Photobiomodulation, photomedicine, and laser surgery最新文献

{"title":"Laser as an Accessory Treatment in Dentistry: A Narrative Review on Its Efficacy in Complex Root Canal System Infections, Pain Control, and Dental Tissue Regeneration.","authors":"Jiayi Liu, Xiao Zhang","doi":"10.1177/25785478261453340","DOIUrl":"10.1177/25785478261453340","url":null,"abstract":"<p><p>Conventional root canal therapy relies on mechanical instrumentation and chemical irrigation; however, the complex anatomy of the root canal system often compromises complete disinfection, particularly of anaerobic bacterial biofilms, resulting in persistent or recurrent infections. Laser-assisted endodontic therapy has emerged as an effective adjunct, enhancing antimicrobial efficacy through photothermal effects, photodynamic action, and cavitation, thereby improving disinfection in anatomically inaccessible regions. In addition, laser therapy has been shown to stimulate stem cell proliferation, modulate inflammatory responses, reduce postoperative pain, and promote apical tissue regeneratiojn. Currently, Er:YAG, diode, Nd:YAG, and CO₂ lasers are widely used for refractory infection control, smear layer removal, and dentin hypersensitivity reduction. Moreover, laser-nanoparticle interactions further enhance antibacterial efficacy. This narrative review summarizes the applications of laser technology in root canal disinfection, pulp regeneration, and pain management, providing a scientific and clinical basis for the treatment of persistent fistulas and refractory root canal infections.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"401-413"},"PeriodicalIF":1.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 635 nm Photobiomodulation on Human Gingival Fibroblast Proliferation: A Preliminary In Vitro Study.","authors":"Maria Teresa Colangelo, Rita Antonelli, Francesca Marti, Roberta Iaria, Roberto Sala, Stefano Guizzardi, Carlo Galli, Paolo Vescovi, Marco Meleti","doi":"10.1177/25785478261434252","DOIUrl":"10.1177/25785478261434252","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the effects of photobiomodulation (PBM) at 635 nm on human gingival fibroblast (HGF) behavior in an in vitro wound-healing model.</p><p><strong>Background: </strong>PBM has gained increasing interest in periodontal therapy due to its potential to modulate inflammation and stimulate regenerative processes. Despite promising applications, the most effective parameters for periodontal tissue remain unclear, particularly regarding wavelength, energy density, and irradiation frequency. Understanding cellular responses under controlled conditions is essential to define PBM's therapeutic role in periodontal regeneration.</p><p><strong>Methods: </strong>HGFs were cultured in a wound-healing model and subjected to PBM using a 635 nm diode laser. Cell proliferation, migration, wound closure, and morphology were assessed at 24 and 48 h and compared with untreated controls. To distinguish proliferation from migration, wound closure was also evaluated in the presence of mitomycin C, and metabolic activity was measured by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] at 48 h.</p><p><strong>Results: </strong>PBM significantly accelerated defect closure at 24 h, with higher cell density along the wound margin and increased mitotic figures. By 48 h, wound closure percentages converged between groups. In the presence of mitomycin C, PBM did not significantly enhance migration, indicating that the early wound closure is primarily driven by proliferation. PBM-treated cultures also displayed a more uniform wound margin, suggesting moderated migratory activity. MTT assay confirmed increased metabolic activity in PBM-treated cells at 48 h.</p><p><strong>Conclusions: </strong>PBM at 635 nm promotes early enhancement of fibroblast growth and gap colonization in vitro, with effects most evident within the first 24 h. These findings suggest that PBM primarily stimulates cell growth rather than migration in the early phase of wound healing and support its potential as an adjunctive tool in gingival and soft tissue repair, particularly in contexts requiring a balance between cellular proliferation and migration.