Canadian respiratory journal最新文献

{"title":"Integrated Mindfulness and Cardiopulmonary Rehabilitation Improves Cardiopulmonary Performance and Psychological Stress in Pulmonary Arterial Hypertension.","authors":"Jingjuan Qian, Chunjie Song, Meng Yuan, Yanfeng Bai, Dan Li, Yani Chen","doi":"10.1155/carj/3058088","DOIUrl":"10.1155/carj/3058088","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of mindfulness-based stress reduction (MBSR) combined with cardiopulmonary rehabilitation (CR) training on cardiopulmonary function, oxygen delivery efficiency, and psychological stress in patients with pulmonary arterial hypertension (PAH).</p><p><strong>Methods: </strong>A total of 50 clinically stable PAH patients were randomly assigned to an intervention group (N = 25) and a control group (N = 25). The intervention group received a 6-week program combining MBSR and standardized CR, while the control group received conventional health education and standard pharmacological management. Cardiopulmonary exercise capacity, hemodynamic parameters, and psychological stress levels were assessed before and after the intervention.</p><p><strong>Results: </strong>After 6 weeks, the intervention group showed significantly improved percentage of predicted peak oxygen uptake (84.3 ± 12.1% vs. 71.2 ± 13.4%, p = 0.001), oxygen delivery (1650 ± 410 mL/min vs. 1388 ± 375 mL/min, p = 0.022), and arterial oxygen content (18.5 ± 2.1 mL/dL vs. 17.1 ± 1.8 mL/dL, p = 0.015). Hemodynamically, pulmonary vascular resistance significantly decreased (415 ± 265 vs. 586 ± 310 dyn·s/cm⁵, p = 0.040), and pulmonary artery compliance increased (2.12 ± 0.46 mL/mmHg vs. 1.76 ± 0.42 mL/mmHg, p = 0.009). In terms of psychological stress, the intervention group showed significantly lower scores in HAMA (11.28 ± 3.94 vs. 14.22 ± 4.06, p = 0.013), HAMD (11.36 ± 4.32 vs. 15.26 ± 4.89, p = 0.011), and SPBS (18.04 ± 4.83 vs. 23.02 ± 5.44, p = 0.001) compared with the control group.</p><p><strong>Conclusion: </strong>MBSR combined with CR significantly improves cardiopulmonary exercise performance, oxygen transport capacity, and hemodynamic function in PAH patients, while also reducing psychological stress levels. This combined intervention demonstrates good safety and promising clinical applicability.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e3058088"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of Radiologic Bronchiolocentric Interstitial Pneumonia Patterns and Associated Factors in Welders.","authors":"Yusuf Samir Hasanlı, İpek Candemir, Yeliz Aktürk","doi":"10.1155/carj/3335338","DOIUrl":"10.1155/carj/3335338","url":null,"abstract":"<p><strong>Background: </strong>Bronchiolocentric interstitial pneumonia (BIP) is an airway-centered pattern observed in various interstitial lung diseases. This study aimed to evaluate the clinical, occupational, and radiological factors associated with the frequency of the BIP pattern on HRCT in welders.</p><p><strong>Methods: </strong>In this retrospective cross-sectional study, an operational HRCT-based methodology was used to systematically define the BIP pattern in 73 male welders. The frequency of the BIP pattern and its associations with clinical, demographic, and occupational factors were investigated by comparing cases according to BIP status. Cases were compared according to the presence of BIP, which was defined based on operational radiological criteria. Appropriate parametric and nonparametric tests were used for statistical analyses.</p><p><strong>Results: </strong>The BIP pattern was detected in 21.9% of welders (n = 16; 13 nonfibrotic and 3 fibrotic). Although BIP frequency did not differ significantly between never-smokers and current smokers (13.3% vs. 16.2%; p = 0.102), cumulative smoking exposure was higher among BIP-positive cases (32.5 vs. 20 pack-years; p = 0.021). DLCO and KCO were significantly lower in BIP-positive cases among the 33 patients with available diffusion capacity measurements (p = 0.007 and p = 0.002, respectively). Cases with the BIP pattern also had higher mMRC dyspnea scores (p = 0.032). The most frequent HRCT findings were bronchiolar wall thickening and centrilobular ground-glass nodules.</p><p><strong>Conclusion: </strong>The BIP pattern is observed at a notable frequency on HRCT in welders. The findings suggest that BIP is not specific to hypersensitivity pneumonitis and may represent a morphological pattern associated with various inhalational etiologies. Occupational history should be carefully assessed in cases exhibiting the BIP pattern.