Prostaglandins, leukotrienes, and essential fatty acids最新文献

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Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles 肿瘤微环境衍生的单酰基甘油脂肪酶引发肿瘤特异性免疫反应和脂质谱。
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-09-01 DOI: 10.1016/j.plefa.2023.102585
Eva Gruden , Melanie Kienzl , Carina Hasenoehrl , Arailym Sarsembayeva , Dusica Ristic , Sophie Theresa Schmid , Kathrin Maitz , Ulrike Taschler , Lisa Hahnefeld , Robert Gurke , Dominique Thomas , Julia Kargl , Rudolf Schicho
{"title":"Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles","authors":"Eva Gruden ,&nbsp;Melanie Kienzl ,&nbsp;Carina Hasenoehrl ,&nbsp;Arailym Sarsembayeva ,&nbsp;Dusica Ristic ,&nbsp;Sophie Theresa Schmid ,&nbsp;Kathrin Maitz ,&nbsp;Ulrike Taschler ,&nbsp;Lisa Hahnefeld ,&nbsp;Robert Gurke ,&nbsp;Dominique Thomas ,&nbsp;Julia Kargl ,&nbsp;Rudolf Schicho","doi":"10.1016/j.plefa.2023.102585","DOIUrl":"10.1016/j.plefa.2023.102585","url":null,"abstract":"<div><p>We recently described that monoacylglycerol lipase (MGL) is present in the tumor microenvironment (TME), increasing tumor growth. In this study we compare the implications of MGL deficiency in the TME in different tumor types.</p><p>We show that subcutaneous injection of KP (Kras<sup>LSL-G12D</sup>/p53<sup>fl/fl</sup>, mouse lung adenocarcinoma) or B16-F10 cells (mouse melanoma) induced tumor growth in MGL wild type (WT) and knockout (KO) mice. MGL deficiency in the TME attenuated the growth of KP cell tumors whereas tumors from B16-F10 cells increased in size. Opposite immune cell profiles were detected between the two tumor types in MGL KO mice. In line with their anti-tumorigenic function, the number of CD8<sup>+</sup> effector T cells and eosinophils increased in KP cell tumors of MGL KO vs. WT mice whereas their presence was reduced in B16-F10 cell tumors of MGL KO mice. Differences were seen in lipid profiles between the investigated tumor types. 2-arachidonoylglycerol (2-AG) content significantly increased in KP, but not B16-F10 cell tumors of MGL KO vs. WT mice while other endocannabinoid-related lipids remained unchanged. However, profiles of phospho- and lysophospholipids, sphingomyelins and fatty acids in KP cell tumors were clearly distinct to those measured in B16-F10 cell tumors.</p><p>Our data indicate that TME-localized MGL impacts tumor growth, as well as levels of 2-AG and other lipids in a tumor specific manner.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"196 ","pages":"Article 102585"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10168941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of a pescetarian and vegan diet on fatty acid composition in blood and spermatozoa in young healthy men 素食主义者和素食主义者饮食对年轻健康男性血液和精子中脂肪酸组成的影响。
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-09-01 DOI: 10.1016/j.plefa.2023.102582
Rodrigo Chamorro , Rut Farías , Paulina Allende , Mariana Acuña , Paula Cáceres , Fernanda Gómez , Abigail Ortiz , Daniela Tapia , Camila Farías , Rodrigo Valenzuela
{"title":"Effect of a pescetarian and vegan diet on fatty acid composition in blood and spermatozoa in young healthy men","authors":"Rodrigo Chamorro ,&nbsp;Rut Farías ,&nbsp;Paulina Allende ,&nbsp;Mariana Acuña ,&nbsp;Paula Cáceres ,&nbsp;Fernanda Gómez ,&nbsp;Abigail Ortiz ,&nbsp;Daniela Tapia ,&nbsp;Camila Farías ,&nbsp;Rodrigo Valenzuela","doi":"10.1016/j.plefa.2023.102582","DOIUrl":"10.1016/j.plefa.2023.102582","url":null,"abstract":"<div><h3>Introduction</h3><p>There is a growing interest in vegetarian and vegan diets, but both can potentially affect tissue fatty acids (FA) composition. We aimed to evaluate the effect of vegetarian diets on plasma, erythrocytes, and sperm n-3 polyunsaturated fatty acids (n-3 PUFA) status in healthy young men.</p></div><div><h3>Methods</h3><p>Four groups were studied: <em>i)</em> men consuming a regular omnivore diet (OMV-1, <em>n</em> = 35); <em>ii)</em> men consuming an omnivore diet but excluding fish and seafood (OMV-2, <em>n</em> = 34); <em>iii)</em> men consuming a pescetarian diet (including dairy, eggs, fish, and seafood) (PESC, <em>n</em> = 36); and <em>iv)</em> men following a strict vegan diet (VEG, <em>n</em> = 35). Participants in each group should follow their diet for at least the previous 12 months. Diet evaluation used a structured validated food frequency questionnaire. FA composition was measured in plasma, erythrocyte phospho-lipids, and spermatozoa by gas-liquid chromatography, expressed as a mole percentage of the total FA content.