Resuscitation plus最新文献

{"title":"CardioPulmonary resuscitation with Argon (CPAr): A protocol for a randomised controlled multicentre clinical trial","authors":"Giuseppe Ristagno ,&nbsp;Lidia Staszewsky ,&nbsp;Giulia Merigo ,&nbsp;Aurora Magliocca ,&nbsp;Alberto Cucino ,&nbsp;Jennifer Meessen ,&nbsp;Francesca Fumagalli ,&nbsp;Matteo Pozzi ,&nbsp;Alessandro Galazzi ,&nbsp;Claudio Sandroni ,&nbsp;Marco Meneguzzi ,&nbsp;Anna Marangone ,&nbsp;Chiara Robba ,&nbsp;Erik Roman-Pognuz ,&nbsp;Giovanni Salati ,&nbsp;Edoardo Picetti ,&nbsp;Deborah Novelli ,&nbsp;Giacomo Bellani ,&nbsp;Mauro Panigada ,&nbsp;Lars Wik ,&nbsp;Simone Savastano","doi":"10.1016/j.resplu.2025.101096","DOIUrl":"10.1016/j.resplu.2025.101096","url":null,"abstract":"<div><h3>Aims</h3><div>The CardioPulmonary resuscitation with Argon (CP<em>Ar</em>) trial evaluates the clinical neuroprotective efficacy and safety of post-resuscitation ventilation with a 70/30 argon/oxygen (Ar/O₂) gas mixture compared to standard care ventilation with 30% O₂ in unconscious adults resuscitated from out-of-hospital cardiac arrest (OHCA).</div></div><div><h3>Methods</h3><div>CP<em>Ar</em> is an allocation-concealed, single-blinded, multi-centre, phase II, pre-marketing, randomised controlled trial (RCT). The study aims to recruit 120 patients across tertiary intensive care units (ICUs) in Italy. Eligible participants are unconscious adult OHCA survivors with a shockable presenting rhythm. Upon ICU admission, patients are individually randomised in a 1:1 ratio to receive either 4-h ventilation with 70/30 Ar/O₂ via an experimental ventilator, or standard ICU ventilation with 30% O₂. All patients receive guideline-based post-resuscitation care. Inclusion is conducted under a deferred consent model, with consent obtained from patients or legal representatives once clinically appropriate.</div><div>The primary clinical efficacy outcome is serum neuron-specific enolase (NSE) concentration at 48 h, as a surrogate marker of neurological injury. Secondary outcomes include markers of myocardial and multiorgan injury, neuroimaging signs of brain injury, survival, and neurological recovery (Cerebral Performance Category, CPC) up to 6 months. Safety outcomes include the incidence, timing, and duration of O₂ desaturation requiring discontinuation of Ar, and haemodynamic adverse events. Patients are followed up to 6 months, with outcome assessment at ICU/hospital discharge, 1- and 6-months post-CA. A centralized plasma and serum biobank will support future mechanistic analyses.</div></div><div><h3>Conclusion</h3><div>CP<em>Ar</em> trial is the first RCT to assess the efficacy and safety of Ar ventilation in humans following OHCA and may inform future neuroprotective strategies in post-resuscitation care.</div></div><div><h3>Trial registration</h3><div>EudraCT-No.: 2018-003047-32; CTIS code: 2024-516864-27-00; <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> identifier: NCT05482945.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101096"},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145227046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kids and others save lives – All generations globally involved in World Restart a Heart 2024 to save the world!","authors":"Z. Al-Hilali ,&nbsp;N. Rott ,&nbsp;B.W. Böttiger ,&nbsp;A. Lockey","doi":"10.1016/j.resplu.2025.101095","DOIUrl":"10.1016/j.resplu.2025.101095","url":null,"abstract":"","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101095"},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, management, and outcomes of acute myocardial infarction-related cardiogenic shock patients with and without out-of-hospital cardiac arrest: a Gulf region registry analysis","authors":"Amin Daoulah ,&nbsp;Omar Kanbr ,&nbsp;Ahmed Elmahrouk ,&nbsp;Mohammed Al Jarallah ,&nbsp;Nooraldaem Yousif ,&nbsp;Ahmed Jamjoom ,&nbsp;Muhammad Nouman