Impact of n-3 polyunsaturate fatty acids supplementation on visual health throughout the life cycle: A systematic review

IF 3.2
Claudia Tabilo , Valentina Squella , Paola Illesca , Yasna Muñoz , Camila Farías , Rodrigo Valenzuela
{"title":"Impact of n-3 polyunsaturate fatty acids supplementation on visual health throughout the life cycle: A systematic review","authors":"Claudia Tabilo ,&nbsp;Valentina Squella ,&nbsp;Paola Illesca ,&nbsp;Yasna Muñoz ,&nbsp;Camila Farías ,&nbsp;Rodrigo Valenzuela","doi":"10.1016/j.plefa.2025.102686","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>N-3 polyunsaturated fatty acids (n-3 PUFA) are important for mammals and have relevant functions in the body. These fatty acids play an important role in brain development, in the protection of the retina, and in the prevention of macular degeneration. Currently, clinical trials do not yet confirm a clear benefit of n-3 PUFA supplementation on vision throughout the life cycle. Therefore, the aim of this study is to systematically evaluate the available scientific evidence to determine the effects of n-3 PUFA supplementation on visual health throughout the life cycle.</div></div><div><h3>Material and Methods</h3><div>A search of scientific literature was performed, based on randomized, controlled clinical studies, published in PubMed, using keywords. We included people of both sexes throughout the life cycle that evaluated the impact of n-3 PUFA supplementation on visual health.</div></div><div><h3>Results</h3><div>Of the 87 articles included in this review, there are important contradictions in the literature regarding the effects of supplementation in pregnant women, infants and older adults. While some studies highlight beneficial effects, an equal number of studies report no impact. In the case of preschoolers and schoolchildren, predominantly positive effects were identified, especially in children with Attention Deficit Hyperactivity Disorder (ADHD). For youth and adults, the impact of supplementation varied according to the health condition assessed, mostly supporting significant benefits in individuals with dry eye symptoms.</div></div><div><h3>Conclusion</h3><div>Evidence supports supplementation with n-3 PUFA, especially docosahexaenoic acid (DHA), to improve visual development in infants, schoolchildren, especially those with ADHD. Despite variability in visual outcomes, these findings suggest a crucial role of n-3 PUFA supplementation in visual health in the first steps of life, but in adults and older adults remain uncertain or null. Therefore, it is critical to investigate optimal dosing, duration of the intervention as the age of the participants in future research.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"206 ","pages":"Article 102686"},"PeriodicalIF":3.2000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952327825000237","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

N-3 polyunsaturated fatty acids (n-3 PUFA) are important for mammals and have relevant functions in the body. These fatty acids play an important role in brain development, in the protection of the retina, and in the prevention of macular degeneration. Currently, clinical trials do not yet confirm a clear benefit of n-3 PUFA supplementation on vision throughout the life cycle. Therefore, the aim of this study is to systematically evaluate the available scientific evidence to determine the effects of n-3 PUFA supplementation on visual health throughout the life cycle.

Material and Methods

A search of scientific literature was performed, based on randomized, controlled clinical studies, published in PubMed, using keywords. We included people of both sexes throughout the life cycle that evaluated the impact of n-3 PUFA supplementation on visual health.

Results

Of the 87 articles included in this review, there are important contradictions in the literature regarding the effects of supplementation in pregnant women, infants and older adults. While some studies highlight beneficial effects, an equal number of studies report no impact. In the case of preschoolers and schoolchildren, predominantly positive effects were identified, especially in children with Attention Deficit Hyperactivity Disorder (ADHD). For youth and adults, the impact of supplementation varied according to the health condition assessed, mostly supporting significant benefits in individuals with dry eye symptoms.

Conclusion

Evidence supports supplementation with n-3 PUFA, especially docosahexaenoic acid (DHA), to improve visual development in infants, schoolchildren, especially those with ADHD. Despite variability in visual outcomes, these findings suggest a crucial role of n-3 PUFA supplementation in visual health in the first steps of life, but in adults and older adults remain uncertain or null. Therefore, it is critical to investigate optimal dosing, duration of the intervention as the age of the participants in future research.
补充n-3多不饱和脂肪酸对整个生命周期视觉健康的影响:系统综述
n-3多不饱和脂肪酸(n-3 PUFA)在哺乳动物体内具有重要的功能。这些脂肪酸在大脑发育、保护视网膜和预防黄斑变性方面发挥着重要作用。目前,临床试验尚未证实n-3 PUFA补充剂在整个生命周期内对视力的明显益处。因此,本研究的目的是系统地评估现有的科学证据,以确定补充n-3 PUFA对整个生命周期视觉健康的影响。材料和方法基于PubMed上发表的随机对照临床研究,使用关键词对科学文献进行检索。我们纳入了在整个生命周期中评估n-3 PUFA补充对视觉健康影响的男性和女性。结果在本综述纳入的87篇文章中,关于孕妇、婴儿和老年人补充叶酸的效果,文献中存在重要的矛盾。虽然一些研究强调了有益的影响,但同样数量的研究报告没有影响。在学龄前儿童和学龄儿童中,主要是积极的影响,特别是在患有注意力缺陷多动障碍(ADHD)的儿童中。对于青少年和成年人,补充维生素d的影响根据评估的健康状况而有所不同,主要支持对有干眼症状的个体的显着益处。结论有证据支持补充n-3 PUFA,特别是二十二碳六烯酸(DHA)可改善婴幼儿、学龄儿童,尤其是ADHD儿童的视力发育。尽管视力结果存在差异,但这些发现表明,在生命的最初阶段,补充n-3 PUFA对视力健康起着至关重要的作用,但在成年人和老年人中仍然不确定或无效。因此,在未来的研究中,研究最佳剂量、干预持续时间随参与者年龄的变化是至关重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
发文量
0
审稿时长
64 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信