Prostaglandins, leukotrienes, and essential fatty acids最新文献

{"title":"Corrigendum to Changes in erythrocyte fatty acid profile after 12 weeks of omega-3 fatty acid (EPA+DHA) supplementation and endurance training in amateur runners. Prostaglandins, Leukotrienes and Essential Fatty Acids (2025): 102710.","authors":"Maja Tomczyk, Agnieszka Kowalska, Magdalena Dzitkowska-Zabielska, Philip C Calder, Helena L Fisk, Bartosz Kulczyński, Jędrzej Antosiewicz","doi":"10.1016/j.plefa.2026.102779","DOIUrl":"https://doi.org/10.1016/j.plefa.2026.102779","url":null,"abstract":"","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":" ","pages":"102779"},"PeriodicalIF":3.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 polyunsaturated fatty acids mitigate working memory decline through feeding a low-carbohydrate and high-protein diet in healthy mice","authors":"Takeru Shima ,&nbsp;Daichi Hirose","doi":"10.1016/j.plefa.2026.102724","DOIUrl":"10.1016/j.plefa.2026.102724","url":null,"abstract":"<div><div>A low-carbohydrate, high-protein (LC-HP) diet improves metabolic parameters but declines working memory, as shown by reduced hippocampal lipoprotein receptor-related protein 6 (<em>Lrp6</em>) mRNA expression in healthy mice. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), could modulate hippocampal function and Wnt signaling pathway, which is regulated by LRP6 and controls cell proliferation and differentiation. Thus, we hypothesized that intake of n-3 PUFAs alleviates LC-HP diet-induced memory decline. We utilized an LC-HP diet (25.1 % carbohydrate, 57.2 % protein, and 17.7 % fat by caloric content) and a control diet (58.9 % carbohydrate, 24.0 % protein, and 17.1 % fat). Eight-week-old male C57BL/6J mice assigned to six groups: control+vehicle, control+EPA, control+DHA, LC-HP+vehicle, LC-HP+EPA, and LC-HP+DHA. EPA, DHA (0.5 g/kg body weight), or vehicle were administered orally once daily for four weeks. Following the intervention, mice underwent the Y-maze test and hippocampal mRNA analysis. The LC-HP diet declined an alternation rate during Y-maze test, which reflects working memory, n-3 PUFA supplementation enhanced it. Notably, DHA significantly reversed the LC-HP diet-induced downregulation of hippocampal <em>Lrp6</em> and <em>Dcx</em> mRNA expressions. Although hippocampal <em>Wnt5</em> mRNA levels were unaffected, hippocampal <em>Lrp6, Wnt5a</em>, and <em>Dcx</em> mRNA levels showed significant positive correlations in LC-HP diet-fed mice (LC-HP+vehicle, LC-HP+EPA, and LC-HP+DHA groups). These findings suggest that n-3 PUFA, particularly DHA, may counteract LC-HP diet-induced memory decline by modulating hippocampal LRP6-related noncanonical Wnt signaling.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"208 ","pages":"Article 102724"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arachidonic acid is preferentially biomagnified over DHA in fetal erythrocytes: evidence from 172 paired maternal–cord samples in Oman","authors":"Mohammed Al Sinani ,&nbsp;Mark Johnson ,&nbsp;Michael Crawford ,&nbsp;Mohammed Al Maqbali","doi":"10.1016/j.plefa.2026.102726","DOIUrl":"10.1016/j.plefa.2026.102726","url":null,"abstract":"<div><div>The selective transfer of long-chain polyunsaturated fatty acids (LCPUFAs) from mother to fetus is essential for fetal development, particularly neurodevelopment and membrane synthesis. While docosahexaenoic acid (DHA) has been the focus of research, emerging evidence suggests arachidonic acid (AA) may be more strongly biomagnified across the placenta. We hypothesized that arachidonic acid (AA) would be preferentially biomagnified over docosahexaenoic acid (DHA) in fetal erythrocytes compared to maternal erythrocytes. This cross-sectional study investigated fatty acid biomagnification using erythrocyte membrane composition as a long-term indicator of status. Paired maternal venous and umbilical cord blood samples were collected at delivery from 172 healthy Omani mother–infant pairs. Fatty acids were analyzed via gas chromatography and expressed as relative proportions (%) and absolute concentrations (mg/mL). Wilcoxon signed-rank tests and Spearman correlations assessed differences and associations. AA showed significant biomagnification, increasing from 13.55 % in maternal to 14.87 % in fetal erythrocytes (<em>p</em> &lt; 0.001), while DHA increased modestly (4.11 to 4.40%, <em>p</em> = 