Plant signaling & behavior最新文献

{"title":"<i>Target of Rapamycin</i> is involved in root hair development in <i>Phaseolus vulgaris</i>.","authors":"Hugo Alberto Monreal Contreras, Manoj-Kumar Arthikala, Miguel Lara, Kalpana Nanjareddy","doi":"10.1080/15592324.2025.2507736","DOIUrl":"10.1080/15592324.2025.2507736","url":null,"abstract":"<p><p>Root hairs are essential for nutrient acquisition and rhizosphere interactions in vascular plants. While the Target of Rapamycin (TOR) kinase is a well established regulator of growth and metabolism, its role in root hair development in <i>Phaseolus vulgaris</i> remains underexplored. In this study, we investigated the role of TOR in root hair morphogenesis using RNA interference (RNAi)-mediated downregulation of <i>PvTOR</i> and transcriptomic profiling. Microscopic examination of <i>PvTOR</i>-RNAi roots confirmed significant reductions in root hair length and density. Transcriptomic analysis revealed differential expression of 148 <i>P. vulgaris</i> homologs of <i>Arabidopsis thaliana</i> root hair-related genes, with 63 genes downregulated and 85 upregulated. Gene Ontology enrichment analysis indicated that these differentially expressed genes (DEGs) were primarily involved in cellular development, cell differentiation, and redox regulation. Upregulation of phosphoinositide metabolism genes, ROS generators, and cell wall-related extensins suggests compensatory tip growth responses under TOR suppression. On the otherhand, repression of key auxin signaling genes and cell wall-loosening proteins such as <i>EXPA1</i> and <i>ENDOGLUCANASE5</i> indicates a shift away from elongation processes. Protein - protein interaction network analysis highlighted phosphoinositide and ROP GTPase signaling hubs as major pathways affected by TOR inhibition, suggesting that TOR indirectly modulates cell polarity and membrane dynamics essential for root hair development. These findings provide further evidence of TOR as a central integrator of hormonal, metabolic, and structural cues during root hair formation.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2507736"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZmBAK1 confers maize resistance to <i>Gibberella</i> stalk rot caused by <i>Fusarium graminearum</i> via activating PAMP-triggered immunity.","authors":"Fugui Xie, Yali Sun, Huilan Zhang, Junjie Cui, Qing Wang, Xiquan Gao","doi":"10.1080/15592324.2025.2502739","DOIUrl":"10.1080/15592324.2025.2502739","url":null,"abstract":"<p><p>Gibberella stalk rot (GSR) caused by <i>Fusarium graminearum</i> is one of the most devastating diseases of maize, not only seriously affecting its yield and the application of mechanized harvest technology but also producing a variety of toxins, thus seriously impacting the food safety. BAK1 (Brassinosteroid-Insensitive 1-Associated Receptor Kinase 1, BAK1) is the well-studied co-receptor of PRRs (Pattern Recognition Receptors), which is involved in the regulation of growth and development regulation as well as the response to diverse biological stresses. However, little is known about the role of BAK1 in the interaction between maize and pathogens, especially in maize against GSR. In this study, we found that ZmBAK1 (<i>Zm00001d037297</i>) was located at the cytoplasmic membrane. Furthermore, <i>ZmBAK1</i> was induced by multiple PAMPs (Pathogen-Associated Molecular Patterns), while PTI (PAMP-Triggered Immunity) response including ROS (Reactive Oxygen Species) burst and callose deposition, as well as cell death, and immune gene expression was weakened in <i>bak1</i> mutant upon PAMP treatment. On the contrary, the ROS production and cell death in <i>BAK1</i>-OE were significantly stronger than wild type. Furthermore, <i>bak1</i> mutant is more susceptible to GSR, while <i>BAK1</i>-OE is more resistant, compared to wild types. Taken together, our data suggested that ZmBAK1 plays a positive role in maize GSR resistance, likely via activating PTI signaling pathway.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2502739"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taurine priming improves redox balance, osmotic adjustment, and nutrient acquisition to lessen phytotoxic effects of neutral and alkaline salts on pea (<i>Pisum sativum</i> L.).","authors":"Umer Farooq, Ayesha Rehman, Muhammad Arslan Ashraf, Rizwan Rasheed, Mudassar Shahid, Shafaqat Ali, Pallab K Sarker","doi":"10.1080/15592324.2025.2480224","DOIUrl":"10.1080/15592324.2025.2480224","url":null,"abstract":"<p><p>Taurine (TAR) intricately mediates a plethora of physiological processes. This investigation aimed to elucidate the impact of TAR (50, 100, 150, and 200 mg L^-1) seed priming on redox homeostasis, glutathione metabolism, photosynthetic efficiency, osmotic