Clustered Cystic Changes in Long-Term Follow-Up Thin-Section Computed Tomographic Findings in Fibrotic Nonspecific Interstitial Pneumonia

IF 2.1 4区 医学 Q3 RESPIRATORY SYSTEM
Masanori Akira, Narufumi Suganuma
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Abstract

Objectives. The purpose of this study was to retrospectively assess cystic changes in findings on follow-up CT scans of patients with fibrotic nonspecific interstitial pneumonia (NSIP). Methods. The initial and last high-resolution CT scans of 58 patients with pathologically proven fibrotic NSIP were evaluated retrospectively. The median follow-up periods were 48 months (range, 12–183 months). The pattern, extent, and distribution of abnormal CT findings were compared with findings in the same region on previous and subsequent CT scans with a focus on cystic lesions. Results. Cystic lesions in a cluster were shown in 16 patients (28%) with fibrotic NSIP on the last CT scans. Focal clustered cysts were found in 5 cases and diffuse clustered cysts were seen in 11 cases. Focal clustered cysts mimicked honeycombing seen in usual interstitial pneumonia (UIP). Diffuse cysts were uniform in size in 7 of the 11 cases. Traction bronchiectasis in a cluster was seen in 3 of the 7 cases. The clustered cystic changes on CT during the course of NSIP mainly consisted of traction bronchiectasis and bronchiolectasis. Conclusions. Long-standing NSIP did not form honeycombing. The clustered cysts in patients with fibrotic NSIP were mainly remodeling of bronchiectasis.
纤维化非特异性间质性肺炎长期随访薄层计算机断层扫描结果中的簇状囊性变化
研究目的本研究旨在回顾性评估纤维化非特异性间质性肺炎(NSIP)患者随访 CT 扫描结果中的囊性变化。研究方法对58例经病理证实的纤维化非特异性间质性肺炎患者的初次和最后一次高分辨率CT扫描结果进行回顾性评估。中位随访时间为 48 个月(12-183 个月)。将异常 CT 结果的模式、范围和分布与之前和之后的 CT 扫描在同一区域的结果进行了比较,重点是囊性病变。结果显示在最近一次 CT 扫描中,16 名(28%)纤维化 NSIP 患者出现了成群的囊性病变。其中 5 例为局灶性簇状囊肿,11 例为弥漫性簇状囊肿。局灶性簇状囊肿与常见间质性肺炎(UIP)中的蜂窝状囊肿相似。在 11 个病例中,7 个病例的弥漫性囊肿大小一致。在 7 例病例中,有 3 例出现了簇状牵引性支气管扩张。在 NSIP 的病程中,CT 上的簇状囊变主要包括牵引性支气管扩张和支气管扩张。结论是久治不愈的 NSIP 不会形成蜂窝状囊肿。纤维化NSIP患者的簇状囊肿主要是支气管扩张的重塑。
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来源期刊
Canadian respiratory journal
Canadian respiratory journal 医学-呼吸系统
CiteScore
4.20
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.
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