Canadian respiratory journal最新文献

{"title":"Effect and Safety of Bronchoscopy Based on Imaging Evaluation in Patients With Acute Exacerbation of Bronchiectasis.","authors":"Biliang Li, Zeng Juan, Mingfeng Wang, Wei Kang, Bo Li","doi":"10.1155/carj/3117887","DOIUrl":"10.1155/carj/3117887","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of imaging-assisted bronchoscopic interventions in acute bronchiectasis exacerbations and analyze their effects on pulmonary function, inflammation, and quality of life for evidence-based clinical support.</p><p><strong>Methods: </strong>A total of 80 inpatients with acute bronchiectasis exacerbations were randomized into a control group (n = 40), receiving conventional anti-infective and symptomatic treatment, and an intervention group (n = 40), receiving additional imaging-assisted bronchoscopic intervention. Pulmonary function, inflammatory markers (C-reactive protein [CRP], procalcitonin [PCT], and white blood cell count [WBC]), and St George's Respiratory Questionnaire (SGRQ) quality of life scores were assessed preintervention and at 1, 2, and 4 weeks. Adverse events (e.g., hemoptysis, pneumothorax, and infection spread) and overall effectiveness were recorded.</p><p><strong>Results: </strong>No significant intergroup differences were observed in baseline characteristics, preintervention pulmonary function (forced expiratory volume in the first second [FEV₁], forced vital capacity [FVC], and FEV₁/FVC), inflammatory markers (CRP, PCT, and WBC), or SGRQ scores (p > 0.05). After 1, 2, and 4 weeks, the intervention group demonstrated significantly greater improvements: higher FEV₁, lower CRP and PCT levels, and reduced SGRQ scores compared with the control group (p < 0.05). The generalized estimation equation (GEE) model revealed that the improvement magnitude in the intervention group increased over time (p < 0.001). The overall adverse event rate in the intervention group was 10.00% (4/40), significantly lower than the control group's 37.50% (15/40); the total effective rate was 92.50% (37/40), surpassing the control group's 70.00% (28/40) (p < 0.05).</p><p><strong>Conclusion: </strong>Bronchoscopy intervention guided by imaging improves lung function, reduces inflammation and adverse events, enhances quality of life, and demonstrates good safety with high clinical value in acute bronchiectasis exacerbations. The therapeutic benefit is likely attributable to the bronchoscopic procedure itself, including targeted pathogen identification and subsequent antibiotic modification, rather than solely to transient sputum clearance.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e3117887"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Analysis of Risk Factors for Death in Patients With TB Based on Clinical and Imaging Characteristics.","authors":"Jing Han, Peng Li, Lixia Shi, Yi Xie, Xiaolong Liu, Wanjie Yang, Zhiheng Xing","doi":"10.1155/carj/1050817","DOIUrl":"10.1155/carj/1050817","url":null,"abstract":"<p><strong>Background: </strong>This study was performed to explore the predictive factors for mortality among patients with tuberculosis undergoing directly observed treatment, short-course (DOTS) therapy and to develop a clinically applicable visualization tool for mortality risk prediction.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 9270 patients (8884 survivors and 386 deaths, yielding a mortality rate of 4.16%) from 2014 to 2024, utilizing data from the tuberculosis management information system in Tianjin. Cox proportional hazards regression was used to identify independent risk factors, a nomogram model was constructed, and model performance was evaluated using cross-validation and ROC curves.</p><p><strong>Results: </strong>Male sex, advanced age, human immunodeficiency virus-positive status, pulmonary cavities, initial sputum positivity, pericardial effusion, and miliary nodules emerged as independent risk factors for DOTS mortality. The nomogram demonstrated an area under the curve of 0.81 for predictions at 2, 6, and 12 months; calibration curves revealed high concordance between predicted and actual risk (with average absolute errors of 0.001, 0.001, and 0.004, respectively); receiver operating characteristic curves confirmed robust discriminative ability of the model.