adjustment and nutrient acquisition in pea plants subjected to 100 mm salinity of neutral (NaCl and Na₂SO₄) and alkaline (Na₂CO₃) salts. Salinity diminished growth, chlorophyll, and photosynthetic efficiency alongside a concurrent rise in reactive oxygen species (ROS), lipid peroxidation, and relative membrane permeability. Seed priming with 150 mg L^-1 TAR efficiently enhanced growth by reducing oxidative damage to plants under salinity. Taurine enhanced leaf relative water content through osmotic adjustment facilitated by the induced accumulation of proline, glycine betaine, soluble sugars, and total free amino acids. Taurine increased the levels of antioxidant compounds and the activities of enzymes, which assisted in the detoxification of ROS and methylglyoxal. Taurine maintained chlorophyll integrity and enhanced photosynthetic efficiency by alleviating oxidative stress. Taurine diminished Na content, which improved the acquisition of essential nutrients under the salinity of neutral and alkaline salts. The results suggest that TAR has a potential role in maintaining ion homeostasis, crucial for enhancing pea tolerance to salt stress.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2480224"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational identification and experimental validation of novel <i>Saccharum officinarum</i> microRNAs along with their targets through RT-PCR approach.","authors":"Abdul Baqi, Samiullah, Jadoon Khan, Asma Sadiq, Yousaf Khan, Shahid Ali, Syed Nadeem Ul Hassan Mohani, Naqeebullah Khan, Tawaf Ali Shah, Khalid S Almaary, Youssouf Ali Younous, Mohammed Bourhia","doi":"10.1080/15592324.2025.2452334","DOIUrl":"10.1080/15592324.2025.2452334","url":null,"abstract":"<p><p>Various metabolic and cell signaling processes impact the functions of sugarcane plant cells. MicroRNAs (miRNAs) play critical regulatory roles in enhancing yield and providing protection against various stressors. This study seeks to identify and partially characterize several novel miRNAs in sugarcane using <i>in silico</i> tools, while also offering a preliminary assessment of their functions. This was accomplished by predicting novel conserved miRNAs in sugarcane plants using a variety of genomics-based techniques like BLASTn, MFOLD, psRNA Target, sequence logo, Weblogo, primer-3, etc. and annotated using miRBase and NCBI. For validation, RT-PCR method was used along with agarose gel. After the preparation of fourteen randomly chosen primers, they were validated by RT-PCR. Accordingly, they contain fifty specific targeted proteins with substantial targets in the structural, transcriptional protein, etc. Furthermore, the sof-miR5025a directs the heat repeat protein while the voltage-dependent anion is governed by sof-miR8005a. Similarly, the sof-miR7768b and sof-miR6249b monitor the pathogenesis-related protein and zinc finger, C₂H₂ type protein, which assist as transcription factors. Thus, the novel sugarcane miRNAs target a wide range of important genes help regulate the environment for sugarcane to generate a higher-quality crop.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2452334"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the efficacy of drought tolerant, IAA-producing plant growth-promoting rhizobacteria for sustainable agriculture.","authors":"Malika Uzma, Atif Nisar, Atia Iqbal, Shahida Hasnain, Mohamed H Mahmoud, Muhammad Abdul Rahim, Tehseen Gull, Roberto Castro-Muñoz, Eliasse Zongo","doi":"10.1080/15592324.2025.2452331","DOIUrl":"10.1080/15592324.2025.2452331","url":null,"abstract":"<p><p>The growing human population and abiotic stresses pose significant threats to food security, with PGPR favorable as biofertilizers for plant growth and stress relief. In one study, soil samples from both cultivated and uncultivated plants in various cities were used to isolate rhizobacterial populations. Using 50 soil samples from both cultivated and uncultivated plants, isolated rhizobacterial populations were screened for various biochemical changes, PGP activities and morphological characteristics. A total of 199 rhizobacteria were isolated and screened for IAA production. The strain M28 produced maximum IAA 378.44 ± 2.5 µg ml^-1, M9 formed only 34.72 ± 0.15 µg ml^-1. About 19% of IAA producers were isolated from Multan, 18% Lahore, 15% from soils of Faisalabad and Sheikhupura, while 7% from Gujrat. The 21 isolates were drought tolerant to -0.14Mpa, 14 of those were PSB and 15 were N fixers. In PGP traits, maximum zinc solubility was expressed by M4 as 2 ± 0.5 cm of zone. The strain M22 produced amount of HCN, 40.12 ± 0.052 ppm. All isolates showed diverse behavior in biocompatibility, motility patterns and hydrophobicity. Selected drought tolerant strains were genetically identified by ribotyping. Multitrait PGPR could be effective biofertilizers rather than with single trait. The strain M28 having highest production of IAA, was gelatinase, methyl red positive and was also capable of nitrogen fixation. Moreover, it had maximum swimming (8.9 mm) and swarming (8.7 mm) activities after 24 h, indicating its best PGP traits for future use.