Prostaglandins, leukotrienes, and essential fatty acids最新文献

{"title":"Sex-dependent differences in tissue and blood n-3 PUFA levels following ALA or ALA + DHA feeding of liver-specific Elovl2-KO and control mice","authors":"Kuorosh Rezaei,&nbsp;Ashley M. Bejoy,&nbsp;Ruxandra D. Rotarescu,&nbsp;Brinley J. Klievik,&nbsp;Adam H. Metherel","doi":"10.1016/j.plefa.2024.102621","DOIUrl":"10.1016/j.plefa.2024.102621","url":null,"abstract":"<div><p>Docosahexaenoic acid (DHA, 22:6n-3) must be consumed from the diet or synthesized from polyunsaturated fatty acid (PUFA) precursors, such as α-linolenic acid (ALA, 18:3n-3). Elongase 2 (encoded by <em>Elovl2</em> gene) catalyzes two elongation reactions in the PUFA biosynthesis pathway and may be important in regulating the observed sex differences in n-3 PUFA levels. Our aim was to determine how targeted knockout of liver <em>Elovl2</em> affects tissue and blood n-3 PUFA levels in male and female C57BL/6J mice. Twenty-eight-day old male and female liver <em>Elovl2</em>-KO and control mice were placed onto one of two dietary protocols for a total of 8 weeks (4–8 mice per genotype, per diet, per sex): 1) an 8-week 2 % ALA in total fat diet or 2) a 4-week 2 % ALA diet followed by a 4-week 2 % ALA + 2 % DHA diet. Following this 8-week feeding period, 12-week-old mice were sacrificed and serum, red blood cells (RBC), liver, heart and brain were collected and fatty acid levels measured. Significant interaction effects (<em>p</em> &lt; 0.05, sex x genotype) for serum, RBC, liver and heart DHA levels were identified. In serum and liver, DHA levels were significantly different (<em>p</em> &lt; 0.01) between all groups with male controls &gt; female controls &gt; female KO &gt; male KO in serum and female controls &gt; male controls &gt; female KO &gt; male KO in liver. In RBCs and the heart, female controls = male controls &gt; female KO &gt; male KO (<em>p</em> &lt; 0.001). The addition of DHA to diet removed the interaction effects on DHA levels in the serum, liver and heart, yielding a significant sex effect in serum, liver (female &gt; male, <em>p</em> &lt; 0.01) and brain (male &gt; female, <em>p</em> &lt; 0.05) and genotype effect in serum and heart (control &gt; KO, <em>p</em> &lt; 0.05). Ablation of liver <em>Elovl2</em> results in significantly lower blood and tissue DHA in a sex-dependent manner, suggesting a role for <em>Elovl2</em> on sex differences in n-3 PUFA levels.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"201 ","pages":"Article 102621"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952327824000152/pdfft?md5=882d465ce2a8bf1102905cb9c3202a76&pid=1-s2.0-S0952327824000152-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141033521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum phospholipid fatty acids are associated with bone mass in healthy 4-years-old children","authors":"Malin Garemo ,&nbsp;Valter Sundh ,&nbsp;Dan Mellström ,&nbsp;Birgitta Strandvik","doi":"10.1016/j.plefa.2023.102606","DOIUrl":"10.1016/j.plefa.2023.102606","url":null,"abstract":"<div><h3>Background</h3><p>Fatty acids are involved in bone development but knowledge in children is limited. The aim of this study was to investigate bone mass and mineral density in healthy preschool children in relation to fatty acids.</p></div><div><h3>Material and methods</h3><p>In 111 healthy 4-yrs-old children (20 % overweight) bone was analysed by dual X-ray absorptiometry and serum phospholipid fatty acid by gas chromatography. Fat intake was calculated from 7 days self-reported dietary records and food frequency questionnaire.</p></div><div><h3>Results</h3><p>Total bone mass content (BMC) and mineral density (BMD) differed by sex in normal weight, but not in overweight children showing generally higher bone mass density than children with normal weight. Linoleic acid intake was strongly correlated to BMC and femoral BMD in normal weight children. Serum concentration of docosahexaenoic acid correlated positively to BMD in all children (<em>p</em> = 0.01), but linoleic and arachidonic acids, and monounsaturated fatty acids showed diverging associations with bone in normal weight and overweight children.</p></div><div><h3>Conclusion</h3><p>Serum phospholipid DHA was associated with bone density. Other fatty acids associations to bone sites differed in overweight children, analogue to the pattern in healthy 8-yrs-old.The finding need to be confirmed longitudinally and in a larger group of overweight individuals.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"200 ","pages":"Article 102606"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139023856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: “Curcumin and linseed oil co-delivered in phospholipid nanoemulsions enhances the levels of docosahexaenoic acid in serum and tissue lipids of rats”","authors":"No Authors","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"202 ","pages":"Article 102630"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952327824000243/pdfft?md5=72a2e9cf7f2c46986031a236515523a4&pid=1-s2.0-S0952327824000243-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arachidonic acid level is related to early motor recovery following intracerebral hemorrhage with severe motor paralysis","authors":"Takeo Sato ,&nbsp;Motohiro Okumura ,&nbsp;Junichiro Takahashi ,&nbsp;Tatsushi Kokubu ,&nbsp;Maki Tanabe ,&nbsp;Asako Onda ,&nbsp;Teppei Komatsu ,&nbsp;Kenichi Sakuta ,&nbsp;Kenichiro Sakai ,&nbsp;Tadashi Umehara ,&nbsp;Hidetaka Mitsumura ,&nbsp;Masato Matsushima ,&nbsp;Yasuyuki Iguchi","doi":"10.1016/j.plefa.2023.102603","DOIUrl":"10.1016/j.plefa.2023.102603","url":null,"abstract":"<div><h3>Background</h3><p>Low arachidonic acid (AA) levels are reportedly associated with unfavorable outcomes in intracerebral hemorrhage (ICH).