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"370-377"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Photobiomodulation into Routine Care in the Absence of Guidelines: An Approach Based on Combining Available Data from the Literature with Clinical Experience.","authors":"Lidvine Godaert, Hélène Dewaele, Antoine Lemaire, Moustapha Dramé","doi":"10.1177/25785478261443160","DOIUrl":"10.1177/25785478261443160","url":null,"abstract":"<p><p><i>Background:</i> The literature data suggests that it would be attractive to integrate photobiomodulation (PBM) into the routine management of patients in a variety of pathologies, although there are no practice guidelines to date on the indications for PBM use.<i>Objective:</i> This article presents an approach for rigorously developing medical treatment protocols for certain conditions that incorporate PBM in the absence of existing recommendations in five steps.<i>Method:</i> The first step is to determine how medical indications potentially eligible could be chosen, for example, diseases where current treatment options are not totally effective or satisfactory. The second step is to define the most appropriate PBM protocol. Experts have emphasized the need to adhere to several dosimetric parameters to ensure the effectiveness of PBM (wavelengths, fluence, irradiance, total dose, session frequency, etc.). The total energy dose delivered is of paramount importance. The third step is to choose scales to evaluate effectiveness and tolerability. The scale selected must be acceptable to the patient and informative to the operator regarding the effectiveness of the treatment by PBM. In the fourth step, the protocol must be designed to be integrated into daily practice without making it more burdensome. The final step is to objectively evaluate the protocol to decide on its relevance.<i>Conclusion:</i> At each stage, the assessment must be based on data published in the literature and expert opinions.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"394-399"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erbium-Doped Yttrium Aluminum Garnet Laser and Photochemical Functionalization of Polyetheretherketone Post Surface: Comparative Push-Out Bond Strength Evaluation Using Total-Etch and Self-Adhesive Resin Cements.","authors":"Saleh Ali Alqahtani","doi":"10.1177/25785478261442478","DOIUrl":"10.1177/25785478261442478","url":null,"abstract":"<p><strong>Aim: </strong>Evaluating the effect of surface conditioning protocols-sulfuric acid (SA), Er: YAG (erbium-doped yttrium aluminum garnet) laser, and Rose Bengal-activated photochemical functionalization (RB-PCF)-on the surface roughness (R_a) and push-out bond strength (PBS) of polyetheretherketone (PEEK) posts bonded to canal dentin using total-etch conventional resin cement (TE-CRC) and self-adhesive resin cement (SARC).</p><p><strong>Material and method: </strong>Briefly, 60 extracted, caries-free human maxillary canines were decoronated to 15 mm root length. Endodontic therapy was performed using the ProTaper Next system, followed by obturation. Post space preparation was carried out with Peeso reamers. Briefly, 90 PEEK posts were allocated into 3 groups (<i>n</i> = 30) based on the surface conditioning methods. Group 1: SA, Group 2: Er: YAG laser, Group 3: RB-PCF. R_a was assessed using a profilometer, and surface topography was evaluated by scanning electron microscopy. The remaining 20 posts were subdivided based on the cement type used for bonding to canal dentin: TE-CRC and SARC (<i>n</i> = 10 each). Specimens were sectioned into cervical, middle, and apical thirds and tested for PBS, after which failure modes were examined. Data analysis was performed using analysis of variance and post hoc Tukey (<i>p</i> < 0.05).</p><p><strong>Results: </strong>Group 1 (SA) showed the highest R_a (1.32 ± 0.32 µm), while Group 3 (RB-PCF) exhibited the lowest R_a (0.56 ± 0.21 µm). The highest PBS was observed in the cervical third of Group 1A (SA + TE-CRC), whereas the lowest occurred in the apical third of Group 3A (RB-PCF + TE-CRC).</p><p><strong>Conclusion: </strong>Er: YAG laser conditioning appears to be a viable alternative to SA for surface pretreatment of PEEK posts. Self etch resin cement showed improved performance compared with TE-CRC.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"378-386"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Er:YAG Laser for Disinfection of Infected Carious Dentin: Microbiological Evaluation and Scanning Electron Microscopy Analysis.","authors":"Maria Olivia Marcondes Pinto, Victor E Arana-Chavez, Livia Tosi Trevelin, Patricia Moreira Freitas, Sérgio Luiz Pinheiro","doi":"10.1177/25785478261444876","DOIUrl":"10.1177/25785478261444876","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the antimicrobial efficacy of Er:YAG laser for disinfection of softened carious dentin using subablative parameters.