Canadian respiratory journal最新文献

{"title":"Mortality Trends in Patients Aged 25 and Older With Comorbid COPD and Diabetes Mellitus in the United States: A CDC WONDER Database Study From 2000 to 2023.","authors":"Muhammad Ahmed, Saba Fatima, Shaheer Bin Shafiq, Khubaib Tariq Mansoor, Fatima Aqsa, Muhammad Abdullah Naveed, Ahila Ali, Harigopal Sandhyavenu, Binish Qureshi, Sivaram Neppala","doi":"10.1155/carj/3655829","DOIUrl":"10.1155/carj/3655829","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD) are among the leading chronic diseases that significantly impact global morbidity and mortality. Growing evidence indicates a bidirectional interplay between metabolic and pulmonary dysfunction. This study aims to identify the demographic and regional trends of DM and COPD-related mortality in the United States from 2000 to 2023.</p><p><strong>Methodology: </strong>DM- and COPD-related deaths in the United States from 2000 to 2023 were obtained from the CDC WONDER database using ICD-10 code E10-14 for DM and J40-44 as the underlying cause of death. Results are presented as age-adjusted mortality rates (AAMR) per 100,000 population, with Joinpoint regression used for trend analysis and to calculate annual percentage change (APC).</p><p><strong>Results: </strong>A total of 796,757 DM- and COPD-related deaths were recorded. From 2000 to 2008, the AAMR for DM and COPD increased from 11.19 to 14.32, remaining relatively stable until 2018. This was followed by a significant rise to 19.03 in 2021 (APC: 10.57), before declining to 16.28 in 2023 (APC: -9.08). Men demonstrated a higher AAMR (19.28) than women (12.02); however, both experienced decline post-2021, with rates falling to 20.54 in men (APC: -9.08) and 13.02 in women (APC: -8.33). AAMR increased among all racial groups except Asians and Hispanics. From 2000 to 2021, American Indians had the highest AAMR (30.48). After 2021, AAMR declined across all groups. Rural areas reported higher AAMR (19.02), compared to urban areas (12.85). AAMR in rural areas increased markedly from 2018 to 2020 (13.67). State-level comparisons revealed substantial variation in AAMR. Oklahoma had the highest rate at 28.79, followed by West Virginia (28.53), Kentucky (26.74), Vermont (23.95), and Mississippi (20.83). In contrast, Hawaii (6.69), Utah (7.33), and Massachusetts (7.99) reported the lowest rates, all below 10. Regionally, the Midwest had the highest average AAMR (16.30).</p><p><strong>Conclusion: </strong>COPD-related diabetes mortality rose from 2000 to 2020, highest among men, Non-Hispanic American Indians, and rural populations, and then declined post-2021. Findings indicate increased vulnerability during acute events, highlighting the need for targeted interventions.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e3655829"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embosphere With or Without Coils in the Treatment of Hemoptysis: A Propensity-Matched Analysis of Recurrence and Safety.","authors":"Hong-Dou Xu, Liang Yang, Yao Xing, Shi-Bing Hu, Teng Xia","doi":"10.1155/carj/5015609","DOIUrl":"10.1155/carj/5015609","url":null,"abstract":"<p><strong>Background: </strong>BAE has become a well-established, minimally invasive first-line therapy for hemoptysis. Coils may be useful in selected vascular lesions, including pseudoaneurysms and arteriovenous malformations, but their more proximal occlusive effect may limit distal access and could affect later retreatment and whether adding coils to embosphere embolization improves clinical outcomes remains uncertain. We compared recurrence and safety after embosphere-based BAE performed with or without adjunctive coils.</p><p><strong>Methods: </strong>We retrospectively reviewed all consecutive adult patients who underwent first-time BAE for hemoptysis at our single tertiary care center between January 2019 and December 2024. Patients treated with embosphere were grouped according to whether coils were also deployed. Residual confounding arising from baseline covariate imbalances was mitigated via 1:1 propensity score-based matching, with matched pairs constrained to a caliper of 0.2 standard deviations of the logit of the propensity score. Kaplan-Meier analysis was used to estimate survival without hemoptysis recurrence, and the results were further analyzed based on the cause of hemoptysis. Factors linked to recurrent hemoptysis were evaluated using Cox proportional hazards models.