</p></div><div><h3>Objective</h3><p>We aimed to clarify whether serum AA levels might be associated with a good recovery from severe motor paralysis in the early stage of hospitalization.</p></div><div><h3>Methods</h3><p>From among consecutive ICH patients between October 2012 and December 2021, patients with a sum of upper and lower extremity National Institutes of Health stroke scale (NIHSS) scores of 4–8 at admission (severe motor paralysis) were included. We defined good early recovery from severe motor paralysis as a sum of upper and lower extremity NIHSS scores of 0–3 on day 7 after admission, and that of individual upper and lower extremities as NIHSS scores of 0–1 on day 7 after admission. We aimed to assess whether serum AA levels might be associated with good early recovery from severe motor paralysis.</p></div><div><h3>Results</h3><p>We screened 377 consecutive ICH patients, including 140 with severe motor paralysis (88 (63%) males, median age 64 years). Recovery from severe motor paralysis was seen in 48 (34%). Higher AA levels (PR 1.243, 95% CI 1.042 to 1.483, <em>p</em> = 0.016) were independently associated with good overall recovery, and good recovery of upper and lower extremities separately (upper extremity: PR 1.319, 95% CI 1.101 to 1.580, <em>p</em> = 0.003; lower extremity: PR 1.293, 95% CI 1.115 to 1.499, <em>p</em> = 0.001).</p></div><div><h3>Conclusions</h3><p>Higher AA levels may contribute to a good early motor recovery in patients with severe motor paralysis due to ICH.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"200 ","pages":"Article 102603"},"PeriodicalIF":3.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138684899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of age and dietary habits on Red Blood Cell membrane fatty acids in a Southern Europe population (Basque Country)","authors":"Gerard Marrugat ,&nbsp;Ainara Cano ,&nbsp;Javier Amézaga ,&nbsp;Sara Arranz ,&nbsp;Nieves Embade ,&nbsp;Óscar Millet ,&nbsp;Carla Ferreri ,&nbsp;Itziar Tueros","doi":"10.1016/j.plefa.2023.102602","DOIUrl":"10.1016/j.plefa.2023.102602","url":null,"abstract":"<div><p>The levels of blood eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are very variable and, in general, low in most of the world population. In this study, the effects of age, sex, COVID-19, and dietary habits on the lipid profile of the erythrocyte membranes were assessed in a sub-cohort of healthy population (<em>N</em> = 203) from a large cohort of individuals from the Basque Country, Spain, (AKRIBEA). Sex did not have an effect on RBC lipid profile. COVID-19 infected participants showed higher levels of DGLA. Oldest participants showed higher oleic acid, EPA and DHA levels. Arachidonic acid in RBC correlated positively with the intake of sunflower oil, butter, eggs, processed and red meat, whereas DHA and EPA correlated positively with oily and lean fish. Basque Country population showed lipid profiles similar to other high fish consuming countries, such as Italy and Japan. Baseline levels of the whole lipidomic profile of the RBC including SFA, MUFA and PUFA should be examined to obtain a better description of the health and nutritional status.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"200 ","pages":"Article 102602"},"PeriodicalIF":3.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952327823000716/pdfft?md5=f41f9a4ec142773819ddbc92b153011f&pid=1-s2.0-S0952327823000716-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138684793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Roux-en-Y Gastric Bypass on circulating oxylipin profile in women with obesity and type 2 diabetes","authors":"Daiane Cavalari Mancuzo ,&nbsp;Natasha Mendonça Machado ,&nbsp;Juliana Teppedino ,&nbsp;Lucas Santander ,&nbsp;Philip C. Calder ,&nbsp;Dan Linetzky Waitzberg ,&nbsp;Raquel Susana Torrinhas","doi":"10.1016/j.plefa.2023.102605","DOIUrl":"10.1016/j.plefa.2023.102605","url":null,"abstract":"<div><p>Background &amp; Aims: Chronic inflammation associated with obesity directly contributes to metabolic comorbidities, including type 2 diabetes (T2D). Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for obesity-associated T2D. We investigated the effect of RYGB on the circulating profile of oxylipins derived from arachidonic (ARA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids as a potential mechanism underlying the metabolic benefits of the surgery. Methods: Plasma samples were collected from 28 women with obesity and T2D before and 3 months after RYGB. Circulating levels of oxylipins and their precursors, along with biochemical markers of glucose homeostasis, were evaluated using untargeted mass spectrometry and routine biochemical techniques, respectively. Results: No significant changes were observed in the levels of oxylipins derived from EPA and DHA. However, there was an increase in ARA and its derived oxylipins, TXB2 (an inert derivative of TXA2) and PGD2 (Wilcoxon, <em>p</em> ≤ 0.05). Positive correlations were observed between hemoglobin A1c levels and TXB2 as well as ARA levels (Spearman, <em>p</em> ≤ 0.05). Conclusions: Our data suggest that the anti-inflammatory oxylipins derived from EPA and DHA may not be involved in the metabolic benefits associated with RYGB. However, the findings indicate that the pro-inflammatory oxylipin TXA2 and its precursor ARA may negatively impact glucose homeostasis both before and after RYGB.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"200 ","pages":"Article 102605"},"PeriodicalIF":3.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138631658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An association between PPARα-L162V polymorphism and increased plasma LDL cholesterol levels after risperidone treatment","authors":"Sergej Nadalin ,&nbsp;Lena Zatković ,&nbsp;Vjekoslav Peitl ,&nbsp;Dalibor Karlović ,&nbsp;Maja Vilibić ,&nbsp;Ante Silić ,&nbsp;Sanja Dević Pavlić ,&nbsp;Alena Buretić-Tomljanović","doi":"10.1016/j.plefa.2023.102604","DOIUrl":"https://doi.org/10.1016/j.plefa.2023.102604","url":null,"abstract":"<div><p>Peroxisome proliferator-activated receptor alpha (PPARα) and antipsychotic medications both influence polyunsaturated fatty acids (PUFA) homeostasis, and thus PPARα polymorphism may be linked to antipsychotic treatment response. Here we investigated whether the functional leucine 162 valine (L162V) polymorphism in PPARα influenced antipsychotic treatment in a group of psychosis patients (N = 186), as well as in a patient subgroup with risperidone, paliperidone, or combination treatment (N = 65). Antipsychotic-naïve first-episode patients and nonadherent chronic individuals were genotyped by polymerase chain reaction analysis. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed the patients’ Positive and Negative Syndrome Scale (PANSS) scores; PANSS factors; and metabolic syndrome-related parameters, including fasting plasma lipid and glucose levels, and body mass index. In the total patient group, PPARα polymorphism did not affect PANSS psychopathology or metabolic parameters. However, in the subgroup of patients with risperidone, paliperidone, or combination treatment, PPARα polymorphism influenced changes in plasma LDL cholesterol. Specifically, compared to PPARα-L162L homozygous patients, PPARα-L162V heterozygous individuals exhibited significantly higher increases of LDL cholesterol levels after antipsychotic treatment. The PPARα polymorphism had a strong effect size, but a relatively weak contribution to LDL cholesterol level variations (∼12.8 %).</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"200 ","pages":"Article 102604"},"PeriodicalIF":3.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Hemodialysis and Biotransformation of Erythrocyte Epoxy Fatty Acids in Peripheral Tissue”","authors":"Tong Liu ,&nbsp;Inci Dogan ,&nbsp;Michael Rothe ,&nbsp;Julius V. Kunz ,&nbsp;Felix Knauf ,&nbsp;Maik Gollasch ,&nbsp;Friedrich C. Luft ,&nbsp;Benjamin Gollasch","doi":"10.1016/j.plefa.2022.102521","DOIUrl":"10.1016/j.plefa.2022.102521","url":null,"abstract":"","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"198 ","pages":"Article 102521"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952327822001338/pdfft?md5=a245bdac3f9b7f13db4a98408627f6bd&pid=1-s2.0-S0952327822001338-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10373442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to Editor","authors":"KV. Giriraja ,&nbsp;SK. Bhanagar ,&nbsp;L. Tomlinson ,&nbsp;F. Sancilio","doi":"10.1016/j.plefa.2023.102594","DOIUrl":"10.1016/j.plefa.2023.102594","url":null,"abstract":"","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"198 ","pages":"Article 102594"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92158162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Selection of statistical tests influences the interpretation of a study outcome” a comment on “Giriraja KV, Bhatnagar SK, Tomlinson L, Sancilio F. An open-label, multicenter, phase 2 study of a food enriched with docosahexaenoic acid in adults with sickle cell disease. Prostaglandins Leukot Essent Fatty Acids. 2023 Jun; 193:102574. Doi: 10.1016/j.plefa.2023.102574. Epub 2023 Apr 7. PMID: 37121179”","authors":"Ashwin P Patel","doi":"10.1016/j.plefa.2023.102591","DOIUrl":"10.1016/j.plefa.2023.102591","url":null,"abstract":"<div><p>Parametric tests such as t-tests require a normal distribution of data. However, the determination of normal distribution may not be conclusive while dealing with a small sample size. Non-parametric tests such as Wilcoxon tests may be used in this situation, as these tests do not require normal distribution.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"198 ","pages":"Article 102591"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}