Maternal blood glucose level is correlated to offspring brain fatty acid composition in a mouse model for gestational diabetes mellitus

IF 3.2

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2025-08-15 DOI:10.1016/j.plefa.2025.102700

Lidewij Schipper , Noela Schaap , Yixian Liu , Hongyu Li , Weiping Han , Louise Harvey

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Abstract

Gestational diabetes mellitus (GDM) may increase the risk of suboptimal neurocognitive development in infants. Maternal supply of omega-3 and -6 long chain polyunsaturated fatty acids (LCPUFAs), including eicosapentaeonic acid, docosahexaenoic acid and arachidonic acid, are critical for offspring brain development. To study the effects of GDM on offspring brain fatty acid composition, C57BL/6J mice were exposed to short-term high-fat diet feeding and low-dose streptozotocin treatments before pregnancy. Maternal blood glucose levels positively correlated to offspring brain omega 6:omega 3 ratio at postnatal day 2 and day 21, which appeared to be driven specifically by higher omega-6 LCPUFA levels. GDM may be associated with impaired brain fatty acid profile in offspring, and this may underpin altered neurodevelopmental outcomes after GDM pregnancies. These findings support further investigation into the therapeutic potential of postnatal dietary interventions targeting fatty acid status in infants born after GDM.

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在妊娠糖尿病小鼠模型中，母体血糖水平与子代脑脂肪酸组成相关

妊娠期糖尿病（GDM）可能增加婴儿神经认知发育次优的风险。母体提供omega-3和-6长链多不饱和脂肪酸（LCPUFAs），包括二十碳五烯酸、二十二碳六烯酸和花生四烯酸，对后代大脑发育至关重要。为了研究GDM对子代脑脂肪酸组成的影响，在妊娠前给C57BL/6J小鼠短期高脂饲料喂养和低剂量链脲佐菌素治疗。在出生后第2天和第21天，母亲的血糖水平与后代大脑中的omega-6:omega - 3比例呈正相关，这似乎是由更高的omega-6 LCPUFA水平特别驱动的。GDM可能与后代脑脂肪酸谱受损有关，这可能是GDM妊娠后神经发育结果改变的基础。这些发现支持进一步研究针对GDM后出生的婴儿的脂肪酸状态的产后饮食干预的治疗潜力。

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