Iqbal ,&nbsp;Amr A. Arafat ,&nbsp;Kralovic Damon ,&nbsp;Rasha Al-Bawardy ,&nbsp;Prashanth Panduranga ,&nbsp;Abdulrahman Arabi ,&nbsp;Bandar Alamro ,&nbsp;Waleed Alharbi ,&nbsp;Ethan M. Ross ,&nbsp;Mohamed Ajaz Ghani ,&nbsp;Amir Lotfi ,&nbsp;Vincent Marsh ,&nbsp;Shaber Seraj ,&nbsp;Neal Johnson ,&nbsp;Rajesh Rajan","doi":"10.1016/j.resplu.2025.101091","DOIUrl":"10.1016/j.resplu.2025.101091","url":null,"abstract":"<div><h3>Background</h3><div>Out-of-hospital cardiac arrest (OHCA) in the setting of acute myocardial infarction-related cardiogenic shock (AMI-CS) represents a particularly high-risk subgroup. The Cardiac Arrest Hospital Prognosis (CAHP) score is a prognostic tool used in post-arrest care; however, its utility in predicting in-hospital mortality among OHCA survivors with AMI-CS in the Gulf region remains unclear. This study assessed differences in clinical characteristics and outcomes between AMI-CS patients with and without OHCA and evaluated the discriminative ability of the CAHP score.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed using data from the Gulf-CS registry, including 1513 patients diagnosed with AMI-CS from 2020 to 2022. Patients were stratified by the presence of OHCA at presentation.</div></div><div><h3>Results</h3><div>Among the cohort, 138 patients (9.1 %) experienced OHCA and survived to hospital presentation. These patients were younger and with fewer comorbidities. ST-elevation myocardial infarction (STEMI) was significantly more common in the OHCA group (89.1 % vs. 72.3 %, P &lt; 0.001). Despite the severity of OHCA, in-hospital mortality was lower in this group compared to those without arrest (34.8 % vs. 46.5 %, P = 0.009), although they had a higher incidence of cerebrovascular accidents (9.4 % vs. 5.2 %, P = 0.042). The CAHP score was strongly associated with in-hospital mortality (OR: 1.067, P &lt; 0.001), with the highest risk observed in those with scores &gt;200 (64.6 % mortality).</div></div><div><h3>Conclusion</h3><div>Among AMI-CS patients, those with OHCA who survive to hospital presentation exhibit lower in-hospital mortality. The CAHP score demonstrated good discriminative ability for in-hospital mortality in this population.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101091"},"PeriodicalIF":2.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac arrest events on Australian beaches","authors":"David Reid ,&nbsp;Kye Bostwick ,&nbsp;Jasmin C. Lawes ,&nbsp;Ogilvie Thom ,&nbsp;Ned Douglas","doi":"10.1016/j.resplu.2025.101092","DOIUrl":"10.1016/j.resplu.2025.101092","url":null,"abstract":"<div><h3>Background</h3><div>Surf Life Saving Australia (SLSA) members respond to cardiac arrests near their patrolling location and have successfully resuscitated many community members over the years. In addition, members often act as first responders to cardiac arrest events in community settings, workplaces or through applications such as GoodSAM®. The outcomes achieved are not known after an update to resuscitation guidelines.</div></div><div><h3>Objective</h3><div>We aimed to analyse Surf Life Saving Australia data on cardiopulmonary resuscitation (CPR) and describe the epidemiology and outcomes of cardiac arrest on Australian beaches and factors associated with survival after CPR.</div></div><div><h3>Methods</h3><div>Using SLSA’s national Incident Reporting Database held by Surf Life Saving Australia, anonymised incident report forms were analysed to determine the incidence, aetiology and outcomes of CPR events attended by SLSA members on Australian beaches.</div></div><div><h3>Results</h3><div>Between December 2000 and May 2020 there were 158 incidents where CPR was provided SLSA members. Mean patient age was 46 years of age (SD 18.9), and 83 % were male. The majority (68 %) of patients were involved in water activities at the time of their requirement for CPR including swimming, wading, and watercraft activity.