0.034). Linoleic acid (LA), a precursor to AA, was significantly lower in fetal blood, indicating selective exclusion. Ratios such as AA/LA, AA/DHA, and (AA+DHA)/MUFAS were elevated in fetal erythrocytes, suggesting strong placental lipid selectivity. In contrast, monounsaturated fatty acids (MUFAS) and precursors such as α-linolenic acid (ALA) and EPA were reduced. Significant maternal–fetal correlations were found for AA, DHA, and composite indices. These findings demonstrate preferential biomagnification of AA, underscoring its physiological importance during gestation. Erythrocyte membrane profiling provides a stable measure of fatty acid transfer and highlights the need to revisit maternal dietary guidelines and infant formula composition.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"208 ","pages":"Article 102726"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in erythrocyte fatty acid profile after 12 weeks of omega-3 fatty acid (EPA+DHA) supplementation and endurance training in amateur runners","authors":"Maja Tomczyk ,&nbsp;Agnieszka Kowalska ,&nbsp;Magdalena Dzitkowska-Zabielska ,&nbsp;Philip C. Calder ,&nbsp;Helena L. Fisk ,&nbsp;Bartosz Kulczyński ,&nbsp;Jędrzej Antosiewicz","doi":"10.1016/j.plefa.2025.102710","DOIUrl":"10.1016/j.plefa.2025.102710","url":null,"abstract":"<div><div>Fatty acid (FA) profiles can be examined in both plasma and red blood cells (RBCs), with the latter showing the average FA concentrations over the past 3-4 months and not being susceptible to daily fluctuations dependent on diet or supplementation. This study provides data on changes in the FA profile in RBCs as a result of 12 weeks supplementation with long chain omega-3 polyunsaturated fatty acids (n-3 PUFAs; EPA and DHA) and training intervention in amateur runners. The study included 26 amateur runners, 14 of whom were assigned to the n-3 PUFA supplementation group (2234 mg of EPA and 916 mg of DHA daily) and 12 to the placebo group; both groups underwent the exercise training. After the 12-week intervention, runners taking n-3 PUFAs showed statistically significant increases in EPA, docosapentanoic acid, DHA and total PUFAs, and decreases in lignoceric, palmitoleic, vaccenic, gondoic, linoleic, eicosadienoic, dihomo-γ-linolenic, and arachidonic acids compared to placebo group. In addition, increases in omega-3 index, delta 9-desaturase index (C16), and PUFA/MUFA index, and a decrease in monounsaturated fatty acids (MUFAs) and AA/EPA ratio was observed. There were no changes in RBC FAs in the placebo group indicating that exercise training had no effect on RBC FAs. This study provides novel insights into the changes in FA profile in RBCs with n-3 PUFA supplementation, the importance of which in both sports and health scenarios requires further research.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"208 ","pages":"Article 102710"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of perinatal α-linolenic acid deficiency combined with high-fat diet consumption on tissue-specific fatty acid profiles in rats: Maternal and offspring analysis","authors":"María Paz Beyer ,&nbsp;Lorena Mercado-Lopez ,&nbsp;Camila Farias ,&nbsp;Robinson Carrasco-Gutiérrez ,&nbsp;Alejandra Espinosa ,&nbsp;Alexies Dagnino-Subiabre ,&nbsp;Yasna Muñoz ,&nbsp;Ignacio Alvear E ,&nbsp;Luis A. Videla ,&nbsp;Rodrigo Valenzuela","doi":"10.1016/j.plefa.2026.102723","DOIUrl":"10.1016/j.plefa.2026.102723","url":null,"abstract":"<div><h3>Background</h3><div>An imbalance in the dietary ratio of omega-6 (n-6) to omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and/or a high-fat diet (HFD) may disrupt the metabolic conversion of essential PUFAs, such as linoleic acid (LA) and α-linolenic acid (ALA), into their long-chain derivatives (LC-PUFAs), thereby altering their accumulation in various tissues. To determine the effects of low maternal intake of ALA and/or an HFD on FA composition in maternal tissues (liver, adipose tissue, and erythrocytes) and offspring tissues (liver, erythrocytes, adipose tissue, heart, kidney, intestine, muscle, brain, eye, lung, and stomach contents) in rats.</div></div><div><h3>Methods</h3><div>A prospective, randomized, controlled experimental study was conducted in Sprague-Dawley rats. Animals were assigned to one of four dietary intervention groups: CD-&lt;1%-ALA, CD-2%-ALA, HFD-&lt;1%-ALA, and HFD-2%-ALA. The diets were administered throughout the pregestational, gestational, and postnatal periods. Following euthanasia, tissue samples were collected and analyzed for FA composition using gas chromatography.