Canadian respiratory journal最新文献

{"title":"Association Between Pulmonary Function Parameters and Apnea Hypopnea Index in Asthmatic Children Living at High Altitude.","authors":"María Isabel Escamilla, Diego Fernando Severiche-Bueno, Jennifer Benavides, Andrea Parra- Buitrago, Elida Dueñas-Mesa, Mauricio Gonzalez-Garcia","doi":"10.1155/carj/6769563","DOIUrl":"https://doi.org/10.1155/carj/6769563","url":null,"abstract":"<p><strong>Introduction: </strong>Obstructive sleep apnea (OSA) has been associated with poorer asthma outcomes in children, including reduced disease control and a greater risk of exacerbation. However, little is known about the relationship between sleep-disordered breathing severity and pulmonary function in pediatric patients residing at high altitude.</p><p><strong>Methods: </strong>We conducted a cross-sectional study including children aged 3-12 years with physician-diagnosed asthma who underwent overnight polysomnography at a referral center in Bogotá, Colombia (2640 m above sea level), between 2012 and 2017. Clinical characteristics, spirometric measurements, oscillometry parameters, and polysomnographic variables were collected and analyzed. Associations between pulmonary function indices and apnea-hypopnea measures were evaluated using Spearman correlation analysis.</p><p><strong>Results: </strong>Sixty-four children were included, of whom 59.4% had moderate-to-severe asthma and 59.4% had uncontrolled disease. In oscillometry, airway resistance at 5 Hz (R5) demonstrated an inverse correlation with AHI before bronchodilator administration (r = -0.440, p < 0.05) and after bronchodilator administration (r = -0.491, p < 0.05). Similar inverse correlations were observed between R5 and OAHI. Among spirometric variables, postbronchodilator FEV1 was negatively correlated with OAHI (r = -0.329, p < 0.05). No significant associations were found between OSA severity and asthma severity, body mass index, or nocturnal oxygen saturation.</p><p><strong>Conclusions: </strong>Our findings revealed an association between the AHI and VEF1 in asthmatic children residing in a tropical city at high altitude. However, the results regarding the relationship between AHI and R5 were contradictory.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e6769563"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Impact of Biologic Use on Asthma-Related Hospitalization: An Epidemiological Study in Hong Kong.","authors":"Wang Chun Kwok, Chung Ki Tsui, Ting Fung Ma, Shuk Man Ngai, Lu Zhou, Isaac Sze Him Leung, Man Fung Tsoi, Raymond Yau Hang Leung, Ru Zhang, James Chung Man Ho","doi":"10.1155/carj/5535762","DOIUrl":"10.1155/carj/5535762","url":null,"abstract":"<p><strong>Background: </strong>While the individual effects of biologics in asthma are well demonstrated, the potential impact of the use of biologics on overall asthma-related hospitalization at a population-based level has not been reported.</p><p><strong>Methods: </strong>A territory-wide study conducted in Hong Kong, involving all adult patients with asthma managed in Hospital Authority. The primary outcome was the change in asthma-related hospitalization from 2014 to 2023, correlating with the number of biologic use among patients with asthma and adjusted for Air Quality Health Index and influenza case number.</p><p><strong>Results: </strong>The weekly asthma-related hospitalization was 96 episodes at the start of the study period and 78 episodes at the end of the study period. There was a significant reduction of asthma-related hospitalization associated with biologic usage, giving the estimated risk ratio of 0.994 (95% CI = 0.991-0.996, p value < 0.05). The estimated break-point for the change in asthma-related hospitalization was at Week 169 (95% CI = 130.3-207.7), which was the week of 19/3/2017 to 25/3/2017. The slopes before and after the break-point were 0.022 and -0.191 with the difference in the two slope estimates being significant (p < 0.001) according to the Davies test. The significant difference in the slope before and after the break-point suggested that beyond Week 169, there was a trend of significant reduction in asthma-related hospitalization.