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e3335338"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics Approach Identifies Novel Genetic Determinants and Therapeutic Targets for Asthma.","authors":"Fang Liu, Hongtao Cui, Yan Mei, Keyu Li, Yan Xu, Shuman Li, Chao Yuan","doi":"10.1155/carj/6447989","DOIUrl":"10.1155/carj/6447989","url":null,"abstract":"<p><p>Asthma constitutes a widespread chronic respiratory disease with multifactorial origins, in which definitive genetic components remain incompletely understood. This investigation synthesized transcriptomic data and Mendelian randomization (MR) to delineate causative genes contributing to asthma predisposition. Evaluation of the GSE43696 cohort disclosed 267 genes displaying expression alterations between healthy controls (n = 20) and asthmatic cases (n = 88). MR methods discerned seven causal genes, consisting of six protective determinants (GPRIN3, SHISA2, DUSP5, FCER1A, USP36, and LGALS2; OR < 1) and one risk-associated determinant (CXCL6; OR > 1). Independent validation with the GSE63142 series verified pronounced suppression of five genes in asthma specimens. Functional enrichment studies connected these genes to immune-related cascades, including IL-17/NF-κB signal transduction and Th17 cell differentiation, alongside metabolic activities. Single-cell transcriptomic assessment of 32,809 cells exposed compartmentalized expression profiles: FCER1A and LGALS2 predominated in dendritic cells, DUSP5 in goblet cells, SHISA2 in ionocytes, and USP36 in T cells. Immune cell infiltration evaluation demonstrated shifted distributions of mast cells, eosinophils, and monocytes, exhibiting substantial linkages with immune mediators such as CCR5 and CXCL10. Transcription factor exploration recognized cisbp__M0561 as the predominant regulatory element. Connectivity Map-based interrogation nominated KI-8751, verrucarin-A, and homoharringtonine as plausible therapeutic candidates. This consolidated multiomics framework elucidates previously uncharacterized pathological processes and prospective treatment avenues for asthma.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e6447989"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13175393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Individualized Nursing in Perioperative Management of Patients With Obstructive Sleep Apnea: A Retrospective Cohort Study.","authors":"Qunyu Lin, Yihong Yang, Chunmiao Huang, Dongdong Huang, Chao Fang","doi":"10.1155/carj/9293028","DOIUrl":"10.1155/carj/9293028","url":null,"abstract":"<p><strong>Background: </strong>Patients with obstructive sleep apnea (OSA) are at increased risk of perioperative complications, such as hypoxemia, respiratory depression, and airway obstruction. This study aims to evaluate the effectiveness of individualized nursing in the perioperative management of patients with OSA.</p><p><strong>Methods: </strong>We retrospectively analyzed 107 patients with OSA undergoing elective surgery between January 2023 and January 2025, who were allocated to a conventional group (n = 55) or an individualized group (n = 52) according to the nursing approach. Perioperative respiratory safety (postanesthesia care unit [PACU], minimum oxygen saturation [SpO₂], Aldrete score, and respiratory adverse events within 48 h), analgesia and functional recovery (visual analog scale [VAS] scores, opioid consumption, time to first ambulation), postoperative Epworth Sleepiness Scale (ESS) scores, continuous positive airway pressure (CPAP) adherence, Short Form-36 (SF-36) quality of life, complications, ICU transfer, length of stay, and hospitalization costs were compared between groups.</p><p><strong>Results: </strong>Compared with the conventional group, the individualized nursing group showed significantly higher PACU minimum SpO₂ (p = 0.001) and Aldrete scores (p < 0.001), a lower incidence of postoperative respiratory adverse events within 48 h (p < 0.05), reduced 24-h and 48-h VAS scores and opioid consumption (p < 0.05), and earlier ambulation (p < 0.001). During the 6-month follow-up, the individualized group demonstrated lower ESS scores, improved CPAP adherence, and greater improvements across all SF-36 domains (all p < 0.001), as well as reduced overall complications, ICU transfer rates, length of hospital stay, and hospitalization costs (p < 0.05).</p><p><strong>Conclusion: </strong>Individualized nursing is associated with improved perioperative respiratory safety and recovery quality, better long-term sleep outcomes and quality of life, and reduced complications and healthcare resource use in patients with OSA.