</p></div><div><h3>Results</h3><p>Main findings showed higher alpha-linolenic fatty acid (ALA) and total n-3 PUFA dietary intake in the VEG group. In plasma, arachidonic and eicosapentaenoic acids were higher in OMV and PESC groups, whereas docosahexaenoic acid (DHA) level was lower in VEG. Higher ALA, but reduced DHA and total n-3 PUFA levels were found in erythrocytes and spermatozoa in the VEG group.</p></div><div><h3>Conclusion</h3><p>Higher dietary ALA intake was found in pescetarians and vegan men. However, the higher ALA intake was not reflected in higher DHA content in the evaluated tissues. PUFA assessment, with particular emphasis in DHA, are necessary to improve PUFA status in vegan men.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"196 ","pages":"Article 102582"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythrocyte fatty acids and desaturase indices in early pregnancy are associated with risk of preeclampsia 妊娠早期的红细胞脂肪酸和去饱和酶指数与先兆子痫的风险相关。
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-09-01 DOI: 10.1016/j.plefa.2023.102583
A.A. Godhamgaonkar , N.S. Wadhwani , K.N. Randhir , S.S. Selukar , S. Dalvi , K. Dangat , G.N. Wagh , S. Lalwani , N. Chandhiok , B. Kulkarni , C. Fall , H.P.S. Sachdev , S. Gupte , S.R. Joshi
{"title":"Erythrocyte fatty acids and desaturase indices in early pregnancy are associated with risk of preeclampsia","authors":"A.A. Godhamgaonkar ,&nbsp;N.S. Wadhwani ,&nbsp;K.N. Randhir ,&nbsp;S.S. Selukar ,&nbsp;S. Dalvi ,&nbsp;K. Dangat ,&nbsp;G.N. Wagh ,&nbsp;S. Lalwani ,&nbsp;N. Chandhiok ,&nbsp;B. Kulkarni ,&nbsp;C. Fall ,&nbsp;H.P.S. Sachdev ,&nbsp;S. Gupte ,&nbsp;S.R. Joshi","doi":"10.1016/j.plefa.2023.102583","DOIUrl":"10.1016/j.plefa.2023.102583","url":null,"abstract":"<div><p>Preeclampsia (PE) is a pregnancy disorder that may be associated with inadequate maternal nutrition. Fatty acids are vital for placental and fetal growth. Fatty acid desaturases, key enzymes influencing the metabolism of polyunsaturated fatty acids, are reported to be associated with cardiometabolic risk. Any imbalance in the levels of omega-3 and omega-6 fatty acids can result in increased inflammatory response. The current study reports the levels of erythrocyte fatty acids and desaturase index across gestation in women who develop PE (<em>n</em> = 108) and compares them with non-PE women (<em>n</em> = 216). Maternal erythrocyte fatty acids were measured at 4 time points during pregnancy (i.e., 11–14, 18–22, 26–28 weeks and at delivery) using gas chromatography. Maternal total erythrocyte saturated fatty acids and omega-6/omega-3 fatty acid ratio was higher in the PE group as compared to the non-PE group at 11–14 weeks and 18–22 weeks respectively. Maternal Δ5 desaturase index was lower while Δ6 desaturase index was higher in the PE group at 11–14 and 18–22 weeks. Maternal stearoyl CoA desaturase-18 (SCD-18) index was lower at 11–14 weeks and at delivery. These changes were mainly observed in the early onset PE (EOP) group. Δ6 desaturase index at 11–14 weeks predicted the risk of EOP. Imbalance in fatty acid levels and desaturase indices predate the clinical diagnosis of PE, indicating their role in its pathophysiology. Measurement of fatty acids and desaturase indices in early pregnancy merits evaluation as predictors of risk of PE.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"196 ","pages":"Article 102583"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10531221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma signatures of Congenital Generalized Lipodystrophy patients identified by untargeted lipidomic profiling are not changed after a fat-containing breakfast meal 通过非靶向脂质组学分析确定的先天性全身性脂营养不良患者的血浆特征在含脂肪早餐餐后没有改变。
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-09-01 DOI: 10.1016/j.plefa.2023.102584
