Radiation oncology journal最新文献

Role of radiotherapy in the management of breast cancer with skin involvement. 放疗在皮肤受累乳腺癌治疗中的作用。

Radiation oncology journal Pub Date : 2025-06-01 Epub Date: 2025-04-21 DOI: 10.3857/roj.2024.00122

Sun Ho Min, Jee Suk Chang, Yong Bae Kim, Seo Hee Choi, Ik Jae Lee, Jaiwo Lee, Hyeok Choi, Youn Ji Hur, Hwa Kyung Byun

{"title":"Role of radiotherapy in the management of breast cancer with skin involvement.","authors":"Sun Ho Min, Jee Suk Chang, Yong Bae Kim, Seo Hee Choi, Ik Jae Lee, Jaiwo Lee, Hyeok Choi, Youn Ji Hur, Hwa Kyung Byun","doi":"10.3857/roj.2024.00122","DOIUrl":"10.3857/roj.2024.00122","url":null,"abstract":"Purpose: This study aimed to evaluate the effect of radiotherapy (RT) on symptomatic relief and tumor control in patients with breast cancer with skin involvement.Materials and methods: This retrospective study included patients who received palliative RT of the breast or chest wall for breast cancer with skin involvement. Progression-free survival, freedom from local progression (FFLP), and symptomatic response were evaluated. The prescribed dose to tumor was calculated as the biologically effective dose (BED) using α/β of 4. Symptomatic responses were evaluated until 6 months after RT.Results: Of the 43 patients included in this study, 48 Gy in 15 fractions was the most common regimen, and the median BED was 86.4 Gy (range, 24.0 to 120.0). With a median follow-up of 15.1 months (range, 1.6 to 63.5), the median FFLP and progression-free survival were 8.4 and 3.6 months, respectively. The 1-year FFLP rates in patients who received BED >75 Gy and BED ≤75 Gy were 78.3% and 49.7%, respectively (p = 0.046). Within 6 months after RT, 75% of patients showed relief of discharge, 67% showed relief of bleeding, and 37% showed relief of pain. There was no grade 3 or higher skin toxicity or other adverse events.Conclusion: Palliative RT is a safe and effective treatment option for patients with breast cancer with skin involvement, providing symptomatic relief. The administration of BED ≥75 Gy can offer a benefit in achieving durable local control.","PeriodicalId":94184,"journal":{"name":"Radiation oncology journal","volume":"43 2","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dosimetric analysis of different whole brain radiotherapy treatment planning methods: three types of 3-dimensional versus hippocampal avoidant. 不同全脑放射治疗计划方法的剂量学分析：三种类型的三维与海马回避。

Radiation oncology journal Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.3857/roj.2023.01039

Jonathan Robert Gabriel, Angela Mariah Locke, Brian William Miller, Jared Rex Robbins

{"title":"Dosimetric analysis of different whole brain radiotherapy treatment planning methods: three types of 3-dimensional versus hippocampal avoidant.","authors":"Jonathan Robert Gabriel, Angela Mariah Locke, Brian William Miller, Jared Rex Robbins","doi":"10.3857/roj.2023.01039","DOIUrl":"10.3857/roj.2023.01039","url":null,"abstract":"Purpose: Our purpose was to compare four whole brain radiotherapy (WBRT) delivery types: opposed lateral (OL) 3-dimensional-conformal radiotherapy (3D-CRT), a novel opposed lateral sparing (OLS) 3D-CRT technique, 3D optimized dynamic conformal arcs (optDCA), and hippocampal-avoidant WBRT (HA-WBRT).Materials and methods: Ten patients previously undergoing HA-WBRT were retrospectively planned using OL, OLS, and optDCA techniques. OLS technique involved multi-leaf collimator (MLC) modifications to protect the lacrimal and parotid glands. OptDCA was inverse-planned 3D-CRT with dynamic conformal arcs. A dosimetric, cost, and resource utilization comparison was performed.Results: Planning target volume coverage to prescription dose between 3D planning techniques was not significantly different between OL and OLS techniques (96.8% vs. 96.6%, p = 0.855), or between OL, OLS, and optDCA (95.0%) techniques (p = 0.079). There was no difference in the heterogeneity index between 3D plans (p = 0.482); all were less heterogeneous than HA-WBRT (p < 0.001). OptDCA was more conformal than OL and OLS, and similar in conformity to HA-WBRT. OLS achieved significant sparing of lacrimal and parotid glands over OL. There were significant step-function reductions in organ at risk (OAR) dose when comparing OL to OLS to optDCA to HA-WBRT plans. HA-WBRT was 57% more expensive than OL and OLS technique. HA-WBRT took approximately six times longer to plan.Conclusion: We showed adequate and equivalent target coverage using OL, OLS, and optDCA techniques. Lacrimal and parotid dosages can be greatly reduced with the implementation of minor MLC adjustments. OptDCA therapy represented further improvement of these modifications, and was comparable to HA-WBRT in terms of OAR dose, while being about two-thirds the cost and more efficient to plan.","PeriodicalId":94184,"journal":{"name":"Radiation oncology journal","volume":"43 2","pages":"63-72"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An isoradiotopic response of lichen planus: a case report and review of literature. 扁平地衣的等放射反应：1例报告及文献复习。

