcomes of pleth variability index (PVi) supported hemodynamic management during early hospital admission with those of standard hemodynamic management.</div></div><div><h3>Methods and trial design</h3><div>From March 2019 to August 2023, all mechanically ventilated patients adults admitted alive after a non-traumatic out-of-hospital cardiac arrest (OHCA) to the emergency department of Saint-Pierre University Hospital in Brussels, were screened for inclusion in this prospective, parallel, randomised, single-blind study. We enrolled patients with signs of tissue hypoperfusion after cardiac arrest. Patients were randomly allocated (1:1) to undergo hemodynamic treatment based on the PVi (intervention) or standard monitoring (control). Hemodynamic interventions targeted mean blood pressure above 70 mmHg, a capillary refill time below 3 s and urine output above 0.5 ml/kg/minute. The primary outcome was lactate clearance at 3 h. We hypothesized that PVi guided hemodynamic management would result in a faster lactate clearance at 3 h.</div></div><div><h3>Results</h3><div>96 patients underwent randomization. Due to non-consent and loss to follow-up 82 patients were included in the analysis, 39 in the intervention and 43 in the control group. The median lactate clearance 3 h after inclusion was not different between groups (57.4% [Interquartile range (IQR): 27.7–75.8%] in the control group versus 61.5% [IQR: 39.3–74.7%] in the intervention group), with a mean difference of 4.9% (95% CI, −7.5–17.2; <em>p</em> = 0.44) between the two groups. No side effects were observed.</div></div><div><h3>Conclusion</h3><div>A pleth variability index-based protocol did not significantly improve the lactate clearance compared with standard care (NCT03841708).</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100933"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a specialized neuroprognostication consultation program and associated provider attitudes: A survey-based study","authors":"David Fischer ,&nbsp;Sahily Reyes-Esteves ,&nbsp;Connor Law ,&nbsp;Alice Ford ,&nbsp;Peter Schwab ,&nbsp;Benjamin S. Abella ,&nbsp;Andrea L.C. Schneider ,&nbsp;Monisha A. Kumar","doi":"10.1016/j.resplu.2025.100932","DOIUrl":"10.1016/j.resplu.2025.100932","url":null,"abstract":"<div><h3>Introduction</h3><div>Neuroprognostication for disorders of consciousness, particularly after cardiac arrest, is critical. However rapidly evolving research has translated little to clinical practice, with neuroprognostication frequently deviating from evidence and clinical guidelines. We implemented a novel program that provides specialized, interdisciplinary, and longitudinal care to improve the practice of neuroprognostication. The objective of this study was to evaluate the impact of this program on provider attitudes and satisfaction towards neuroprognostication after cardiac arrest.</div></div><div><h3>Methods</h3><div>We disseminated surveys across our health system to critical care providers and neurologists in the years before (2021, 2022) and after (2023) implementation of the program. The surveys assessed perceptions of, and satisfaction with, neuroprognostication after cardiac arrest. We used Fisher exact tests to compare program-exposed respondents to historical controls (2021 and 2022 respondents) and contemporary controls (2023 respondents without program exposure).</div></div><div><h3>Results</h3><div>We received 545 responses from neurologists and critical care providers, including nurses, trainees, and attendings. Program-exposed respondents, relative to historical and contemporary controls respectively, reported greater usefulness of neuroprognostication (94% reporting often or always useful, versus 69% [<em>p</em> &lt; 0.01]) and 68% [<em>p</em> &lt; 0.01]), comprehensiveness of neuroprognostication (94% reporting often or always comprehensive, versus 76% [<em>p</em> = 0.02] and 66% [<em>p</em> &lt; 0.01]), and greater satisfaction with neuroprognostication, particularly in comparison to the conventional model (63% reporting the program was “much better”).</div></div><div><h3>Conclusion</h3><div>Implementation of a specialized neuroprognostication program was associated with largely favorable attitudes towards neuroprognostication among providers. These findings encourage further study of this paradigm, and consideration of broader adoption to improve the practice of neuroprognostication.