Camilla O.D. Araújo , Amanda P. Pedroso , Valter T. Boldarine , Anna Maria A.P. Fernandes , José J.M. Perez , Renan M. Montenegro Jr. , Ana Paula D.R. Montenegro , Annelise B. de Carvalho , Virgínia O. Fernandes , Lila M. Oyama , Patrícia O. Carvalho , Carla S.C. Maia , Allain A. Bueno , Eliane B. Ribeiro , Mônica M. Telles
{"title":"Plasma signatures of Congenital Generalized Lipodystrophy patients identified by untargeted lipidomic profiling are not changed after a fat-containing breakfast meal","authors":"Camilla O.D. Araújo ,&nbsp;Amanda P. Pedroso ,&nbsp;Valter T. Boldarine ,&nbsp;Anna Maria A.P. Fernandes ,&nbsp;José J.M. Perez ,&nbsp;Renan M. Montenegro Jr. ,&nbsp;Ana Paula D.R. Montenegro ,&nbsp;Annelise B. de Carvalho ,&nbsp;Virgínia O. Fernandes ,&nbsp;Lila M. Oyama ,&nbsp;Patrícia O. Carvalho ,&nbsp;Carla S.C. Maia ,&nbsp;Allain A. Bueno ,&nbsp;Eliane B. Ribeiro ,&nbsp;Mônica M. Telles","doi":"10.1016/j.plefa.2023.102584","DOIUrl":"10.1016/j.plefa.2023.102584","url":null,"abstract":"<div><h3>Background</h3><p>The incapacity to store lipids in adipose tissue in Congenital Generalized Lipodystrophy (CGL) causes hypoleptinemia, increased appetite, ectopic fat deposition and lipotoxicity. CGL patients experience shortened life expectancy. The plasma lipidomic profile has not been characterized fully in CGL, nor has the extent of dietary intake in its modulation. The present work investigated the plasma lipidomic profile of CGL patients in comparison to eutrophic individuals at the fasted state and after a breakfast meal.</p></div><div><h3>Method</h3><p>Blood samples from 11 CGL patients and 10 eutrophic controls were collected after 12 h fasting (T0) and 90 min after an <em>ad libitum</em> fat-containing breakfast (T90). The lipidomic profile of extracted plasma lipids was characterized by non-target liquid chromatography mass spectrometry.</p></div><div><h3>Results</h3><p>Important differences between groups were observed at T0 and at T90. Several molecular species of fatty acyls, glycerolipids, sphingolipids and glycerophospholipids were altered in CGL. All the detected fatty acyl molecular species, several diacylglycerols and one triacylglycerol species were upregulated in CGL. Among sphingolipids, one sphingomyelin and one glycosphingolipid species showed downregulation in CGL. Alterations in the glycerophospholipids glycerophosphoethanolamines, glycerophosphoserines and cardiolipins were more complex. Interestingly, when comparing T90 versus T0, the lipidomic profile in CGL did not change as intensely as it did for control participants.</p></div><div><h3>Conclusions</h3><p>The present study found profound alterations in the plasma lipidomic profile of complex lipids in CGL patients as compared to control subjects. A fat-containing breakfast meal did not appear to significantly influence the CGL profile observed in the fasted state. Our study may have implications for clinical practice, also aiding to a deeper comprehension of the role of complex lipids in CGL in view of novel therapeutic strategies.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"196 ","pages":"Article 102584"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10177653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females: Implication of menopause and ageing 脂肪组织脂肪酸作为肥胖女性代谢功能障碍的生物标志物:绝经和衰老的含义
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-08-01 DOI: 10.1016/j.plefa.2023.102581
Sara Sousa , Diogo Pestana , Gil Faria , Cristina Delerue-Matos , Conceição Calhau , Valentina Fernandes Domingues
{"title":"Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females: Implication of menopause and ageing","authors":"Sara Sousa ,&nbsp;Diogo Pestana ,&nbsp;Gil Faria ,&nbsp;Cristina Delerue-Matos ,&nbsp;Conceição Calhau ,&nbsp;Valentina Fernandes Domingues","doi":"10.1016/j.plefa.2023.102581","DOIUrl":"10.1016/j.plefa.2023.102581","url":null,"abstract":"<div><p>Fatty acids (FA) are biomarkers of metabolic dysfunction. Adipose tissue is the largest reservoir of FA and acts differently in obese individuals. Menopause by itself significantly alters metabolism, lipid metabolism dysregulation, and adipose tissue distribution. How adipose tissue FA alters an obese individual's metabolism depending on a female's menopausal status is yet poorly understood.