Resuscitation plus最新文献

{"title":"The impact of the COVID-19 pandemic on resuscitation attempts, bystander CPR and survival outcomes in Australia and New Zealand: A binational population-based, Epistry study","authors":"Stuart Howell ,&nbsp;Ziad Nehme ,&nbsp;Stephen Ball ,&nbsp;Tan Doan ,&nbsp;Judith Finn ,&nbsp;Emma Bosley ,&nbsp;Steven Faddy ,&nbsp;Bridget Dicker ,&nbsp;Andy Swain ,&nbsp;Peter Cameron ,&nbsp;Melanie Thorrowgood ,&nbsp;Andrew Thomas ,&nbsp;Samuel Perillo ,&nbsp;Mike McDermott ,&nbsp;Matt Green ,&nbsp;Nicole Packham ,&nbsp;Ashanti Dantanarayana ,&nbsp;Joe Cuthbertson ,&nbsp;Janet Bray ,&nbsp;Aus-ROC OHCA Epistry Management Committee","doi":"10.1016/j.resplu.2025.100894","DOIUrl":"10.1016/j.resplu.2025.100894","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to assess the impact of the COVID-19 pandemic on out-of-hospital cardiac arrest (OHCA) incidence, bystander cardiopulmonary resuscitation (CPR), EMS resuscitation attempts and survival across Australia and New Zealand.</div></div><div><h3>Method</h3><div>Data were extracted for all OHCAs patients attended by emergency medical services (EMS) between 2017 and 2021 from the Aus-ROC OHCA Epistry (Epidemiological registry). Logistic regression was used to explore differences between the pre-COVID-19 (January 1, 2017 to March 15, 2020) and COVID-19 (March 16, 2020 to December 31, 2021) periods for bystander CPR, EMS-attempted resuscitation, survival to hospital arrival (event survival) and survival to hospital discharge/30 days.</div></div><div><h3>Results</h3><div>The incidence of OHCA increased during COVID-19 in Australia and New Zealand, although this varied regionally. When compared to the pre-COVID-19 period, COVID-19 was associated with a significant increase in the odds of an EMS-attempted resuscitation in Queensland (adjusted odds ratio (aOR) = 1.19; 95%CI: 1.01–1.40, p = 0.03) and Western Australia (aOR = 1.26; 95%CI: 1.03–1.54, p = 0.02). The COVID-19 period was associated with a decrease in survival to hospital arrival in Australia overall (aOR = 0.91; 95% CI:0.83–0.99, p = 0.04), and by region in Victoria (aOR = 0.74; 95% CI:0.63–0.87, p &lt; 0.01) and Tasmania (aOR = 0.48; 95% CI:0.25–0.91, p = 0.02), and with a decrease in survival to hospital discharge/30 days in Australia (aOR = 0.82; 95% CI:0.70–0.96, p = 0.01), and by region in Victoria (aOR = 0.70; 95% CI:0.54–0.91, p &lt; 0.01) and South Australia (aOR = 0.61; 95% CI:0.37–0.99, p = 0.04). There were no significant changes in survival during COVID-19 in New Zealand.</div></div><div><h3>Conclusion</h3><div>Regional variations were observed with respect to the associations of COVID-19 with resuscitation attempts and OHCA survival.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100894"},"PeriodicalIF":2.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public awareness of automated external defibrillator (AED)s and their location: Results of a cross-sectional survey in North Carolina","authors":"Harman Yonis,&nbsp;Lisa A. Kaltenbach,&nbsp;Nina Nouhravesh,&nbsp;Daniel Mark,&nbsp;Audrey L. Blewer,&nbsp;Carolina Malta Hansen,&nbsp;Kristian Kragholm,&nbsp;Christian Torp-Pedersen,&nbsp;Monique A. Starks,&nbsp;Sana M. Al-Khatib,&nbsp;Lisa Monk,&nbsp;James Jollis,&nbsp;Comilla Sasson,&nbsp;Konstantin A. Krychtiuk,&nbsp;Christopher B. Granger,&nbsp;RACE-CARS Study Team","doi":"10.1016/j.resplu.2025.100897","DOIUrl":"10.1016/j.resplu.2025.100897","url":null,"abstract":"","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100897"},"PeriodicalIF":2.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deprivation and adverse outcomes from cardiac arrest","authors":"Adam J. Boulton,&nbsp;Terry Brown","doi":"10.1016/j.resplu.2025.100895","DOIUrl":"10.1016/j.resplu.2025.100895","url":null,"abstract":"","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100895"},"PeriodicalIF":2.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenaline has a limited effect on myocardial microvascular blood flow: A randomised experimental study in a porcine cardiac arrest model","authors":"Henrik Wagner ,&nbsp;Mikuláš Mlček ,&nbsp;Petra Krupičková ,&nbsp;Michaela Popkova ,&nbsp;Alan Mejstrik ,&nbsp;Tomas Boucek ,&nbsp;Pavel Michálek ,&nbsp;Otomar Kittnar ,&nbsp;Jan Belohlavek","doi":"10.1016/j.resplu.2025.100893","DOIUrl":"10.1016/j.resplu.2025.100893","url":null,"abstract":"<div><h3>Background</h3><div>Adrenaline (ADR) is a cornerstone of advanced life support (ALS) in cardiac arrest (CA), although its neurologically favourable survival outcomes remain unclear. ADR increases coronary perfusion pressure (CPP), with levels &gt;15 mmHg associated with successful defibrillation. This study aimed to elucidate the relationship between ADR, myocardial microvascular blood flow, and resuscitation outcomes using a porcine CA model simulating refractory ventricular fibrillation (VF).