</p><p><strong>Conclusion: </strong>The nomogram developed in this study successfully integrates multiple mortality predictive factors and exhibits exhibiting excellent discriminatory power and calibration performance, thereby providing quantitative decision support for early identification and personalized intervention strategies in high-risk patients with tuberculosis receiving DOTS therapy.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e1050817"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13342835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated HMGB1 Levels in Neonates With Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.","authors":"Hejia Li, Jiao Li, Shanshan Li, Xiaojuan Huang, Shuaiyi Li, Wenhui Wu, Yuqing Fan, Yurun Wang, Yue Zhang, Jiashun Liu, Lu Zou, Changjun Ren, Shangbin Li","doi":"10.1155/carj/2816142","DOIUrl":"10.1155/carj/2816142","url":null,"abstract":"<p><strong>Background: </strong>To assess the clinical relevance of high-mobility group box 1 (HMGB1) in bronchopulmonary dysplasia (BPD), we conducted a systematic review and meta-analysis comparing HMGB1 levels in neonates with and without BPD.</p><p><strong>Methods: </strong>Eight databases (PubMed, Cochrane Library, Web of Science, Embase, CNKI, VIP, Wanfang, and CBM) were searched up to March 1, 2025. Cohort studies reporting serum or bronchoalveolar lavage fluid (BALF) HMGB1 levels in neonates were included. Meta-analysis was performed using RevMan 5.4.</p><p><strong>Results: </strong>Seven studies (n = 527 neonates; 308 BPD, 219 controls) were included. HMGB1 concentrations in BALF were significantly higher in neonates with BPD than in those without BPD (mean difference [MD], 5.04 ng/mL; 95% confidence interval [CI], 4.09-5.99; p < 0.00001). Serum HMGB1 concentrations were also higher in neonates with BPD (MD, 7.24 ng/mL; 95% CI, 4.53-9.96; p < 0.00001). Subgroup analyses across postnatal time points indicated that serum HMGB1 levels tended to be higher in infants with BPD than in controls; however, the progressive increase observed from Stage I to Stage III plateaued thereafter, with no further increase in Stage IV (> 20 days).</p><p><strong>Conclusion: </strong>Total HMGB1 concentrations in serum and BALF are elevated in neonates with BPD, which may reflect BPD-associated inflammatory lung injury. However, the clinical utility of HMGB1 is limited by its lack of disease specificity and the inability of current assays to distinguish among biologically distinct redox isoforms. Further prospective studies are needed to clarify its diagnostic and therapeutic relevance.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e2816142"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Integrated Mendelian Randomization and Single-Cell RNA Sequencing Analyses Reveal Lactate Metabolism as a Key Pathway in COVID-19-Induced Pulmonary Fibrosis\".","authors":"","doi":"10.1155/carj/9867178","DOIUrl":"https://doi.org/10.1155/carj/9867178","url":null,"abstract":"","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e9867178"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Novel Therapeutic Strategies for Pulmonary Arterial Hypertension.","authors":"Yalei Wang, Jiacheng Wu, Qian Ma, Hao Chen, Erha Lama, Yulu Yang, Jianwu Huang, Changhu Liu, Xiaofei Ni, Zhihua Qiu, Zihua Zhou","doi":"10.1155/carj/8046858","DOIUrl":"10.1155/carj/8046858","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) is a progressive, life-threatening disease characterized by vascular remodeling, endothelial dysfunction, and chronic inflammation. Despite existing targeted therapies, long-term outcomes remain poor, underscoring the need for more effective treatment. This review summarizes recent advancements in PAH therapy, emphasizing the integration of conventional medicine of the key pathways with nanoparticle-mediated drug delivery systems (nano-DDS), transforming growth factor beta/bone morphogenetic protein receptor type II, tyrosine kinase-based interventions, immunotherapies targeting inflammation and immune imbalance, and emerging molecular targets, including NOTCH3/HES-5 and E-selectin. Nano-DDS has improved drug bioavailability and targeting, opening new therapeutic possibilities. This article also discusses innovative approaches, such as endothelial-like progenitor cell-based cell therapy and the ETRQβ-002 vaccine. Future advancements in PAH treatment may result from the integration of conventional drugs, nanotechnology, and immunotherapy through multidisciplinary efforts.