</div></div><div><h3>Results</h3><div>The accumulation of n-3 PUFAs varied across the analyzed tissues, suggesting tissue-specific uptake or incorporation of ALA. The liver exhibited the highest capacity for PUFA biosynthesis in rats, whereas extrahepatic tissues showed limited activity. Moreover, maternal diet did not consistently correlate with PUFA concentrations in the offspring.</div></div><div><h3>Conclusions</h3><div>The increase in ALA is tissue-specific, reflecting differential incorporation among tissue types. Maternal n-3 PUFA stores become a critical source for the transfer of these FAs to the offspring, particularly under dietary stress conditions such as low ALA intake or HFDs.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"208 ","pages":"Article 102723"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal peripartum and fetal perirenal and omental adipose tissue dynamics: Analysis of fatty acid composition and adipocyte morphology in sheep","authors":"Jerry Nguyen ,&nbsp;Minna Holopainen ,&nbsp;Reijo Käkelä ,&nbsp;Panu Kiviranta ,&nbsp;Juha Räsänen ,&nbsp;Heikki Huhta ,&nbsp;Ella Vuoti ,&nbsp;Anne-Mari Mustonen ,&nbsp;Petteri Nieminen ,&nbsp;Sanna Palosaari ,&nbsp;Petri Lehenkari","doi":"10.1016/j.plefa.2026.102725","DOIUrl":"10.1016/j.plefa.2026.102725","url":null,"abstract":"<div><div>Fatty acids (FAs) play essential roles in fetal development and physiological processes, serving as precursors for signaling molecules, structural components of cellular membranes, and components of lipids in energy reserves. The long-term storage of FAs in adipocyte triacylglycerols provides the growing fetus with structurally and functionally different FAs, which have diverse effects on developmental and metabolic health.</div><div>Adipose tissue samples were obtained from perirenal, omental, mediastinal, mesenteric, subcutaneous, and periorbital depots of six pregnant ewes and six fetuses. Histological analysis of adipocyte sizes was performed using the QuPath and Adipocyte Tools, and gas chromatography–mass spectrometry was employed to analyze FA compositions. Principal component analysis was utilized to identify patterns in FA profiles separating maternal and fetal tissues.</div><div>Analysis of adipocyte size distribution revealed significantly larger adipocytes in ewes compared with fetuses. Maternal perirenal and omental adipose tissues contained the largest cells. Monounsaturated FAs and biologically active long-chain n-3 and n-6 polyunsaturated FAs were more abundant in fetal tissues, while saturated FAs were more abundant in maternal tissues.</div><div>In conclusion, fetal and maternal adipose tissues demonstrated significant differences in morphology and FA composition, reflecting their distinct functional roles. While fetal FA composition is heavily influenced by fetoplacental FA transfer, and the observed FA patterns are consistent with endogenous metabolic processing in fetuses, further transcriptomic data will be required for more detailed metabolic interpretation. Still, these findings could reflect a degree of metabolic independence of fetuses in this ruminant model and help generate hypotheses for future translational studies.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"208 ","pages":"Article 102725"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbance affects inflammatory resolution in Long COVID","authors":"Larissa C. Engert ,&nbsp;Rammy Dang ,&nbsp;Surya Daniel ,&nbsp;Suzanne M. Bertisch ,&nbsp;Jason H. Maley ,&nbsp;Tamara G. Fong ,&nbsp;Charles N. Serhan ,&nbsp;Janet M. Mullington ,&nbsp;Monika Haack","doi":"10.1016/j.plefa.2026.102728","DOIUrl":"10.1016/j.plefa.2026.102728","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbance, which is a common symptom in Long COVID, promotes a pro-inflammatory state and dysregulates lipid-derived specialized pro-resolving mediators (SPMs), presumably contributing to chronic unresolved inflammation. This study aimed to investigate the role of sleep disturbance in inflammatory resolution in Long COVID.