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2452331"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phylogenetic relationship of WRKY transcription factors in <i>Solanum</i> and potato genes in response to hormonal and biotic stresses.","authors":"Dequan Jiang, Wenjuan Huang, Jia Liu","doi":"10.1080/15592324.2025.2491465","DOIUrl":"https://doi.org/10.1080/15592324.2025.2491465","url":null,"abstract":"<p><p>WRKY transcription factors are important regulators of plant responses to environmental stresses and hormone signaling. This study analyzes the WRKY gene family in <i>Solanum tuberosum</i> by examining the phylogenetic relationships, expression profiles, and their roles in abiotic stress and hormone responses. Phylogenetic tree was constructed using 322 WRKY genes from four <i>Solanum</i> species: <i>S. tuberosum, S. pennellii, S. pimpinellifolium</i>, and <i>S. lycopersicum</i>. The results revealed conserved and expanded WRKY genes across these species. We then studied the expression of 75 SotuWRKY genes in response to salt, drought, heat stresses, and hormone treatments (IAA, ABA, BABA, GA3, and BAP). Results showed that 19, 25, and 29 genes were regulated under salt, drought, and heat stresses, respectively. Several WRKY genes (e.g. SotuWRKY03 and SotuWRKY24) were also regulated by biotic stresses like <i>Phytophthora infestans</i> infection and hormone treatments, indicating their involvement in plant defense mechanisms. A gene co-expression network was constructed based on gene-to-gene correlations, where <i>SotuWRKY52</i> was identified as a hub gene, positively regulating six WRKY genes and negatively regulating four. These findings suggest that potato WRKY genes play key roles in regulating stress responses and hormone signaling, potentially enhancing potato resistance to stresses and diseases. This study provides new insights into WRKY transcription factors in <i>S. tuberosum</i> and other <i>Solanum</i> species.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2491465"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biochemical and molecular mechanisms of plants: a review on insect herbivory.","authors":"Afeez Adesina Adedayo, Richard Musser, Mari Aanaenson, Olubukola Oluranti Babalola","doi":"10.1080/15592324.2024.2439248","DOIUrl":"https://doi.org/10.1080/15592324.2024.2439248","url":null,"abstract":"<p><p>Biochemical and molecular mechanisms have been essential mechanisms to reduce various insect attacks on plants. The biochemical methods are wide involving direct and indirect defenses. The defensive chemical substances are secreted effectively to the wound caused by the herbivores (insects and phytopathogens) on plants. Plants responded by producing VOCs which draw the natural enemies of the insects and phytopathogens. The progress observed in the cognition of the stimulus in plants and their potential to control the responses is characterized by the modification observed in molecular mechanisms which shifts our attention to the development of the endogenous resistance methods of preserving crops. The main objective of implementing a biotechnological mechanism in crop production is to employ durable and multimechanistic alternatives to insect pests via the stimulus the plant produces upon encountering the insect attack.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2439248"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do strigolactones play a role in the ascent and attachment behavior of <i>Pisum sativum</i>?","authors":"Bianca Bonato, Tom Bennett, Silvia Guerra, Sara Avesani, Umberto Castiello","doi":"10.1080/15592324.2024.2447455","DOIUrl":"https://doi.org/10.1080/15592324.2024.2447455","url":null,"abstract":"<p><p>Strigolactones (SLs) are signaling compounds made by plants. They play a crucial role in acting as long-distance signals from root to shoot to coordinate shoot growth with root environmental conditions. Here, we test whether and how SLs play a role in the climbing behavior of pea plants by studying the circumnutation of the tendrils using three-dimensional (3D) kinematical analysis. To assess this, we compare the typical behavior of <i>P. sativum</i>, a wild-type plant that produces and perceives SLs, with mutants defective in SLs synthesis or signaling, known as <i>ramosus</i>(<i>rms</i>) mutants. The results indicate that mutant plants seem unable to locate and grasp a potential support. Their movement appears to be disoriented and much less energized. We contend that this research opens new avenues for exploring SLs' role in plant behavior, a novel lens through which the role of SLs in root-to-shoot communication can be observed and analyzed.