</p><p><strong>Results: </strong>The study cohort included 260 patients (median age, 56 years; 161 women), of whom 82 received embosphere plus coils and 178 received embosphere without coils. Propensity score matching yielded 62 patients in each group. At 1, 3, and 5 years prior to matching, recurrence-free survival stood at 92.6%, 75.0%, and 59.2% in the coil cohort, respectively, compared with 90.9%, 76.0%, and 50.3% in the control cohort (p = 0.979). After matching, the corresponding rates were 91.8%, 73.8%, and 51.8% versus 85.2%, 66.8%, and 40.5% (p = 0.358). Etiology-stratified analyses also showed no significant benefit from coil use after matching (bronchiectasis, p = 0.770; tuberculosis [TB] sequelae, p = 0.868; non-TB and nonbronchiectasis, p = 0.835). The duration of the procedure varied significantly between the groups (p = 0.003), while the rates of complications showed no significant difference (p = 0.181). On multivariable analysis, TB sequelae emerged as an independent predictor of recurrent bleeding, with a hazard ratio (HR) of 1.69 (95% CI 1.20-2.15, p = 0.002). Systemic arterial-pulmonary shunts (SPSs) were also independently tied to recurrence, carrying an HR of 1.52 (95% CI 1.32-3.72, p = 0.048).</p><p><strong>Conclusions: </strong>In patients undergoing embosphere-based BAE for hemoptysis, adjunctive coils did not improve long-term recurrence-free survival or reduce complications. Coil use was associated with shorter procedure duration.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e5015609"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Prediction of Necrotizing Pneumonia in Children With Mycoplasma pneumoniae: A Model Based on Early Response to Therapy.","authors":"Jia Feng Zheng, Meng Yao Zhang, Han Quan Dong, Bo Wang, Yong Sheng Xu","doi":"10.1155/carj/3623045","DOIUrl":"10.1155/carj/3623045","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify factors that predict progression to necrotizing pneumonia (NP) in children with Mycoplasma pneumoniae pneumonia (MPP) who fail to respond to initial therapy and to develop a predictive model to support early clinical decision-making.</p><p><strong>Methods: </strong>We retrospectively analyzed clinical and laboratory data of children with macrolide-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP) admitted to Tianjin Children's Hospital from January 2021 to January 2025. MUMPP was defined as persistent fever (≥ 38.5°C, lasting ≥ 4 h/day) after ≥ 72 h of standardized intravenous macrolide therapy. Patients were classified into an observation group (n = 106, those who developed NP) and a control group (n = 130, those who did not). Independent predictors of NP were identified by multivariable logistic regression and incorporated into a nomogram. Model performance was evaluated using ROC analysis, calibration plots, and decision curve analysis.</p><p><strong>Results: </strong>In multivariable analysis, increased white blood cell (WBC) count (OR = 2.484, 95% CI: 1.406-4.613), longer fever duration (OR = 1.618, 95% CI: 1.217-2.193), pleural effusion (OR = 3.955, 95% CI: 1.664-10.00), and elevated C-reactive protein (CRP) (OR = 2.152, 95% CI: 1.547-3.074) were independently associated with NP among children with MPP after initial treatment failure. Calibration curves indicated close agreement between predicted and observed risks in both the derivation cohort (p = 0.588) and the validation cohort (p = 0.424). The model showed good discrimination, with an AUC of 0.848 (95% CI: 0.789-0.908) in the derivation cohort and 0.889 (95% CI: 0.815-0.963) in the validation cohort. Decision curve analysis suggested net clinical benefit across relevant threshold probabilities.</p><p><strong>Conclusion: </strong>Among children with MUMPP, higher WBC count, prolonged fever, pleural effusion, and higher CRP identify increased risk of NP.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e3623045"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Rosiglitazone Supplementation Mitigates Pulmonary Cellular Stress Response During Lipopolysaccharide-Evoked Acute Lung Injury in Mice.","authors":"Jun-Ping Wei, Wei Cao, Zhao-Fei Liu, Zhen Liu, Zhen-Zhen Cao, Xiu Lu, Jia-Le Li, Min-Min Tang, Dong-Xu Hua, Lin Fu, Jun Fei, Ling Zheng","doi":"10.1155/carj/1600008","DOIUrl":"10.1155/carj/1600008","url":null,"abstract":"<p><p>Cellular stress is implicated in the progression of lipopolysaccharide (LPS)-evoked acute lung injury (ALI). The goal of this study was to evaluate the effect of oral supplementation with rosiglitazone (RSG), which is an agonist of peroxisome proliferator-activated receptor (PPAR)-γ, on pulmonary inflammatory response, oxidative stress, and endoplasmic reticulum (ER) stress during LPS-evoked ALI in mice. The mice were randomly divided into four groups and orally supplemented