</p><p><strong>Conclusion: </strong>We observed a reduction in asthma-related hospitalizations throughout the study period with a potential temporal association with the increase in biologic prescription. While biologics provided benefits in individual level, the possible benefits in a population-based level could be related to a more comprehensive care in severe asthma patients from the introduction of biologics for severe asthma.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e5535762"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13370790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148444581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Melatonin in Smoking Cessation and COPD Management: A Randomized Controlled Trial.","authors":"Mohsen Gholinataj Jelodar, Negin Haddad, Farahnaz Hoseinzadeh, Samaneh Mirzaei, Adeleh Sahebnasagh, Vahid Ramezani, Mohammad Hossein Mohammadi, Fatemeh Saghafi","doi":"10.1155/carj/7322988","DOIUrl":"10.1155/carj/7322988","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a leading global health concern, characterized by persistent airflow obstruction and a significant burden on quality of life. Smoking cessation is critical for COPD management, but nicotine addiction poses challenges. Emerging evidence suggests that melatonin may aid in addiction management, though its efficacy in COPD remains underexplored.</p><p><strong>Methods: </strong>This randomized, triple-blind, controlled clinical trial evaluated the impact of melatonin on nicotine dependence and COPD outcomes over 180 days. Sixty male COPD patients with a history of smoking were randomized to receive melatonin (5 mg or placebo). Smoking behavior, psychological well-being, and hospitalization rates were assessed using validated scales.</p><p><strong>Results: </strong>Both groups exhibited reduced cigarette consumption and improved psychological scores over time, with no significant differences between groups. Hospitalization rates due to COPD exacerbations were lower in the melatonin group (4% vs. 24% in placebo), indicating a nonsignificant trend that warrants further investigation, although the difference was not statistically significant.</p><p><strong>Conclusion: </strong>While melatonin did not significantly affect smoking cessation or psychological outcomes, the observed reduction in hospitalization rates should be interpreted cautiously as an exploratory finding. Larger, long-term, and adequately powered studies are needed to confirm these results and further investigate the potential role of melatonin as an adjunct therapy in COPD management.</p><p><strong>Trial registration: </strong>Iranian Registry of Clinical Trials (IRCT): IRCT20190810044500N25.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e7322988"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of CC10 Combined With CysLTs in Predicting Subsequent Wheezing in RSV-Infected Bronchiolitis.","authors":"Meng Deng, Qiujin Yuan, Sisi Chen, Zhengzhen Tang","doi":"10.1155/carj/6698429","DOIUrl":"10.1155/carj/6698429","url":null,"abstract":"<p><strong>Objective: </strong>To clarify the predictive role of club cell 10-kDa protein (CC10) and cysteinyl leukotrienes (CysLTs) for subsequent wheezing after RSV infection.</p><p><strong>Methods: </strong>From October 1, 2022, to October 31, 2023, children diagnosed with RSV-induced bronchiolitis hospitalized in the pediatric ward were included. Nasopharyngeal aspirates (NPAs) were obtained on the day of admission. NPAs from hospitalized children without respiratory infections served as the control group. We analyzed the correlation between CC10 and CysLTs levels in NPAs and disease severity. Follow-up assessments were conducted to observe the subsequent wheezing.</p><p><strong>Results: </strong>There were 169 hospitalized infants diagnosed with RSV-bronchiolitis, and 22 healthy controls matched for age were selected. The levels of CC10 in the NPAs were significantly lower in the RSV group (219.4 ± 83.1 pg/mL) than those in the control group (284.1 ± 68.1 pg/mL; p < 0.001). Levels of CysLTs were significantly greater in the RSV group (346.3 ± 98.1 pg/mL) than in the control group (288.3 ± 82.5 pg/mL; p < 0.05). Pearson correlation analysis showed that CC10 protein level was negatively correlated with severity (r² = 0.34, p < 0.001). Conversely, the level of CysLTs was positively correlated with severity (r² = 0.09, p < 0.001). 