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e8046858"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13060647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Risk Factors and Development of a Predictive Nomogram for Bronchiolitis Obliterans in Children With Severe Adenovirus Pneumonia: A Retrospective Study.","authors":"Gang Chen, Xing Liu, Xiuchang Ma, Jinhuan Wu, Yaowen Liang, Yuchen Du, Xiaoyu Song, Wenxian Qian, Apeng Chen, Changhua Yi, Man Tian","doi":"10.1155/carj/2606203","DOIUrl":"10.1155/carj/2606203","url":null,"abstract":"<p><strong>Background: </strong>Bronchiolitis obliterans (BO) is a rare chronic pulmonary condition in pediatric patients, characterized by irreversible fibrotic constriction of the small airways. This study aims to analyze the risk factors for BO caused by severe adenovirus pneumonia (SAP) and to develop a nomogram model for personalized prediction.</p><p><strong>Methods: </strong>We retrospectively analyzed 251 children with SAP admitted to the Children's Hospital of Nanjing Medical University between January 2017 and March 2024. Among them, 77 were classified into the BO group and 174 into the non-BO group. A predictive nomogram was developed based on independent risk factors identified through univariate analysis, least absolute shrinkage and selection operator (LASSO) regression, and multivariate logistic regression.</p><p><strong>Results: </strong>Multivariable analysis identified the following independent risk factors for BO: wheezing (odds ratio [OR] = 4.78; 95% confidence interval [CI], (2.00∼11.40); p < 0.001), large lobar consolidation (OR = 8.53; 95% CI, 3.63∼20.02; p < 0.001), length of hospital stay (OR = 1.20; 95% CI, 1.08-1.33; p < 0.001), and duration of fever (OR = 1.20; 95% CI, 1.09-1.32; p < 0.001). Mechanical ventilation showed a trend toward increased risk but did not reach statistical significance (OR = 5.35; 95% CI, 0.74-38.56; p = 0.096). The nomogram demonstrated excellent discriminative ability, with an area under the curve of 0.90 (95% CI: 0.85-0.94). Calibration curves indicated good agreement between predicted and observed outcomes. Decision curve analysis showed a net clinical benefit within a clinically relevant threshold probability range of 0.10-0.70.</p><p><strong>Conclusions: </strong>A nomogram incorporating five independent risk factors-wheezing, duration of fever, length of hospital stay, mechanical ventilation, and large lobar consolidation-was developed to predict BO risk in children with SAP.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e2606203"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Lung Biopsy in Infants up to 3 Months With Diffuse Lung Disease in a Resource-Limited Setting.","authors":"Pierre Goussard, Pawel Schubert, Lizelle van Wyk, Lynn Booysen, André Gie, Michael Urban, Jacques Janson, Savvas Andronikou, Ernst Eber","doi":"10.1155/carj/1509295","DOIUrl":"10.1155/carj/1509295","url":null,"abstract":"<p><strong>Introduction: </strong>Neonatal lung biopsy guides management of unusually severe, diffuse lung disease with an uncertain diagnosis. Childhood interstitial lung disease (chILD) constitutes a diverse group of uncommon respiratory diseases which are associated with major morbidity and mortality. The incidence, outcome and mortality of chILD and other severe respiratory diseases in resource-limited settings (RLS) are unclear.</p><p><strong>Objective: </strong>This retrospective, descriptive study examined lung biopsy in an RLS on infants up to 3 months of age to diagnose and facilitate management. This study included neonates with severe respiratory distress not responding to surfactant replacement.</p><p><strong>Results: </strong>Lung biopsy was diagnostic in 94% (29/31) of patients without procedure-related mortality. The mean gestational age at birth was 35.8 weeks (SD ± 4.6). The mean presentation age was 20 days of life (IQR 1-28). Of 31 participants, 16% (n = 5) had histological findings in keeping with pulmonary interstitial glycogenosis (PIG) only. Sixteen percent (n = 5) of biopsies showed findings in keeping with adenosine triphosphate (ATP)-binding cassette subfamily A member 3 (ABCA3) deficiency in combination with features of PIG on electron microscopy. Surfactant protein (SFTP)-B deficiency and undefined surfactant deficiency were equally prevalent (6% (n = 2). Pulmonary hypertension (PHT) featured in 61% (n = 17) of infants. Genetic testing was performed on 29% (n = 9) of infants, with 56% (n = 5) showing normal results. The cohort mortality was 42% (n = 13).