</div></div><div><h3>Methods</h3><div>This study involved 24 domestic pigs. After instrumentation, intubation, and baseline measurements, the animals were randomised into the ADR or control (saline) groups. VF was induced, and cardiopulmonary resuscitation was initiated using continuous mechanical chest compressions and ventilation. ADR or saline was administered following ALS guidelines. After 21 min of ALS, defibrillation was performed. Continuous measurements of arterial and venous blood pressures using an electrocardiogram and index of myocardial resistance (IMR) and transit mean time (Tmn) 1 min before and after each injection or peak blood pressure were recorded and compared between the groups. CPP–IMR, amplitude spectrum area (AMSA)–IMR, CPP–Tmn, and AMSA–Tmn correlations were assessed.</div></div><div><h3>Results</h3><div>Compared with six animals in the control group, three in the ADR group achieved a return of spontaneous circulation. No difference was observed in IMR or AMSA; however, significant increases in CPP and arterial end-diastolic blood pressure were observed at several time points. Tmn differed between groups only at two time points.</div></div><div><h3>Conclusion</h3><div>Repeated ADR doses during prolonged ALS simulating refractory VF did not improve myocardial microvascular blood flow, as measured using IMR, despite leading to an increase in CPP.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100893"},"PeriodicalIF":2.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenaline for traumatic cardiac arrest: A post hoc analysis of the PARAMEDIC2 trial","authors":"C. Ji ,&nbsp;H. Pocock ,&nbsp;C.D. Deakin ,&nbsp;T. Quinn ,&nbsp;J.P. Nolan ,&nbsp;N. Rees ,&nbsp;K. Charlton ,&nbsp;J. Finn ,&nbsp;A. Rosser ,&nbsp;R. Lall ,&nbsp;G.D. Perkins","doi":"10.1016/j.resplu.2025.100890","DOIUrl":"10.1016/j.resplu.2025.100890","url":null,"abstract":"<div><h3>Introduction</h3><div>There is controversy about the effectiveness of adrenaline in traumatic cardiac arrest. This study reports the patient characteristics and outcomes of adults with trauma-related out of hospital cardiac arrest treated with adrenaline or placebo.</div></div><div><h3>Methods</h3><div>This post-hoc, sub-group analysis of the Pre-hospital Randomised Assessment of Adrenaline in Cardiac Arrest-2 (PARAMEDIC-2) trial explored the effect of adrenaline on survival to hospital admission, longer-term survival and neurological outcomes amongst adults with trauma related out of hospital cardiac arrest. Individual patients were randomised through opening a single treatment pack which contained either 10 doses of 1 mg adrenaline or 0.9% saline placebo. Treating clinicians, investigators, outcome assessors and patients were blinded to treatment allocation. The primary outcome was survival to 30 days post cardiac arrest.</div></div><div><h3>Results</h3><div>123 of 8,014 enrolled patients (1.5%) sustained a traumatic cardiac arrest (66 in the adrenaline arm and 57 in the placebo arm). Three times as many patients were admitted to hospital alive in the adrenaline arm 16/66 (24.2%) compared to 5/56 (8.9%) in the placebo arm, unadjusted odds ratio 3.3 (95% confidence interval 1.1 to 9.6), <em>p</em> = 0.03; adjusted odd ratio 5.6 (95% CI 1.6 to 20.4), <em>p</em> = 0.009. A single patient, in the adrenaline arm, survived beyond 30 days (1/66 (1.5%) compared to 0/57 (0%)), who also experienced a favourable neurological outcome.</div></div><div><h3>Conclusion</h3><div>Adrenaline was associated with a trebling of the rate of survival to hospital admission. These data support the use of adrenaline in trauma related out of hospital cardiac arrest.</div></div><div><h3>Registration</h3><div>ISRCTN73485024.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100890"},"PeriodicalIF":2.