Resuscitation plus最新文献

{"title":"First attempt success rate of intraosseous access in preterm infants and neonates: a systematic review","authors":"Markus Ortner ,&nbsp;Alexandra Kaider ,&nbsp;Georg Heinze ,&nbsp;Tamara Odar ,&nbsp;Ewald Unger ,&nbsp;Gunpreet Coudert Oberoi","doi":"10.1016/j.resplu.2026.101334","DOIUrl":"10.1016/j.resplu.2026.101334","url":null,"abstract":"<div><h3>Objectives</h3><div>While intraosseous (IO) access is an established and safe alternative route for vascular access in children and adults when intravenous (IV) access is not possible, its use in preterm and term neonates ≤28 days and young infants remains challenging. Success rates are lower in preterm infants and neonates due to anatomical and technical factors. We conducted a systematic literature review to examine the first-attempt success rates of tibial IO access in preterm and term neonates and young infants, comparing clinical outcomes with anatomical evidence to identify limitations, complications, and gaps in device suitability for this vulnerable population.</div></div><div><h3>Data sources</h3><div>Data were obtained through systematic searches of PubMed, Ovid MEDLINE and the Cochrane Library, covering English-language studies. The search was conducted in December 2025, using predefined search terms.</div></div><div><h3>Study selection</h3><div>Eligible studies included prospective or retrospective clinical and cadaveric studies and reported per‑leg first‑attempt outcomes involving preterm and term neonates and young infants ≤6 months and ≤8 kg, reporting success rates for drill-assisted tibial IO access. Manual-assisted access methods, simulation and animal studies were excluded.</div></div><div><h3>Data extraction</h3><div>Two reviewers independently screened and extracted data on study design, population, device type, success rates, and complications.</div></div><div><h3>Data synthesis</h3><div>A total of six studies were included, comprising 108 documented tibial intraosseous (IO) insertions. Clinical data accounted for 40 attempts, with 23 successful first attempts, while cadaveric data included 68 tibial sites, with 30 successful insertions. Using random-effects meta-analysis models applied separately to each study group, the combined first-attempt success rate in clinical studies was 54.1% [95% CI: 30.6–75.9%]. In cadaveric studies, the combined success rate was 44.1% [95% CI: 32.9–56.1%]. These success rates are substantially lower than those reported for older children and adults, in whom first-attempt IO placement typically exceeds 80–95% with drill-assisted systems. The decrease in preterm and term neonatal success reflects the anatomical, technical, and procedural challenges unique to this population.</div></div><div><h3>Conclusions</h3><div>First-attempt intraosseous access success in neonates and young infants appears lower than in older paediatric populations, likely due to anatomical limitations and the use of devices not specifically designed for this patient group. Neonatal-specific device development and further prospective research are needed to improve procedural success and safety.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"29 ","pages":"Article 101334"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147803315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear recovery trajectories after cardiac arrest: implications for enrolment and outcome selection","authors":"Lorenzo Gamberini ,&nbsp;Martina Masi ,&nbsp;Daniele Celin ,&nbsp;Riccardo Tucci ,&nbsp;Elio Fabbri","doi":"10.1016/j.resplu.2026.101354","DOIUrl":"10.1016/j.resplu.2026.101354","url":null,"abstract":"","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"29 ","pages":"Article 101354"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147945115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative review of rationale for IV deferoxamine plus intranasal insulin to ameliorate brain damage following resuscitation from cardiac arrest","authors":"Blaine C. White ,&nbsp;Jonathon M. Sullivan ,&nbsp;James H. Paxton ,&nbsp;Thomas H. Sanderson ,&nbsp;Joseph M. Wider ,&nbsp;Anthony T. Lagina ,&nbsp;Brian J. O’Neil","doi":"10.1016/j.resplu.2026.101345","DOIUrl":"10.1016/j.resplu.2026.101345","url":null,"abstract":"<div><div>Patients with out of hospital cardiac arrest suffer brain ischemia, and many die from brain injury despite cardiac resuscitation. Upon brain reperfusion molecular mechanisms of neuronal injury are amplified by iron toxicity, activated proteases, and inhibited protein synthesis. This narrative review covers the growth of our understanding of reperfusion injury together with suggestion of a therapeutic approach to limit or reverse neuronal injury during early reperfusion.