with or without RSG (10 mg/kg) once daily for 5 consecutive days before LPS (1 mg/kg) intraperitoneal injection. The mice were sacrificed at 12 h after LPS injection. As expected, LPS-evoked ALI and death were attenuated in mice that were pretreated with RSG. LPS-evoked increase in chemokines (KC, MIP-2, and MCP-1) and proinflammatory cytokines (TNF-α and IL-1β) was inhibited in the mouse lungs by RSG. RSG pretreatment significantly mitigated LPS-evoked nuclear translocation of NF-κB p65 and p50, which regulate inflammatory gene transcription in the lungs. Additionally, LPS-evoked glutathione depletion and lipid peroxidation were alleviated by RSG. The abnormal expression of NADPH oxidases and antioxidant enzymes was restored in the lung tissues by RSG. Further experiments revealed that LPS-evoked upregulation of GRP78, p-IRE1α, and p-EIF2α was blocked by RSG pretreatment. Mechanistically, RSG pretreatment enhanced PPARγ activity in the mouse lungs and bronchial epithelial cells. RSG promoted the interaction between NF-κB p65 and PPARγ in the mouse lungs. Overall, RSG pretreatment protects against LPS-evoked ALI partially through enhancing PPARγ activity and inhibiting the cellular stress response in the mouse lungs.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e1600008"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current Application Status of Pulmonary Function Testing in West China: A Cross-Sectional Survey and Analysis.","authors":"Naer An, Lijuan Gao, Jiangyue Qin, Weiguo Xu, Hailong Wei, Meng Li, Weiling Cai, Zhenni Chen, Lian Liu, Binmiao Liang, Yongchun Shen, Fuqiang Wen","doi":"10.1155/carj/7373734","DOIUrl":"10.1155/carj/7373734","url":null,"abstract":"<p><p>Pulmonary function testing (PFT) is a critical diagnostic and management tool for respiratory diseases, yet its implementation in China, particularly within primary hospitals, remains suboptimal. To investigate the current application status of PFTs specifically in western China, a cross-sectional survey based on an online questionnaire was conducted. Physicians from various hospitals completed this questionnaire, designed according to Chinese PFT Guidelines, during 2023-2024, and the analysis focused on the final valid responses. The study ultimately included data from 488 hospitals. A total of 97.13% were public institutions. A total of 38.32% had established independent respiratory departments. The overall PFT availability was 56.76%, 100.00% in tertiary hospitals, and only 25.00% in primary hospitals. A total of 42.24% of the hospitals had a daily workload of less than 5 people. The primary tests included pulmonary ventilation tests (100.00%), pulmonary volume tests (73.65%), and bronchial dilation tests (72.92%). Instrument calibration was performed in 83.03% of the hospitals, and 68.59% of the hospitals considered filter resistance. Over 60.00% of hospitals used estimated values provided by instruments as sources for PFT. A total of 65.70% of hospitals had a limited number of operators. In conclusion, the application of PFT in western China is characterized by a low implementation rate, imbalanced distribution, limited test variety, and insufficient personnel, especially in primary hospitals. It is essential to promote the widespread implementation and standardization of PFTs in western China.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e7373734"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicosis Among Engineered Stone Workers in Ontario, Canada: A Case Series of 20 Patients.","authors":"Abeer Abdelsayad, Ambrose Lau, Susan M Tarlo","doi":"10.1155/carj/9386297","DOIUrl":"10.1155/carj/9386297","url":null,"abstract":"<p><strong>Background: </strong>Silicosis is a preventable occupational lung disease caused by inhalation of respirable crystalline silica. Although traditionally associated with mining, it is increasingly recognized among workers who fabricate engineered stone, also referred to as artificial stone, for kitchen and other countertops. In Canada, updated surveillance data are limited, and no published case series have characterized engineered stone-associated silicosis.</p><p><strong>Methods: </strong>We report a retrospective case series of 20 patients diagnosed with silicosis following occupational exposure to engineered stone in Ontario, Canada, between November 2015 and September 2025. Demographic, occupational, clinical, radiologic, and functional data were extracted from medical records. Continuous variables are reported as median and interquartile range (IQR).