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical chest compression increases intrathoracic hemorrhage complications in patients receiving extracorporeal cardiopulmonary resuscitation","authors":"Yoshihisa Matsushima ,&nbsp;Tatsuhiro Shibata ,&nbsp;Kodai Shibao ,&nbsp;Rei Yamakawa ,&nbsp;Miyu Hayashida ,&nbsp;Toshiyuki Yanai ,&nbsp;Takashi Ishimatsu ,&nbsp;Takehiro Homma ,&nbsp;Shoichiro Nohara ,&nbsp;Maki Otsuka ,&nbsp;Yoshihiro Fukumoto","doi":"10.1016/j.resplu.2025.100892","DOIUrl":"10.1016/j.resplu.2025.100892","url":null,"abstract":"<div><h3>Background</h3><div>Mechanical cardiopulmonary resuscitation (CPR) devices address the limitations of manual CPR, but their impact on intrathoracic injuries during extracorporeal CPR (ECPR) remains unclear. This study investigated the relationship between mechanical CPR and severe intrathoracic hemorrhage during ECPR compared to manual CPR.</div></div><div><h3>Methods</h3><div>We conducted a single-center retrospective study of consecutive patients who underwent ECPR from April 2017 to March 2024 according to a standard institutional protocol. Patients were divided into a mechanical CPR group (piston-driven compressions before veno-arterial extracorporeal membrane oxygenation [VA-ECMO]) and a manual CPR group. The primary outcome was intrathoracic hemorrhage requiring transcatheter arterial embolization (TAE). Secondary outcomes included other intrathoracic injuries and 180-day survival.</div></div><div><h3>Results</h3><div>A total of 91 patients were enrolled (mechanical <em>n</em> = 48, manual <em>n</em> = 43). Intrathoracic hemorrhage requiring TAE occurred more frequently in the mechanical CPR group (18.8% vs. 2.3%, <em>p</em> = 0.030). On multivariate analysis, mechanical CPR was independently associated with this outcome (adjusted odds ratio 6.29; 95% confidence interval 1.20–65.10). In the mechanical group, older age and larger thoracic transverse diameter were significantly related to intrathoracic hemorrhage requiring TAE. Mediastinal hematoma (18.8% vs. 2.3%, <em>p</em> = 0.030) and hemothorax (20.8% vs. 4.7%, <em>p</em> = 0.049) were also more frequent in the mechanical group. The 180-day survival rates did not differ significantly between groups (27.7% vs. 25.0%, log-rank <em>p</em> = 0.540).</div></div><div><h3>Conclusions</h3><div>Mechanical CPR during ECPR is associated with an increased risk of severe intrathoracic hemorrhage. While mechanical CPR devices may provide benefits in certain scenarios, clinicians should carefully consider individual patient characteristics and closely monitor for complications.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100892"},"PeriodicalIF":2.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of bra for pad placement and defibrillation – A scoping review","authors":"Anne Storgaard Nørskov ,&nbsp;Julie Considine ,&nbsp;Ziad Nehme ,&nbsp;Theresa M. Olasveengen ,&nbsp;Laurie J. Morrison ,&nbsp;Peter Morley ,&nbsp;Janet E. Bray ,&nbsp;the International Liaison Committee on Resuscitation Basic Life Support Task Force","doi":"10.1016/j.resplu.2025.100885","DOIUrl":"10.1016/j.resplu.2025.100885","url":null,"abstract":"<div><h3>Background</h3><div>In some regions, females are less likely to receive public-initiated resuscitation, potentially due to the need to expose the chest and breasts for proper automated external defibrillator (AED) pad placement. We conducted a scoping review to investigate the breadth of the existing literature and knowledge gaps on bra (brassière) removal and AED pad application.</div></div><div><h3>Methods</h3><div>Studies that examined bra removal and outcomes associated with AED pad placement and defibrillation in cardiac arrest were eligible. We searched three databases (Medline, Embase, and Cochrane) from inception to September 26, 2024. Google and Google Scholar (first 20 pages) were searched for grey literature on October 1, 2024. The study followed the scoping review framework by the Joanna Briggs Institute.</div></div><div><h3>Results</h3><div>The search identified 287 references. Three studies met the eligibility criteria, including one animal and two manikin studies, of which two were conference abstracts. No studies examined patient outcomes. No adverse events were reported with defibrillation in a pig model with AED pads in direct contact with a bra’s underwire. No difference in time to pad placement or shock delivery was seen with bra removal in simulation. One simulation study reported female manikins were less likely to be completely de-robed, including bra removal, which was attributed to social norms, modesty, and lack of awareness.