</p><p>Hence, the subcutaneous (scAT) and visceral adipose tissue (vAT) FA profile for 173 obese premenopausal and postmenopausal women was measured and associated with biochemical parameters. scAT and vAT FA profiles were distinct by themselves and in menopause. In total 816 associations were found with biochemical parameters, where only 58 were independent of the menopausal status.</p><p>The associations found to emphasize the importance of assessing the adipose tissue FA profile and how their behavior changes with menopause. The FA are crucial in metabolic processes and can be helpful biomarkers in the prevention/treatment and follow-up of female obesity.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"195 ","pages":"Article 102581"},"PeriodicalIF":3.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-esterified erythrocyte linoleic acid, arachidonic acid, and subjective sleep outcomes 非酯化红细胞亚油酸、花生四烯酸和主观睡眠结果。
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-08-01 DOI: 10.1016/j.plefa.2023.102580
Anne E. Sanders , E. Diane Wallace , Brandie M. Ehrmann , Paul S. Soma , Saame R. Shaikh , John S. Preisser , Richard Ohrbach , Roger B. Fillingim , Gary D. Slade
{"title":"Non-esterified erythrocyte linoleic acid, arachidonic acid, and subjective sleep outcomes","authors":"Anne E. Sanders ,&nbsp;E. Diane Wallace ,&nbsp;Brandie M. Ehrmann ,&nbsp;Paul S. Soma ,&nbsp;Saame R. Shaikh ,&nbsp;John S. Preisser ,&nbsp;Richard Ohrbach ,&nbsp;Roger B. Fillingim ,&nbsp;Gary D. Slade","doi":"10.1016/j.plefa.2023.102580","DOIUrl":"10.1016/j.plefa.2023.102580","url":null,"abstract":"<div><h3>Objective</h3><p>This study investigated whether non-esterified erythrocyte omega-6 PUFAs were associated with subjective assessment of sleep quality and duration, and risk for obstructive sleep apnea.</p></div><div><h3>Methods</h3><p>In this secondary analysis of the cross-sectional OPPERA-II study, 538 adults completed the Pittsburgh Sleep Quality Index (PSQI), reported their usual hours of sleep, and answered STOP screening questions for obstructive sleep apnea. Circulating non-esterified erythrocyte concentrations of omega-6 PUFA linoleic acid and arachidonic acid were quantified by liquid chromatography tandem mass spectroscopy. Sleep outcomes were dichotomized as poor (PSQI ≤5) vs good (PSQI ≥6) sleep quality, insufficient or excessive (≤6 or &gt;9 h) vs good (7-9 h) sleep duration, and high (≥2 affirmative responses) vs low (&lt;2 affirmative responses) risk for obstructive sleep apnea. Non-esterified omega-6 PUFAs and the continuous covariates of body mass index, Short Form (SF) 12 Health Survey Physical and Mental Component scores and resting measures of systolic and diastolic blood pressure were standardized for multivariable analysis. Categorical covariates were study site, age, sex, and race/ethnicity. Multivariable-adjusted logistic regression first estimated odds ratios (OR) and 95% confidence limits (CL) for sleep outcomes using linoleic acid as the main exposure. Analysis was then repeated using arachidonic acid as the main exposure.</p></div><div><h3>Results</h3><p>In the multivariable-adjusted model, each standard deviation increase in non-esterified erythrocyte linoleic acid was associated with higher odds of poor sleep quality (OR=1.2, 95% CL: 1.1, 1.5), insufficient or excessive sleep (OR= 1.3, 95% CL: 1.1, 1.6) and high-risk for obstructive sleep apnea (OR=1.3, 95% CL: 1.1, 1.6). Likewise, for each standard deviation increase in non-esterified erythrocyte arachidonic acid, odds increased of poor sleep quality (OR=1.2, 95% CL: 1.1, 1.5), and insufficient or excessive sleep (OR=1.2, 95% CL: 1.1, 1.5). Odds of being high risk for obstructive sleep apnea increased with greater circulating arachidonic acid, but the association did not reach statistical significance (OR=1.1, 95% CL: 0.9, 1.4).</p></div><div><h3>Conclusion</h3><p>Non-esterified erythrocyte linoleic acid and arachidonic acid were associated with poor sleep quality and insufficient or excessive sleep duration. Linoleic acid, but not arachidonic acid, was also associated with high risk for obstructive sleep apnea.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"195 ","pages":"Article 102580"},"PeriodicalIF":3.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9968595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Genome-wide association study of Red Blood Cell fatty acids in the Women's Health Initiative Memory Study 妇女健康倡议记忆研究中红细胞脂肪酸的全基因组关联研究