</div></div><div><h3>Methods</h3><div>We studied 39 participants (30F/9M, age range 22–68 years), including 31 individuals with Long COVID and 8 SARS-CoV-2-infected controls, who did not develop Long COVID. The study consisted of a 14-day at-home phase followed by a 1-day (24-h) in-laboratory stay. Sleep disturbance was assessed using PROMIS Sleep Disturbance T-scores. During the in-laboratory stay, a fasting morning blood sample was taken for assessment of lipid mediators. Data were analyzed using generalized linear mixed models.</div></div><div><h3>Results</h3><div>Participants with Long COVID reported higher sleep disturbance than controls (<em>p</em>&lt;.001). Pro-inflammatory lipid pathways were upregulated in Long COVID compared to control, as indicated by higher prostaglandin E₂ (PGE₂) levels (<em>p</em>&lt;.05). Long COVID participants with high sleep disturbance (PROMIS Sleep Disturbance T-score ≥60) had lower SPM levels, including the precursor of D-series resolvins 17-hydroxydocosahexaenoic acid (17-HDHA), 17<em>R</em>/<em>S</em>-resolvin D1 (17<em>R</em>/<em>S</em>-RvD1), 15<em>R</em>-lipoxin B4 (15<em>R</em>-LXB4), and protectin D1_{n-3 DPA} (PD1_{n-3 DPA}) than those with low sleep disturbance (T-score &lt;60) (<em>p</em>&lt;.05).</div></div><div><h3>Conclusions</h3><div>This study suggests that sleep disturbance may contribute to chronic inflammation in Long COVID by compromising certain inflammatory resolution pathways. Promoting inflammatory resolution physiology in particular in those individuals with Long COVID suffering from sleep disturbance may serve as a mechanistic target to mitigate inflammation and symptom burden in Long COVID.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov NCT05606211.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"208 ","pages":"Article 102728"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission plasma levels of fatty acids and kidney function in patients with ST-segment elevation myocardial infarction","authors":"Christa Meisinger ,&nbsp;Timo Schmitz ,&nbsp;Philip Raake ,&nbsp;Jakob Linseisen","doi":"10.1016/j.plefa.2025.102712","DOIUrl":"10.1016/j.plefa.2025.102712","url":null,"abstract":"<div><h3>Background</h3><div>Prior studies suggested a link between polyunsaturated fatty acids (PUFAs) and the development of chronic kidney disease (glomerular filtration rate [GFR] &lt; 60 ml/min/1.73 m²), but so far there are no studies on the association between PUFAs and kidney function in patients with acute myocardial infarction (AMI). We aimed to investigate whether and how plasma fatty acids levels at admission were associated with kidney function in patients with acute ST-elevation myocardial infarction (STEMI).</div></div><div><h3>Methods</h3><div>This study was based on data from 717 patients with STEMI aged 29 to 98 years admitted to the University Hospital Augsburg between May 2009 and July 2013. In arterial blood samples taken from these patients immediately after admission a panel of plasma fatty acids was measured by a high-throughput nuclear magnetic resonance spectroscopy platform (Nightingale Health, Finland). To examine the association between the fatty acid groups (exposure) and kidney function (continuous eGFR; outcome), linear regression models were calculated. P values were FDR-adjusted.</div></div><div><h3>Results</h3><div>In multivariable analyses the concentrations of total PUFAs, total omega-6 fatty acids, linoleic acid, and docosahexaenoic acid (DHA) were positively associated with serum eGFR values at admission. These findings were supported by a significantly positive association between these fatty acids in relation to total fatty acids (except for the ratio DHA/total fatty acids). While the concentration of monounsaturated fatty acids (MUFAs) was not associated with eGFR, a significantly inverse association was observed between the ratio MUFAs/total fatty acids and kidney function.</div></div><div><h3>Conclusions</h3><div>PUFAs, particularly omega-6 fatty acids, seem to be associated with kidney function in patients with AMI. Given the prognostic importance of renal function in coronary heart disease/AMI patients, further research on interventions to minimize worsening renal function and protect kidney function in this patient group is warranted.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"207 ","pages":"Article 102712"},"PeriodicalIF":3.