</div></div><div><h3>Conclusion</h3><div>Scant evidence is available on the need for bra removal and outcomes associated with AED application. Further research is needed to explore whether bra removal is imperative for AED pad placement and defibrillation.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100885"},"PeriodicalIF":2.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand vs. leg-heel: Evaluating a viable second line approach for chest compressions to bridge the ‘bystander’s window’","authors":"Antje Degel ,&nbsp;Shufan Huo ,&nbsp;Hans-Christian Mochmann ,&nbsp;Jan Breckwoldt","doi":"10.1016/j.resplu.2025.100891","DOIUrl":"10.1016/j.resplu.2025.100891","url":null,"abstract":"<div><h3>Introduction</h3><div>High quality bystander cardiopulmonary resuscitation (CPR) substantially improves outcomes from cardiac arrest. However, chest compression (CC) quality may be impaired in situations of physical incapacitation, low body weight or rescuer fatigue. For such situations, the leg-heel’-approach has been proposed as an alternative. No study, however, has yet explored this method in a standardized setting over a realistic time span, e.g., until professional rescue teams arrive.</div></div><div><h3>Methods</h3><div>In a cross-over design, final year medical students performed continuous CC on a manikin using conventional (C-CPR) and ‘leg-heel’-CPR (LH-CPR) for five minutes each with no pause between methods. Students were randomly assigned to the order of approaches. For the LH-CPR, a chair was provided for the rescuer to stabilize the upper body.</div></div><div><h3>Results</h3><div>121 students were included, and all participants completed the whole ten-minute-task.</div><div>Mean absolute CC depth (C-CPR: 49.8 mm [SD 8.7, CI 48.2–51.4] vs. LH-CPR: 49.9 mm [SD 9.4, CI 48.2–51.5], <em>p</em> = 0.974) and mean leaning depth (C-CPR: 10.9 mm [SD 7.4, CI 9.6–12.3] vs. LH-CPR: 10.9 [SD 7.6, CI 9.6–12.3]), were similar, while mean CC frequency was higher in C-CPR (120/min [SD 13, CI 118–123] vs. 113/min [SD 16, 110–116], <em>p</em> &lt; 0.01). With C-CPR, CC rate steadily increased over time up to 125/min whereas with LH-CPR it remained within the guideline target of 100–120/min. Over time, rescuer fatigue was slightly less pronounced in LH-CPR.</div></div><div><h3>Discussion</h3><div>In a standardized setting over a realistic time span, the ‘leg-heel’-approach led to equal CPR quality as the conventional approach. Application of the ‘leg-heel’-approach however, has to be considered with caution as its effects on haemodynamics and resuscitation-related injuries are unknown. Cases should therefore be carefully observed.</div></div><div><h3>Summary</h3><div>This finding may justify developing training algorithms for ‘leg-heel’-CPR as a second line alternative in situations of fatigue, low body weight or physical incapacitation.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100891"},"PeriodicalIF":2.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defibrillation pad placement accuracy among Advanced Life Support instructors: A manikin-based observational study examining experience, self-evaluation, and actual performance","authors":"Dennie Wulterkens ,&nbsp;Freek Coumou ,&nbsp;Cornelis Slagt ,&nbsp;Reinier A. Waalewijn ,&nbsp;Lars Mommers","doi":"10.1016/j.resplu.2025.100886","DOIUrl":"10.1016/j.resplu.2025.100886","url":null,"abstract":"<div><h3>Background</h3><div>Ventricular fibrillation is common in patients with out-of-hospital cardiac arrest. Early and effective defibrillation is important for their survival. Effective defibrillation depends highly on correct positioning of the defibrillation pads. Teaching this correctly by ALS instructors is therefore crucial.</div></div><div><h3>Methods</h3><div>Fifty certified advanced life support instructors were recruited from a large training institute. Participants were asked to place defibrillation pads on an anatomically and real-weight (90 kg) manikin. Primary outcome was the placement of defibrillation pads placed in the sternal-apical and anterior-posterior positions. Secondary outcomes were performance self-assessment, defibrillation experience, self-perceived competence and self-efficacy in teaching defibrillation. These measures were evaluated using an 11-point Likert scale.