</p><p><strong>Background: </strong>Current literature lacks robust scientific evidence supporting the use of Er:YAG laser for disinfection of the entire carious dentin without mechanical removal.</p><p><strong>Methods: </strong>Ninety permanent third molars were used; 75 were allocated to microbiological evaluation and 15 to scanning electron microscopy. Artificial dentin carious lesions were produced using a microcosm biofilm model, and specimens were randomly assigned to five groups according to the cavity disinfection protocol (<i>n</i> = 15): Group C (positive control)-carious lesions with no disinfection procedure; Group antimicrobial photodynamic therapy (aPDT, negative control)-application of 0.005% methylene blue followed by low-level laser irradiation delivering 9 J of energy; Group Er:YAG, parameter A-irradiation with Er:YAG laser at 50 mJ of energy; Group Er:YAG, parameter B-irradiation at 40 mJ; and Group Er:YAG, parameter C-irradiation at 20 mJ. A repetition rate of 15 Hz was used for all Er:YAG-irradiated groups. Microbiological outcomes (CFU/mL) were analyzed using the nonparametric Kruskal-Wallis test followed by Dunn's post hoc test, with a significance level set at 5%.</p><p><strong>Results: </strong>A significant microbial reduction in dentin carious lesions was observed after irradiation with Er:YAG laser at 50 mJ (parameter A) and aPDT (<i>p</i> < 0.0001). In contrast, irradiation at 40 mJ (parameter B) and 20 mJ (parameter C) did not result in a significant reduction of the cariogenic microbiota (<i>p ></i> 0.05). No significant difference was detected between the microbial reduction achieved with Er:YAG laser at 50 mJ (parameter A) and aPDT (<i>p ></i> 0.05).</p><p><strong>Conclusions: </strong>Er:YAG laser irradiation at 50 mJ demonstrated antimicrobial efficacy comparable with aPDT for disinfection of softened carious dentin, with a shorter operative time, supporting its potential use as an alternative treatment in minimally invasive dentistry.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"387-393"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tooth Bleaching and Desensitization on Shear Bond Strength of Orthodontic Brackets.","authors":"Li Wang, Lin Li, Jiang Shang, ShengZhao Xiao","doi":"10.1177/25785478261425318","DOIUrl":"10.1177/25785478261425318","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of beyond cold light whitening and desensitization on shear bond strength of orthodontic metal brackets.</p><p><strong>Materials and methods: </strong>Ninety-eight extracted human premolars were randomly divided into seven groups (<i>n</i> = 14). Group 1 was the control (no treatment). Group 2 underwent bleaching, followed by bonding after 24 h. Group 3 received desensitization, then bonding after 24 h. Group 4 combined bleaching and desensitization, with bonding after 24 h. Groups 5, 6, and 7 followed the same procedure as Group 4, but bonding occurred 1, 2, and 3 weeks later, respectively. All samples were stored in 37°C artificial saliva after treatment and bonded with 3 M light-cure composite resin using halogen light. Shear bond strength was tested with a universal testing machine (INSTRON 5848). Adhesive remnant index (ARI) scores were assessed post-debonding. Statistical analysis was conducted using Analysis of Variance (ANOVA), Tukey's test, and chi-square tests, with significance set at <i>p</i> < 0.05.</p><p><strong>Result: </strong>The shear bond strength 24 h after bleaching (7.5 ± 1.77 MPa) was significantly lower than the control (12.24 ± 3.71 MPa, <i>p</i> < 0.05). Desensitization alone (11.68 ± 3.49 MPa) showed no significant difference compared with the control (<i>p</i> > 0.05). Shear bond strength significantly decreased 24 h after bleaching and desensitization (<i>p</i> < 0.05) but recovered to control levels after 1 week (<i>p</i> > 0.05). ARI scores showed no significant differences.</p><p><strong>Conclusions: </strong>(1) Brackets bonded 24 h after bleaching or combined treatment showed reduced shear bond strength but were clinically acceptable; (2) The use of nano-biomaterial desensitizers slightly reduces the shear strength of brackets, but it will repair the damage of teeth caused by bleaching; (3) The impacts of bleaching and desensitization gradually reduce and return to normal levels after 1 week.