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the relationships between reported fish oil supplement use and health outcomes in the UK Biobank","authors":"Nada R. Abuknesha ,&nbsp;James H. O’Keefe ,&nbsp;William S. Harris","doi":"10.1016/j.plefa.2025.102711","DOIUrl":"10.1016/j.plefa.2025.102711","url":null,"abstract":"<div><h3>Introduction</h3><div>Recent lay and medical headlines reported that fish oil supplement (FOS) use in the UK Biobank (UKBB) increased risk for atrial fibrillation (AF) in the general population. The publicity generated by this report (the conclusions of which have since been questioned) led us to consider what other FOS-disease outcome relationships have been examined in this very large population study.</div></div><div><h3>Methods</h3><div>We surveyed the medical literature for papers reporting on the associations between reported FOS use in the UKBB and risk for a wide variety of diseases.</div></div><div><h3>Results</h3><div>In addition to two similar reports on FOS use and AF, we reviewed 32 other UKBB studies examining the associations between FOS use and disease/condition. Collectively, these studies reported 60 FOS vs disease/condition associations of which 44 were significant and favorable for FOS use, and one was significant and unfavorable for FOS use (osteoarthritis). Studies linking circulating blood levels of omega-3 fatty acids provide a more objective measure of exposure than a yes-no answer to a FOS use questionnaire. Thus, we highlight the results of six published meta-analyses using blood biomarkers that have reported 11 statistically significant, favorable relationships with major disease outcomes, and one neutral association (hemorrhagic stroke) and no unfavorable associations.</div></div><div><h3>Conclusions</h3><div>Together, these consistent findings across UKBB FOS and biomarker-based meta-analyses support the hypothesis that higher omega-3 status (however achieved) is generally beneficial for health. Because of the wide variety of outcomes favorably linked with FOS use (and elevated omega-3 blood levels) it seems unlikely that a “healthy user bias” and not the bioactivity of omega-3 fatty acids themselves; can explain all these relationships.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"207 ","pages":"Article 102711"},"PeriodicalIF":3.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excess maternal vitamin B12 supplementation increases oxidative stress and differentially influences fatty acids profile in a rat model","authors":"Sunaina Chhetri,&nbsp;Nisha Kemse,&nbsp;Juhi Nema,&nbsp;Sadhana Joshi","doi":"10.1016/j.plefa.2025.102715","DOIUrl":"10.1016/j.plefa.2025.102715","url":null,"abstract":"<div><div>Vitamin B₁₂ status during pregnancy is an important determinant for non-communicable disease risk in later life. Vitamin B₁₂ and fatty acid are interlinked in one carbon cycle. The effect of vitamin B₁₂ deficiency on adverse pregnancy outcomes and fatty acid status is well known. However, the effects of excess vitamin B₁₂ supplementation during pregnancy are less explored. This study investigates the influence of prenatal excess vitamin B₁₂ supplementation on pregnancy outcome, fatty acids, oxidative stress, inflammation and cardiometabolic variables in Wistar rats. Female rats were divided (pre-pregnancy to pregnancy) into 3 groups as control (0.375 μg/day of vitamin B₁₂), intermediate group (1.5 μg/day) and excess group (120 μg/day). At d20 of gestation, dams were sacrificed to collect blood and placenta for biochemical estimation. We found higher plasma vitamin B₁₂ levels in the intermediate group and excess group (<em>p</em> &lt; 0.01 for both), while folate and homocysteine levels were found to be similar across groups. The pregnancy outcome was similar between groups. We found higher erythrocyte saturated fatty acids, lower omega-6 fatty acids, omega-6/omega-3 fatty acid ratio, and Δ5 desaturase index (<em>p</em> &lt; 0.05 for all) in excess group in comparison with the control group. In comparison with the control group, higher placental Δ6 desaturase index (<em>p</em> &lt; 0.05) and plasma malondialdehyde levels were found (<em>p</em> &lt; 0.01) in excess group. Our study demonstrates that supplementation of excess maternal vitamin B₁₂ during pregnancy leads to increased oxidative stress and differentially influences various fatty acid levels.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"207 ","pages":"Article 102715"},"PeriodicalIF":3.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}