</div></div><div><h3>Results</h3><div>A total of 31 medical doctors and 19 registered nurses were enrolled in this study. Defibrillation pads were placed (mean ± SD) 42 ± 21 mm, 38 ± 23 mm, 35 ± 19 mm and 61 ± 48 mm from the reference point for the sternal, apical, anterior and posterior pads respectively, resulting in a respectively correct placement of 18%, 20%, 32% and 28%. The average number of correctly applied pads per instructor was 0.98 ± 0.74 out of four.</div><div>Self-assessment of defibrillation pads placed by the participants were 8.56 ± 1.33 and 7.88 ± 1.64 for the sternal-apical and anterior-posterior positions respectively. Personal defibrillation experience showed that the majority had applied over 20 standard defibrillations. Experience with anterior-posterior pad placement was less and experience with bi-axillary and double sequential external defibrillation positions were absent in most participants. Self-perceived competence for the sternal-apical, anterior-posterior, bi-axillary and dual external synchronized positions were 8.68 ± 1.06, 8.08 ± 1.37, 5.57 ± 2.95 and 5.11 ± 2.67 respectively. Self-efficacy score for teaching defibrillation was 8.59 ± 0.81. No association was found between the number of correctly applied pads and any of the participants’ variables.</div></div><div><h3>Conclusion</h3><div>This study corroborates and expands upon existing knowledge regarding the challenges of defibrillator pad placement, revealing substantial variation in placement accuracy among instructors. Our novel analysis of pad angles and anterior-posterior analysis demonstrates that a significant portion of pads are incorrectly placed. These findings highlight the need for standardized approaches and improved training methodologies in defibrillator pad placement.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100886"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143315515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest","authors":"Magnus Gylling ,&nbsp;Johanna Krøll ,&nbsp;Peder Emil Warming ,&nbsp;Carolina Malta Hansen ,&nbsp;Fredrik Folke ,&nbsp;Steen M. Hansen ,&nbsp;Lars Køber ,&nbsp;Christian Torp-Pedersen ,&nbsp;Rodrigue Garcia ,&nbsp;Jacob Tfelt-Hansen ,&nbsp;Peter E. Weeke","doi":"10.1016/j.resplu.2025.100889","DOIUrl":"10.1016/j.resplu.2025.100889","url":null,"abstract":"<div><h3>Aim</h3><div>How a family history of cardiovascular disease (CVD) or death influences the risk of out-of-hospital cardiac arrest (OHCA) is unknown. This study examined the prevalence of family histories of CVD and death in patients with OHCA and if these factors were associated with OHCA.</div></div><div><h3>Methods</h3><div>Patients (&lt;70 years) with OHCA’s of presumed cardiac origin and available kinship information were identified from the Danish Cardiac Arrest Register (2001–2014). Patients with OHCA were matched 1:4 (age, sex, and number of identifiable parents) with individuals from the background population (controls) to compare family histories (events in first-degree relatives before OHCA) of CVD, all-cause death, cardiovascular death, and premature death (death &lt;60 years). In conditional multivariable logistic regressions, we examined associations between parental history and offspring OHCA risk.</div></div><div><h3>Results</h3><div>Of 45,293 patients with OHCA 4,994, were eligible for inclusion (median age 50 years at OHCA, 76% male). Of these 47.7% had a family history of CVD (vs. 42.1% of controls), 68.2% of all-cause death (vs. 60.9%), 23% of premature death (vs. 15.8%) and 33.3% of cardiovascular death (vs. 27%) (<em>p</em> &lt; 0.001 for all). A family history of a single parent with CVD (OR: 1.13, 95%CI: 1.05,1.23), all-cause death (OR: 1.42, 95%CI: 1.29,1.56), cardiovascular death (OR: 1.35, 95%CI: 1.24, 1.47), and premature death (OR: 1.45, 95%CI: 1.32,1.59) were all associated with OHCA (<em>p</em> &lt; 0.001 for all).</div></div><div><h3>Conclusion</h3><div>A family history of CVD and death is more common among patients with OHCA compared to a matched background population, as well as being significantly associated with OHCA.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"22 ","pages":"Article 100889"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}