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"359-369"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phototherapy for Acne Vulgaris: Strategies and Clinical Applications in Sebum Modulation, Inflammation Control, and Scar Management.","authors":"Xinyi Ren, Lan Ge, Zhiqiang Song","doi":"10.1177/25785478261438102","DOIUrl":"10.1177/25785478261438102","url":null,"abstract":"<p><p><i>Background:</i> Acne vulgaris is a chronic inflammatory skin disease, and photo-based therapies have been adopted as noninvasive alternatives to pharmacological treatment.<i>Objective:</i> To systematically evaluate the therapeutic strategies and biological mechanisms of photo-based therapies in the management of acne vulgaris, focusing on sebum modulation, inflammation control, and the treatment of acne sequelae to inform phenotype-oriented clinical decision-making.<i>Methods:</i> Following PRISMA 2020 guidelines, a systematic search was conducted in PubMed and Web of Science for studies published between 2005 and 2025. From an initial 2,218 records, 64 articles comprising 42 clinical trials and 22 experimental studies were selected for inclusion based on their focus on the efficacy, safety, and molecular mechanisms of light-emitting diodes (LED), intense pulsed light (IPL), laser systems, and photodynamic therapy (PDT).<i>Results:</i> Analysis revealed that photo-based modalities target acne through three primary pathways: 1. Sebum Modulation: Aminolevulinic acid (ALA)-PDT demonstrates superior, durable efficacy in moderate-to-severe acne by inducing sebocyte apoptosis and downregulating lipogenesis via the PI3K/Akt/mTOR and OLR1-Wnt/β-catenin pathways. 2. Inflammation Control: Blue and red light (LED) and IPL provide gradual anti-inflammatory effects suitable for mild-to-moderate acne by reducing C. acnes colonization and modulating cytokines such as TGF-β1, IL-10, and TNF-α. 3. Tissue Remodeling: For acne sequelae, fractional CO2 and picosecond lasers promote collagen remodeling to improve atrophic scars, while vascular-targeted lasers (PDL, Nd:YAG) and IPL effectively reduce post-inflammatory erythema (PAE) and hyperpigmentation (PIH).<i>Conclusions:</i> Photo-based therapies are phenotype-specific rather than interchangeable. Strategies targeting sebaceous activity and inflammation are central to treating active lesions, while tissue-remodeling interventions are most effective for managing sequelae. This review establishes a strategy-oriented framework that supports personalized, evidence-based treatment planning in routine clinical practice.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"345-358"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Morphine Consumption with Photobiomodulation in Head and Neck Cancer: A Matched Cohort of 280 Cases.","authors":"Nicolas Giraud, Anne-Charlotte Delhiat, Andréa Lafitte, Jean-Pierre Sagardiluz, Margaux Yaouanq, Célestine Renard, Alexis Desbourdes, Khemaïes Slimane, Véronique Vendrely, Charles Dupin","doi":"10.1177/25785478261432857","DOIUrl":"10.1177/25785478261432857","url":null,"abstract":"<p><strong>Introduction: </strong>Radiation-induced oral mucositis (RIOM) may cause severe pain and impaired quality of life during head and neck radiotherapy (RT). Preventive photobiomodulation (PBM) has shown promising clinical benefits.</p><p><strong>Materials and methods: </strong>Eligible patients had oropharyngeal or oral cavity cancer and were opioid-naïve at the start of curative-intent RT. Patients in the PBM group were treated between 2020 and 2023. PBM was applied to the entire oral mucosa at 2.25 J/cm² (<i>λ</i> = 660 nm). Extraoral PBM was delivered using an LED cluster device at 6 J/cm² (<i>λ</i> = 810 nm) to target the pharyngolaryngeal mucosa. PBM was administered three times per week by trained radiation therapists. A historical control cohort treated between 2012 and 2019 was matched 1:1 based on tumor site, concurrent systemic therapy, and prior surgery. The primary objective was to evaluate differences in daily morphine consumption at the end of RT according to the preventive use of thrice-weekly oral PBM in patients receiving curative-intent RT for head and neck cancer.</p><p><strong>Results: </strong>A total of 280 patients were included: 45% had oral cavity cancers, 43% were treated postoperatively, and 42% received RT without systemic therapy. Morphine use was significantly lower in the PBM group at the end of RT (22.9 vs. 37.4 mg/day; <i>p</i> = 0.002) and 1 month post-RT (10.3 vs. 27.2 mg/day; <i>p</i> = 0.0001). No morphine was required in 60% of PBM patients compared with 47% of controls. PBM appeared particularly beneficial in oropharyngeal cancer, in patients receiving definitive RT, and with concurrent treatment. In contrast, rates of grade 3-4 RIOM at the end of RT were identical (63% in both groups), and grade 3-4 mucositis-free survival did not differ (<i>p</i> = 0.99).