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e9293028"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Mortality in Intensive Care Unit Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) Using an Interpretable Machine Learning Model: A Retrospective Cohort Study.","authors":"Jing Zhang, Juntao Tang, Jinjuan Li, Xinghua Liu, Ye Sun, Peng Wang","doi":"10.1155/carj/1423700","DOIUrl":"10.1155/carj/1423700","url":null,"abstract":"<p><strong>Background: </strong>Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease caused by Aspergillus infection, with severe cases often requiring admission to the intensive care unit (ICU). Early prediction of in-hospital mortality in ICU ABPA patients is crucial for optimizing clinical decision-making and resource allocation.</p><p><strong>Methods: </strong>This retrospective study collected clinical data from ICU patients diagnosed with ABPA at Yuebei People's Hospital between January 2020 and July 2024. An in-hospital mortality prediction model was developed using an explainable XGBoost machine learning algorithm. SHapley Additive Explanations (SHAP) was employed to interpret key predictive factors, and internal validation was conducted to assess model performance.</p><p><strong>Results: </strong>A total of 82 ICU ABPA patients were included, with mortality rates of 46.3% (26/57) in the training set and 48% (12/25) in the validation set. The XGBoost model demonstrated excellent predictive performance, achieving areas under the receiver operating characteristic (ROC) curve (AUC) of 0.995 (95% CI: 0.903-1.000) in the training set and 0.881 (95% CI: 0.846-0.909) in the validation set. SHAP analysis identified key predictors of mortality, including BMI, peak procalcitonin level, peak eosinophil count, age, asthma history, peak leukocyte count, and lowest platelet count.</p><p><strong>Conclusion: </strong>The XGBoost model effectively predicts in-hospital mortality in ICU ABPA patients and provides interpretable results using SHAP analysis. Although the model performed well in internal validation, external validation is needed to enhance its generalizability. Future multicenter studies and integration of dynamic biomarkers are recommended to optimize predictive accuracy and support individualized clinical decision-making.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e1423700"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity Status and Related Factors of Lung Transplant Patients Within One Year After Surgery: A Single-Center Observational Study.","authors":"Xin Chen, Xing He, DingDing Zhang, JianQiong Gao, Tian Xu, XiangLing Yue, ChunHan Cui","doi":"10.1155/carj/5036015","DOIUrl":"10.1155/carj/5036015","url":null,"abstract":"<p><strong>Background: </strong>After undergoing lung transplantation, patients' mobility is closely associated with postoperative survival outcomes. This study aimed to assess the physical activity levels of lung transplant recipients at 1-year postsurgery and identify its influencing factors.</p><p><strong>Methods: </strong>A prospective follow-up evaluation was used to investigate the relationship between preoperative, intraoperative, and postoperative clinical factors and functional recovery outcomes. The Duke activity status index (DASI) score was evaluated at 1 year after surgery. SPSS software was used for statistical analysis.</p><p><strong>Results: </strong>Thirty lung transplant recipients were enrolled, with 27 males and 3 females. The age ranged from 23 to 72 years. The mean DASI score at 1 year postoperatively was 23.84 ± 13.66 points. Univariate analysis showed that age greater than 60 years was a relevant factor influencing DASI at 1 year postoperatively in lung transplant recipients (t = 3.562, p = 0.002). Multivariate analysis indicated that factors such as being over 60 years old (β = -0.476, p = 0.010), having a lower preoperative body mass index (BMI) (β = 0.592, p = 0.003), and a shorter hospital stay in the ICU (β = 0.480, p = 0.004) might be associated with a decline in postoperative activity ability of lung transplant patients.</p><p><strong>Conclusion: </strong>This suggests that patients over 60 years of age should be prioritized for postoperative mobility management. Among the various aspects of management for lung transplant recipients, avoiding a low preoperative BMI may be more beneficial for improving their long-term postoperative mobility. These findings apply primarily to male lung-transplant patients, and the generalizability of the results needs to be validated in larger cohorts.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e5036015"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Short-Wave Diathermy to High-Frequency Chest Wall Oscillation for Acute Exacerbation of COPD: A Randomized Controlled Trial.","authors":"Qinqin Li, Jielu Sun, Lujing Ying, Zaishuang Ying","doi":"10.1155/carj/6813132","DOIUrl":"10.1155/carj/6813132","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the efficacy and safety of combining short-wave diathermy (SWD) with high-frequency chest wall oscillation (HFCWO) compared with HFCWO alone and routine treatment in patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD).</p><p><strong>Methods: </strong>This single-center, parallel-group randomized controlled trial enrolled 89 patients with AECOPD admitted to Yongkang First People's Hospital between March 2024 and March 2025. Participants were randomly assigned (1:1:1) to receive routine treatment alone (control group), routine treatment plus HFCWO (HFCWO group), or routine treatment plus combined SWD and HFCWO (combined group) for 72 h. Primary and secondary outcomes were assessed at baseline and after 72 h of intervention, with both within-group and between-group comparisons performed. Primary outcomes included changes in the COPD Assessment Test (CAT) and Breathlessness, Cough, and Sputum Scale (BCSS) scores. Secondary outcomes included lung function parameters (FEV₁, FVC, and FEV₁/FVC), arterial blood gas parameters (PaO₂ and PaCO₂), inflammatory markers (interleukin-6, C-reactive protein, and white blood cell count), and quantitative sputum indices (24-h sputum volume, total cell count, and differential counts).</p><p><strong>Results: </strong>After the 72-h intervention, the combined therapy group demonstrated significantly greater reductions in CAT and BCSS scores compared with both the HFCWO group and the control group (p < 0.05). Combined therapy also achieved superior improvements in arterial blood gas parameters (PaO₂ and PaCO₂) and sputum clearance indices (24-h sputum volume and neutrophil and eosinophil percentages) compared with HFCWO alone or routine treatment. In contrast, no significant differences were observed in lung function parameters (FEV₁ and FVC) or inflammatory markers (IL-6, CRP, and WBC).</p><p><strong>Conclusions: </strong>The combined intervention significantly improves respiratory symptoms, arterial oxygenation, and sputum clearance in patients with AECOPD compared with HFCWO alone or routine treatment. The addition of thermal therapy enhances the clinical efficacy of mechanical airway clearance, offering a feasible adjunctive strategy for acute-phase management of AECOPD.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e6813132"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Dysregulation of DNA Methylation in Epigenetics of Idiopathic Pulmonary Fibrosis.","authors":"Guorao Wu, Xinhong Tang, Yinjian Zhou, Yi Wang, Danlei Yang, Lei Zhang","doi":"10.1155/carj/2927505","DOIUrl":"10.1155/carj/2927505","url":null,"abstract":"<p><p>Idiopathic pulmonary fibrosis (IPF), the continuously advancing and frequently lethal idiopathic interstitial pneumonia, is pathologically characterized by abnormal deposition of extracellular matrix constituents, leading to progressive pulmonary scarring. Although substantial research efforts have been devoted to elucidating its pathogenesis, the etiology, molecular mechanisms, and effective treatment strategies for IPF remain inadequately characterized, contributing to a median postdiagnostic survival period of merely three to five years. Epigenetic modifications, particularly DNA methylation, have emerged as a potential missing link between the genetic background and environmental risk factors contributing to the pathogenesis of fibrotic disorders, including IPF. DNA methylation entails the attachment of a methyl group to the cytosine residue, frequently occurring at CpG dinucleotides, which are concentrated in clusters known as CpG islands and orchestrates the target gene expression. In this review, we will explore the mechanism of DNA methylation and provide insights into recent advancements concerning its role in major profibrotic cells within lung tissues during the progression of IPF, and by which, we aim to generate valuable evidence that can facilitate the advancement of antifibrotic therapies for clinical applications.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e2927505"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastroesophageal Reflux, Sleep-Disordered Breathing, and Outcomes in Patients With Idiopathic Pulmonary Fibrosis.","authors":"Braden Ellis, Daniel Morris, Andrea Peterson, Isabella Marquetti, Luke Manietta, Mikal Borg, Stephen Halliday, Amy Malik, Nathan Sandbo, Ronald Gangnon, Christopher J Francois, Mihaela Teodorescu","doi":"10.1155/carj/4228567","DOIUrl":"10.1155/carj/4228567","url":null,"abstract":"<p><strong>Background: </strong>Gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA) may negatively impact idiopathic pulmonary fibrosis (IPF), but data on their concurrent contributions are lacking. We aimed to test the contributions of GERD and sleep-disordered breathing (SDB) to IPF outcomes.