</p><p><strong>Results: </strong>The median age at diagnosis was 52 years (IQR: 41.5-64.5), and all patients were male, predominantly immigrants from Southeast Asia. Median occupational exposure to silica was 19 years (IQR: 10.5-27.5). Although 80% reported respirator use, adherence was inconsistent, and workplace controls were often inadequate. Cough and dyspnea were the most common presenting symptoms (60% each), with a median diagnostic delay of 13.5 months. Imaging showed simple silicosis in 70% and progressive massive fibrosis in 30%. Pulmonary function tests demonstrated predominantly restrictive impairment with reduced diffusion capacity. Outcomes were significant, including 15% mortality, median age at death of 43 years, chronic hypoxia in 35%, and lung transplant referral in 30%.</p><p><strong>Conclusions: </strong>Engineered stone-associated silicosis in Ontario is characterized by prolonged silica exposure, inadequate workplace protections, delayed diagnosis, and severe disease at presentation. These findings underscore the urgent need for strengthened regulatory measures to protect engineered stone workers: more effective occupational silica exposure controls, systematic respiratory health surveillance of workers at risk, and earlier recognition and diagnosis of silicosis.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e9386297"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular Loop Ligation for Securing Endobronchial Valve in the Treatment of Bronchial Stump Fistula.","authors":"Liping Wang, Jiagan Xu, Zhongliang He, Shunxin Xin, Congbin Peng, Weihua Xu","doi":"10.1155/carj/3080005","DOIUrl":"10.1155/carj/3080005","url":null,"abstract":"<p><strong>Background: </strong>Bronchial stump fistula (BSF), which is located on the bronchial stump following pulmonary resection, represents a distinct subtype of bronchopleural fistula (BPF). Although the endobronchial valve (EBV) has been used to treat BPF, few clinical studies involve BSF occluded by EBV because the abnormal bronchial stump makes EBV implantation challenging. The present research reports novel methods of using a circular loop ligation technique for securing EBV to achieve BSF occlusion and a new classification of BSF that is compatible with these novel methods.</p><p><strong>Methods: </strong>Based on the length of the bronchial stump, small visible BSF (SVBSF, less than 8 mm) is classified into the following types: SVBSF1 (< 3 mm), SVBSF2 (≥ 3 mm but shorter than a normal bronchus), and SVBSF3 (preserves a complete bronchial structure). SVBSF2 is further classified into SVBSF2a (the stump base remains partially intact) and SVBSF2b (complete destruction of the stump base). This retrospective research involved SVBSF2 patients who underwent EBV fixation with circular loop ligation. Detailed medical records were collected and analyzed to evaluate the efficacy of the novel procedure.</p><p><strong>Results: </strong>A total of 15 patients underwent EBV implantation and fixation. All patients achieved a resolution of air leakage. Postoperative assessment revealed no instances of EBV displacement among VBSF2a patients, with all cases exhibiting significant improvement.</p><p><strong>Conclusions: </strong>The circular loop ligation methods for securing the EBV enable effective BSF closure in SVBSF2, especially SVBSF2a cases. This technique enables some BSF patients with abnormal structures at bronchial stumps to successfully perform the EBV occlusion.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e3080005"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13507704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Endothelial Cell Perspective in Pulmonary Fibrosis: From Cell Fate Decisions, Intercellular Communication, and EndoMT to Emerging Therapies.","authors":"Danni Chen, Fei Xiang","doi":"10.1155/carj/6653364","DOIUrl":"10.1155/carj/6653364","url":null,"abstract":"<p><p>Pulmonary fibrosis (PF) is a progressive fibrotic interstitial lung disease characterized by aberrant activation of myofibroblasts and excessive deposition of extracellular matrix. In light of the complexity of its pathogenesis and the limited availability of approved antifibrotic drugs, PF remains a refractory lung disease imposing a substantial burden on patients. Current research into the pathogenesis of PF has largely revolved around the core hypothesis of recurrent microinjuries to alveolar epithelial cells. However, in recent years, increasing attention has been directed toward the role of endothelial dysfunction in the progression of fibrosis. This review focuses on pulmonary microvascular endothelial cells and systematically examines their regulatory mechanisms in the initiation and progression of PF from three perspectives: endothelial cell senescence and programmed cell death, intercellular crosstalk between endothelial cells and surrounding cells, and endothelial-mesenchymal transition (EndoMT). Furthermore, we summarize antifibrotic drugs and therapeutic strategies targeting endothelial cells, providing theoretical insights and research directions to elucidate the pathogenesis of PF and explore novel therapeutic approaches.