Radiation oncology journal Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.3857/roj.2024.00668

Arun Somasundaram, Gajula Sai Avanija, Malathi Munisamy, Bheemanathi Hanuman Srinivas, Gunaseelan Karunanithi

引用次数: 0

Optimal radiotherapy dose and fractionation for stereotactic radiotherapy in excised brain metastases. 切除脑转移瘤立体定向放疗的最佳放疗剂量和分割。

Radiation oncology journal Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.3857/roj.2024.00556

Kelvin Cheuk Man Cheung, Gavin Tin Chun Cheung, Ka Man Cheung, James Chung Hang Chow, Kwok Hung Au

{"title":"Optimal radiotherapy dose and fractionation for stereotactic radiotherapy in excised brain metastases.","authors":"Kelvin Cheuk Man Cheung, Gavin Tin Chun Cheung, Ka Man Cheung, James Chung Hang Chow, Kwok Hung Au","doi":"10.3857/roj.2024.00556","DOIUrl":"10.3857/roj.2024.00556","url":null,"abstract":"Purpose: Stereotactic radiotherapy (SRT) is an important adjunctive treatment after excision of brain metastases. We investigated efficacy and safety outcomes of such treatment and the impact of radiotherapy dose fractionations in a real-world multi-center cohort.Materials and methods: All patients who received resection cavity SRT between 2018-2022 were identified from institutional databases of two tertiary oncology centers. Patient and treatment characteristics were summarized using descriptive statistics. Local control rate (LCR), distant brain control rate (DBCR), and overall survival (OS) were estimated. Prognostic factors were investigated using univariate/multivariate Cox regression. The incidence of radiation necrosis (RN) was reported.Results: Sixty-five cavities were analyzed. The most used SRT prescription was 30 Gy/5 fractions. One-year LCR, DBCR, and OS were 69.0%, 51.9%, and 71.0%, respectively. BED10 (biological effective dose using α/β ratio of 10) was a significant factor for improved local control on both univariate (hazard ratio [HR], 0.862; 95% confidence interval [CI], 0.787 to 0.944; p = 0.001) and multivariate analysis (HR, 0.890; 95% CI, 0.803 to 0.986; p = 0.026). Cavities prescribed BED10 ≥45 Gy had superior local control than those prescribed BED10 <45 Gy (p = 0.002). The rate of RN was 6.2%. Single-fraction treatment had higher rates of RN (p = 0.030). There was no significant difference in LCR between single-fraction and fractionated subgroups in cavities with BED10 ≥45 Gy (p = 0.542).Conclusion: BED10 independently predicts LCR in resection cavity SRT. Fractionated treatment is associated with a lower risk of RN and did not appear to compromise outcomes as long as prescription BED10 ≥45 Gy.","PeriodicalId":94184,"journal":{"name":"Radiation oncology journal","volume":"43 2","pages":"79-87"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To irradiate or to wait: practical considerations when planning for stereotactic radiosurgery for kidney tumors using magnetic resonance-guided online adaptive radiotherapy. 放射还是等待：磁共振引导在线自适应放射治疗肾肿瘤立体定向放射手术计划的实际考虑。

Radiation oncology journal Pub Date : 2025-06-01 Epub Date: 2025-06-23 DOI: 10.3857/roj.2025.00339