</p><p><strong>Methods: </strong>We performed a cross-sectional, exploratory study on subjects with IPF. Clinically established GERD diagnosis, questionnaires (Nocturnal GERD Symptom Severity and Impact Questionnaire [N-GSSIQ], the NIH Patient-Reported Outcomes Measurement Information System [PROMIS] sleep impairment and fatigue scales, and Short Form-36 [SF-36]), full pulmonary function tests (PFT), six-minute walk test (6MWT), and nocturnal polysomnography (PSG) were obtained.</p><p><strong>Results: </strong>Among <i>n</i> = 24 subjects, 17 (71%) had clinically diagnosed GERD. N-GSSIQ scores indicated a nocturnal burden, which was adversely related to sleep impairment (<i>p</i> = 0.010) and daytime fatigue (<i>p</i> = 0.001), tiredness (<i>p</i> = 0.026) and SF-36 social functioning (<i>p</i> = 0.005), energy/fatigue (<i>p</i> = 0.015), pain (<i>p</i> = 0.030), and health change in the prior year (<i>p</i> = 0.035). From PSG, GERD correlated with worse sleep architecture (GERD diagnosis, all <i>p</i> < 0.05) and periodic leg movements index (PLMI) (N-GSSIQ, <i>p</i> = 0.02). GERD was not associated with pulmonary or exercise physiology. Overall, apnea-hypopnea index (AHI) was (median [25% quartile, 75% quartile]) 18.2 (8.1, 27.8)/h, and 19 (79%) subjects had OSA (AHI ≥ 5/h), with most (15/19 [79%]) having moderate or severe disease. SDB measures adversely related to gas exchange and distance walked (all <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>A nocturnal burden of GERD was detected and related to sleep disruption, including PLMs, and to daytime complaints. SDB/OSA, of a severity known to have significant health consequences, was common; it was adversely related to pulmonary diffusion and exercise capacity. These findings call for comprehensive, early evaluation of GERD and OSA for improved IPF outcomes.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2025 ","pages":"4228567"},"PeriodicalIF":2.1,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12745840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of <i>TFDP1</i> and <i>CDC27</i> Plays an Important Role in Bronchiectasis.","authors":"Kang-Kang Hong, Guo-Sheng Li, Rong-Quan He, Zhi-Guang Huang, Yi-Zhi Feng, Jin-Liang Kong, Lao-Dong Li","doi":"10.1155/carj/2891024","DOIUrl":"10.1155/carj/2891024","url":null,"abstract":"<p><strong>Background: </strong>Noncystic fibrosis (non-CF) bronchiectasis is a chronic respiratory disease characterized by irreversible bronchial dilation, with an increasing global prevalence and substantial clinical burden. Despite the advances in symptomatic management, the underlying molecular mechanisms remain poorly understood. Transcription factor DP-1 (<i>TFDP1</i>) and cell division cycle protein 27 (<i>CDC27</i>), which are implicated in tumorigenesis and cell cycle regulation, have not been explored in bronchiectasis.</p><p><strong>Methods: </strong>Gene expression data from the Gene Expression Omnibus dataset GSE97298 (27 patients with bronchiectasis vs. nine healthy controls) were analyzed to identify differentially expressed genes (DEGs) using edgeR (log₂ fold-change value ≥ 1.2, adj.<i>p</i> < 0.05). Protein-protein interaction (PPI) networks were constructed using STRING software. Clinical validation included 71 patients with bronchiectasis and 29 healthy controls. <i>TFDP1</i> and <i>CDC27</i> mRNA levels were quantified using real-time polymerase chain reaction. Regulatory relationships were assessed using ChIP-seq data (Cistrome DB), and pathway enrichment was performed using clusterProfiler to explore the potential molecular mechanisms of action of <i>TFDP1</i> and <i>CDC27</i> in non-CF bronchiectasis.</p><p><strong>Results: </strong>In total, 355 DEGs were identified (45 upregulated and 310 downregulated genes). <i>TFDP1</i> and <i>CDC27</i> were significantly upregulated in patients with bronchiectasis (<i>p</i> < 0.01) and exhibited a strong positive correlation (<i>r</i> = 0.6104, <i>p</i> < 0.0001). ChIP-seq confirmed <i>TFDP1</i> binding to the <i>CDC27</i> promoter region. Enrichment analysis revealed TFDP1-associated DEGs involved in the cell cycle. <i>TFDP1</i> expression was correlated with the bronchiectasis severity index (<i>r</i> = 0.2904, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>This study demonstrated the synergistic upregulation of <i>TFDP1</i> and <i>CDC27</i> in bronchiectasis and explored cell cycle regulation as an important potential mechanism by which <i>TFDP1</i> and <i>CDC27</i> contribute to the development of bronchiectasis. Therefore, <i>TFDP1</i> may serve as a biomarker of disease severity.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2025 ","pages":"2891024"},"PeriodicalIF":2.1,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}