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-07-01 DOI: 10.1016/j.plefa.2023.102577
Jason Westra , Carmen Annevelink , Tonya Orchard , Lifang Hou , William S. Harris , Timothy D. O'Connell , Gregory Shearer , Nathan Tintle
{"title":"Genome-wide association study of Red Blood Cell fatty acids in the Women's Health Initiative Memory Study","authors":"Jason Westra ,&nbsp;Carmen Annevelink ,&nbsp;Tonya Orchard ,&nbsp;Lifang Hou ,&nbsp;William S. Harris ,&nbsp;Timothy D. O'Connell ,&nbsp;Gregory Shearer ,&nbsp;Nathan Tintle","doi":"10.1016/j.plefa.2023.102577","DOIUrl":"10.1016/j.plefa.2023.102577","url":null,"abstract":"<div><p><span>Despite their widespread associations with a wide variety of disease phenotypes, the genetics of red blood cell fatty acids remains understudied. We present one of the first genome-wide association studies of red blood cell fatty acid levels, using the Women's Health Initiative Memory study – a prospective cohort of </span><em>N</em> = 7,479 women aged 65–79. Approximately 9 million SNPs were measured directly or imputed and, in separate linear models adjusted for age and genetic principal components of ethnicity, SNPs were used to predict 28 different fatty acids. SNPs were considered genome-wide significant using a standard genome-wide significance level of <em>p</em> &lt; 1 × 10–8. Twelve separate loci were identified, seven of which replicated results of a prior RBC-FA GWAS. Of the five novel loci, two have functional annotations directly related to fatty acids (ELOVL6 and ACSL6). While overall explained variation is low, the twelve loci identified provide strong evidence of direct relationships between these genes and fatty acid levels. Further studies are needed to establish and confirm the biological mechanisms by which these genes may directly contribute to fatty acid levels.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"194 ","pages":"Article 102577"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9744869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients PLA2基因多态性与抗精神病药物治疗反应之间的关系:antipsychotic-naïve首发精神病患者和非依从性慢性精神病患者的研究
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-07-01 DOI: 10.1016/j.plefa.2023.102578
Sergej Nadalin , Lena Zatković , Vjekoslav Peitl , Dalibor Karlović , Branka Vidrih , Antonia Puljić , Sanja Dević Pavlić , Alena Buretić-Tomljanović
{"title":"Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients","authors":"Sergej Nadalin ,&nbsp;Lena Zatković ,&nbsp;Vjekoslav Peitl ,&nbsp;Dalibor Karlović ,&nbsp;Branka Vidrih ,&nbsp;Antonia Puljić ,&nbsp;Sanja Dević Pavlić ,&nbsp;Alena Buretić-Tomljanović","doi":"10.1016/j.plefa.2023.102578","DOIUrl":"10.1016/j.plefa.2023.102578","url":null,"abstract":"<div><p>Here we investigated whether antipsychotic treatment was influenced by three polymorphisms: rs10798059 (BanI) in the phospholipase A2 (PLA2)G4A gene, rs4375 in PLA2G6, and rs1549637 in PLA2G4C. A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis/restriction fragment length polymorphism. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). We found that PLA2G4A polymorphism influenced changes in PANSS psychopathology, and PLA2G6 polymorphism influenced changes in PANSS psychopathology and metabolic parameters. PLA2G4C polymorphism did not show any impact on PANSS psychopathology or metabolic parameters. The polymorphisms’ effect sizes were estimated as moderate to strong, with contributions ranging from around 6.2–15.7%. Furthermore, the polymorphisms’ effects manifested in a gender-specific manner.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"194 ","pages":"Article 102578"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9676149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An open-label, multicenter, phase 2 study of a food enriched with docosahexaenoic acid in adults with sickle cell disease 一项开放标签、多中心、2期研究,研究一种富含二十二碳六烯酸的食物在成人镰状细胞病中的作用
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-06-01 DOI: 10.1016/j.plefa.2023.102574
K.V. Giriraja , S.K. Bhatnagar , L. Tomlinson , F. Sancilio