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100932"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum glial fibrillary acidic protein and protein gene product 9.5 for predicting neurological outcomes in cardiac arrest patients with cortical response to somatosensory evoked potentials","authors":"Chenchen Hang ,&nbsp;Rui Shao ,&nbsp;Xingsheng Wang,&nbsp;Luying Zhang,&nbsp;Weijie Cheng,&nbsp;Zihao Jiang,&nbsp;Ziqi Zhong,&nbsp;Le An,&nbsp;Ziren Tang","doi":"10.1016/j.resplu.2025.100931","DOIUrl":"10.1016/j.resplu.2025.100931","url":null,"abstract":"<div><h3>Aim</h3><div>Predicting neurological prognosis after cardiac arrest remains challenging. Somatosensory evoked potential N20 absence is highly specific but lacks sensitivity. Glial fibrillary acidic protein and protein gene product 9.5 are potential biomarkers for brain injury, yet their roles in cardiac arrest patients with preserved somatosensory evoked potential N20 remain underexplored.</div></div><div><h3>Methods</h3><div>From January 2023 to December 2024, 69 cardiac arrest patients were enrolled, of whom 46 had preserved somatosensory evoked potential N20 responses. Serum glial fibrillary acidic protein, protein gene product 9.5 and neuron-specific enolase levels were measured at 72 h post-resuscitation. Patients were evaluated for neurological outcomes at 3 months using the Glasgow-Pittsburgh Classification of Cerebral Function scale. Receiver operating characteristic analysis determined biomarker thresholds for poor prognosis.</div></div><div><h3>Results</h3><div>In patients with preserved somatosensory evoked potential N20 responses, glial fibrillary acidic protein and protein gene product 9.5 levels were significantly higher in those with poor outcomes (<em>P</em> &lt; 0.001). Glial fibrillary acidic protein (area under the curve = 0.908) had an optimal cutoff of 64.1 pg/mL (sensitivity 87.5%, specificity 82.4%) and a 100% specificity threshold of 149 pg/mL. Protein gene product 9.5 (area under the curve = 0.864) had an optimal cutoff of 448.4 pg/mL (sensitivity 87.5%, specificity 70.6%) and a 100% specificity threshold of 1253 pg/mL. The prognostic significance of combining serum glial fibrillary acidic protein, protein gene product 9.5, or neuron-specific enolase levels was explored, with glial fibrillary acidic protein + neuron-specific enolase achieving the highest area under the curve of 0.949 (0.882–1.000).</div></div><div><h3>Conclusions</h3><div>Serum glial fibrillary acidic protein and protein gene product 9.5 could be valuable predictors of poor neurological outcomes in cardiac arrest patients with cortical response to somatosensory evoked potential, though further studies are required to validate these findings.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100931"},"PeriodicalIF":2.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-resuscitation blood pressure management: Effects of different MAP targets on cerebral perfusion and inflammation in a porcine model","authors":"Andreas García Bardon ,&nbsp;Jens Kamuf ,&nbsp;Alexander Ziebart ,&nbsp;Christian Breit ,&nbsp;Karsten Sommer ,&nbsp;Erik K. Hartmann ,&nbsp;Maren Paul ,&nbsp;Tanghua Liu ,&nbsp;Petra Leukel ,&nbsp;Victoria Albertsmeier ,&nbsp;Isra Hale ,&nbsp;Robert F. Kelm ,&nbsp;Christoph Jänig ,&nbsp;Laura Maria Schreiber ,&nbsp;Willi Schmidbauer ,&nbsp;Serge C. Thal","doi":"10.1016/j.resplu.2025.100930","DOIUrl":"10.1016/j.resplu.2025.100930","url":null,"abstract":"<div><h3>Background</h3><div>Post-resuscitation care aims to optimize organ perfusion while mitigating reperfusion injury following the return of spontaneous circulation (ROSC). However, the optimal mean arterial pressure (MAP) target for neuroprotection remains undefined. This study investigates the impact of different MAP targets on cerebral perfusion and inflammatory responses in a well-established porcine model of cardiac arrest.</div></div><div><h3>Methods</h3><div>Thirty-five anesthetized pigs underwent a standardized protocol of 7 min of ventricular fibrillation, followed by standardized cardiopulmonary resuscitation. ROSC was achieved in 28 animals, which were randomized into three groups based on target MAP levels: LOW (45–55 mmHg), NORMO (60–70 mmHg), and HIGH (80–90 mmHg). MAP was actively controlled and maintained for 8 h. Cerebral perfusion was assessed using high-resolution magnetic resonance imaging with arterial spin labeling. Systemic hemodynamic parameters, including cardiac output, were continuously monitored. Inflammatory marker expression in brain, kidney, and intestinal tissues was quantified via real-time PCR.