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e6653364"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Bronchiectasis Health Questionnaire (BHQ) in Chinese Patients With Noncystic Fibrosis Bronchiectasis.","authors":"Wang Chun Kwok, Terence Chi Chun Tam, Samuel Shung Kay Chan, James Chung Man Ho, Edmond Pui Hang Choi","doi":"10.1155/carj/5551480","DOIUrl":"10.1155/carj/5551480","url":null,"abstract":"<p><strong>Background: </strong>The Bronchiectasis Health Questionnaire (BHQ) was developed to assess the health-related quality of life (HRQOL) in patients with noncystic fibrosis (CF) bronchiectasis. This study aimed to translate, culturally adapt, and validate the BHQ for use among Chinese patients.</p><p><strong>Methods: </strong>The traditional Chinese version of the BHQ (TC-BHQ) was created through a process of translation, cognitive debriefing interviews, and expert panel reviews. The psychometric evaluation of the TC-BHQ encompassed assessments of factor structure, convergent validity, known-group comparison, internal consistency, and test-retest reliability.</p><p><strong>Results: </strong>We recruited 150 non-CF bronchiectasis patients. Confirmatory factor analysis (CFA) supported the one-factor structure of the BHQ. In terms of concurrent validity, the TC-BHQ total score showed a significant correlation with the St. George's Respiratory Questionnaire (SGRQ) total score (r = -0.77,  p < 0.01). In addition, the TC-BHQ total score significantly correlated with all SGRQ subscale scores, including the symptom score (r = -0.62,  p < 0.01), activity score (r = -0.60,  p < 0.01), and impact score (r = -0.75,  p < 0.01). There was a statistically significant change in the total score between baseline and follow-up (p = 0.007). Both internal consistency and test-retest reliability of the TC-BHQ were acceptable.</p><p><strong>Conclusion: </strong>TC-BHQ is a promising tool for assessing HRQOL in patients with non-CF bronchiectasis. It has the potential to be a useful instrument in both clinical and research settings.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e5551480"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis Between Immune Status and Bronchoscopic Airway Findings in Various Ages of SMPP Children.","authors":"Peng Li, Ruiyang Sun, Jiapu Hou, Zewen Ding, Wanyu Jia, Shuqin Fu, Junhao Cui, Chunlan Song","doi":"10.1155/carj/6145605","DOIUrl":"10.1155/carj/6145605","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between trends in immune markers and airway mucosal changes in SMPP by controlling for age.</p><p><strong>Study design: </strong>A total of 302 children with SMPP admitted to Henan Children's Hospital from 2018 to 2024 were selected as the study subjects for retrospective analysis, while 133 children with GMPP were selected as the control group. The children were divided into infancy groups, toddler groups, preschool age groups, and school age groups according to their ages.</p><p><strong>Results: </strong>(1) There were significant differences in some clinical manifestations and laboratory hematological indices among SMPP children of various ages. (2) In the SMPP group, compared to toddlers and preschool children, school-aged children had a higher rate of mucosal erosion, and compared to infants, school-aged children had a higher rate of mucous plug blockage (p < 0.05). (3) Pearson correlation analysis revealed that IgM was positively correlated with mucosal erosion and mucous plug plugging, the AGR was negatively correlated with mucosal erosion and mucous plug plugging, and the NLR and D-D were positively correlated with mucous plug plugging in preschool-aged and school-aged children. IgA and FIB were positively correlated with mucous plug blockage, and FIB was positively correlated with mucosal erosion in school-aged children with SMPP (p < 0.05).</p><p><strong>Conclusion: </strong>IgM, IgA, NLR, AGR, FIB, and D-D in preschool-aged and school-aged children with MP infection are potential markers of disease severity and the degree of airway mucosal damage.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e6145605"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}