{"title":"An open-label, multicenter, phase 2 study of a food enriched with docosahexaenoic acid in adults with sickle cell disease","authors":"K.V. Giriraja ,&nbsp;S.K. Bhatnagar ,&nbsp;L. Tomlinson ,&nbsp;F. Sancilio","doi":"10.1016/j.plefa.2023.102574","DOIUrl":"10.1016/j.plefa.2023.102574","url":null,"abstract":"<div><p>Sickle cell disease (SCD) induces red blood cell sickling, which causes debilitating symptoms including vaso-occlusion and inflammation. We investigated a food enriched with omega-3 fatty acids to determine its effect on certain factors: blood cell membrane fatty acid composition (including anti-inflammatory elements—docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)—and the pro-inflammatory, arachidonic acid (AA)); the inflammation biomarker, C-reactive protein (CRP); and vaso-occlusive crisis (VOC) pain. Ten adults with SCD ingested the food, daily, for 28 days. Evaluated measures included blood cell membrane fatty acid ratios (AA vs omega-3 (DHA+EPA)), CRP (mg/L) levels, and Visual Analogue Scale (VAS) scores (a VOC assessment). The food was well tolerated and led to a statistically significant CRP reduction (39%). However, changes in omega-3 fatty acid ratios and VAS scores were not significant. Overall, while the omega-3-enriched food reduced inflammation, larger, blinded studies are needed to assess its effectiveness on other measures.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"193 ","pages":"Article 102574"},"PeriodicalIF":3.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9627244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials 长链omega-3多不饱和脂肪酸对减轻成人焦虑和/或抑郁的作用随机对照试验的系统回顾和荟萃分析
IF 3
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-05-01 DOI: 10.1016/j.plefa.2023.102572
Christos F. Kelaiditis , E.Leigh Gibson , Simon C. Dyall
{"title":"Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials","authors":"Christos F. Kelaiditis ,&nbsp;E.Leigh Gibson ,&nbsp;Simon C. Dyall","doi":"10.1016/j.plefa.2023.102572","DOIUrl":"10.1016/j.plefa.2023.102572","url":null,"abstract":"<div><p>The omega-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic- (EPA), docosahexaenoic- (DHA) and docosapentaenoic acid (DPAn-3) are promising therapeutic options in reducing the severity of anxious and depressive symptoms. However, meta-analyses of randomised controlled trials (RCTs) yield mixed findings. This systematic review and meta-analysis reviewed the evidence and assessed the efficacy of EPA, DHA and DPAn-3 in reducing the severity of anxiety and depression with specific consideration to methodological complications unique to the field e.g., dose and ratio of omega-3 PUFAs and placebo composition. Random-effects meta-analysis of ten RCTs comprising 1426 participants revealed statistically significant reduction in depression severity with EPA-enriched interventions at proportions ≥ 60% of total EPA + DHA (SMD: -0.36; 95% CI: -0.68, -0.05; <em>p</em> = 0.02) (I<sup>2</sup> = 86%) and EPA doses between ≥ 1 g/day and &lt; 2 g/day (SMD: -0.43; 95% CI: -0.79, -0.07; <em>p</em> = 0.02) (I<sup>2</sup> = 88%); however, EPA doses ≥ 2 g/day were not associated with significant therapeutic effects (SMD: -0.20; 95% CI: -0.48, 0.07; <em>p</em> = 0.14). Only one study reported significant reduction in anxiety severity with 2.1 g/day EPA (85.6% of total EPA + DHA), therefore meta-analysis was not possible. No trials administering DPAn-3 were identified. Visual examination of the funnel plot revealed asymmetry, suggesting publication bias and heterogeneity amongst the trials. These results support the therapeutic potential of EPA in depression at proportions ≥ 60% of total EPA + DHA and doses ≥ 1 g/day and &lt; 2 g/day. The observed publication bias and heterogeneity amongst the trials reflect the need for more high-quality trials in this area with consideration to the unique nature of omega-3 PUFAs research, to more fully elucidate the therapeutic potential of EPA, DHA and DPAn-3.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"192 ","pages":"Article 102572"},"PeriodicalIF":3.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9629903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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