</p><p><strong>Conclusions: </strong>ChILD should be considered in neonates with severe respiratory distress and PHT not responding to surfactant replacement. Lung biopsy is safe and diagnostic and may prevent long and futile treatment. Histopathological diagnosis frequently assists treatment decisions. Future multicentre studies should include children from an RLS to collect information on diagnoses, genetics and treatment responses.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e1509295"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13533072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening Potential Diagnostic Biomarkers of Lung Adenocarcinoma Related to Immune Infiltration Based on Single-Cell Proteomic Integration Analysis.","authors":"Ningxin Xu, Yuwei Zhang, Qiongke Lian, Yanan Cai, Mingli Ni","doi":"10.1155/carj/7004493","DOIUrl":"https://doi.org/10.1155/carj/7004493","url":null,"abstract":"<p><strong>Background: </strong>Macrophages play a crucial role in mediating immune infiltration in lung adenocarcinoma (LUAD). However, the potential of macrophage-related targets in the diagnosis and treatment of LUAD remains largely unexplored.</p><p><strong>Methods: </strong>The proteome data of LUAD were obtained from the CPTAC database, and the single-cell sequencing (scRNA-seq) data of non-small-cell lung cancer (NSCLC) were collected from the GEO database. The differentially expressed proteins (DEPs) of LUAD and module proteins closely associated with clinical features were analyzed by the limma tool and WGCNA. The 61 intersection targets of DEPs and WGCNA were obtained for GO and KEGG pathway enrichment analysis. Machine learning (random forest algorithm, LASSO regression analysis, and support vector machine recursive feature elimination algorithm) approaches screened the hub targets related to macrophages in LUAD. The CIBERSORT method and GSEA were used to explore the connection between key targets and immune cells. ROC curve was used to construct genetic diagnosis model, and the potential targeted drugs of four hub genes were screened by DSigDB database.</p><p><strong>Results: </strong>A total of 1149 DEPs in LUAD and 65 proteins associated with clinical features were screened. After the intersection, 61 targets were obtained for GO and KEGG analysis. Macrophages were the key cell type in LUAD, which had 5438 differentially expressed genes in LUAD. Moreover, 13 intersection targets were obtained by taking the intersection of proteomes (61 targets) and macrophage-related genes (5438 genes). And seven targets (CRYAB, EHD2, FHL1, TNS1, TNXB, SORBS2, and LTBP4) were obtained through machine learning. Based on CIBERSORT method and GSEA enrichment results, four genes (TNS1, EHD2, CRYAB, and TNXB) related to immune infiltration were screened. ROC analysis combined with the nomogram-related model showed that only four hub genes (EHD2, FHL1, TNS1, and SORBS2) could be used as diagnostic biomarkers, and their potential therapeutic drugs were revealed.</p><p><strong>Conclusion: </strong>This study identified four hub targets, which have certain value in the diagnosis and the development of targeted drugs for LUAD.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e7004493"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Errors in Inhaler Technique Among Patients With Asthma and COPD: A Cross-Sectional Study in a Real-World Setting.","authors":"Italo Henrique Medeiros Damasceno, Ricardo José Fonseca De Oliveira, Sabrina Joany Felizardo Neves, Rand Randall Martins, Rodrigo Dos Santos Diniz","doi":"10.1155/carj/8222875","DOIUrl":"10.1155/carj/8222875","url":null,"abstract":"<p><strong>Background: </strong>The correct use of inhalation devices is essential for achieving adequate control of asthma and COPD; however, critical errors in inhalation technique are frequent and substantially reduce treatment effectiveness. This study's objective was to evaluate the prevalence of inadequate inhalation technique among patients with asthma and COPD and to identify the most common critical errors and the factors associated with incorrect use.