142 cases were completed with follow-up within a year after discharge. 47 cases (33.1%) had experienced subsequent wheezing, and 95 cases (66.9%) did not have subsequent wheezing. The multivariate logistic regression analysis indicates a higher likelihood of subsequent wheezing in children with CysLTs levels over 335.3 pg/mL (OR = 5.496), allergy history (OR = 3.466), and longer ventilation duration (OR = 1.364).</p><p><strong>Conclusions: </strong>While CC10 and CysLTs levels correlated with the severity of RSV-bronchiolitis, only CysLTs, along with allergy history and duration of ventilation, showed a suggestive link to subsequent wheezing, but further validation is needed.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e6698429"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Study on the Effect of Bronchial Epithelial Cell-Released Autophagosome (BA)-Induced Neutrophils on Bronchial Epithelial Cells.","authors":"Rong Gao, Yuting Wu, Hongnian Lu, Zhifa Wen, Weizhen Qiao, Tingting Wang, Xiaoshan Li","doi":"10.1155/carj/9539112","DOIUrl":"10.1155/carj/9539112","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the regulatory effects of bronchial epithelial cell-released autophagosome (BA)-induced neutrophils on bronchial epithelial cells and the underlying mechanisms.</p><p><strong>Methods: </strong>Transmission electron microscopy and western blotting were used to identify autophagosomes in 16HBE cells stimulated with house dust mite (HDM) antigen. The production of reactive oxygen species (ROS) and neutrophil extracellular traps (NETs) was detected after BA were cocultured with human peripheral blood neutrophils. Flow cytometry was used to detect the apoptosis rate of 16HBE cells incubated with cocultured supernatant, and BAX, Bcl-2, and cleaved caspase 3 expression was detected by western blotting. In mouse acute asthma, hematoxylin and eosin (HE) staining was used to detect lung tissue injury. Apoptosis was detected by TUNEL, and neutrophils, macrophages, LC3, BAX, and Bcl-2 were detected by immunohistochemistry.</p><p><strong>Results: </strong>HDM induced the release of autophagosomes by 16HBE cells. BA induced ROS production in neutrophils by activating NF-κB signaling pathway and further promotes the formation of NETs, which induced apoptosis of 16HBE cells and was mediated by the regulation of BAX, Bcl-2, and cleaved caspase 3. In the HDM-induced mouse acute asthma, the lung tissue structure was destroyed, the content of neutrophils and macrophages increased, the macrophages showed M1 polarization, and the expression of LC3, BAX, Bcl-2, and apoptosis increased.</p><p><strong>Conclusion: </strong>HDM-stimulated 16HBE cells released autophagosomes, which induced ROS production in neutrophils via NF-κB pathway activation and further promoted NET formation, ultimately leading to 16HBE cell apoptosis and lung injury in mice.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e9539112"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis\".","authors":"","doi":"10.1155/carj/9862083","DOIUrl":"10.1155/carj/9862083","url":null,"abstract":"","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e9862083"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared Genetic Susceptibility Between Asthma and Immune-Mediated Inflammatory Diseases.","authors":"Liping Zhou, Kai Sun","doi":"10.1155/carj/4534431","DOIUrl":"10.1155/carj/4534431","url":null,"abstract":"<p><strong>Background: </strong>Existing studies lack comprehensive evaluations of the genetic relationships between asthma and a broader spectrum of immune-mediated inflammatory diseases (IMIDs). This study aims to elucidate the genetic correlation and potential causal interplay between asthma and IMIDs, thereby advancing insights into their shared genetic underpinnings.</p><p><strong>Methods: </strong>Using genome-wide association study (GWAS) data, we investigated the shared genetic relationships between asthma and IMIDs through linkage disequilibrium score regression, multitrait GWAS analysis, and genotype-tissue expression analysis.