</div></div><div><h3>Results</h3><div>Cerebral perfusion progressively increased in all groups. After 6 h, the HIGH MAP group exhibited significantly higher cerebral blood flow (CBF) compared to the LOW and NORMO MAP groups (<em>p</em> &lt; 0.05). However, inflammatory marker expression (TNF-alpha, IL-6, LCN-2) was significantly elevated in the HIGH MAP group, particularly in the hippocampus, suggesting heightened neuroinflammatory activity. Post-ROSC Pearson correlation analysis revealed a progressive increase in the relationship between CBF and MAP, surpassing <em>r</em> = 0.3 after 5 h, suggesting delayed changes in cerebral autoregulation. No significant differences in inflammatory marker expression were observed in renal or intestinal tissues.</div></div><div><h3>Conclusions</h3><div>Our findings indicate that high MAP targets enhance cerebral perfusion but concurrently exacerbate neuroinflammation. The observed autoregulatory impairment appears to emerge as a delayed phenomenon following cardiac arrest and ROSC, rather than as a direct consequence of elevated MAP levels. These results underscore the need for individualized blood pressure management strategies post-ROSC, weighing the potential benefits of increased cerebral perfusion against the risk of neuroinflammation.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100930"},"PeriodicalIF":2.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended reality technologies in adult basic life support education: A scoping review","authors":"Nino Fijačko ,&nbsp;Špela Metličar ,&nbsp;Boža Janžekovič ,&nbsp;Benjamin S. Abella ,&nbsp;Vinay M. Nadkarni ,&nbsp;Todd P. Chang ,&nbsp;Robert Greif","doi":"10.1016/j.resplu.2025.100927","DOIUrl":"10.1016/j.resplu.2025.100927","url":null,"abstract":"<div><h3>Aim</h3><div>In recent years, virtual and augmented reality (VR/AR) technologies have gained increasing attention as innovative tools for education, including in the field of adult Basic Life Support (BLS). While existing reviews on this topic primarily focus on comparing VR/AR with other educational approaches, our research aimed to identify the VR/AR hardware and software applications assessed in published studies and their alignment with learning objectives in adult BLS education.</div></div><div><h3>Methods</h3><div>We conducted a scoping literature review using the Population, Exposure, and Outcome (PEO) framework to analyse publications from 2018 to 2024. The review focused on the impact of VR/AR (exposure) on affective, behavioral, and cognitive learning outcomes (outcome) in adult BLS education among laypersons, healthcare professionals, pre-licensure students, and duty-to-respond laypersons (population).</div></div><div><h3>Results</h3><div>From 1,282 database records and 54 alternative sources, 31 articles were selected for comprehensive analysis. Many of the studies (11/31; 36%) targeted pre-licensure students, such as nursing students, and laypersons (9/31; 20%), primarily high school students. Only one study focused on duty-to-respond laypersons (1/31; 3%). VR studies (24/31; 77%) were more common than AR studies (6/31; 19%), featuring a broad spectrum of ten VR headsets compared to just two types of AR headsets. Among the assessed software applications, twenty-one commercial programs were examined—sixteen designed for VR and five for AR. Most studies investigated affective outcomes (25/31; 81%), while behavioural outcomes were also commonly examined (22/31; 71%). In contrast, cognitive outcomes were explored in fewer studies (9/31; 29%).</div></div><div><h3>Conclusion</h3><div>Our review identified several challenges in existing studies, including variability in software and hardware, diverse learning outcomes, and accessibility issues with extended reality (XR) technology. To maximize its effectiveness, XR should be aligned with specific learning objectives rather than adopted for its novelty. Prioritizing educational efficacy ensures that XR enhances learning by addressing precise gaps, ultimately improving the understanding and retention of resuscitation skills among both laypersons and healthcare professionals.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100927"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of coronary perfusion pressure and diastolic blood pressure calculation methods in a swine model of pediatric cardiopulmonary resuscitation","authors":"Jeremy C. Zuckerberg ,&nbsp;Tiffany Ko ,&nbsp;M. Katie Weeks ,&nbsp;Nicholas J. Widmann ,&nbsp;Martha F. Kienzle ,&nbsp;Hunter A. Gaudio ,&nbsp;Luiz Eduardo V. Silva ,&nbsp;Ron W. Reeder ,&nbsp;Robert M. Sutton ,&nbsp;Robert A. Berg ,&nbsp;Todd J. Kilbaugh ,&nbsp;Ryan W. Morgan","doi":"10.1016/j.resplu.2025.100928","DOIUrl":"10.1016/j.resplu.2025.100928","url":null,"abstract":"<div><h3>Introduction</h3><div>Measurement of coronary perfusion pressure (CoPP) and diastolic blood pressure (DBP) during cardiopulmonary resuscitation (CPR) is important for titration of physiologic-directed CPR. However, agreement between different calculation methods and their relative performance as outcome discriminators are not well established.