</div><div>Return of spontaneous circulation (ROSC) was achieved before transport to hospital in 34 (22 %) of cases. An automated external defibrillator (AED) was applied on 42 patients, with seven being defibrillated. The two variables associated with higher odds of survival were the incident occurring in the flagged area (OR 4.0 [95 % CI: 1.5–11.2]) and the use of oxygen therapy (OR 2.8 [95 % CI: 1.1–7.1]).</div></div><div><h3>Conclusion</h3><div>Cardiac arrest at the beach is an uncommon event. Cardiac arrest close to patrolling location and the use of oxygen were associated with improved odds of ROSC.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101092"},"PeriodicalIF":2.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying clinical error patterns in nursing students’ CPR performance: a mixed-methods OSCE study","authors":"Kheizaran Miri ,&nbsp;Alireza Sardashti ,&nbsp;Sajedeh Moradi ,&nbsp;Arefeh Naseri ,&nbsp;Amirhossein Mirzaei","doi":"10.1016/j.resplu.2025.101089","DOIUrl":"10.1016/j.resplu.2025.101089","url":null,"abstract":"<div><h3>Background</h3><div>Basic Life Support (BLS) competency is critical for healthcare professionals, yet persistent performance gaps exist in training settings. This study aimed to identify error patterns in nursing students’ cardiopulmonary resuscitation (CPR) performance during Objective Structured Clinical Examinations (OSCEs) and, through stakeholder insights, identify perceived challenges and suggest remediation strategies to improve learning outcomes.</div></div><div><h3>Methods</h3><div>A sequential explanatory mixed-methods study was conducted (2021–2024) with 250 eighth-semester nursing students. The quantitative phase analyzed OSCE performance using: 1) a validated 20-item BLS knowledge test, 2) a 17-item skills checklist, and 3) Laerdal QCPR® mannequin metrics. The qualitative phase included interviews with 25 stakeholders (students, instructors, examiners). Data were analyzed using descriptive/inferential statistics (SPSS v25) and thematic analysis (MAXQDA 2022).</div></div><div><h3>Results</h3><div>Significant deficiencies were identified: 68 % failed to achieve guideline-compliant compression depth (mean: 40–50 mm vs. recommended 50–60 mm), 45 % demonstrated incorrect rates, and only 18 % properly applied AED pads. Qualitative analysis revealed stress (89 % prevalence) and inadequate feedback (75 %) as key performance barriers. Gender disparities emerged, with female students delivering 40 % shallower compressions (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study reveals persistent gaps in nursing students’ ability to translate BLS knowledge into competent CPR performance during OSCEs. Deficiencies in compression quality, AED use, and decision-making highlight limitations of current training models. Integrating high-fidelity simulation, real-time feedback, and stress-mitigation strategies may strengthen skill acquisition. Further multicenter research is needed to establish evidence-based approaches that ensure graduates are prepared to deliver high-quality resuscitative care.</div><div><strong>Clinical trial number:</strong> not applicable.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101089"},"PeriodicalIF":2.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood glucose upon return of spontaneous circulation and neurological outcomes following out-of-hospital cardiac arrest","authors":"Ryo Yamamoto ,&nbsp;Kazuki Matsumura ,&nbsp;Daiki Kaito ,&nbsp;Tomoyoshi Tamura ,&nbsp;Koichiro Homma ,&nbsp;Masaru Suzuki ,&nbsp;Tomohisa Nomura ,&nbsp;Nobuya Kitamura ,&nbsp;Takashi Tagami ,&nbsp;Hideo Yasunaga ,&nbsp;Shotaro Aso ,&nbsp;Junichi Sasaki ,&nbsp;SOS-KANTO 2017 Study Group","doi":"10.1016/j.resplu.2025.101088","DOIUrl":"10.1016/j.resplu.2025.101088","url":null,"abstract":"<div><h3>Background</h3><div>To elucidate the association between blood glucose levels at the return of spontaneous circulation (ROSC) and neurological outcomes following out-of-hospital cardiac arrest (OHCA), a post hoc analysis was conducted using data from a prospective observational study involving 41 hospitals in Tokyo and its suburbs from 2019 to 2021. Adults with nontraumatic OHCA who achieved ROSC were included.