</p><p><strong>Conclusion: </strong>In this large matched cohort, preventive PBM reduced morphine consumption during and after RT, supporting its use to alleviate RIOM-related pain in head and neck cancer patients.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"336-343"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Adjunctive Photodynamic Therapy with Periodontal Regenerative Surgery in Severe Periodontitis: A Randomized Controlled Trial on Gingival Thickness Remodeling and Inflammatory Cytokine Modulation.","authors":"Dahai Huang, Lu Wang, Xiangyun Wang","doi":"10.1177/25785478261424556","DOIUrl":"10.1177/25785478261424556","url":null,"abstract":"<p><strong>Objective: </strong>Assess clinical efficacy of photodynamic therapy (PDT) combined with periodontal regenerative surgery (PTR) in severe periodontitis, focusing on gingival thickness (GT), inflammatory markers, and bone repair.</p><p><strong>Methods: </strong>Sixty patients were randomized to Combination (PDT + PTR) or Control (PTR alone) groups. PDT utilized 660 nm laser with methylene blue. Outcomes included probing depth (PD), clinical attachment loss (CAL), bleeding on probing (BOP), keratinized tissue width (KTW), GT, cone-beam computed tomography bone parameters, and gingival crevicular fluid cytokines (IL-1β, TNF-α, PGE2, MMP-8) at 3/6/12 months.</p><p><strong>Results: </strong>At 12 months, Combination group showed superior PD reduction (<i>p</i> < 0.05), CAL gain (<i>p</i> < 0.05), lower BOP (16.67% vs. 43.33%, <i>p</i> < 0.05), increased KTW/GT, and enhanced bone density/defect filling versus Control. Inflammatory markers were significantly reduced at 3 months (<i>p</i> < 0.05). Three-wall defects exhibited better CAL/GT outcomes than two-wall defects (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The combined PDT and PTR therapy demonstrated significant improvements in key clinical parameters, reduced inflammatory biomarkers, and enhanced radiographic bone fill in severe periodontitis patients.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"302-312"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Acne Scar Treatment in Indian Skin with Fractional Picosecond Laser.","authors":"Byalakere Shivanna Chandrashekar, Chaithra Shenoy, Paulomi Vartak, Oliver Clement Lobo, Mysore Seshadri Roopa, Irene Fusco, Tiziano Zingoni","doi":"10.1177/25785478251404194","DOIUrl":"10.1177/25785478251404194","url":null,"abstract":"<p><strong>Background: </strong>Patients of Asian descent with Fitzpatrick skin types III-V who experience facial acne scars are a relatively under-researched demographic in medical literature, with limited studies specifically addressing their unique skin characteristics and treatment responses. Traditional treatments have variable efficacy and risk of complications. A novel technique that has shown potential in managing scars is the Q-Switched, 1064 nm neodymium-doped yttrium aluminum garnet laser with a fractional beam profile. Picosecond lasers, with extremely short pulse durations, minimize thermal damage and induce tissue remodeling, reducing post-inflammatory hyperpigmentation risk.</p><p><strong>Aim: </strong>This prospective study was proposed to judge the efficacy of 1064 nm fractional picosecond laser for treating atrophic acne scars in the Indian skin type.</p><p><strong>Methods: </strong>Twenty-two patients completed the study; all were treated at monthly intervals for three sessions. Evaluation based on Investigator's Global assessment along with patient satisfaction scores was carried out for all patients. The safety of the laser was evaluated by noting down adverse effects.</p><p><strong>Results: </strong>Fourteen patients showed improvement of 26-50% by Investigator's Global Assessment, which was similar to the patient satisfaction scores. Post-treatment edema, pinpoint bleeding, and mild erythema were the only side effects noted. Postinflammatory hyperpigmentation was not noted in any of the patients.</p><p><strong>Conclusions: </strong>Fractional picosecond laser can be considered a viable and safe option to treat acne scars in patients with dark skin type.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"288-292"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}