Jun Won Kim

引用次数: 0

Definitive radiotherapy for unresectable extrahepatic cholangiocarcinoma: is it time for an update? 不可切除肝外胆管癌的最终放疗：是更新的时候了吗？

Radiation oncology journal Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.3857/roj.2024.00437

Pervin Hurmuz, Alper Kahvecioglu, Gokhan Ozyigit, Omer Dizdar, Mustafa Cengiz

{"title":"Definitive radiotherapy for unresectable extrahepatic cholangiocarcinoma: is it time for an update?","authors":"Pervin Hurmuz, Alper Kahvecioglu, Gokhan Ozyigit, Omer Dizdar, Mustafa Cengiz","doi":"10.3857/roj.2024.00437","DOIUrl":"10.3857/roj.2024.00437","url":null,"abstract":"Purpose: For patients with unresectable extrahepatic cholangiocarcinoma, radiotherapy (RT) is the definitive treatment. In this study, we aimed to evaluate the role of two different RT techniques for definitive treatment of unresectable extrahepatic cholangiocarcinoma.Materials and methods: Eighteen patients with unresectable extrahepatic cholangiocarcinoma treated with either conventionally fractionated radiotherapy (CFRT) or stereotactic body radiotherapy (SBRT) were evaluated retrospectively. Patients treated with CFRT also received elective nodal irradiation (ENI) in addition to the primary tumor.Results: Median doses of CFRT and SBRT were 50.4 Gy (range, 45 to 59.4) in 25-33 fractions and 37.5 Gy (range, 27.5 to 50) in 3-5 fractions, respectively. Median follow-up was 22 months (range, 7 to 138). During follow-up, local failure occured in one patient (12.5%) in the SBRT group and six patients (60.0%) in the CFRT group (p = 0.041). On the other hand, regional failure occured in five patients (62.5%) in the SBRT group and in two patients (20.0%) in the CFRT group (p = 0.047). Two-year overall survival (OS), local-regional failure-free survival (LRFFS), and distant metastasis-free survival (DMFS) rates were 35%, 30%, and 24%, respectively. Younger age (≤55 years) was associated with better OS, LRFFS, and DMFS. None of the patients experienced ≥grade 3 acute or late toxicity.Conclusion: While SBRT may provide better local tumor control compared to CFRT, the absence of ENI can result in increased regional recurrences. Hence, conducting prospective studies to examine the safety and efficacy of integrating hypofractionated ENI into SBRT is warranted.","PeriodicalId":94184,"journal":{"name":"Radiation oncology journal","volume":"43 2","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of radiotherapy for steroid-resistant thyroid eye disease: clinical outcomes in orbital inflammation and exophthalmos. 放疗治疗类固醇抵抗性甲状腺眼病的疗效：眼眶炎症和突出眼的临床结果。

Radiation oncology journal Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.3857/roj.2025.00115

Junhee Park, Jeong Eun Lee

{"title":"The efficacy of radiotherapy for steroid-resistant thyroid eye disease: clinical outcomes in orbital inflammation and exophthalmos.","authors":"Junhee Park, Jeong Eun Lee","doi":"10.3857/roj.2025.00115","DOIUrl":"10.3857/roj.2025.00115","url":null,"abstract":"Purpose: This study aims to evaluate the efficacy of radiotherapy (RT) in patients with steroid-resistant thyroid eye disease (TED) by assessing clinical outcomes in orbital inflammation and exophthalmos.Materials and methods: Sixty-two patients with confirmed TED and resistance to intravenous steroid therapy were treated with RT. Most patients received intravenous methylprednisolone (500 mg weekly for 6 weeks, followed by 250 mg weekly for 6 weeks). After steroid treatment, patients underwent RT with a total dose of 20 Gy delivered in 10 fractions. Clinical parameters were assessed at five time points: initial presentation, post-intravenous steroid therapy, and 1, 6, and 12 months after RT. Inflammation was evaluated using clinical activity score (CAS). Exophthalmos was quantified through posterior scleral distance (PSD) measurements on computed tomography imaging. Statistical analysis involved repeated measures analysis of variance and Cohen's d effect size calculations.Results: CAS showed significant reduction from baseline (mean, 3.309) to 12 months post-RT (mean, 0.187), with the largest effect size observed between baseline and 12 months (Cohen's d = 10.88). PSD showed worsening after intravenous steroid therapy but gradually improved after RT, approaching baseline values at 12 months. Disease reactivation occurred in only two patients, and three required strabismus correction surgery. Minimal adverse events were reported during follow-up.Conclusion: RT demonstrated significant efficacy in treating steroid-resistant TED, with sustained improvements in both orbital inflammation and exophthalmos. These findings suggest RT as a viable alternative for patients unresponsive to steroid therapy, offering meaningful long-term clinical benefits with minimal adverse effects.","PeriodicalId":94184,"journal":{"name":"Radiation oncology journal","volume":"43 2","pages":"88-98"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance linear accelerator boost for para-urethral cancer: a new treatment paradigm replacement for brachytherapy. 磁共振直线加速器增强治疗尿道旁癌：替代近距离治疗的新治疗模式。