</div><div>Ischemic ATP depletion causes dysregulation of mitochondrial electron transport and Ca²⁺ overloading of neuronal cytoplasm from both extracellular fluid and depletion of the endoplasmic reticulum Ca²⁺ stores. Increased cytoplasmic Ca²⁺ causes activation of the protease calpain-1 and phospholipase, which releases arachidonate from membranes. Upon reperfusion both mitochondria and metabolism of free arachidonate produce excessive superoxide, which reduces ferritin-stored Fe³⁺ to soluble Fe²⁺ (labile iron), thereby initiating ferroptosis lipid peroxidation. Depletion of endoplasmic reticulum Ca²⁺ and ATP recovery cause an endoplasmic reticulum kinase to greatly inhibit protein synthesis. Thus, immediately upon reperfusion a biochemical crisis of iron-dependent lipid peroxidation, protease activation, and inhibited protein synthesis is present in vulnerable neurons.</div><div>High-dose IV insulin given at reperfusion induces in vulnerable neurons activation of the survival kinase Akt, which can inhibit ferroptosis, reduce cytosolic Ca²⁺, downregulate proteases, drive recovery of protein synthesis, inhibit apoptosis, and improve neuron survival and neurological outcome. Brain Akt is also activated by intranasal insulin, which quickly reaches the brain with very little absorbed into the bloodstream in human studies. Research pharmacology suggests ∼200 U intranasal insulin can safely provide a human brain concentration similar to that from high-dose IV insulin. However, the toxic 4-hydroxynonenal product of iron-dependent lipid peroxidation can form inactivating adducts on Akt. Iron chelation by deferoxamine inhibits lipid peroxidation during brain reperfusion, and Phase-1 dosing and safety studies have been completed in stroke patients. Together these results form a rationale for prompt assessment of combined therapy with IV deferoxamine and intranasal insulin to improve neurological outcome after resuscitation.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"29 ","pages":"Article 101345"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147859140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basic life support and use of automated external defibrillator by dentists in Greece: a questionnaire-based cross-sectional study","authors":"Ioannis Tranoulis ,&nbsp;Anastasios Stefanakis ,&nbsp;Marilena Giannoudi ,&nbsp;Konstantinos Ioannidis","doi":"10.1016/j.resplu.2026.101341","DOIUrl":"10.1016/j.resplu.2026.101341","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac arrest is a leading cause of death; timely intervention with basic life support (BLS) is crucial for healthcare providers, including dentists. This study aimed to assess awareness, educational level, and knowledge regarding the application of BLS and the use of an automated external defibrillator (AED) among dentists in Greece.</div></div><div><h3>Methods</h3><div>A cross-sectional survey using an online questionnaire was conducted to collect demographic data, knowledge of BLS/Advanced Life Support (ALS), and experience in managing medical emergencies in dental practices. The results were statistically analysed, with the level of significance set at <em>P</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Overall, the national response rate among Greek dentists was 2.5%. A total of 354 dentists across Greece participated in the study. Attendance at CPR/AED courses was recorded for 67.5% of participants, while 29.4% reported holding active certification. A small proportion of the surveyed dentists had an AED in their dental practices (8.5%), and 47.4% did not possess a self-injectable adrenaline. Syncope was the most common medical emergency during dental procedures (50.3%). Dentists who attended BLS training sessions demonstrated more appropriate practice in managing medical emergencies (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Continuous training and ongoing professional development for dentists are essential for effectively handling medical emergencies. This study promotes a more proactive approach to enhancing competency in emergency care and the appropriate management of medical emergencies in dental practices.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"29 ","pages":"Article 101341"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147859138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary resuscitation in blind and visually impaired individuals: a pilot study of skill acquisition and public attitudes","authors":"Dóra Takács,&nbsp;Henrietta Bánfai-Csonka,&nbsp;Bálint Bánfai","doi":"10.1016/j.resplu.2026.101330","DOIUrl":"10.1016/j.resplu.2026.101330","url":null,"abstract":"","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"29 ","pages":"Article 101330"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147803316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Automated external defibrillator cabinets without scissors: a hidden barrier to effective resuscitation”","authors":"Kentaro Omatsu ,&nbsp;Gen Toyama ,&nbsp;Eiji Hori ,&nbsp;Yutaka Takei","doi":"10.1016/j.resplu.2026.101350","DOIUrl":"10.1016/j.resplu.2026.101350","url":null,"abstract":"","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"29 ","pages":"Article 101350"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147945117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of in situ coaching on cardiopulmonary resuscitation quality: a multicenter randomized simulation study","authors":"Océane Barbe ,&nbsp;Lorine Hervieu ,&nbsp;Estelle Lefrançois ,&nbsp;Cécile Sénémeaud ,&nbsp;Florian Michel ,&nbsp;Richard Macrez ,&nbsp;Guillaume Debaty ,&nbsp;Christian Creveuil ,&nbsp;Romain Clanet","doi":"10.1016/j.resplu.2026.101352","DOIUrl":"10.1016/j.resplu.2026.101352","url":null,"abstract":"<div><h3>Background</h3><div>A previous manikin-based simulation study among healthcare professionals developed a cardiopulmonary resuscitation (CPR) coaching method that significantly improved CPR quality compared with real-time audiovisual feedback provided by a defibrillator monitor. This study aimed to determine whether these findings could be replicated in a larger, multicenter trial involving first responders.</div></div><div><h3>Methods</h3><div>We conducted a multicenter, block-randomized trial among French firefighters. Participants were randomized into three groups (<em>n</em> = 36 each): CPR coaching, defibrillator monitor or control. Each participant performed three 2-min external chest compression sequences on an adult cardiac arrest simulator, which measured CPR quality, compression rate, chest recoil, and depth.</div></div><div><h3>Results</h3><div>A total of 108 participants were enrolled across two centers; one participant withdrew. In the second external chest compression sequence, the CPR coaching group achieved significantly higher CPR quality than the defibrillator monitor group (median 99% [interquartile range (IQR) 99–100] vs 99% [78–99]; <em>p</em> = 0.0022). This difference persisted in the third sequence (<em>p</em> = 0.0017). Compared with the control group, CPR quality in the CPR coaching group was significantly improved in both sequences (<em>p</em> &lt; 0.001), whereas the defibrillator monitor group did not show a significant difference versus control.</div></div><div><h3>Conclusion</h3><div>The study confirmed the findings of our previous study with healthcare professionals, demonstrating the superiority of CPR coaching over defibrillator monitor feedback for improving CPR quality in a simulation-based setting with lay rescuers.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"29 ","pages":"Article 101352"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147945178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemolysis correction factor in the reporting of serum neuron-specific enolase – Clinical utility in neuroprognostication after cardiac arrest","authors":"Christina Jungar ,&nbsp;Erik Alinder ,&nbsp;Charlotte Becker ,&nbsp;Marion Moseby-Knappe ,&nbsp;Anna Lybeck","doi":"10.1016/j.resplu.2025.101208","DOIUrl":"10.1016/j.resplu.2025.101208","url":null,"abstract":"<div><h3>Background</h3><div>Neuron-specific enolase (NSE) from 48 h after cardiac arrest is the only biomarker of brain injury with recommended cut-offs for use in neuroprognostication. Hemolysis elevates levels of NSE and may result in false outcome predictions.</div></div><div><h3>Methods</h3><div>A correction-factor for hemolysis in reporting of levels of NSE was established and evaluated in (1) incoming routine samples and (2) biobank samples from 48 h after cardiac arrest from the SweCrit biobank. Comparisons were made with three methods for handling hemolysis: Hemolysis Index (HI) 30 mg/dL or HI 50 mg/dL as the highest acceptable level of hemolysis, or a graded approach.</div></div><div><h3>Results</h3><div>Five-hundred and fifty-six routine samples and 263 biobank samples were analyzed. A correction factor of 0.33 µg/L per HI significantly increased the number of reported routine samples, when compared to the three other methods for handling hemolysis (HI 30 mg/dL or HI 50 mg/dL as the highest acceptable level of hemolysis, or a graded approach). Use of the correction factor did not affect the number of reported biobank samples. The prognostic accuracy of NSE was unaffected by use of the correction factor compared to the other tested methods for handling hemolysis: area under the curve (AUC) 0.88 (95 % Cl 0.84–0.92) vs 0.87 (95 % Cl 0.83–0.92) at HI ≤ 30 mg/dL, 0.87 (95 % Cl 0.83–0.92) at HI ≤ 50 mg/dL and 0.87 (95 % CI 0.83–0.92) with the graded approach. Levels of hemolysis were low in the biobank samples.</div></div><div><h3>Conclusion</h3><div>Due to the low levels of hemolysis in the biobank samples, the effects of a correction factor on neuroprognostication after cardiac arrest in routine samples remains uncertain. Clinical use of a correction factor may lead to more reported samples but risks over-correction.