</div></div><div><h3>Methods</h3><div>A total of 1533 patients were analyzed. A spline curve for estimating neurological outcomes (Cerebral Performance Category score ≤2 at 30 days) by blood glucose level at ROSC was generated. Patients were classified into low, moderate, and high blood glucose groups, defined as &lt;100, 100–300, and ≥300 mg/dL, respectively. Neurological outcomes were compared using generalized estimating equations adjusted for patient and institutional characteristics.</div></div><div><h3>Results</h3><div>Favorable neurologic outcomes were fewer in the low and high blood glucose groups than in the moderate group (8/132 [6.1 %] and 62/485 [12.8 %] vs. 181/807 [22.4 %]). The adjusted model revealed that low and high glucose levels at ROSC were associated with fewer favorable outcomes (odds ratios, 0.43 [0.18–0.96] and 0.59 [0.42–0.84]). High blood glucose levels showed unfavorable effects in subgroups with cardiogenic or noncardiogenic etiology, age &lt;65 years, and low-flow time ≤30 min, whereas low blood glucose levels showed unfavorable effects only in cardiogenic cases.</div></div><div><h3>Conclusions</h3><div>Blood glucose levels &lt;100 and ≥300 mg/dL were associated with unfavorable neurological outcomes, with a nonlinear inverted U-shaped relationship.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101088"},"PeriodicalIF":2.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehospital factors of survival to hospital admission in blunt traumatic out-of-hospital cardiac arrest: a nationwide 11-year study","authors":"Thanakorn Laksanamapune ,&nbsp;Welawat Tienpratarn ,&nbsp;Chaiyaporn Yuksen ,&nbsp;Danaiporn Suktarom ,&nbsp;Phunyapat Pankeaw ,&nbsp;Irada Somawong ,&nbsp;Sittichok Leela-Amornsin","doi":"10.1016/j.resplu.2025.101086","DOIUrl":"10.1016/j.resplu.2025.101086","url":null,"abstract":"<div><h3>Background</h3><div>Blunt traumatic out-of-hospital cardiac arrest (TOHCA) is consistently associated with poor survival outcomes. Although the prehospital interventions may influence prognosis. This study<!--> <!-->aimed to identify independent prehospital factors associated with survival to hospital admission among patients of blunt TOHCA in Thailand.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used nationwide data from the Information Technology of Emergency Medical System database between 2012 and 2022. Patients of all ages with blunt TOHCA who received prehospital resuscitation and were transported to the emergency department were included. The primary outcome was survival to hospital admission. Multivariable logistic regression was used to identify associated prehospital factors.</div></div><div><h3>Results</h3><div>Of 18,612 patients with blunt TOHCA, 3,004 (16.1 %) survived to hospital admission. The survival rate declined from 28 % in 2012 to 13 % in 2022. Several independent factors associated with improved survival, including external bleeding control (adjusted odds ratio [aOR] 1.20, 95 % confidence interval [CI]: 1.03–1.40), endotracheal intubation (aOR 2.12, 95 % CI: 1.74–2.58), intravenous fluid administration (aOR 1.65, 95 % CI: 1.32–2.06), defibrillation (aOR 2.40, 95 % CI: 1.99–2.90), longer on-scene time (aOR 1.03, 95 % CI: 1.02–1.03), and head/neck injuries (aOR 1.30, 95 % CI: 1.11–1.51). In contrast, longer hospital-to-scene distances, chest/clavicle injuries, and open/closed fractures were associated with decreased odds of survival.