Radiation oncology journal Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.3857/roj.2024.00584

Amir Owrangi, David Chiu, Star Okolie, Kevin Albuquerque

{"title":"Magnetic resonance linear accelerator boost for para-urethral cancer: a new treatment paradigm replacement for brachytherapy.","authors":"Amir Owrangi, David Chiu, Star Okolie, Kevin Albuquerque","doi":"10.3857/roj.2024.00584","DOIUrl":"10.3857/roj.2024.00584","url":null,"abstract":"This study evaluates the use of magnetic resonance-guided radiation therapy (MRgRT) as an alternative to brachytherapy in treating para-urethral gynecological cancers, particularly for patients who are not candidates for brachytherapy. Five female patients with advanced para-urethral gynecological cancers underwent MRgRT using a custom 3-dimensional-printed intravaginal cylinder for image registration and treatment alignment. MRgRT was administered as a five-fraction adaptive boost following standard chemoradiation, with each fraction utilizing the cylinder to achieve precise positioning and improve organ sparing. A 1.5T magnetic resonance linear accelerator was used to deliver adapt-to-shape treatment, allowing real-time adjustments to compensate for anatomical variations. The cylinder served not only as a surrogate for accurate image registration but also as a spacer to displace the rectum from high-dose regions. The median follow-up period was 14.4 months, during which all patients completed treatment with no grade >3 genitourinary toxicities. Acute toxicities included dysuria and vaginal pain, while chronic toxicities, such as urinary incontinence and mild cystitis, were recorded in a subset of patients. Treatment achieved an overall survival rate of 100% and a recurrence-free survival rate of 80%. Dosimetric analysis demonstrated effective target coverage with minimal exposure to surrounding organs, particularly sparing the urethra from hotspots, unlike traditional brachytherapy. These results suggest that MRgRT with a vaginal cylinder offers a promising approach for managing para-urethral gynecological cancers in patients ineligible for brachytherapy. Further studies are warranted to validate these findings and refine treatment protocols.","PeriodicalId":94184,"journal":{"name":"Radiation oncology journal","volume":"43 2","pages":"104-108"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing clinical target volume margins for multifocal glioblastoma: a multi-institutional analysis of patterns of recurrence and treatment response. 减少多灶性胶质母细胞瘤的临床靶体积边缘：复发模式和治疗反应的多机构分析。

Radiation oncology journal Pub Date : 2025-03-01 Epub Date: 2024-12-19 DOI: 10.3857/roj.2024.00059

Francesco Marampon, Giovanni Luca Gravina, Elisa Cinelli, Lucy Zaccaro, Miriam Tomaciello, Nunzia Di Meglio, Francesco Gentili, Alfonso Cerase, Armando Perrella, Mariya Yavorska, Sami Aburas, Luciano Mutti, Maria Antonietta Mazzei, Giuseppe Minniti, Paolo Tini