</div></div><div><h3>Methods</h3><div>Four calculation methods, differentiated by sampling technique, were retrospectively applied to pressure waveforms from piglet CPR: late diastole (CoPP₆₅, DBP₆₅), mid-diastole (CoPP₅₀, DBP₅₀), diastolic minimum (CoPP_min, DBP_min), and diastolic mean (CoPP_mean, DBP_mean). Intermethod agreement was assessed by Bland-Altman analysis and Cohen’s kappa statistic. Logistic regression was used to evaluate performance in discriminating return of spontaneous circulation (ROSC) and to identify optimal thresholds.</div></div><div><h3>Results</h3><div>Relative to CoPP₆₅, measurements by CoPP₅₀, CoPP_min, and CoPP_mean were within 5 mmHg limits of agreement (LOA) in 97%, 64%, and 99% of instances with kappa 0.88, 0.76, and 0.91, respectively. Relative to DBP₆₅, measurements by DBP₅₀, DBP_min, and DBP_mean were within 5 mmHg LOA in 98%, 71%, and 99% of instances with kappa 0.90, 0.80, and 0.91, respectively. The areas under the ROC curves (AUC) for CoPP₆₅, CoPP₅₀, CoPP_min, and CoPP_mean were 0.777, 0.792, 0.787, and 0.788, and optimal thresholds to discriminate ROSC were 15.3, 15.8, 12.3, and 14.7 mmHg, respectively. The AUCs for DBP₆₅, DBP₅₀, DBP_min, and DBP_mean were 0.813, 0.827, 0.833, and 0.826, and optimal thresholds to discriminate ROSC were 28.6, 27.3, 26.2, and 29.7 mmHg, respectively.</div></div><div><h3>Conclusions</h3><div>During piglet CPR, measurements by late diastole, mid-diastole, and diastolic mean strongly agreed, whereas those at diastolic minimum were more discrepant. All methods performed similarly in discrimination of ROSC.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100928"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of the OverCool study: Lung-conservative liquid ventilation for the induction of Ultra-Rapid Cooling after Cardiac Arrest (OverCool)","authors":"Renaud Tissier ,&nbsp;Fabio Silvio Taccone ,&nbsp;Lionel Lamhaut ,&nbsp;Eric Vicaut ,&nbsp;Fabrice Paublant ,&nbsp;Jean-Damien Ricard ,&nbsp;Alain Mercat ,&nbsp;Alain Cariou","doi":"10.1016/j.resplu.2025.100926","DOIUrl":"10.1016/j.resplu.2025.100926","url":null,"abstract":"<div><h3>Background</h3><div>The therapeutic window within which induced hypothermia might be effective after cardiac arrest is still unknown. In animal cardiac arrest models, early induction and faster cooling are independently associated favorable outcome. However, induction of Ultra-Rapid Therapeutic Hypothermia (achieving core body temperature of 33.0 ± 0.5 °C within 60 min after the start of the procedure) still need to be evaluated in the human setting. Total liquid ventilation with temperature-controlled breathable liquids provided such rapid cooling (i.e. &gt;15 °C/h cooling rate) in both small and large animals. This method was shown to improve neurological outcome in animals. A new medical device system, Vent2Cool, was developed for clinical use in the Intensive Care Unit to achieve ultra-rapid therapeutic hypothermia by total liquid ventilation to patients.</div></div><div><h3>Materials and methods</h3><div>The non-blinded and single-arm OverCool pilot trial will evaluate the feasibility, cooling performance and safety of ultra-rapid therapeutic hypothermia by total liquid ventilation in 24 patients resuscitated after in- or out-of-hospital cardiac arrest. Inclusion criteria will include presumption to start ultra-rapid cooling procedure in the Intensive Care Unit within less than 120 min after resuscitation. The primary outcome will be the achievement of a core temperature of 33.0 ± 0.5 °C, as well as successful return to conventional gas ventilation within &lt;60 min after procedure initiation. Secondary outcomes will include time to reach target temperature, vital status, systemic and pulmonary parameters and modified-Rankin Score at 28 days post- cardiac arrest.</div></div><div><h3>Conclusion</h3><div>The OverCool study is a pilot study to validate performance and safety of ultra-rapid therapeutic hypothermia using total liquid ventilation for resuscitated cardiac arrest patients.</div></div><div><h3>Registration and authorization</h3><div>NCT06798818. Authorized by the French “Agence nationale de sécurité du médicament et des produits de santé” and “Comité de Protection des Personnes” (Ethics Committee).