</div></div><div><h3>Conclusion</h3><div>This study highlights critical challenges in the prehospital management of blunt TOHCA in Thailand. Timely and appropriate interventions, including bleeding control, airway management, intravenous fluid administration, and defibrillation, may enhance survival outcomes.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101086"},"PeriodicalIF":2.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of esophageal temperature probe tip placement on core temperature measurement accuracy in cold environments: a randomized crossover trial with implications for cardiac arrest management","authors":"Giulia Roveri ,&nbsp;Tomas Dal Cappello ,&nbsp;Alex Hofer ,&nbsp;Franziska Breidt ,&nbsp;Othmar Kofler ,&nbsp;Erik Popp ,&nbsp;Hermann Brugger ,&nbsp;Simon Rauch","doi":"10.1016/j.resplu.2025.101087","DOIUrl":"10.1016/j.resplu.2025.101087","url":null,"abstract":"<div><h3>Introduction</h3><div>Accurate core temperature (CT) measurement is critical for staging and management in accidental hypothermia, particularly in cardiac arrest, where it guides extracorporeal rewarming decisions. Esophageal temperature monitoring is considered the reference method in the prehospital setting in patients with a secured airway, provided the probe tip is positioned in the distal third of the esophagus behind the heart. However, the effect of proximal misplacement on measurement accuracy remains unknown. We hypothesized that a probe tip positioned behind the trachea would yield falsely low readings during cold air exposure.</div></div><div><h3>Methods</h3><div>In this randomized crossover study (May 2024 at Eurac Research, Bolzano, Italy), healthy volunteers underwent nasal esophageal probe placement using a height-based formula. Two probe positions were defined via posteroanterior chest radiographs: correct (behind the heart) and incorrect (5 cm above the tracheal bifurcation). Participants were exposed to –20 °C for 20 min in a climate chamber, once with the probe in the correct and once in the incorrect position, in randomized order, separated by a washout period.</div></div><div><h3>Results</h3><div>Fifteen participants (7 male, 8 female) completed the study. Mean correct insertion depth was 41.1 (2.5) cm for males and 39.3 (1.5) cm for females. At baseline and throughout –20 °C exposure, mean CT was on average 0.6 °C lower when the probe was incorrectly positioned. Temperature fluctuations were also greater with proximal misplacement.</div></div><div><h3>Conclusion</h3><div>Proximal misplacement of esophageal probes during cold air exposure results in falsely low and more variable CT readings. This may critically affect triage and treatment, particularly in hypothermic cardiac arrest.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101087"},"PeriodicalIF":2.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145105621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral oxygen monitoring during out-of-hospital cardiac arrest: A scoping review","authors":"Ingjerd Baugstø ,&nbsp;Nora Gjesdal ,&nbsp;Sarah Elizabeth King ,&nbsp;Sindre Andre Pedersen ,&nbsp;Lars Petter Bache-Wiig Bjørnsen ,&nbsp;Nils Kristian Skjærvold ,&nbsp;Oddvar Uleberg","doi":"10.1016/j.resplu.2025.101082","DOIUrl":"10.1016/j.resplu.2025.101082","url":null,"abstract":"<div><h3>Background</h3><div>Cerebral tissue oxygen saturation is not routinely monitored during out-of-hospital cardiac arrest (OHCA) but can be assessed using cerebral oxygen monitoring (COM). This non-invasive technique provides real-time measurements of brain oxygenation. The aim of this scoping review (ScR) was to map and describe published studies on the use of COM in OHCA in prehospital and emergency department (ED) settings.