{"title":"Reducing clinical target volume margins for multifocal glioblastoma: a multi-institutional analysis of patterns of recurrence and treatment response.","authors":"Francesco Marampon, Giovanni Luca Gravina, Elisa Cinelli, Lucy Zaccaro, Miriam Tomaciello, Nunzia Di Meglio, Francesco Gentili, Alfonso Cerase, Armando Perrella, Mariya Yavorska, Sami Aburas, Luciano Mutti, Maria Antonietta Mazzei, Giuseppe Minniti, Paolo Tini","doi":"10.3857/roj.2024.00059","DOIUrl":"10.3857/roj.2024.00059","url":null,"abstract":"Purpose: No guidelines exist to delineate radiation therapy (RT) targets for the treatment of multiple glioblastoma (mGBM). This study analyzes margins around the gross tumor volume (GTV) to create a clinical target volume (CTV), comparing response parameters and modalities of recurrence. Material and Methods: One-hundred and three mGBM patients with a CTV margin of 2 cm (GTV + 2.0 cm) or 1 cm (GTV + 1.0 cm) were retrospectively analyzed. All patients received a total dose of 59.4-60 Gy in 1.8-2.0 Gy daily fractions, delivered from 4 to 8 weeks after surgery, concomitantly with temozolomide (75 mg/m2). Overall survival (OS) and progression-free survival (PFS) were calculated from the date of surgery until diagnosis of disease progression performed by magnetic resonance imaging and classified as marginal, in-field, or distant, comparing site of progression with dose distribution in RT plan.Results: OS in mGBM CTV1 group was 11.2 months (95% confidence interval [CI], 10.3-12.1), and 9.2 months in mGBM CTV2 group (95% CI, 9.0-11.3). PFS in mGBM CTV1 group occurred within 8.3 months (95% CI, 7.3-9.3), and 7.3 months in mGBM CTV2 group (95% CI, 6.4-8.1). No difference was observed between the two groups in terms of OS and PFS time distribution. Adjusted to a multivariate Cox risk model, epidermal growth factor receptor amplification resulted a negative prognostic factor for both OS and PFS.Conclusion: In mGBM, the use of a 1 cm CTV expansion seems feasible as it does not significantly affect oncological outcomes and progression outcome.","PeriodicalId":94184,"journal":{"name":"Radiation oncology journal","volume":" ","pages":"13-21"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility and safety study of ultra-hypofractionated neoadjuvant radiotherapy to margins-at-risk in retroperitoneal sarcoma. 超低分割新辅助放疗治疗腹膜后边缘高危肉瘤的可行性及安全性研究。

Radiation oncology journal Pub Date : 2025-03-01 Epub Date: 2025-01-15 DOI: 10.3857/roj.2024.00297

Ru-Xin Wong, Valerie Shi Wen Yang, Clarame Shulyn Chia, Wen Shen Looi, Wen Long Nei, Chin-Ann Johnny Ong

{"title":"Feasibility and safety study of ultra-hypofractionated neoadjuvant radiotherapy to margins-at-risk in retroperitoneal sarcoma.","authors":"Ru-Xin Wong, Valerie Shi Wen Yang, Clarame Shulyn Chia, Wen Shen Looi, Wen Long Nei, Chin-Ann Johnny Ong","doi":"10.3857/roj.2024.00297","DOIUrl":"10.3857/roj.2024.00297","url":null,"abstract":"Purpose: Retroperitoneal sarcomas (RPS) are rare tumors that present unique challenges, often due to late presentation, and the proximity of critical organs makes complete surgical resection challenging. This study aimed to assess the feasibility of neoadjuvant short-course radiotherapy (SCRT) targeting margins-at-risk and to assess its potential impact on outcomes.Materials and methods: This is a single-center, prospective, non-randomized feasibility study. SCRT was administered via image-guided volumetric modulated arc therapy, consisting of 5 fractions of daily radiotherapy followed by immediate surgery. As a starting dose, patients were prescribed 25 Gy in 5 fractions. For the escalation stage, patients were prescribed 30 Gy in 5 fractions. Only the presumed threatened surgical margins were delineated for large tumors.Results: Patients with either primary or recurrent RPS were recruited. Eight patients underwent SCRT but one patient did not have a resection as planned. Seven patients underwent surgical resection, of whom one passed away 3 months postoperative from a cardiac event. After a median follow-up of 20.5 months for the six postoperative survivors, there were no overt long-term toxicities and one patient relapsed out-of-radiotherapy-field.Conclusion: SCRT to RPS with a margin boost followed by immediate surgery is worth investigating. A starting dose of 30 Gy in 5 fractions is recommended for further studies. Longer-term follow-up is necessary.","PeriodicalId":94184,"journal":{"name":"Radiation oncology journal","volume":" ","pages":"6-12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0