</p><p><strong>Results: </strong>Among 19 IMIDs, we identified significant genetic correlations between asthma and 13 IMIDs, with the strongest correlation observed with allergic rhinitis (rg = 0.665, p = 8.79 × 10^-27). Multitrait GWAS analysis and Bayesian colocalization analysis identified 15 genetic loci with pleiotropic effects, of which nine loci exhibited shared causal relationships across multiple traits, which were predominantly clustered near genes associated with immune regulation and inflammatory response. Additionally, we demonstrated tissue- and cell-type-specific enrichment of shared signals, with significant enrichment observed in the lung and spleen, as well as in B-cells.</p><p><strong>Conclusions: </strong>Our findings reveal a significant genetic correlation between asthma and IMIDs. Further investigations are warranted to dissect the associations between these conditions and to elucidate the underlying mechanisms of the implicated loci.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e4534431"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DLGAP5 Drives Lung Adenocarcinoma Cell Growth by Promoting Autophagy Activity.","authors":"Shuying You, Xiangbo Zeng, Na Li, Lile Wang","doi":"10.1155/carj/2731987","DOIUrl":"10.1155/carj/2731987","url":null,"abstract":"<p><strong>Background: </strong>Autophagy is reported to participate in tumorigenesis and plays a vital role in tumor cell survival. Here, we aimed to elucidate the regulatory mechanism between discs large homolog-associated protein 5 (DLGAP5) and autophagy in lung adenocarcinoma (LUAD) development.</p><p><strong>Methods: </strong>RT-qPCR and western blot methods were utilized to assess DLGAP5 expression. Cell proliferation and apoptosis abilities were monitored utilizing Cell Counting Kit 8 (CCK-8), EdU, and flow cytometry assays. Autophagy-related proteins were quantified using western blot and immunofluorescence analysis. A xenograft tumor model was established to measure tumor growth.</p><p><strong>Results: </strong>DLGAP5 was significantly overexpressed in LUAD cell lines compared to 16HBE cells, especially in PC-9 and A549 cells. Functional assays highlighted that loss of function of DLGAP5 repressed cell proliferation and triggered apoptosis both in vitro and in vivo, while DLGAP5 overexpression had the opposite effect. After DLGAP5 blockage, the autophagy-related LC3II/I and Beclin1 expressions declined, while p62 expression increased. Moreover, the increased proliferation and autophagy activity and suppressed apoptosis mediated by DLGAP5 overexpression were greatly restrained after 3-MA (an autophagy-specific inhibitor).</p><p><strong>Conclusion: </strong>To sum up, DLGAP5 could contribute to proliferation and impede apoptosis of LUAD cells by activating autophagy activity, suggesting that targeting DLGAP5 might be a promising approach for LUAD treatment.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e2731987"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Bronchiectasis in Alpha-1 Antitrypsin Deficiency.","authors":"Joshua De Soyza, Philipp Höger, Paul Ellis, Oliver Weinheimer, Franziska Trudzinski, Alice M Turner","doi":"10.1155/carj/5419612","DOIUrl":"10.1155/carj/5419612","url":null,"abstract":"<p><strong>Introduction: </strong>Alpha-1 antitrypsin deficiency (AATD) may be directly related to bronchiectasis. However, radiological diagnosis of mild bronchiectasis is subjective, and visual assessment of airway tapering is time-consuming. CT algorithms have been used to quantify airway tapering in other bronchiectasis aetiologies. We assessed whether this process can be used in AATD.</p><p><strong>Methods: </strong>Historic CT scans from patients with severe AATD in the Birmingham registry were processed with YACTA software (Weinheimer et al., 2017), and data on bronchiectasis index (BEI), airway wall thickness (AWPi10) and emphysema (PD15) were extracted. Correlation with visual data was assessed using standard statistical tests. Receiver operating characteristic (ROC) curves were used to find thresholds at which algorithm data are associated with visual data. Regression models assessed the impact of algorithm data on lung function decline, exacerbation rate, mortality and bronchiectasis severity index (BSI), corrected for age, sex, smoking status and PD15.