</div></div><div><h3>Methods</h3><div>This review followed the JBI Manual for Evidence Synthesis and the Preferred Reporting Items for Systematic reviews and Meta-Analyses ScR (PRISMA-ScR) checklist. Peer-reviewed primary studies reporting the use of COM in OHCA patients in prehospital and/or ED settings were eligible. MEDLINE, Embase, CINAHL, Cochrane Library, and Web of Science were searched from inception to August 8th, 2025.</div></div><div><h3>Results</h3><div>A total of 2166 records were screened, and 57 publications representing 51 studies were included. The studied populations were mainly adult males and included patients with non-traumatic causes of arrest. Most studies were small observational cohorts from Japan, conducted in the ED. Near-infrared spectroscopy (NIRS) was the predominant technology used. Studies commonly examined associations between COM values and return of spontaneous circulation (ROSC) or neurological outcomes. Few papers evaluated COM’s impact on clinical decision-making or treatment.</div></div><div><h3>Conclusion</h3><div>The evidence base is dominated by small, ED-based observational studies with limited geographical diversity. While many publications explored the association between COM values and ROSC or neurological outcomes, few reported outcomes data or investigated COM’s role in influencing treatment. Future research should focus on methodological standardization, broader international representation, and the clinical utility of COM-guided interventions.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101082"},"PeriodicalIF":2.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with recurrent out-of-hospital cardiac arrest after hospital discharge: a population-based study","authors":"Sih-Shiang Huang ,&nbsp;Cheng-Yi Fan ,&nbsp;Yun-Ting Chih ,&nbsp;Edward Pei-Chuan Huang ,&nbsp;Chih-Wei Sung","doi":"10.1016/j.resplu.2025.101083","DOIUrl":"10.1016/j.resplu.2025.101083","url":null,"abstract":"<div><h3>Background</h3><div>Survivors of out-of-hospital cardiac arrest (OHCA) remain at significant risk of recurrence; however, the factors associated with a subsequent OHCA episode requiring hospitalisation are not well characterised. Dependence on indwelling devices may indicate a state of chronic vulnerability. This study aimed to identify risk factors for recurrent OHCA using a nationwide cohort.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using Taiwan’s National Health Insurance Research Database from 2010 to 2020. Adult non-traumatic OHCA survivors discharged alive were included and followed for up to five years. Demographics, comorbidities, healthcare utilisation, and long-term indwelling device use (nasogastric tube, Foley catheter, tracheostomy with ventilator) were analysed. The primary outcome was a second OHCA requiring hospitalisation. Multivariable logistic regression identified independent risk factors, with adjusted odds ratios (aORs) and 95 % confidence intervals (CIs) reported.</div></div><div><h3>Results</h3><div>Among 15,617 OHCA survivors, 1,123 (7.2 %) experienced a second OHCA requiring hospitalisation within five years. Patients with recurrence were older (62.6 vs. 61.0 years, <em>p</em> &lt; 0.001), and more frequently used indwelling devices. In multivariable analysis, nasogastric tube (aOR 1.82, 95 % CI 1.50–2.19, <em>p</em> &lt; 0.001), Foley catheter (aOR 1.20, 95 % CI 1.00–1.43, <em>p</em> = 0.05), and tracheostomy with ventilator (aOR 0.85, 95 % CI 0.73–1.00, <em>p</em> = 0.043) were independently associated with recurrent OHCA, while age, sex, and pre-arrest diseases were not.</div></div><div><h3>Conclusion</h3><div>Functional dependence and healthcare utilisation were associated with recurrent OHCA among survivors hospitalised for a recurrent event. Device dependence may serve as a marker of vulnerability, highlighting the need for ongoing monitoring and follow-up.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"26 ","pages":"Article 101083"},"PeriodicalIF":2.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}