</p><p><strong>Methods: </strong>This cross-sectional observational study included 575 patients (aged ≥ 18 years) with asthma and/or COPD, recruited from a university hospital outpatient pulmonology clinic and a public specialized pharmacy (Natal, Brazil). Participants completed sociodemographic questionnaires and demonstrated their inhaler technique, which was assessed using device-specific checklists to identify critical errors. Factors associated with critical errors were analyzed using multivariable logistic regression.</p><p><strong>Results: </strong>Only 8.2% of participants correctly performed all steps of the inhalation technique. At least one critical error was observed in 73.4% of the cohort. In multivariable analysis, advanced age (OR: 1.029; 95% CI: 1.016-1.044), use of multiple devices (OR: 2.500; 95% CI: 1.754-3.562), and type of mechanism independent of inspiration (OR: 0.262; 95% CI: 0.160-0.430; protective factor) were significantly associated with critical errors (p < 0.001).</p><p><strong>Conclusions: </strong>Inadequate inhalation technique, particularly the occurrence of critical errors, was highly prevalent, especially among older patients and those using multiple devices. Inhalers dependent on inspiratory effort demonstrated greater vulnerability to incorrect use.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e8222875"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Trends and Research Frontiers in Climate Change and Asthma: Insights From a Two-Decade Bibliometric Analysis.","authors":"Yixin Wang, Huanxia Qu, Xinchen Shu, Qi Liu, Jiaxin Cao, Yuxin Liu, Feng Jiang, Jin Shu","doi":"10.1155/carj/5546333","DOIUrl":"10.1155/carj/5546333","url":null,"abstract":"<p><strong>Background: </strong>Climate change has emerged as a major public health challenge, with significant implications for respiratory diseases such as asthma. Environmental factors, including air pollution, aeroallergens, and extreme weather events, are closely linked to asthma exacerbations, yet the global research landscape on this topic remains fragmented. This study aimed to systematically map research trends, hotspots, and emerging frontiers in the field of climate change and asthma over the past two decades.</p><p><strong>Methods: </strong>Publications from January 1, 2005, to March 31, 2025, were retrieved from the Web of Science Core Collection (WoSCC) using a defined search strategy. Only articles and reviews in English were included, resulting in a final dataset of 1033 publications. CiteSpace was employed for bibliometric analysis, including coauthorship, cocitation, and keyword co-occurrence mapping, as well as cluster and burst detection, to identify influential contributors, collaborative networks, and thematic evolution.</p><p><strong>Results: </strong>Annual publications increased steadily, peaking in 2024. The United States and China were the most prolific countries, with Harvard T.H. Chan School of Public Health, Harvard University, and Columbia University among the leading institutions. Key research hotspots included climate-related environmental exposures (e.g., PM2.5, ozone, and temperature variability), allergen dynamics (e.g., pollen, ragweed, and fungal spores), vulnerable populations (particularly children), and public health impacts. Emerging frontiers encompassed interdisciplinary integration, predictive modeling, mechanistic studies focusing on oxidative stress and immune regulation, and climate adaptation strategies. Despite progress, challenges remain in integrating asthma-specific measures into climate-health policies, conducting long-term multinational studies, and advancing translational research.</p><p><strong>Conclusions: </strong>This bibliometric analysis provides a comprehensive overview of the global research landscape on climate change and asthma, revealing thematic evolution from allergen and epidemiological studies toward mechanistic and policy-oriented research. Strengthening interdisciplinary collaboration, enhancing global data sharing, and embedding asthma prevention into broader climate mitigation and adaptation frameworks will be critical for reducing the respiratory health burden in a changing climate.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e5546333"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}