ILD-GAP联合Charlson共病指数评分(ILD-GAPC)作为间质性肺疾病患者的预后预测模型

IF 2.1 4区 医学 Q3 RESPIRATORY SYSTEM
Hiroaki Fujii, Yu Hara, Yusuke Saigusa, Yoichi Tagami, Kota Murohashi, Ryo Nagasawa, Ayako Aoki, Ami Izawa, Kenichi Seki, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
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引用次数: 1

摘要

背景:ILD- gap评分系统已被广泛用于预测间质性肺疾病(ILD)患者的预后。探讨ILD- gap评分系统联合Charlson共病指数评分(CCIS) (ILD- gapc)预测ILD预后的能力。方法:在2013年4月至2017年4月期间治疗的ILD患者,包括特发性肺纤维化(IPF)、特发性非特异性间质性肺炎(iNSIP)、胶原血管病相关间质性肺炎(CVD-IP)、慢性超敏性肺炎(CHP)和不可分类ILD (UC-ILD),回顾性评估基线临床参数(包括年龄、性别、CCIS、ILD诊断、肺功能检查结果和疾病结局)之间的关系。比较ILD-GAP和ILD-GAPC模型对预后的预测能力。结果:共185例患者(平均年龄71.9岁)接受肺功能测试,包括预测的一氧化碳扩散能力百分比。诊断为IPF 57例,iNSIP和CVD-IP 117例,CHP 6例,UC-ILD 5例。与ILD-GAP(0.721)相比,ILD-GAPC在预测3年ild相关事件时提供了更大的受试者工作特征曲线下面积(0.758)。此外,log-rank检验显示,低、中、高ILD-GAPC评分的Kaplan-Meier曲线差异显著(P < 0.001),与ILD-GAP评分不同(P = 0.083)。结论:ILD- gapc模型比ILD- gap模型更能准确预测ILD患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ILD-GAP Combined with the Charlson Comorbidity Index Score (ILD-GAPC) as a Prognostic Prediction Model in Patients with Interstitial Lung Disease.

ILD-GAP Combined with the Charlson Comorbidity Index Score (ILD-GAPC) as a Prognostic Prediction Model in Patients with Interstitial Lung Disease.

ILD-GAP Combined with the Charlson Comorbidity Index Score (ILD-GAPC) as a Prognostic Prediction Model in Patients with Interstitial Lung Disease.

ILD-GAP Combined with the Charlson Comorbidity Index Score (ILD-GAPC) as a Prognostic Prediction Model in Patients with Interstitial Lung Disease.

Background: The ILD-GAP scoring system has been widely used to predict the prognosis of patients with interstitial lung disease (ILD). The ability of the ILD-GAP scoring system combined with the Charlson Comorbidity Index score (CCIS) (ILD-GAPC) to predict ILD prognosis was investigated.

Methods: In ILD patients, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (iNSIP), collagen vascular disease-related interstitial pneumonia (CVD-IP), chronic hypersensitivity pneumonitis (CHP), and unclassifiable ILD (UC-ILD), treated between April 2013 and April 2017, the relationships between baseline clinical parameters, including age, sex, CCIS, ILD diagnosis, pulmonary function test results, and disease outcomes, were retrospectively assessed, and the ability to predict prognosis was compared between the ILD-GAP and ILD-GAPC models, respectively.

Results: A total of 185 patients (mean age, 71.9 years), all of whom underwent pulmonary function testing, including percentage predicted diffusion capacity for carbon monoxide, were assessed. ILD diagnosis consisted of IPF in 57 cases, iNSIP and CVD-IP in 117 cases, CHP in 6 cases, and UC-ILD in 5 cases. The ILD-GAPC provided a greater area under the receiver operating characteristic curve (0.758) for predicting 3-year ILD-related events than the ILD-GAP (0.721). In addition, log-rank tests showed that the Kaplan-Meier curves differed significantly among low, middle, and high ILD-GAPC scores (P < 0.001), unlike ILD-GAP scores (P = 0.083).

Conclusions: The ILD-GAPC model could provide more accurate information for predicting prognosis in patients with ILD than the ILD-GAP model.

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来源期刊
Canadian respiratory journal
Canadian respiratory journal 医学-呼吸系统
CiteScore
4.20
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.
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