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2447455"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and transcriptomic profiling of tobacco growth-promoting arbuscular mycorrhizal fungi.","authors":"Shuang-Lin Yang, Xiao-Xu Bi, Bo Huang, Ti-Yuan Xia, Li-Juan Deng, Xiao-Qin Luo, Yu Zhong, Yu-Ping Zhang, Ying-Ying Qian, Min Yin, Zhen Ren","doi":"10.1080/15592324.2025.2467935","DOIUrl":"10.1080/15592324.2025.2467935","url":null,"abstract":"<p><p>Tobacco is a significant economic crop cultivated in various regions of China. Arbuscular mycorrhizal fungi (AMF) can establish a symbiotic relationship with tobacco and regulate its growth. However, the influences of indigenous AMF on the growth and development of tobacco and their symbiotic mechanisms remain unclear. In this study, a pot inoculation experiment was conducted, revealing that six inoculants - <i>Acaulospora bireticulata</i>(Ab), <i>Septoglomus viscosum</i>(Sv), <i>Funneliformis mosseae</i>(Fm), <i>Claroideoglomus etunicatum</i>(Ce), <i>Rhizophagus intraradices</i>(Ri), and the mixed inoculant (H) - all formed stable symbiotic relationships with tobacco. These inoculants were found to enhance the activities of SOD, POD, PPO, and PAL in tobacco leaves, increase chlorophyll content, IAA content， CTK content， soluble sugars, and proline levels while reducing malondialdehyde content. Notably, among these inoculants, Fm exhibited significantly higher mycorrhizal infection density, arbuscular abundance, and soil spore density in the root systems of tobacco plants compared to other treatments. Membership function analysis confirmed that Fm had the most pronounced growth-promoting effect on tobacco. The transcriptome analysis results of different treatments of CK and inoculation with Fm revealed that 3,903 genes were upregulated and 4,196 genes were downregulated in the roots and stems of tobacco. Enrichment analysis indicated that the majority of these genes were annotated in related pathways such as biological processes, molecular functions, and metabolism. Furthermore, differentially expressed genes associated with auxin, cytokinin, antioxidant enzymes, and carotenoids were significantly enriched in their respective pathways, potentially indirectly influencing the regulation of tobacco plant growth. This study provides a theoretical foundation for the development and application of AMF inoculants to enhance tobacco growth.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2467935"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plants have two minds as we do.","authors":"Tomonori Kawano, Yoshiaki Ushifusa, Stefano Mancuso, Frantisek Baluška, Lucia Sylvain-Bonfanti, Delphine Arbelet-Bonnin, François Bouteau","doi":"10.1080/15592324.2025.2474895","DOIUrl":"10.1080/15592324.2025.2474895","url":null,"abstract":"<p><p>This discussion paper carefully analyzes the cognition-related theories proposed for behavioral economics, to expand the concepts from human behaviors to those of plants. Behavioral economists analyze the roles of the intuitive sense and the rational thoughts affecting the human behavior, by employing the psychology-based models such as Two Minds theory (TMT) highlighting intuitive rapid thoughts (System 1) and rational slower thoughts (System 2) and Prospect theory (PT) with probability (<i>p</i>)-weighting functions explaining the human tendencies to overrate the low <i>p</i> events and to underrate the high <i>p</i> events. There are similarities between non-consciously processed System 1 (of TMT) and overweighing of low-<i>p</i> events (as in PT) and also, between the consciously processed System 2 (of TMT) and underrating of high-<i>p</i> events (as in PT). While most known <i>p</i>-weighting mathematical models employed single functions, we propose a pair of Hill-type functions reflecting the collective behaviors of two types of automata corresponding to intuition (System 1) and rationality (System 2), as a metaphor to the natural light processing in layered plant leaves. Then, the model was applied to two different TMT/PT-related behaviors, namely, preference reversal and habituation. Furthermore, we highlight the behaviors of plants through the above conceptual frameworks implying that plants behave as if they have Two Minds. Lastly, the possible evolutionary origins of the nature of Two Minds are discussed.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"20 1","pages":"2474895"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}