Ge Sun , John R. Davies , Tracey Mell , Mark Harland , Rasha M.H. Saleh , Amanda D. Race , Paul M. Loadman , Elizabeth A. Williams , Anne Marie Minihane , Mark A. Hull
{"title":"多发性结直肠息肉患者的 APOE 基因型、二十碳五烯酸 (EPA) 补充剂和 n-3 高度不饱和脂肪酸 (HUFA) 水平：seAFOod息肉预防试验的二次分析。","authors":"Ge Sun , John R. Davies , Tracey Mell , Mark Harland , Rasha M.H. Saleh , Amanda D. Race , Paul M. Loadman , Elizabeth A. Williams , Anne Marie Minihane , Mark A. Hull","doi":"10.1016/j.plefa.2024.102623","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>We examined the relationship between <em>Apolipoprotein E</em> (<em>APOE</em>) genotype and <em>n</em>-3 highly unsaturated fatty acid (HUFA) levels in participants of the seAFOod trial, who were undergoing colonoscopy surveillance after removal of colorectal polyps.</p></div><div><h3>Methods</h3><p>Baseline and on-treatment (eicosapentaenoic acid [EPA] 2 g daily or placebo for 6 months) levels of <em>n</em>-3 HUFAs, and plasma 18-hydroxyeicosapentaenoic acid (HEPE), were analysed according to <em>APOE</em> genotype (based on polymorphisms rs429358 and rs7412) in 584 participants.</p></div><div><h3>Results</h3><p>Before treatment, <em>APOE2/2</em> individuals had lower levels, and <em>APOE4/4</em> participants had higher levels, of <em>n</em>-3 HUFAs, including EPA, than <em>APOE3/3</em> counterparts (P < 0.01 for the <em>APOE2/2 versus APOE4/4</em> comparison). After EPA supplementation, <em>n</em>-3 HUFA levels were not significantly different when stratified by <em>APOE</em> genotype, although <em>APOE4</em> carriers displayed lower plasma 18-HEPE levels than individuals without an <em>APOE4</em> allele (P = 0.002).</p></div><div><h3>Conclusions</h3><p><em>APOE</em> genotype is associated with differential <em>n</em>-3 HUFA and 18-HEPE levels in individuals with multiple colorectal polyps.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952327824000176/pdfft?md5=e3790c985232a6a3ceacd9722626e95d&pid=1-s2.0-S0952327824000176-main.pdf","citationCount":"0","resultStr":"{\"title\":\"APOE genotype, eicosapentaenoic acid (EPA) supplementation and n-3 highly unsaturated fatty acid (HUFA) levels in patients with multiple colorectal polyps: A secondary analysis of the seAFOod polyp prevention trial\",\"authors\":\"Ge Sun , John R. Davies , Tracey Mell , Mark Harland , Rasha M.H. Saleh , Amanda D. Race , Paul M. Loadman , Elizabeth A. Williams , Anne Marie Minihane , Mark A. Hull\",\"doi\":\"10.1016/j.plefa.2024.102623\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>We examined the relationship between <em>Apolipoprotein E</em> (<em>APOE</em>) genotype and <em>n</em>-3 highly unsaturated fatty acid (HUFA) levels in participants of the seAFOod trial, who were undergoing colonoscopy surveillance after removal of colorectal polyps.</p></div><div><h3>Methods</h3><p>Baseline and on-treatment (eicosapentaenoic acid [EPA] 2 g daily or placebo for 6 months) levels of <em>n</em>-3 HUFAs, and plasma 18-hydroxyeicosapentaenoic acid (HEPE), were analysed according to <em>APOE</em> genotype (based on polymorphisms rs429358 and rs7412) in 584 participants.</p></div><div><h3>Results</h3><p>Before treatment, <em>APOE2/2</em> individuals had lower levels, and <em>APOE4/4</em> participants had higher levels, of <em>n</em>-3 HUFAs, including EPA, than <em>APOE3/3</em> counterparts (P < 0.01 for the <em>APOE2/2 versus APOE4/4</em> comparison). After EPA supplementation, <em>n</em>-3 HUFA levels were not significantly different when stratified by <em>APOE</em> genotype, although <em>APOE4</em> carriers displayed lower plasma 18-HEPE levels than individuals without an <em>APOE4</em> allele (P = 0.002).</p></div><div><h3>Conclusions</h3><p><em>APOE</em> genotype is associated with differential <em>n</em>-3 HUFA and 18-HEPE levels in individuals with multiple colorectal polyps.</p></div>\",\"PeriodicalId\":94179,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0952327824000176/pdfft?md5=e3790c985232a6a3ceacd9722626e95d&pid=1-s2.0-S0952327824000176-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0952327824000176\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952327824000176","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
APOE genotype, eicosapentaenoic acid (EPA) supplementation and n-3 highly unsaturated fatty acid (HUFA) levels in patients with multiple colorectal polyps: A secondary analysis of the seAFOod polyp prevention trial
Introduction
We examined the relationship between Apolipoprotein E (APOE) genotype and n-3 highly unsaturated fatty acid (HUFA) levels in participants of the seAFOod trial, who were undergoing colonoscopy surveillance after removal of colorectal polyps.
Methods
Baseline and on-treatment (eicosapentaenoic acid [EPA] 2 g daily or placebo for 6 months) levels of n-3 HUFAs, and plasma 18-hydroxyeicosapentaenoic acid (HEPE), were analysed according to APOE genotype (based on polymorphisms rs429358 and rs7412) in 584 participants.
Results
Before treatment, APOE2/2 individuals had lower levels, and APOE4/4 participants had higher levels, of n-3 HUFAs, including EPA, than APOE3/3 counterparts (P < 0.01 for the APOE2/2 versus APOE4/4 comparison). After EPA supplementation, n-3 HUFA levels were not significantly different when stratified by APOE genotype, although APOE4 carriers displayed lower plasma 18-HEPE levels than individuals without an APOE4 allele (P = 0.002).
Conclusions
APOE genotype is associated with differential n-3 HUFA and 18-HEPE levels in individuals with multiple colorectal polyps.
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