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101208"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145969131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between early arterial pH, base excess and lactate and 24-h mortality and neurological outcomes after cardiac arrest and cardiopulmonary resuscitation: a translational study","authors":"Francesca Callegari ,&nbsp;Daria De Giorgio ,&nbsp;Giulia Merigo ,&nbsp;Marianna Cerrato ,&nbsp;Ornella Tinelli ,&nbsp;Aurora Magliocca ,&nbsp;Elisa R. Zanier ,&nbsp;Giuseppe Ristagno ,&nbsp;Francesca Fumagalli","doi":"10.1016/j.resplu.2026.101228","DOIUrl":"10.1016/j.resplu.2026.101228","url":null,"abstract":"<div><h3>Aim</h3><div>We aimed to assess the translational relevance of blood gas-derived acid-base parameters measured in rat and pig models of cardiac arrest and cardiopulmonary resuscitation, evaluating their potential as predictors of mortality and poor neurological outcome.</div></div><div><h3>Methods</h3><div>Seventy-seven rats, 83 pigs and 61 patients who experienced cardiac arrest of proven or suspected cardiac origin were retrospectively analyzed<strong>.</strong> Blood gas analyses were performed 4 h after return of spontaneous circulation. Neurological recovery was assessed using Neurological Deficit Score in rats, overall performance category in pigs, and cerebral performance category in patients. Nonlinear associations between blood gas-derived acid-base parameters and outcomes were analyzed using a generalized additive model. Receiver operating characteristics curve analyses were performed.</div></div><div><h3>Results</h3><div>In a multivariate regression analysis area under the curve, considering pH, base excess and lactate, for prediction of mortality were respectively: 0.796 (95%CI: 0.635–0.956), 0.980 (95%CI: 0.946–1.000), 0.959 (95%CI: 0.896–1.000) in rats; 0.908 (95%CI: 0.826–0.990), 0.933 (95%CI: 0.863–1.000), 0.798 (95%CI: 0.588–1.000) in pigs; and 0.830 (95%CI: 0.724–0.936), 0.832 (95%CI: 0.731–0.933), 0.839 (95%CI: 0.738–0.940) in patients. Area under the curve, considering pH, base excess and lactate, for prediction of poor neurological outcome were respectively: 0.673 (95%CI: 0.515–0.831), 0.724 (95%CI: 0.576–0.872), 0.900 (95%CI: 0.760–1.000) in pigs; and 0.835 (95%CI: 0.734–0.937), 0.835 (95%CI: 0.735–0.936), 0.884 (95%CI: 0.793–0.945) in patients.</div></div><div><h3>Conclusion</h3><div>Arterial pH, base excess and lactate were early independent predictors of both 24-h mortality and neurological outcome following cardiac arrest in animal models and in humans. BE showed the highest predictive value for mortality, while lactate was the strongest predictor for poor neurological outcome.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101228"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIS (Cardiac ARrest DIgital Support): study protocol for a randomised controlled trial of a web-based support intervention for cardiac arrest survivors","authors":"Annette Waldemar ,&nbsp;Johan Israelsson ,&nbsp;Katarina Heimburg ,&nbsp;Erik Blennow Nordström ,&nbsp;Per Nordberg ,&nbsp;Anders Bremer ,&nbsp;Kristofer Årestedt ,&nbsp;Ingela Thylén","doi":"10.1016/j.resplu.2026.101235","DOIUrl":"10.1016/j.resplu.2026.101235","url":null,"abstract":"<div><h3>Background</h3><div>Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported outcome measures of a co-created, web-based support programme designed to improve wellbeing, self management, and reintegration into everyday life for cardiac arrest survivors.</div></div><div><h3>Methods</h3><div>CARDIS is a multicentre, parallel-group, randomised controlled trial enrolling cardiac arrest survivors aged &gt;18 years. Participants will be randomised 1:1 to intervention or control. Both groups will receive standard post-cardiac arrest care, including a routine followup visit with screening and management of cognitive, physical and emotional health, as well as a printed booklet. The intervention group will additionally receive access to a webbased selfguided support programme for 3 months. After study completion, control participants will be offered the programme.</div></div><div><h3>Outcomes</h3><div>Primary outcome is overall wellbeing and health (QWB) at 3 months. Secondary outcomes include self-reported cognitive problems, HRQoL, life satisfaction, symptoms of depression and anxiety, post-traumatic stress, fatigue, and sleep disturbances. A process evaluation will evaluate social selection bias, adherence and participants experiences.</div></div><div><h3>Discussion</h3><div>The CARDIS trial will investigate the use of more accessible and standardised follow-up pathways by complementing existing care structures, thereby enhancing equity in long-term recovery and quality-of-life without requiring additional healthcare resources. The process evaluation will provide data on adherence, social selection, and engagement, essential for future implementation.</div><div><strong>Trial registration:</strong> The trial is registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> (NCT07240714).</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101235"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}