</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100926"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technological innovations in layperson CPR education – A scoping review","authors":"Abigail E. Schipper ,&nbsp;Charles S.M. Sloane ,&nbsp;Lydia B. Shimelis ,&nbsp;Ryan T. Kim","doi":"10.1016/j.resplu.2025.100924","DOIUrl":"10.1016/j.resplu.2025.100924","url":null,"abstract":"<div><h3>Background</h3><div>Rapid initiation of CPR is key for survival in out-of-hospital cardiac arrests, making bystander CPR education a key part of the cardiac chain-of-survival. CPR classes continue to include new technologies that enable more widespread and high-fidelity training. We aimed to examine the landscape of technological innovations in layperson CPR training since the onset of the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>We searched Cochrane, Medline, PubMed, and Web of Science from database inception to July 2024 for studies. We included articles with layperson CPR classes that included a technological advance, either in the equipment or mode of delivery of education. We focused on studies published after the start of 2020.</div></div><div><h3>Results</h3><div>Out of 1070 studies screened, 50 met the selection criteria. The primary groups of technology found were extended reality (20), feedback devices (11), asynchronous video instruction (10), tele-education (5), and low-cost CPR manikins (4). These technologies show promise to offer comparable or improved effectiveness compared to traditional options. Several topics may warrant further investigation, such as cognitive load associated with extended reality, the practicality of student-created CPR training devices, and possible interactive effects between technologies.</div></div><div><h3>Conclusion</h3><div>Future systematic reviews should evaluate the specific learning contexts for which these individual technologies, or combinations of these technologies, may be best suited to guide regulating bodies and CPR instructors in their pedagogical decisions.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"23 ","pages":"Article 100924"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten years of Basic Life Support provider course: results and challenges from the Italian Resuscitation Council’s experience","authors":"Giuseppe Stirparo ,&nbsp;Giovanni Gaetti ,&nbsp;Giuseppe Ristagno ,&nbsp;Giovanni Babini ,&nbsp;Samantha Di Marco ,&nbsp;Andrea Scapigliati ,&nbsp;Alessandro Galazzi ,&nbsp;Alberto Cucino ,&nbsp;on behalf of the Italian Resuscitation Council Scientific Committee","doi":"10.1016/j.resplu.2025.100903","DOIUrl":"10.1016/j.resplu.2025.100903","url":null,"abstract":"<div><h3>Introduction</h3><div>Widespread basic life support (BLS) training plays a central role in improving cardiac arrest (CA) survival. This study presents an extensive analysis of numbers, candidates’ characteristics, and outcomes over 10 years of BLS provider courses organized by the Italian Resuscitation Council (IRC) in Italy.</div></div><div><h3>Method</h3><div>This is a retrospective analysis of data recorded in the national IRC BLS training database from January 2014 to December 2023. Candidates’ demographic and professional factors were analyzed with regional differences and course outcomes.</div></div><div><h3>Results</h3><div>Over the study period, a total 906,686 candidates attended the course, 646,743 (71.3%) of whom were healthcare professionals (HP) and 259,943 (28.8%) non-healthcare professionals (NHP). The percentage of candidates passing the final exam was 99.5% for HP and 99.8% for NHP. The rate per 1000 HP per year of physicians and nurses attending the BLS course varied considerably across the Italian regions, ranging from 4.2 in central Italy to 669.7 in some northern areas. The rate per 1000 inhabitants of NHP per year attending the BLS course was also different among regions, varying from 0.1 in the southern and central regions up to 1.7 in the northern and northeastern ones.</div></div><div><h3>Conclusion</h3><div>The pass rate of the BLS provider course is overall very high, indicating that it provides an easy and accessible set of skills for both HP and NHP candidates. Regional disparities (e.g. the rates of trained individuals and distribution between HP and NHP) and the low attendance of retraining courses represent important challenges that need to be addressed. Analysing training registers is a valuable tool for better planning future training projects.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100903"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}