</p><p><strong>Results: </strong>A total of 154 scans were analysed. BEI correlated moderately well with visual scoring of bronchial dilatation (p < 0.001), bronchial wall thickness (BWT, p < 0.001), number of lobes affected (p < 0.001) and morphology (p < 0.001). AWPi10 did not correlate with BWT (p = 0.28). Thresholds were identified for the association of BEI with bronchial dilatation ≥ 2 × arterial diameter; lobar involvement ≥ 3 lobes, and presence of varicose or cystic morphology, though sensitivity and specificity were relatively low. BEI is associated only with BSI (p = 0.002). AWPi10 did not associate with clinical outcomes.</p><p><strong>Conclusion: </strong>Algorithm CT analysis has value in quantifying mild bronchiectasis in AATD and may be used in trials of emerging therapies.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e5419612"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Glycoprotein VI in Acute Pulmonary Embolism: Association With Radiological Thrombus Burden and Clinical Risk Indicators.","authors":"Mert Metin İnan, Mustafa Burak Sayhan, Ömer Salt, Eray Çeliktürk, Sinem Çalın, Esin Seçgin Sayhan","doi":"10.1155/carj/9286221","DOIUrl":"10.1155/carj/9286221","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pulmonary embolism (PE) is a life-threatening condition requiring rapid diagnosis and accurate risk stratification. Biomarkers reflecting thromboinflammatory processes may improve early clinical assessment. Glycoprotein VI (GPVI), a key receptor involved in platelet activation, has been implicated in thrombus formation; however, its clinical relevance in PE remains unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To examine the association of serum GPVI with radiological thrombus burden and clinical risk indicators in acute PE, while retaining the original PE-versus-control comparison only as a secondary exploratory case-control discrimination analysis, not as a diagnostic-accuracy analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this cross-sectional study, the analytic cohort comprised 50 patients with CTPA-confirmed acute PE and 25 control participants. Serum soluble GPVI (sGPVI) was measured by a colorimetric sandwich ELISA. The study-recorded CTPA thrombus-burden categories were analyzed as lower, intermediate, and higher radiological burden and separately from an exploratory ESC-aligned risk reconstruction. For ICU admission, parsimonious multivariable and incremental analyses evaluated GPVI beyond PESI with internal validation. A PE-versus-control ROC comparison with D-dimer was retained only as a secondary exploratory case-control discrimination analysis and was not treated as an estimate of diagnostic accuracy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among patients with PE, GPVI differed across the study-recorded radiological burden categories (lower, n = 16: 192.95 [185.80-215.39]; intermediate, n = 13: 258.54 [238.60-276.29]; higher, n = 21: 307.90 [285.92-321.95] ng/L; p &lt; 0.001). In the exploratory ESC-aligned analysis, GPVI differed across risk categories (Kruskal-Wallis p = 0.045) and showed an ordinal association with increasing risk category (Spearman ρ = 0.331, p = 0.02). GPVI was higher in patients admitted to the ICU than in those not admitted (298.24 [278.42-315.89] vs. 206.17 [191.15-238.33] ng/L, p &lt; 0.001) and had an ICU-admission AUC of 0.969. In a parsimonious model adjusted for PESI, GPVI remained associated with ICU admission (OR per 10 ng/L, 2.31; 95% CI, 1.36-3.92; p = 0.002), although the magnitude should be interpreted cautiously given the small sample size, limited number of ICU events, and strong separation. These effect estimates are exploratory and should not be interpreted as stable clinical effect sizes. Adding GPVI to PESI increased the apparent AUC from 0.885 to 0.968 (ΔAUC, 0.083; bootstrap 95% CI, 0.013-0.200); the optimism-corrected AUC was approximately 0.954, and repeated stratified 5-fold cross-validation yielded a mean AUC of approximately 0.916. In the secondary PE-versus-control analysis, GPVI was higher in PE (268.12 [215.39-298.47] vs. 114.07 [89.10-136.80] ng/L, p &lt; 0.001) and showed an AUC of 0.968 versus 0.884 for D-dimer (ΔAUC, 0.084; bootstrap 95% CI, 0.008-0.168; p = 0.03); thi","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2026 1","pages":"e9286221"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}